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PMC:7068984 / 19598-21843 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
702 234-238 Gene denotes ACE2 Gene:59272
703 452-456 Gene denotes TLR7 Gene:51284
704 458-462 Gene denotes TLR8 Gene:51311
705 468-472 Gene denotes TLR9 Gene:54106
706 578-583 Gene denotes RIG-I Gene:23586
707 610-652 Gene denotes melanoma differentiation-associated gene 5 Gene:64135
708 654-658 Gene denotes MDA5 Gene:64135
709 687-710 Gene denotes cyclic GMP-AMP synthase Gene:115004
710 851-888 Gene denotes TIR-domain-containing adaptor protein Gene:114609
711 899-904 Gene denotes IFN-β Gene:3439
712 906-910 Gene denotes TRIF Gene:148022
713 957-961 Gene denotes MAVS Gene:57506
714 972-1010 Gene denotes stimulator of interferon genes protein Gene:340061
715 1093-1098 Gene denotes MyD88 Gene:4615
716 1173-1178 Gene denotes NF-κB Gene:4790
717 1184-1214 Gene denotes interferon regulatory factor 3 Gene:3661
718 1216-1220 Gene denotes IRF3 Gene:3661
719 1264-1269 Gene denotes IFN-α Gene:3439
720 1638-1642 Gene denotes IL-1 Gene:3552
721 1644-1648 Gene denotes IL-2 Gene:3558
722 1650-1654 Gene denotes IL-4 Gene:3565
723 1656-1660 Gene denotes IL-7 Gene:3574
724 1662-1667 Gene denotes IL-10 Gene:3586
725 1676-1681 Gene denotes IL-13 Gene:3596
726 1683-1688 Gene denotes IL-17 Gene:3605
727 1690-1694 Gene denotes GCSF Gene:1440
728 1696-1732 Gene denotes macrophage colony-stimulating factor Gene:1435
729 1734-1738 Gene denotes MCSF Gene:1435
730 1741-1746 Gene denotes IP-10 Gene:3627
731 1748-1753 Gene denotes MCP-1 Gene:6347
732 1755-1761 Gene denotes MIP-1α Gene:6348
733 1763-1787 Gene denotes hepatocyte growth factor Gene:3082
734 1789-1792 Gene denotes HGF Gene:3082
735 1795-1800 Gene denotes IFN-γ Gene:3458
736 1805-1810 Gene denotes TNF-α Gene:7124
737 712-716 Gene denotes cGAS Gene:115004
738 195-206 Species denotes Coronavirus Tax:11118
739 1618-1626 Species denotes patients Tax:9606
740 2236-2244 Species denotes patients Tax:9606
741 1012-1017 Gene denotes STING Gene:340061
742 63-77 Disease denotes CoV infections MESH:D018352
743 1609-1617 Disease denotes COVID-19 MESH:C000657245
744 1855-1873 Disease denotes COVID-19 pneumonia MESH:C000657245
745 1901-1909 Disease denotes COVID-19 MESH:C000657245
746 1973-1984 Disease denotes lung injury MESH:D055370
747 2227-2235 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T118 183-191 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T119 225-230 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T120 285-288 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T121 485-488 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T122 493-496 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T123 504-512 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T124 533-536 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T125 570-574 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T126 591-600 Body_part denotes cytosolic http://purl.org/sig/ont/fma/fma66836
T127 646-650 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T128 768-771 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T129 776-779 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T130 787-796 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T131 881-888 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T132 948-955 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T133 1003-1010 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T134 1307-1316 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T135 1336-1340 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T136 1551-1557 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T137 1558-1567 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T138 1572-1582 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T139 1638-1642 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T140 1638-1640 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T141 1644-1648 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T142 1644-1646 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T143 1650-1652 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T144 1656-1658 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T145 1662-1664 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T146 1669-1674 Body_part denotes IL-12 http://purl.org/sig/ont/fma/fma86579
T147 1669-1671 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T148 1676-1678 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T149 1683-1685 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T150 1696-1706 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T151 1763-1773 Body_part denotes hepatocyte http://purl.org/sig/ont/fma/fma14515
T152 1973-1977 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T153 2043-2049 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T154 2075-2080 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T155 2144-2152 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T156 2166-2170 Body_part denotes body http://purl.org/sig/ont/fma/fma256135

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T24 1973-1977 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 2043-2049 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T146 67-77 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T147 610-618 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T148 1609-1617 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T149 1855-1863 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T150 1864-1873 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T151 1901-1909 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T152 1978-1984 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T153 2227-2235 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T183 225-230 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T184 254-262 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T185 570-574 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T186 646-650 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T187 812-822 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T188 937-947 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T189 997-1002 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T190 1115-1125 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T191 1170-1171 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T192 1177-1178 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T193 1244-1262 http://purl.obolibrary.org/obo/PR_000024990 denotes type I Interferons
T194 1278-1279 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 1330-1335 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T196 1336-1340 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T197 1362-1363 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T198 1417-1422 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T199 1458-1459 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 1496-1501 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T201 1545-1546 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T202 1551-1557 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T203 1644-1648 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T204 1690-1694 http://purl.obolibrary.org/obo/PR_000005932 denotes GCSF
T205 1789-1792 http://purl.obolibrary.org/obo/CLO_0003740 denotes HGF
T206 1812-1814 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T207 1955-1961 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T208 1973-1977 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T209 1973-1977 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T210 2004-2009 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T211 2043-2049 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T212 2075-2080 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T213 2093-2094 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T76 183-191 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T77 493-496 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T78 555-559 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T79 687-701 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580
T80 694-697 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T82 698-701 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T85 776-779 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T86 881-888 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T87 927-936 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T88 948-955 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89 986-996 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T90 1003-1010 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T91 1055-1064 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T92 1084-1092 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T93 1173-1175 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T96 1184-1194 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T97 1638-1640 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T99 1644-1646 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T101 1650-1652 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T103 1656-1658 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T105 1662-1664 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T107 1669-1671 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T109 1676-1678 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T111 1683-1685 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T113 1741-1746 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T114 1741-1743 Chemical denotes IP http://purl.obolibrary.org/obo/CHEBI_74076
T115 1748-1751 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T28 4-19 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T29 145-160 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T30 812-822 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T31 937-947 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T32 1133-1153 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T33 1133-1146 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T34 1429-1444 http://purl.obolibrary.org/obo/GO_0045087 denotes Innate immunity
T35 1468-1478 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T36 1774-1780 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T37 1920-1941 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T38 2105-2121 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T133 0-176 Sentence denotes The immune response is vital for the control and resolution of CoV infections, while it can also lead to immunopathogenesis, associated with the immune response out of control.
T134 177-289 Sentence denotes The S proteins of Coronavirus binds to the host cells by ACE2, fusing to the membrane and release the viral RNA.
T135 290-414 Sentence denotes The viral RNAs, as pathogen-associated molecular patterns (PAMPs), are detected by the pattern recognition receptors (PRRs).
T136 415-522 Sentence denotes Usually, Toll-like receptor (TLR) 3, TLR7, TLR8, and TLR9 sense viral RNA and DNA in the endosome [60, 61].
T137 523-797 Sentence denotes The viral RNA receptor retinoic-acid inducible gene I (RIG-I) [62], cytosolic receptor melanoma differentiation-associated gene 5 (MDA5) and nucleotidyltransferase cyclic GMP-AMP synthase (cGAS) [63] are responsible for the recognition of viral RNA and DNA in the cytoplasm.
T138 798-1322 Sentence denotes These complex signalling recruit adaptors, including TIR-domain-containing adaptor protein including IFN-β (TRIF), mitochondrial antiviral-signalling protein (MAVS) [64] and stimulator of interferon genes protein (STING) [65] to trigger downstream cascades molecules, involving adaptor molecule MyD88 and lead to the activation of the transcription factor nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3) and the production of type I Interferons (IFN-α /β) and a series of pro-inflammatory cytokines [66].
T139 1323-1428 Sentence denotes Hence, virus-cell interactions produce a diverse set of immune mediators against the invading virus [67].
T140 1429-1544 Sentence denotes Innate immunity is needed in a precise regulation to eliminate the virus, otherwise will result in immunopathology.
T141 1545-1824 Sentence denotes A few plasma cytokines and chemokines were observed ascended in COVID-19 patients, including IL-1, IL-2, IL-4, IL-7, IL-10, IL-12, IL-13, IL-17, GCSF, macrophage colony-stimulating factor (MCSF), IP-10, MCP-1, MIP-1α, hepatocyte growth factor (HGF), IFN-γ and TNF-α [48, 68, 69].
T142 1825-1985 Sentence denotes Of note, an anatomy report of COVID-19 pneumonia corpse [70] indicated that COVID-19 caused an inflammatory response in the lower airway and led to lung injury.
T143 1986-2245 Sentence denotes Collectively, the virus particles invade the respiratory mucosa firstly and infect other cells, triggering a series of immune responses and the production of cytokine storm in the body, which may be associated with the critical condition of COVID-19 patients.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T44 610-618 Phenotype denotes melanoma http://purl.obolibrary.org/obo/HP_0002861
T45 1864-1873 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T46 2144-2158 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

2_test

Id Subject Object Predicate Lexical cue
32169119-11607032-70132230 514-516 11607032 denotes 60
32169119-24655297-70132231 518-520 24655297 denotes 61
32169119-24968321-70132232 586-588 24968321 denotes 62
32169119-23258412-70132233 719-721 23258412 denotes 63
32169119-16125763-70132234 964-966 16125763 denotes 64
32169119-18724357-70132235 1020-1022 18724357 denotes 65
32169119-20404851-70132236 1318-1320 20404851 denotes 66
32169119-19120477-70132237 1424-1426 19120477 denotes 67
32169119-31986264-70132238 1812-1814 31986264 denotes 48
32169119-32114747-70132239 1816-1818 32114747 denotes 68