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PMC:7068984 / 3242-14020 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
133 1791-1799 Gene denotes ORF 1a/b Gene:43740578
134 2130-2161 Gene denotes angiotensin-converting enzyme 2 Gene:59272
135 2163-2167 Gene denotes ACE2 Gene:59272
136 2071-2072 Gene denotes S Gene:43740568
137 1293-1303 Species denotes SARS-CoV-2 Tax:2697049
138 1349-1362 Species denotes coronaviruses Tax:11118
139 1374-1419 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
140 1421-1429 Species denotes SARS-CoV Tax:694009
141 1446-1456 Species denotes SARS-CoV-2 Tax:2697049
142 1546-1552 Species denotes humans Tax:9606
143 1641-1651 Species denotes SARS-CoV-2 Tax:2697049
144 1705-1716 Species denotes coronavirus Tax:11118
145 2089-2099 Species denotes SARS-CoV-2 Tax:2697049
146 2272-2282 Species denotes SARS-CoV-2 Tax:2697049
147 2482-2488 Species denotes people Tax:9606
148 2532-2542 Species denotes SARS-CoV-2 Tax:2697049
149 2431-2440 Disease denotes infection MESH:D007239
181 1113-1144 Gene denotes angiotensin-converting enzyme 2 Gene:59272
182 1146-1150 Gene denotes ACE2 Gene:59272
183 42-52 Species denotes SARS-CoV-2 Tax:2697049
184 58-71 Species denotes β-coronavirus Tax:694002
185 190-203 Species denotes Coronaviruses Tax:11118
186 205-208 Species denotes CoV Tax:11118
187 261-264 Species denotes CoV Tax:11118
188 273-278 Species denotes β-CoV Tax:694002
189 322-325 Species denotes CoV Tax:11118
190 364-368 Species denotes CoVs Tax:11118
191 393-398 Species denotes human Tax:9606
192 432-436 Species denotes CoVs Tax:11118
193 437-446 Species denotes HCoV-229E Tax:11137
194 451-460 Species denotes HCoV-NL63 Tax:277944
195 468-472 Species denotes CoVs Tax:11118
196 473-482 Species denotes HCoV-HKU1 Tax:290028
197 487-496 Species denotes HCoV-OC43 Tax:31631
198 615-619 Species denotes CoVs Tax:11118
199 621-629 Species denotes SARS-CoV Tax:694009
200 634-642 Species denotes MERS-CoV Tax:1335626
201 755-765 Species denotes SARS-CoV-2 Tax:2697049
202 794-797 Species denotes CoV Tax:11118
203 842-850 Species denotes SARS-CoV Tax:694009
204 980-990 Species denotes SARS-CoV-2 Tax:2697049
205 1063-1069 Species denotes humans Tax:9606
206 1092-1102 Species denotes SARS-CoV-2 Tax:2697049
207 1174-1182 Species denotes SARS-CoV Tax:694009
208 1198-1204 Species denotes humans Tax:9606
209 532-552 Disease denotes respiratory symptoms MESH:D012818
210 573-577 Disease denotes cold MESH:D000067390
211 680-708 Disease denotes respiratory tract infections MESH:D012141
223 2930-2940 Species denotes SARS-CoV-2 Tax:2697049
224 3006-3016 Species denotes SARS-CoV-2 Tax:2697049
225 3106-3110 Species denotes CoVs Tax:11118
226 3122-3130 Species denotes SARS-CoV Tax:694009
227 3140-3148 Species denotes MERS-CoV Tax:1335626
228 3256-3259 Species denotes CoV Tax:11118
229 3342-3345 Species denotes CoV Tax:11118
230 3350-3355 Species denotes human Tax:9606
231 3356-3366 Species denotes SARS-CoV-2 Tax:2697049
232 2738-2771 Disease denotes respiratory tract infection broke MESH:D012141
233 3205-3213 Disease denotes COVID-19 MESH:C000657245
252 3713-3718 Species denotes Human Tax:9606
253 3722-3727 Species denotes human Tax:9606
254 3744-3754 Species denotes SARS-CoV-2 Tax:2697049
255 3855-3863 Species denotes patients Tax:9606
256 3922-3930 Species denotes patients Tax:9606
257 3970-3978 Species denotes patients Tax:9606
258 3995-4001 Species denotes people Tax:9606
259 4023-4031 Species denotes patients Tax:9606
260 4128-4136 Species denotes patients Tax:9606
261 4242-4250 Species denotes SARS-CoV Tax:694009
262 4255-4263 Species denotes MERS-CoV Tax:1335626
263 4407-4415 Species denotes patients Tax:9606
264 4467-4475 Species denotes MERS-CoV Tax:1335626
265 4607-4617 Species denotes SARS-CoV-2 Tax:2697049
266 4686-4696 Species denotes SARS-CoV-2 Tax:2697049
267 4119-4127 Disease denotes COVID-19 MESH:C000657245
268 4325-4335 Disease denotes Infections MESH:D007239
269 4454-4463 Disease denotes infection MESH:D007239
309 5205-5212 Gene denotes ORF1a/b Gene:43740578
310 5243-5247 Gene denotes pp1a Gene:5499
311 6295-6299 Gene denotes NSP7 Gene:43740578
312 6369-6373 Gene denotes NSP2 Gene:43740578
313 6375-6379 Gene denotes NSP3 Gene:43740578
314 6381-6386 Gene denotes spike Gene:43740568
315 6496-6500 Gene denotes NSP2 Gene:43740578
316 6505-6509 Gene denotes NSP3 Gene:43740578
317 6308-6316 Gene denotes envelope Gene:43740570
318 7284-7285 Gene denotes S Gene:43740568
319 7232-7233 Gene denotes S Gene:43740568
320 4788-4795 Species denotes patient Tax:9606
321 4869-4880 Species denotes coronavirus Tax:11118
322 4903-4913 Species denotes SARS-CoV-2 Tax:2697049
323 4938-4946 Species denotes SARS-CoV Tax:694009
324 4951-4959 Species denotes MERS-CoV Tax:1335626
325 5072-5076 Species denotes CoVs Tax:11118
326 5829-5837 Species denotes SARS-CoV Tax:694009
327 5950-5955 Species denotes human Tax:9606
328 5994-6002 Species denotes SARS-CoV Tax:694009
329 6007-6015 Species denotes MERS-CoV Tax:1335626
330 6024-6034 Species denotes SARS-CoV-2 Tax:2697049
331 6066-6070 Species denotes CoVs Tax:11118
332 6143-6153 Species denotes SARS-CoV-2 Tax:2697049
333 6169-6178 Species denotes SARS-CoVs Tax:694009
334 6580-6590 Species denotes SARS-CoV-2 Tax:2697049
335 6606-6612 Species denotes people Tax:9606
336 6684-6694 Species denotes SARS-CoV-2 Tax:2697049
337 6699-6707 Species denotes SARS-CoV Tax:694009
338 6846-6854 Species denotes patients Tax:9606
339 6893-6903 Species denotes SARS-CoV-2 Tax:2697049
340 6934-6942 Species denotes patients Tax:9606
341 6995-7005 Species denotes SARS-CoV-2 Tax:2697049
342 7129-7139 Species denotes SARS-CoV-2 Tax:2697049
343 7201-7211 Species denotes SARS-CoV-2 Tax:2697049
344 7409-7426 Species denotes novel coronavirus Tax:2697049
345 7049-7058 Species denotes influenza Tax:11309
346 4769-4787 Disease denotes COVID-19 pneumonia MESH:C000657245
347 6824-6832 Disease denotes COVID-19 MESH:C000657245
349 7477-7488 Species denotes Coronavirus Tax:11118
367 7518-7522 Gene denotes ACE2 Gene:59272
368 7858-7862 Gene denotes ACE2 Gene:59272
369 7961-7965 Gene denotes ACE2 Gene:59272
370 8384-8388 Gene denotes pp1a Gene:5499
371 8695-8697 Gene denotes ER Gene:2069
372 8741-8753 Gene denotes nucleocapsid Gene:43740575
373 7564-7570 Species denotes humans Tax:9606
374 7602-7610 Species denotes SARS-CoV Tax:694009
375 7657-7662 Species denotes human Tax:9606
376 7666-7671 Species denotes human Tax:9606
377 7759-7766 Species denotes patient Tax:9606
378 7808-7818 Species denotes SARS-CoV-2 Tax:2697049
379 7867-7875 Species denotes SARS-CoV Tax:694009
380 7921-7932 Species denotes coronavirus Tax:11118
381 7984-7989 Species denotes human Tax:9606
382 8767-8775 Gene denotes envelope Gene:43740570
383 7750-7758 Disease denotes COVID-19 MESH:C000657245
422 8954-8959 Gene denotes Spike Gene:43740568
423 8981-8985 Gene denotes ACE2 Gene:59272
424 9193-9197 Gene denotes ACE2 Gene:59272
425 9213-9235 Gene denotes Dipeptidyl peptidase-4 Gene:1803
426 9237-9241 Gene denotes DPP4 Gene:1803
427 9246-9249 Gene denotes APN Gene:290
428 9251-9267 Gene denotes Aminopeptidase N Gene:290
429 9357-9361 Gene denotes ACE2 Gene:59272
430 9612-9643 Gene denotes transmembrane protease serine 2 Gene:7113
431 9645-9652 Gene denotes TMPRSS2 Gene:7113
432 8961-8962 Gene denotes S Gene:43740568
433 9479-9484 Gene denotes Spike Gene:43740568
434 8943-8953 Species denotes SARS-CoV-2 Tax:2697049
435 9142-9147 Species denotes β-CoV Tax:694002
436 9170-9175 Species denotes human Tax:9606
437 9207-9212 Species denotes human Tax:9606
438 9293-9303 Species denotes SARS-CoV-2 Tax:2697049
439 9420-9428 Species denotes SARS-CoV Tax:694009
440 9468-9478 Species denotes SARS-CoV-2 Tax:2697049
441 9525-9533 Species denotes SARS-CoV Tax:694009
442 9746-9756 Species denotes SARS-CoV-2 Tax:2697049
443 9859-9869 Species denotes SARS-CoV-2 Tax:2697049
444 9917-9922 Species denotes human Tax:9606
445 9945-9950 Species denotes human Tax:9606
446 9951-9959 Species denotes SARS-CoV Tax:694009
447 10016-10022 Species denotes people Tax:9606
448 10439-10449 Species denotes SARS-CoV-2 Tax:2697049
449 10480-10488 Species denotes SARS-CoV Tax:694009
450 10493-10501 Species denotes MERS-CoV Tax:1335626
451 10676-10681 Species denotes human Tax:9606
452 10685-10690 Species denotes human Tax:9606
453 10737-10747 Species denotes SARS-CoV-2 Tax:2697049
454 9923-9932 Disease denotes infection MESH:D007239
455 10007-10015 Disease denotes infected MESH:D007239
456 10147-10156 Disease denotes pneumonia MESH:D011014
457 10531-10540 Disease denotes mortality MESH:D003643
458 10544-10552 Disease denotes COVID-19 MESH:C000657245
459 10573-10578 Disease denotes death MESH:D003643

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T5 121-124 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T6 680-697 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T7 736-742 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T8 867-873 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T9 1693-1696 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T10 1738-1741 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T11 1827-1835 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T12 1871-1877 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T13 1912-1920 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T14 1942-1954 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T15 1975-1982 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 1995-2002 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T17 2025-2032 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 2061-2069 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T19 2073-2085 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T20 2114-2118 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T21 2326-2334 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T22 2738-2755 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T23 3182-3188 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T24 3242-3248 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T25 3292-3298 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T26 3477-3484 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 4714-4720 Body_part denotes Genome http://purl.org/sig/ont/fma/fma84116
T28 4848-4854 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T29 4980-4983 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T30 4984-4991 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T31 5062-5068 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T32 5167-5170 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T33 5289-5297 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T34 5362-5370 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T35 5395-5401 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T36 5436-5444 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T37 5466-5478 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T38 5499-5506 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T39 5519-5526 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T40 5549-5556 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T41 5590-5598 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T42 5861-5873 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T43 5874-5878 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T44 6016-6022 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T45 6093-6099 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T46 6131-6139 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T47 6225-6232 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 6253-6263 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T49 6339-6347 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T50 6387-6394 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T51 7140-7147 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T52 7537-7560 Body_part denotes lower respiratory tract http://purl.org/sig/ont/fma/fma45662
T53 7584-7588 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T54 7890-7902 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T55 7990-7995 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T56 8004-8016 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T57 8172-8185 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T58 8172-8176 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T59 8291-8297 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T60 8298-8301 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T61 8323-8332 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T62 8351-8354 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T63 8433-8441 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T64 8628-8636 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T65 8652-8660 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T66 8672-8693 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T67 8695-8697 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T68 8736-8739 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T69 8754-8762 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T70 8776-8789 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T71 8882-8897 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T72 8964-8976 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T73 9176-9181 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T74 9345-9352 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T75 9560-9567 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 9588-9600 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T77 9588-9592 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T78 9635-9641 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 680-697 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T4 2738-2755 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T5 7537-7560 Body_part denotes lower respiratory tract http://purl.obolibrary.org/obo/UBERON_0001558
T6 7543-7560 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p13914s6 9343-9352 Protein denotes S-protein
p13914s10 9357-9361 Protein denotes ACE2
p13914s11 9362-9369 Interaction denotes binding

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T31 27-35 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 42-50 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 566-577 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T34 621-629 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 680-708 Disease denotes respiratory tract infections http://purl.obolibrary.org/obo/MONDO_0024355
T36 755-763 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 842-850 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 980-988 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 1092-1100 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 1174-1182 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 1293-1301 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 1374-1407 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T43 1421-1429 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 1446-1454 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 1641-1649 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 2089-2097 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 2272-2280 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 2431-2440 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49 2532-2540 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 2738-2765 Disease denotes respiratory tract infection http://purl.obolibrary.org/obo/MONDO_0024355
T51 2756-2765 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T52 2930-2938 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 3006-3014 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 3122-3130 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T55 3205-3213 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T56 3356-3364 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 3744-3752 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 4119-4127 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T59 4242-4250 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 4371-4375 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T61 4454-4463 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T62 4607-4615 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 4686-4694 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 4769-4777 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T65 4778-4787 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T66 4903-4911 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 4938-4946 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 5829-5837 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 5994-6002 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 6024-6032 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T71 6052-6056 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T72 6143-6151 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 6169-6173 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T74 6525-6535 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T75 6580-6588 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T76 6684-6692 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 6699-6707 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 6824-6832 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T79 6893-6901 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 6995-7003 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T81 7043-7058 Disease denotes avian influenza http://purl.obolibrary.org/obo/MONDO_0018695
T82 7049-7058 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T83 7129-7137 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T84 7201-7209 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 7602-7610 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 7750-7758 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T87 7808-7816 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T88 7867-7875 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T89 8943-8951 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T90 9293-9301 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T91 9420-9428 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 9468-9476 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 9525-9533 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T94 9746-9754 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 9859-9867 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T96 9923-9932 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T97 9951-9959 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T98 10147-10156 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T99 10439-10447 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 10480-10488 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T101 10544-10552 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 10587-10591 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 10737-10745 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T23 56-57 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T24 125-130 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T25 393-398 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T26 411-416 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T27 564-565 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 788-789 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 790-793 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T30 861-866 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T31 920-923 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T32 924-927 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T33 962-967 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T34 1017-1021 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T35 1063-1069 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T36 1198-1204 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T37 1305-1309 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes Bats
T38 1331-1332 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 1437-1444 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T40 1476-1480 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T41 1546-1552 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T42 1554-1559 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T43 1798-1799 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T44 1865-1870 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T45 2114-2118 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T46 2178-2179 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T47 2198-2203 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T48 2246-2254 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T49 2320-2325 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T50 2843-2844 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 2892-2895 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T52 3054-3058 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T53 3088-3089 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 3154-3161 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T55 3163-3165 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T56 3176-3181 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T57 3338-3341 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T58 3350-3355 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T59 3407-3411 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T60 3713-3718 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T61 3722-3727 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T62 4487-4489 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T63 4530-4537 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T64 4561-4568 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T65 4767-4768 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T66 4797-4798 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 4923-4925 http://purl.obolibrary.org/obo/CLO_0007074 denotes kb
T68 4923-4925 http://purl.obolibrary.org/obo/CLO_0051988 denotes kb
T69 5000-5002 http://purl.obolibrary.org/obo/CLO_0007074 denotes kb
T70 5000-5002 http://purl.obolibrary.org/obo/CLO_0051988 denotes kb
T71 5012-5014 http://purl.obolibrary.org/obo/CLO_0007074 denotes kb
T72 5012-5014 http://purl.obolibrary.org/obo/CLO_0051988 denotes kb
T73 5038-5041 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T74 5086-5087 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 5107-5109 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T76 5211-5212 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T77 5389-5394 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T78 5874-5878 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T79 5950-5955 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T80 6062-6065 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T81 6348-6350 http://purl.obolibrary.org/obo/CLO_0008339 denotes p6
T82 6431-6433 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T83 6515-6516 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 7092-7093 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T85 7537-7560 http://purl.obolibrary.org/obo/UBERON_0001558 denotes lower respiratory tract
T86 7564-7570 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T87 7584-7588 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T88 7612-7614 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T89 7657-7662 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T90 7666-7671 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T91 7748-7749 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 7984-7995 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T93 8040-8042 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T94 8047-8049 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T95 8047-8049 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T96 8056-8058 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T97 8074-8079 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T98 8154-8156 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T99 8154-8156 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T100 8166-8171 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T101 8172-8176 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T102 8177-8185 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T103 8264-8272 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T104 8502-8510 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T105 8520-8522 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T106 8567-8568 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T107 8600-8602 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T108 8710-8712 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T109 8882-8888 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T110 8889-8897 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T111 8913-8918 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T112 8998-8999 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T113 9018-9023 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T114 9031-9036 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T115 9170-9181 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T116 9207-9212 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T117 9588-9592 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T118 9720-9728 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T119 9917-9922 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T120 9945-9950 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T121 10616-10618 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T122 10676-10681 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T123 10685-10690 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T5 1113-1124 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T6 1827-1835 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T7 1912-1920 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T8 1942-1954 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T9 1975-1982 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T10 1995-2002 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T11 2025-2032 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 2061-2069 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T13 2073-2085 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T14 2130-2141 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T15 2224-2233 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T16 2326-2334 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T17 3477-3484 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T18 3878-3886 Chemical denotes carriers http://purl.obolibrary.org/obo/CHEBI_78059
T19 5289-5297 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T20 5362-5370 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T21 5436-5444 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T22 5466-5478 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T23 5499-5506 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T24 5519-5526 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T25 5549-5556 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T26 5590-5598 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T27 5861-5873 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T28 6131-6139 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T29 6225-6232 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T30 6253-6263 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T31 6253-6258 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T32 6259-6263 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T33 6339-6347 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T34 6387-6394 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35 7890-7902 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T36 8004-8016 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T37 8047-8049 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T38 8154-8156 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T39 8433-8441 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T40 8628-8636 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T41 8652-8660 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T42 8754-8762 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T43 8776-8789 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T44 8964-8976 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T45 9345-9352 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46 9448-9450 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T47 9560-9567 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48 9635-9641 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T49 9698-9707 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 1277-1289 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T4 1554-1577 http://purl.obolibrary.org/obo/GO_0019048 denotes Virus-host interactions
T5 2246-2267 http://purl.obolibrary.org/obo/GO_0010324 denotes membrane invagination
T6 2283-2294 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T7 2353-2365 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T8 5629-5651 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T9 5636-5651 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T10 6651-6658 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T11 7452-7461 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T12 7452-7461 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T13 7505-7517 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T14 8104-8111 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T15 8177-8192 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T16 8264-8279 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T17 8464-8477 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T18 9720-9741 http://purl.obolibrary.org/obo/GO_0010324 denotes membrane invagination
T19 9757-9768 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T21 0-37 Sentence denotes Origin and transmission of SARS-CoV-2
T22 38-189 Sentence denotes The SARS-CoV-2 is a β-coronavirus, which is enveloped non-segmented positive-sense RNA virus (subgenus sarbecovirus, Orthocoronavirinae subfamily) [6].
T23 190-347 Sentence denotes Coronaviruses (CoV) are divided into four genera, including α−/β−/γ−/δ-CoV. α- and β-CoV are able to infect mammals, while γ- and δ-CoV tend to infect birds.
T24 348-592 Sentence denotes Previously, six CoVs have been identified as human-susceptible virus, among which α-CoVs HCoV-229E and HCoV-NL63, and β-CoVs HCoV-HKU1 and HCoV-OC43 with low pathogenicity, cause mild respiratory symptoms similar to a common cold, respectively.
T25 593-713 Sentence denotes The other two known β-CoVs, SARS-CoV and MERS-CoV lead to severe and potentially fatal respiratory tract infections [7].
T26 714-851 Sentence denotes It was found that the genome sequence of SARS-CoV-2 is 96.2% identical to a bat CoV RaTG13, whereas it shares 79.5% identity to SARS-CoV.
T27 852-1070 Sentence denotes Based on virus genome sequencing results and evolutionary analysis, bat has been suspected as natural host of virus origin, and SARS-CoV-2 might be transmitted from bats via unknown intermediate hosts to infect humans.
T28 1071-1227 Sentence denotes It is clear now that SARS-CoV-2 could use angiotensin-converting enzyme 2 (ACE2), the same receptor as SARS-CoV [8], to infect humans (upper panel, Fig. 1).
T29 1228-1304 Sentence denotes Fig. 1 Viral and host factors that influence the pathogenesis of SARS-CoV-2.
T30 1305-1445 Sentence denotes Bats are the reservoir of a wide variety of coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV) -like viruses.
T31 1446-1553 Sentence denotes SARS-CoV-2 may originate from bats or unknown intermediate hosts and cross the species barrier into humans.
T32 1554-1613 Sentence denotes Virus-host interactions affect viral entry and replication.
T33 1614-1626 Sentence denotes Upper panel:
T34 1627-1640 Sentence denotes Viral factor.
T35 1641-1717 Sentence denotes SARS-CoV-2 is an enveloped positive single-stranded RNA (ssRNA) coronavirus.
T36 1718-1843 Sentence denotes Two-thirds of viral RNA, mainly located in the first open reading frame (ORF 1a/b), encodes 16 non-structure proteins (NSPs).
T37 1844-2070 Sentence denotes The rest part of the virus genome encodes four essential structural proteins, including spike (S) glycoprotein, small envelope (E) protein, matrix (M) protein, and nucleocapsid (N) protein, and also several accessory proteins.
T38 2071-2210 Sentence denotes S glycoprotein of SARS-CoV-2 binds to host cell receptors, angiotensin-converting enzyme 2 (ACE2), that is a critical step for virus entry.
T39 2211-2313 Sentence denotes The possible molecules facilitated membrane invagination for SARS-CoV-2 endocytosis are still unclear.
T40 2314-2366 Sentence denotes Other virus proteins may contribute to pathogenesis.
T41 2367-2465 Sentence denotes Host factors (Lower panel) can also influence susceptibility to infection and disease progression.
T42 2466-2588 Sentence denotes The elderly and people with underlying disease are susceptible to SARS-CoV-2 and tend to develop into critical conditions.
T43 2589-2663 Sentence denotes RBD, receptor-binding domain; HR1, heptad repeats 1; HR2, heptad repeats 2
T44 2665-2707 Sentence denotes Epidemiology − reservoirs and transmission
T45 2708-2860 Sentence denotes The epidemic of unknown acute respiratory tract infection broke out first in Wuhan, China, since 12 December 2019, possibly related to a seafood market.
T46 2861-2949 Sentence denotes Several studies suggested that bat may be the potential reservoir of SARS-CoV-2 [9, 10].
T47 2950-3045 Sentence denotes However, there is no evidence so far that the origin of SARS-CoV-2 was from the seafood market.
T48 3046-3170 Sentence denotes Rather, bats are the natural reservoir of a wide variety of CoVs, including SARS-CoV-like and MERS-CoV-like viruses [11–13].
T49 3171-3467 Sentence denotes Upon virus genome sequencing, the COVID-19 was analyzed throughout the genome to Bat CoV RaTG13 and showed 96.2% overall genome sequence identity [8], suggesting that bat CoV and human SARS-CoV-2 might share the same ancestor, although bats are not available for sale in this seafood market [14].
T50 3468-3712 Sentence denotes Besides, protein sequences alignment and phylogenetic analysis [15] showed that similar residues of receptor were observed in many species, which provided more possibility of alternative intermediate hosts, such as turtles, pangolin and snacks.
T51 3713-3887 Sentence denotes Human-to-human transmission of SARS-CoV-2 occurs mainly between family members, including relatives and friends who intimately contacted with patients or incubation carriers.
T52 3888-4058 Sentence denotes It is reported [16] that 31.3% of patients recent travelled to Wuhan and 72.3% of patients contacting with people from Wuhan among the patients of non-residents of Wuhan.
T53 4059-4208 Sentence denotes Transmission between healthcare workers occurred in 3.8% of COVID-19 patients, issued by the National Health Commission of China on 14 February 2020.
T54 4209-4324 Sentence denotes By contrast, the transmission of SARS-CoV and MERS-CoV is reported to occur mainly through nosocomial transmission.
T55 4325-4491 Sentence denotes Infections of healthcare workers in 33–42% of SARS cases and transmission between patients (62–79%) was the most common route of infection in MERS-CoV cases [17, 18].
T56 4492-4631 Sentence denotes Direct contact with intermediate host animals or consumption of wild animals was suspected to be the main route of SARS-CoV-2 transmission.
T57 4632-4712 Sentence denotes However, the source(s) and transmission routine(s) of SARS-CoV-2 remain elusive.
T58 4714-4752 Sentence denotes Genome structure and key viral factors
T59 4753-4931 Sentence denotes Isolated from a COVID-19 pneumonia patient, a worker in the Wuhan seafood market, the complete genome of Wuhan-Hu-1 coronavirus (WHCV), one strain of SARS-CoV-2, is 29.9 kb [14].
T60 4932-5034 Sentence denotes While SARS-CoV and MERS-CoV have positive-sense RNA genomes of 27.9 kb and 30.1 kb, respectively [19].
T61 5035-5146 Sentence denotes It has been shown that the genome of CoVs contains a variable number (6–11) of open reading frames (ORFs) [20].
T62 5147-5371 Sentence denotes Two-thirds of viral RNA, mainly located in the first ORF (ORF1a/b) translates two polyproteins, pp1a and pp1ab, and encodes 16 non-structural proteins (NSP), while the remaining ORFs encode accessory and structural proteins.
T63 5372-5652 Sentence denotes The rest part of virus genome encodes four essential structural proteins, including spike (S) glycoprotein, small envelope (E) protein, matrix (M) protein, and nucleocapsid (N) protein [21], and also several accessory proteins, that interfere with the host innate immune response.
T64 5653-5770 Sentence denotes Wu et al. [14] have recently performed deep meta-transcriptomic sequencing on WHCV, which contained 16 predicted NSP.
T65 5771-5969 Sentence denotes WHCV exhibits some genomic and phylogenetic similarity to SARS-CoV, particularly in the S-glycoprotein gene and receptor-binding domain (RBD), indicating the capability of direct human transmission.
T66 5970-6109 Sentence denotes Compared with the known SARS-CoV and MERS-CoV genome, SARS-CoV-2 is closer to the SARS-like bat CoVs in terms of the whole genome sequence.
T67 6110-6217 Sentence denotes Most genomic encoded proteins of SARS-CoV-2 are similar to SARS-CoVs, as well as exist certain differences.
T68 6218-6435 Sentence denotes At the protein level, there are no amino acid substitutions that occurred in NSP7, NSP13, envelope, matrix, or accessory proteins p6 and 8b, except in NSP2, NSP3, spike protein, underpinning subdomain, i.e., RBD [22].
T69 6436-6591 Sentence denotes Another recent research suggested [23] that the mutation in NSP2 and NSP3 play a role in infectious capability and differentiation mechanism of SARS-CoV-2.
T70 6592-6779 Sentence denotes This provokes people to explore the difference of the host tropism and transmission between SARS-CoV-2 and SARS-CoV or conduct further investigations on the potential therapeutic targets.
T71 6780-6952 Sentence denotes Zhang et al. [24] analyzed the genotypes of COVID-19 in different patients from several provinces and found that SARS-CoV-2 had been mutated in different patients in China.
T72 6953-7064 Sentence denotes Although the degree of diversification of SARS-CoV-2 is smaller than the mutation of H7N9 avian influenza [25].
T73 7065-7247 Sentence denotes Tang et al. [26] conducted a population genetic analyses of 103 SARS-CoV-2 genomes and classified out two prevalent evolvement types of SARS-CoV-2, L type (~ 70%) and S type (~ 30%).
T74 7248-7342 Sentence denotes The strains in L type, derived from S type, are evolutionarily more aggressive and contagious.
T75 7343-7475 Sentence denotes Thus, virologists and epidemiologists need to closely monitor the novel coronavirus, in order to inspect the virulence and epidemic.
T76 7477-7517 Sentence denotes Coronavirus replication and pathogenesis
T77 7518-7690 Sentence denotes ACE2, found in the lower respiratory tract of humans, is known as cell receptor for SARS-CoV [27] and regulates both the cross-species and human-to-human transmission [28].
T78 7691-7876 Sentence denotes Isolated from the bronchoalveolar lavage fluid (BALF) of a COVID-19 patient, Zhou et al. [8] have confirmed that the SARS-CoV-2 uses the same cellular entry receptor, ACE2, as SARS-CoV.
T79 7877-8001 Sentence denotes The virion S-glycoprotein on the surface of coronavirus can attach to the receptor, ACE2 on the surface of human cells [29].
T80 8002-8055 Sentence denotes S glycoprotein includes two subunits, S1 and S2 [30].
T81 8056-8257 Sentence denotes S1 determines the virus-host range and cellular tropism with the key function domain − RBD, while S2 mediates virus-cell membrane fusion by two tandem domains, heptad repeats 1 (HR1) [31] and HR2 [32].
T82 8258-8524 Sentence denotes After membrane fusion, the viral genome RNA is released into the cytoplasm, and the uncoated RNA translates two polyproteins, pp1a and pp1ab [33], which encode non-structural proteins, and form replication-transcription complex (RTC) in double-membrane vesicle [34].
T83 8525-8661 Sentence denotes Continuously RTC replicate and synthesize a nested set of subgenomic RNAs [35], which encode accessory proteins and structural proteins.
T84 8662-8828 Sentence denotes Mediating endoplasmic reticulum (ER) and Golgi [36], newly formed genomic RNA, nucleocapsid proteins and envelope glycoproteins assemble and form viral particle buds.
T85 8829-8919 Sentence denotes Lastly, the virion-containing vesicles fuse with the plasma membrane to release the virus.
T86 8920-9117 Sentence denotes Because the binding of SARS-CoV-2 Spike (S) glycoprotein and ACE2 receptor is a critical step for virus entry, virus-receptor binding affinity is under intensive study through different approaches.
T87 9118-9309 Sentence denotes Systematic detection of β-CoV receptors showed that human cells expressing ACE2, but not human Dipeptidyl peptidase-4 (DPP4) or APN (Aminopeptidase N), were enhanced entry of SARS-CoV-2 [37].
T88 9310-9520 Sentence denotes While, another study showed that S-protein and ACE2 binding efficiency is 10- to 20- fold higher than that of SARS-CoV, evidenced by Cryo-EM Structure of the SARS-CoV-2 Spike in the prefusion conformation [38].
T89 9521-9787 Sentence denotes For SARS-CoV, the cleavage of trimer S protein is triggered by the cell surface-associated transmembrane protease serine 2 (TMPRSS2) [39] and cathepsin [40], while the possible molecules facilitated membrane invagination for SARS-CoV-2 endocytosis are still unclear.
T90 9788-9960 Sentence denotes Up to the date this review paper was prepared, reports showed that the SARS-CoV-2 may readily transmit, while cause less serious human infection rather than human SARS-CoV.
T91 9961-10071 Sentence denotes Based on the latest WHO report, the number of infected people (over 80,000 globally, updated on 1 March 2020).
T92 10072-10237 Sentence denotes The global outbreak may due to the following factors: firstly, the unknown pneumonia outbroke at the time of China Spring Festival, when the mass population flowing.
T93 10238-10395 Sentence denotes Secondly, more detailed molecular mechanisms of viral binding and entry manners await to be elucidated, which may hamper the development of targeted therapy.
T94 10396-10640 Sentence denotes Thirdly, available data suggested that the SARS-CoV-2 may be less virulent than the SARS-CoV and MERS-CoV, with the currently analyzed mortality of COVID-19 is 3.4%, lower than death rate of SARS (9.6%) and MERS (around 35%), respectively [19].
T95 10641-10778 Sentence denotes Thus, the potential mechanisms for human-to-human transmission and pathogenic mechanisms of the SARS-CoV-2 are under extensively studied.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T10 680-708 Phenotype denotes respiratory tract infections http://purl.obolibrary.org/obo/HP_0011947
T11 2413-2440 Phenotype denotes susceptibility to infection http://purl.obolibrary.org/obo/HP_0002719
T12 2732-2765 Phenotype denotes acute respiratory tract infection http://purl.obolibrary.org/obo/HP_0011948
T13 4778-4787 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T14 10147-10156 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
32169119-31978945-70132188 186-187 31978945 denotes 6
32169119-29052924-70132189 710-711 29052924 denotes 7
32169119-32015507-70132190 1184-1185 32015507 denotes 8
32169119-32004758-70132191 2945-2947 32004758 denotes 10
32169119-16278351-70132192 3163-3165 16278351 denotes 11
32169119-30634396-70132192 3163-3165 30634396 denotes 11
32169119-16195424-70132192 3163-3165 16195424 denotes 11
32169119-32015507-70132193 3318-3319 32015507 denotes 8
32169119-32015508-70132194 3463-3465 32015508 denotes 14
32169119-26336062-70132195 4483-4485 26336062 denotes 17
32169119-28378546-70132196 4487-4489 28378546 denotes 18
32169119-32015508-70132197 4927-4929 32015508 denotes 14
32169119-27344959-70132198 5030-5032 27344959 denotes 19
32169119-30646565-70132199 5142-5144 30646565 denotes 20
32169119-30531947-70132200 5558-5560 30531947 denotes 21
32169119-32015508-70132201 5664-5666 32015508 denotes 14
32169119-25591105-70132202 7060-7062 25591105 denotes 25
32169119-16282461-70132203 7612-7614 16282461 denotes 27
32169119-32015507-70132204 7781-7782 32015507 denotes 8
32169119-31522710-70132205 7997-7999 31522710 denotes 29
32169119-24766432-70132206 8051-8053 24766432 denotes 30
32169119-28643204-70132207 8400-8402 28643204 denotes 33
32169119-15609508-70132208 8520-8522 15609508 denotes 34
32169119-15827143-70132209 8600-8602 15827143 denotes 35
32169119-31399512-70132210 8710-8712 31399512 denotes 36
32169119-30102747-70132211 9516-9518 30102747 denotes 38
32169119-25445340-70132212 9655-9657 25445340 denotes 39
32169119-27344959-70132213 10636-10638 27344959 denotes 19