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PMC:7068984 / 12162-14020 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
422 34-39 Gene denotes Spike Gene:43740568
423 61-65 Gene denotes ACE2 Gene:59272
424 273-277 Gene denotes ACE2 Gene:59272
425 293-315 Gene denotes Dipeptidyl peptidase-4 Gene:1803
426 317-321 Gene denotes DPP4 Gene:1803
427 326-329 Gene denotes APN Gene:290
428 331-347 Gene denotes Aminopeptidase N Gene:290
429 437-441 Gene denotes ACE2 Gene:59272
430 692-723 Gene denotes transmembrane protease serine 2 Gene:7113
431 725-732 Gene denotes TMPRSS2 Gene:7113
432 41-42 Gene denotes S Gene:43740568
433 559-564 Gene denotes Spike Gene:43740568
434 23-33 Species denotes SARS-CoV-2 Tax:2697049
435 222-227 Species denotes β-CoV Tax:694002
436 250-255 Species denotes human Tax:9606
437 287-292 Species denotes human Tax:9606
438 373-383 Species denotes SARS-CoV-2 Tax:2697049
439 500-508 Species denotes SARS-CoV Tax:694009
440 548-558 Species denotes SARS-CoV-2 Tax:2697049
441 605-613 Species denotes SARS-CoV Tax:694009
442 826-836 Species denotes SARS-CoV-2 Tax:2697049
443 939-949 Species denotes SARS-CoV-2 Tax:2697049
444 997-1002 Species denotes human Tax:9606
445 1025-1030 Species denotes human Tax:9606
446 1031-1039 Species denotes SARS-CoV Tax:694009
447 1096-1102 Species denotes people Tax:9606
448 1519-1529 Species denotes SARS-CoV-2 Tax:2697049
449 1560-1568 Species denotes SARS-CoV Tax:694009
450 1573-1581 Species denotes MERS-CoV Tax:1335626
451 1756-1761 Species denotes human Tax:9606
452 1765-1770 Species denotes human Tax:9606
453 1817-1827 Species denotes SARS-CoV-2 Tax:2697049
454 1003-1012 Disease denotes infection MESH:D007239
455 1087-1095 Disease denotes infected MESH:D007239
456 1227-1236 Disease denotes pneumonia MESH:D011014
457 1611-1620 Disease denotes mortality MESH:D003643
458 1624-1632 Disease denotes COVID-19 MESH:C000657245
459 1653-1658 Disease denotes death MESH:D003643

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T72 44-56 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T73 256-261 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T74 425-432 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T75 640-647 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 668-680 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T77 668-672 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T78 715-721 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p13914s6 423-432 Protein denotes S-protein
p13914s10 437-441 Protein denotes ACE2
p13914s11 442-449 Interaction denotes binding

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T89 23-31 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T90 373-381 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T91 500-508 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 548-556 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 605-613 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T94 826-834 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 939-947 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T96 1003-1012 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T97 1031-1039 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T98 1227-1236 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T99 1519-1527 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 1560-1568 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T101 1624-1632 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 1667-1671 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 1817-1825 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T112 78-79 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T113 98-103 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T114 111-116 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T115 250-261 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T116 287-292 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T117 668-672 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T118 800-808 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T119 997-1002 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T120 1025-1030 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T121 1696-1698 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T122 1756-1761 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T123 1765-1770 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T44 44-56 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T45 425-432 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46 528-530 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T47 640-647 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48 715-721 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T49 778-787 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T18 800-821 http://purl.obolibrary.org/obo/GO_0010324 denotes membrane invagination
T19 837-848 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T86 0-197 Sentence denotes Because the binding of SARS-CoV-2 Spike (S) glycoprotein and ACE2 receptor is a critical step for virus entry, virus-receptor binding affinity is under intensive study through different approaches.
T87 198-389 Sentence denotes Systematic detection of β-CoV receptors showed that human cells expressing ACE2, but not human Dipeptidyl peptidase-4 (DPP4) or APN (Aminopeptidase N), were enhanced entry of SARS-CoV-2 [37].
T88 390-600 Sentence denotes While, another study showed that S-protein and ACE2 binding efficiency is 10- to 20- fold higher than that of SARS-CoV, evidenced by Cryo-EM Structure of the SARS-CoV-2 Spike in the prefusion conformation [38].
T89 601-867 Sentence denotes For SARS-CoV, the cleavage of trimer S protein is triggered by the cell surface-associated transmembrane protease serine 2 (TMPRSS2) [39] and cathepsin [40], while the possible molecules facilitated membrane invagination for SARS-CoV-2 endocytosis are still unclear.
T90 868-1040 Sentence denotes Up to the date this review paper was prepared, reports showed that the SARS-CoV-2 may readily transmit, while cause less serious human infection rather than human SARS-CoV.
T91 1041-1151 Sentence denotes Based on the latest WHO report, the number of infected people (over 80,000 globally, updated on 1 March 2020).
T92 1152-1317 Sentence denotes The global outbreak may due to the following factors: firstly, the unknown pneumonia outbroke at the time of China Spring Festival, when the mass population flowing.
T93 1318-1475 Sentence denotes Secondly, more detailed molecular mechanisms of viral binding and entry manners await to be elucidated, which may hamper the development of targeted therapy.
T94 1476-1720 Sentence denotes Thirdly, available data suggested that the SARS-CoV-2 may be less virulent than the SARS-CoV and MERS-CoV, with the currently analyzed mortality of COVID-19 is 3.4%, lower than death rate of SARS (9.6%) and MERS (around 35%), respectively [19].
T95 1721-1858 Sentence denotes Thus, the potential mechanisms for human-to-human transmission and pathogenic mechanisms of the SARS-CoV-2 are under extensively studied.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T14 1227-1236 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
32169119-30102747-70132211 596-598 30102747 denotes 38
32169119-25445340-70132212 735-737 25445340 denotes 39
32169119-27344959-70132213 1716-1718 27344959 denotes 19