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PMC:7068984 / 21845-27503 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
749 13-21 Disease denotes COVID-19 MESH:C000657245
758 318-324 Species denotes People Tax:9606
759 362-370 Species denotes patients Tax:9606
760 462-470 Species denotes patients Tax:9606
761 380-386 Chemical denotes oxygen MESH:D010100
762 95-103 Disease denotes COVID-19 MESH:C000657245
763 222-231 Disease denotes Pneumonia MESH:D011014
764 242-250 Disease denotes COVID-19 MESH:C000657245
765 476-496 Disease denotes refractory hypoxemia MESH:D000860
805 937-950 Gene denotes neuraminidase Gene:4758
806 2073-2078 Gene denotes TNF-α Gene:7124
807 2083-2087 Gene denotes IL-6 Gene:3569
808 710-718 Species denotes SARS-CoV Tax:694009
809 723-731 Species denotes MERS-CoV Tax:1335626
810 1086-1101 Species denotes influenza virus Tax:11308
811 1361-1366 Species denotes mouse Tax:10090
812 2310-2318 Species denotes SARS-CoV Tax:694009
813 2526-2536 Species denotes SARS-CoV-2 Tax:2697049
814 808-819 Species denotes coronavirus Tax:11118
815 963-974 Chemical denotes oseltamivir MESH:D053139
816 976-985 Chemical denotes peramivir MESH:C414210
817 987-996 Chemical denotes zanamivir MESH:D053243
818 1004-1015 Chemical denotes ganciclovir MESH:D015774
819 1017-1026 Chemical denotes acyclovir MESH:D000212
820 1032-1041 Chemical denotes ribavirin MESH:D012254
821 1054-1072 Chemical denotes methylprednisolone MESH:D008775
822 1149-1159 Chemical denotes Remdesivir MESH:C000606551
823 1161-1168 Chemical denotes GS-5734 MESH:C000606551
824 1196-1205 Chemical denotes adenosine MESH:D000241
825 1374-1384 Chemical denotes remdesivir MESH:C000606551
826 1490-1500 Chemical denotes Remdesivir MESH:C000606551
827 1577-1588 Chemical denotes Chloroquine MESH:D002738
828 1650-1661 Chemical denotes Chloroquine MESH:D002738
829 1836-1847 Chemical denotes Chloroquine MESH:D002738
830 1993-2004 Chemical denotes chloroquine MESH:D002738
831 2239-2250 Chemical denotes chloroquine MESH:D002738
832 2444-2454 Chemical denotes remdesivir MESH:C000606551
833 2459-2470 Chemical denotes chloroquine MESH:D002738
834 1119-1127 Disease denotes COVID-19 MESH:C000657245
835 1549-1557 Disease denotes COVID-19 MESH:C000657245
836 1640-1648 Disease denotes COVID-19 MESH:C000657245
837 1685-1692 Disease denotes malaria MESH:D008288
838 1772-1788 Disease denotes viral infections MESH:D001102
839 1947-1965 Disease denotes SARS-CoV infection MESH:C000657245
840 2174-2189 Disease denotes viral infection MESH:D001102
841 2385-2393 Disease denotes COVID-19 MESH:C000657245
842 2394-2403 Disease denotes infection MESH:D007239
843 2412-2414 CellLine denotes E6 CVCL:4582
869 4116-4127 Gene denotes cathepsin B Gene:1508
870 4390-4403 Gene denotes Neuraminidase Gene:4758
871 4451-4464 Gene denotes neuraminidase Gene:4758
872 3556-3561 Species denotes HIV-1 Tax:11676
873 3940-3945 Species denotes Ebola Tax:1570291
874 4171-4176 Species denotes Ebola Tax:1570291
875 4332-4343 Species denotes DNA viruses Tax:2080735
876 4547-4564 Species denotes Influenza viruses Tax:11308
877 4791-4802 Species denotes Herpesvirus Tax:39059
878 5084-5089 Species denotes Ebola Tax:1570291
879 5103-5107 Species denotes H1N1 Tax:114727
880 5391-5396 Species denotes human Tax:9606
881 5404-5417 Species denotes coronaviruses Tax:11118
882 4154-4163 Species denotes Influenza Tax:11309
883 5091-5100 Species denotes influenza Tax:11309
884 3647-3650 Species denotes HIV Tax:12721
885 3505-3524 Chemical denotes Lopinavir/Ritonavir MESH:C558899
886 3716-3727 Chemical denotes Chloroquine MESH:D002738
887 3729-3743 Chemical denotes -aminoquinolin
888 3857-3867 Chemical denotes Remdesivir MESH:C000606551
889 4038-4044 Chemical denotes serine MESH:D012694
890 3651-3655 Disease denotes AIDS MESH:D000163
891 3808-3815 Disease denotes Malaria MESH:D008288
892 3817-3835 Disease denotes autoimmune disease MESH:D001327
893 4820-4878 Disease denotes cytomegalovirus AIDS-associated cytomegalovirus infections MESH:D003586
899 5428-5460 Disease denotes HIV Human immunodeficiency virus MESH:D015658
900 5462-5502 Disease denotes AIDS Acquired immune deficiency syndrome MESH:D000163
901 5504-5542 Disease denotes SARS Severe acute respiratory syndrome MESH:D045169
902 5544-5581 Disease denotes MERS Middle East respiratory syndrome MESH:D018352
903 5583-5604 Disease denotes HCV Hepatitis C virus MESH:D006526
921 2662-2690 Species denotes human immunodeficiency virus Tax:12721
922 2732-2740 Species denotes MERS-CoV Tax:1335626
923 2750-2758 Species denotes SARS-CoV Tax:694009
924 2764-2772 Species denotes patients Tax:9606
925 2795-2808 Species denotes β-coronavirus Tax:694002
926 2835-2842 Species denotes patient Tax:9606
927 2692-2695 Species denotes HIV Tax:12721
928 2608-2617 Chemical denotes lopinavir MESH:D061466
929 2622-2631 Chemical denotes ritonavir MESH:D019438
930 2882-2901 Chemical denotes lopinavir/ritonavir MESH:C558899
931 3044-3063 Chemical denotes lopinavir/ritonavir MESH:C558899
932 3307-3319 Chemical denotes nitazoxanide MESH:C041747
933 3321-3332 Chemical denotes favipiravir MESH:C462182
934 3334-3344 Chemical denotes nafamostat MESH:C032855
935 2647-2656 Disease denotes infection MESH:D007239
936 2826-2834 Disease denotes COVID-19 MESH:C000657245
937 3189-3198 Disease denotes pneumonia MESH:D011014

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T157 538-544 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T158 549-565 Body_part denotes immunoglobulin G http://purl.org/sig/ont/fma/fma62872
T159 1206-1216 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T160 1292-1295 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T161 1347-1351 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T162 1457-1461 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T163 2083-2085 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T164 2415-2420 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T165 2692-2695 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T166 2936-2938 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T167 3103-3110 Body_part denotes Capsule http://purl.org/sig/ont/fma/fma85272
T168 3556-3559 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T169 3575-3582 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T170 3647-3650 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T171 3755-3764 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T172 3878-3888 Body_part denotes Nucleotide http://purl.org/sig/ont/fma/fma82740
T173 3975-3978 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T174 4038-4044 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T175 4276-4280 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T176 4324-4327 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T177 4332-4335 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T178 4506-4510 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T179 4646-4653 Body_part denotes guanine http://purl.org/sig/ont/fma/fma82775
T180 4945-4948 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T181 5063-5066 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T182 5070-5073 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T183 5428-5431 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T26 3103-3110 Body_part denotes Capsule http://purl.obolibrary.org/obo/UBERON_0003893

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p13997s9 2271-2284 MPA denotes glycosylation
p14001s18 2866-2875 NegReg denotes decreased

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T154 13-21 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T155 95-103 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T156 222-231 Disease denotes Pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T157 242-250 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T158 710-718 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T159 1086-1095 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T160 1119-1127 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T161 1161-1163 Disease denotes GS http://purl.obolibrary.org/obo/MONDO_0005773
T162 1549-1557 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T163 1640-1648 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T164 1685-1692 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T165 1772-1788 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T166 1947-1965 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T167 1956-1965 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T168 2174-2189 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T169 2180-2189 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T170 2310-2318 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T171 2385-2393 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T172 2394-2403 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T173 2526-2534 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T174 2647-2656 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T175 2668-2684 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T176 2750-2758 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T177 2826-2834 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T178 3189-3198 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T179 3610-3620 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T180 3651-3655 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T181 3657-3661 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T182 3808-3815 Disease denotes Malaria http://purl.obolibrary.org/obo/MONDO_0005136
T183 3817-3835 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T184 3869-3871 Disease denotes GS http://purl.obolibrary.org/obo/MONDO_0005773
T185 3940-3945 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T186 3947-3951 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T187 4154-4163 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T188 4171-4176 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T189 4350-4354 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T190 4547-4556 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T191 4836-4840 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T192 4852-4878 Disease denotes cytomegalovirus infections http://purl.obolibrary.org/obo/MONDO_0005132
T193 5084-5089 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T194 5091-5108 Disease denotes influenza A(H1N1) http://purl.obolibrary.org/obo/MONDO_0005460
T195 5091-5100 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T196 5438-5454 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T197 5462-5466 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T198 5467-5502 Disease denotes Acquired immune deficiency syndrome http://purl.obolibrary.org/obo/MONDO_0012268
T199 5504-5508 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T200 5509-5542 Disease denotes Severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T201 5587-5598 Disease denotes Hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T202 5587-5596 Disease denotes Hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T203 5610-5624 Disease denotes Herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T204 5636-5645 Disease denotes Varicella http://purl.obolibrary.org/obo/MONDO_0005700
T205 5646-5652 Disease denotes zoster http://purl.obolibrary.org/obo/MONDO_0005609

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T214 131-138 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T215 346-348 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T216 431-439 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T217 538-544 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T218 1096-1101 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T219 1173-1174 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T220 1267-1275 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T221 1296-1303 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T222 1347-1356 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T223 1361-1366 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T224 1475-1483 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T225 1501-1504 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T226 1592-1593 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T227 1662-1665 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T228 1719-1720 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 1909-1916 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T230 1928-1929 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T231 2005-2008 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T232 2106-2107 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 2407-2420 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T234 2427-2428 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T235 2662-2667 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T236 2685-2690 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T237 2777-2780 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T238 2824-2825 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 3119-3120 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 3923-3928 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T241 3959-3960 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T242 3979-3986 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T243 4073-4081 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T244 4126-4127 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T245 4143-4153 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T246 4282-4283 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T247 4299-4307 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T248 4336-4343 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T249 4365-4367 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T250 4429-4437 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T251 4506-4510 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T252 4557-4564 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T253 4565-4570 http://purl.obolibrary.org/obo/CLO_0001625 denotes A [95
T254 4626-4627 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T255 5101-5102 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T256 5245-5246 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T257 5339-5347 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T258 5349-5356 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T259 5357-5358 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T260 5373-5380 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T261 5391-5396 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T262 5397-5403 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T263 5419-5422 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T264 5432-5437 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T265 5455-5460 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T266 5599-5604 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T267 5625-5630 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T268 5653-5658 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T117 69-78 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T118 380-386 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T119 836-841 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T120 855-869 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T121 937-961 Chemical denotes neuraminidase inhibitors http://purl.obolibrary.org/obo/CHEBI_52425
T122 951-961 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T123 963-974 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T124 976-985 Chemical denotes peramivir http://purl.obolibrary.org/obo/CHEBI_85196|http://purl.obolibrary.org/obo/CHEBI_85202
T126 987-996 Chemical denotes zanamivir http://purl.obolibrary.org/obo/CHEBI_50663
T127 1004-1015 Chemical denotes ganciclovir http://purl.obolibrary.org/obo/CHEBI_465284
T128 1017-1026 Chemical denotes acyclovir http://purl.obolibrary.org/obo/CHEBI_2453
T129 1032-1041 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T130 1054-1072 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T131 1161-1168 Chemical denotes GS-5734 http://purl.obolibrary.org/obo/CHEBI_145994
T132 1161-1163 Chemical denotes GS http://purl.obolibrary.org/obo/CHEBI_73516
T133 1178-1183 Chemical denotes cyano http://purl.obolibrary.org/obo/CHEBI_48819
T134 1196-1205 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T135 1206-1216 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T136 1224-1231 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T137 1257-1266 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T138 1374-1384 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T139 1577-1588 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T140 1605-1609 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T141 1650-1661 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T142 1836-1847 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T143 1993-2004 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T144 2083-2085 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T146 2123-2142 Chemical denotes autophagy inhibitor http://purl.obolibrary.org/obo/CHEBI_88230
T147 2133-2142 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T148 2239-2250 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T149 2444-2454 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T150 2459-2470 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T151 2588-2607 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T153 2597-2607 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T154 2608-2631 Chemical denotes lopinavir and ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T155 2608-2617 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T156 2622-2631 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T157 2882-2901 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T158 2882-2891 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T159 2892-2901 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T160 2903-2910 Chemical denotes Kaletra http://purl.obolibrary.org/obo/CHEBI_145924
T161 2936-2938 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T163 3015-3023 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T164 3044-3063 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T165 3044-3053 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T166 3054-3063 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T167 3065-3072 Chemical denotes Kaletra http://purl.obolibrary.org/obo/CHEBI_145924
T168 3076-3083 Chemical denotes arbidol http://purl.obolibrary.org/obo/CHEBI_134730
T169 3141-3149 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T170 3283-3298 Chemical denotes antiviral drugs http://purl.obolibrary.org/obo/CHEBI_36044
T171 3283-3292 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T172 3293-3298 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T173 3321-3332 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T174 3334-3344 Chemical denotes nafamostat http://purl.obolibrary.org/obo/CHEBI_135466
T175 3409-3424 Chemical denotes antiviral drugs http://purl.obolibrary.org/obo/CHEBI_36044
T176 3409-3418 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T177 3419-3424 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T178 3438-3444 Chemical denotes Action http://purl.obolibrary.org/obo/CHEBI_5133
T179 3505-3514 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T180 3534-3544 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T181 3575-3582 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T182 3716-3727 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T183 3787-3807 Chemical denotes autophagy inhibitors http://purl.obolibrary.org/obo/CHEBI_88230
T184 3797-3807 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T185 3869-3876 Chemical denotes GS-5734 http://purl.obolibrary.org/obo/CHEBI_145994
T186 3869-3871 Chemical denotes GS http://purl.obolibrary.org/obo/CHEBI_73516
T187 3878-3888 Chemical denotes Nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T188 3898-3905 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T189 4038-4063 Chemical denotes serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64926
T190 4038-4044 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T191 4045-4063 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T193 4054-4063 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T194 4129-4142 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T195 4215-4224 Chemical denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T196 4225-4235 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T197 4332-4335 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T198 4378-4389 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T199 4390-4413 Chemical denotes Neuraminidase inhibitor http://purl.obolibrary.org/obo/CHEBI_52425
T200 4404-4413 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T201 4608-4618 Chemical denotes Nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T202 4646-4653 Chemical denotes guanine http://purl.obolibrary.org/obo/CHEBI_16235
T203 4737-4748 Chemical denotes Ganciclovir http://purl.obolibrary.org/obo/CHEBI_465284
T204 4749-4759 Chemical denotes Nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T205 4774-4783 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T206 4913-4918 Chemical denotes T-705 http://purl.obolibrary.org/obo/CHEBI_134722
T207 4920-4930 Chemical denotes Nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T208 4945-4969 Chemical denotes RNA polymerase inhibitor http://purl.obolibrary.org/obo/CHEBI_37416
T209 4960-4969 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T210 5070-5073 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T39 1772-1788 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T40 2123-2132 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T41 2123-2132 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T42 2174-2189 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T43 2271-2284 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T44 3787-3796 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T45 3787-3796 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T46 4073-4088 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T47 4129-4153 http://purl.obolibrary.org/obo/GO_0050819 denotes anticoagulant activities
T48 4257-4266 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T49 4484-4491 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T50 4512-4529 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T51 4512-4529 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T52 5017-5029 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T53 5070-5083 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA synthesis
T54 5074-5083 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T55 5216-5222 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T144 0-21 Sentence denotes Treatment of COVID-19
T145 23-40 Sentence denotes Current therapies
T146 41-350 Sentence denotes Given the lack of effective antiviral therapy against COVID-19, current treatments mainly focused on symptomatic and respiratory support according to the Diagnosis and Treatment of Pneumonia Caused by COVID-19 (updated to version 6) issued by National Health Commission of the People’s Republic of China [71].
T147 351-502 Sentence denotes Nearly all patients accepted oxygen therapy, and WHO recommended extracorporeal membrane oxygenation (ECMO) to patients with refractory hypoxemia [72].
T148 503-638 Sentence denotes Rescue treatment with convalescent plasma and immunoglobulin G [73] are delivered to some critical cases according to their conditions.
T149 640-660 Sentence denotes Antiviral treatments
T150 661-825 Sentence denotes Based on the experience of fighting the epidemic SARS-CoV and MERS-CoV previously, we may learn some lessons for some treatment strategies against coronavirus [74].
T151 826-1148 Sentence denotes Antiviral drugs and systemic corticosteroid treatment commonly used in clinical practice previously, including neuraminidase inhibitors (oseltamivir, peramivir, zanamivir, etc), ganciclovir, acyclovir, and ribavirin, as well as methylprednisolone [46, 75] for influenza virus, are invalid for COVID-19 and not recommended.
T152 1149-1304 Sentence denotes Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analog prodrug and shows broad-spectrum antiviral activity against several RNA viruses.
T153 1305-1489 Sentence denotes Based on the data collected from in vitro cell line and mouse model, remdesivir could interfere with the NSP12 polymerase even in the setting of intact ExoN proofreading activity [76].
T154 1490-1576 Sentence denotes Remdesivir has been reported to treat the first US case of COVID-19 successfully [77].
T155 1577-1649 Sentence denotes Chloroquine is a repurposed drug with great potential to treat COVID-19.
T156 1650-1789 Sentence denotes Chloroquine has been used to treat malaria for many years [78], with a mechanism that is not well understood against some viral infections.
T157 1790-1835 Sentence denotes Several possible mechanisms are investigated:
T158 1836-1982 Sentence denotes Chloroquine can inhibit pH-dependent steps of the replication of several viruses [79], with a potent effect on SARS-CoV infection and spread [80].
T159 1983-2088 Sentence denotes Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of TNF-α and IL-6.
T160 2089-2206 Sentence denotes It also works as a novel class of autophagy inhibitor [81], which may interfere with viral infection and replication.
T161 2207-2426 Sentence denotes Several studies have found that chloroquine interfered with the glycosylation of cellular receptors of SARS-CoV [80] and functioned at both entry and at post-entry stages of the COVID-19 infection in Vero E6 cells [82].
T162 2427-2546 Sentence denotes A combination of remdesivir and chloroquine was proven to effectively inhibit the recently emerged SARS-CoV-2 in vitro.
T163 2547-2773 Sentence denotes Scientists previously confirmed that the protease inhibitors lopinavir and ritonavir, used to treat infection with human immunodeficiency virus (HIV) [83], could improve the outcome of MERS-CoV [84] and SARS-CoV [85] patients.
T164 2774-2960 Sentence denotes It has reported that β-coronavirus viral loads of a COVID-19 patient in Korea significantly decreased after lopinavir/ritonavir (Kaletra®, AbbVie, North Chicago, IL, USA) treatment [86].
T165 2961-3382 Sentence denotes Additionally, clinicians combined Chinese and Western medicine treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and gained significant improvement in pneumonia associated symptoms in Shanghai Public Health Clinical Center, China [87].The other antiviral drugs include nitazoxanide, favipiravir, nafamostat, and so on (See Table 1 for details).
T166 3383-3424 Sentence denotes Table 1 Common and potent antiviral drugs
T167 3425-3495 Sentence denotes Status Drugs Action mode Anti-infective mechanism Target diseases Ref.
T168 3496-3675 Sentence denotes Approved Lopinavir/Ritonavir Protease inhibitors Inhibiting HIV-1 protease for protein cleavage, resulting in non-infectious, immature viral particles HIV/AIDS, SARS, MERS [83–85]
T169 3676-3843 Sentence denotes Approved, Investigational, Vet approved Chloroquine 9-aminoquinolin Increasing endosomal pH, immunomodulating, autophagy inhibitors Malaria, autoimmune disease [79–82]
T170 3844-3957 Sentence denotes Experimental Remdesivir (GS-5734) Nucleotide analogue prodrug Interfering with virus post-entry Ebola, SARS, MERS
T171 3958-4000 Sentence denotes (A wide array of RNA viruses) [76, 88, 89]
T172 4001-4185 Sentence denotes Investigational Nafamostat Synthetic serine protease inhibitor Prevents membrane fusion by reducing the release of cathepsin B; anticoagulant activities Influenza, MERS, Ebola [90, 91]
T173 4186-4368 Sentence denotes Approved Ribavirin Synthetic guanosine nucleoside Interfering with the synthesis of viral mRNA (a broad-spectrum activity against several RNA and DNA viruses) HCV, SARS, MERS [92–94]
T174 4369-4575 Sentence denotes Approved Oseltamivir Neuraminidase inhibitor Inhibiting the activity of the viral neuraminidase enzyme, preventing budding from the host cell, viral replication, and infectivity Influenza viruses A [95, 96]
T175 4576-4710 Sentence denotes Approved Penciclovir/ Acyclovir Nucleoside analog A synthetic acyclic guanine derivative, resulting in chain termination HSV, VZV [97]
T176 4711-4883 Sentence denotes Approved, Investigational Ganciclovir Nucleoside analog Potent inhibitor of the Herpesvirus family including cytomegalovirus AIDS-associated cytomegalovirus infections [98]
T177 4884-4938 Sentence denotes Investigational Favipiravir (T-705) Nucleoside analog:
T178 4939-5117 Sentence denotes Viral RNA polymerase inhibitor Acting on viral genetic copying to prevent its reproduction, without affecting host cellular RNA or DNA synthesis Ebola, influenza A(H1N1) [99–101]
T179 5118-5427 Sentence denotes Approved, Investigational, Vet approved Nitazoxanide Antiprotozoal agent Modulating the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, viruses A wide range of viruses including human/animal coronaviruses [102–104]
T180 5428-5658 Sentence denotes HIV Human immunodeficiency virus, AIDS Acquired immune deficiency syndrome, SARS Severe acute respiratory syndrome, MERS Middle East respiratory syndrome, HCV Hepatitis C virus, HSV Herpes simplex virus, VZV Varicella-zoster virus

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T47 222-231 Phenotype denotes Pneumonia http://purl.obolibrary.org/obo/HP_0002090
T48 487-496 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T49 2668-2684 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T50 3189-3198 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T51 3817-3835 Phenotype denotes autoimmune disease http://purl.obolibrary.org/obo/HP_0002960
T52 5438-5454 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T53 5476-5493 Phenotype denotes immune deficiency http://purl.obolibrary.org/obo/HP_0002721
T54 5587-5596 Phenotype denotes Hepatitis http://purl.obolibrary.org/obo/HP_0012115

2_test

Id Subject Object Predicate Lexical cue
32169119-26868298-70132240 821-823 26868298 denotes 74
32169119-29511076-70132241 1485-1487 29511076 denotes 76
32169119-32004427-70132242 1572-1574 32004427 denotes 77
32169119-30396013-70132243 1709-1711 30396013 denotes 78
32169119-14592603-70132244 1918-1920 14592603 denotes 79
32169119-16115318-70132245 1978-1980 16115318 denotes 80
32169119-25727221-70132246 2144-2146 25727221 denotes 81
32169119-16115318-70132247 2320-2322 16115318 denotes 80
32169119-32020029-70132248 2422-2424 32020029 denotes 82
32169119-12662125-70132249 2698-2700 12662125 denotes 83
32169119-31900204-70132250 2742-2744 31900204 denotes 84
32169119-14985565-70132251 2760-2762 14985565 denotes 85
32169119-32056407-70132252 2956-2958 32056407 denotes 86
32169119-12662125-70132253 3669-3671 12662125 denotes 83
32169119-31900204-70132253 3669-3671 31900204 denotes 83
32169119-14985565-70132253 3669-3671 14985565 denotes 83
32169119-14592603-70132254 3837-3839 14592603 denotes 79
32169119-16115318-70132254 3837-3839 16115318 denotes 79
32169119-25727221-70132254 3837-3839 25727221 denotes 79
32169119-32020029-70132254 3837-3839 32020029 denotes 79
32169119-29511076-70132255 3989-3991 29511076 denotes 76
32169119-30987343-70132256 3993-3995 30987343 denotes 88
32169119-31142680-70132257 3997-3999 31142680 denotes 89
32169119-18220789-70132258 4178-4180 18220789 denotes 90
32169119-26346967-70132259 4182-4184 26346967 denotes 91
32169119-30215672-70132260 4362-4364 30215672 denotes 92
32169119-15018130-70132260 4362-4364 15018130 denotes 92
32169119-24811411-70132261 4572-4574 24811411 denotes 96
32169119-29896665-70132262 4707-4709 29896665 denotes 97
32169119-29678260-70132263 4880-4882 29678260 denotes 98
32169119-24084488-70132264 5110-5112 24084488 denotes 99
32169119-25108173-70132265 5419-5422 25108173 denotes 102
32169119-25451075-70132265 5419-5422 25451075 denotes 102
32169119-27095301-70132265 5419-5422 27095301 denotes 102