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PMC:7060195 / 5298-7874 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
152 1433-1464 Gene denotes angiotensin-converting enzyme 2 Gene:59272
153 1466-1470 Gene denotes ACE2 Gene:59272
154 754-755 Gene denotes S Gene:43740568
155 688-689 Gene denotes S Gene:43740568
156 73-84 Species denotes coronavirus Tax:11118
157 193-197 Species denotes CoVs Tax:11118
158 262-270 Species denotes SARS-CoV Tax:694009
159 274-282 Species denotes MERS-CoV Tax:1335626
160 429-437 Species denotes SARS-CoV Tax:694009
161 481-484 Species denotes CoV Tax:11118
162 607-617 Species denotes SARS-CoV-2 Tax:2697049
163 693-703 Species denotes SARS-CoV-2 Tax:2697049
164 777-787 Species denotes SARS-CoV-2 Tax:2697049
165 903-913 Species denotes SARS-CoV-2 Tax:2697049
166 963-972 Species denotes SARS-CoVs Tax:694009
167 1272-1289 Species denotes influenza A virus Tax:11320
168 1502-1511 Species denotes 2019-nCoV Tax:2697049
169 1551-1556 Species denotes human Tax:9606
170 1557-1566 Species denotes SARS-CoVs Tax:694009
171 2039-2048 Species denotes SARS-CoVs Tax:694009
172 2098-2119 Species denotes African green monkeys Tax:9534
173 2154-2162 Species denotes SARS-CoV Tax:694009
174 2207-2215 Species denotes SARS-CoV Tax:694009
175 2245-2253 Species denotes SARS-CoV Tax:694009
176 2438-2448 Species denotes SARS-CoV-2 Tax:2697049
177 1152-1161 Species denotes influenza Tax:11320
178 649-658 Disease denotes infection MESH:D007239
179 1841-1856 Disease denotes viral infection MESH:D001102

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T16 12-20 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T17 96-103 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 127-130 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T19 158-165 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T20 300-307 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T21 348-355 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T22 401-408 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T23 409-412 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T24 466-473 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T25 596-603 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T26 675-687 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T27 766-773 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T28 871-878 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T29 1011-1018 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 1104-1114 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T31 1410-1415 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 1491-1498 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 1604-1615 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T34 1930-1937 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T35 1966-1974 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T36 2143-2150 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 2258-2266 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p10963s4 166-175 NegReg denotes abrogated
p10963s6 180-189 MPA denotes virulence

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T29 262-270 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 429-437 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 607-615 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 693-701 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 777-785 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 903-911 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 963-967 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T36 1152-1161 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T37 1272-1281 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T38 1557-1561 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T39 1841-1856 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T40 1847-1856 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T41 1867-1871 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T42 2039-2043 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T43 2154-2162 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 2207-2215 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 2245-2253 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 2438-2446 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T35 71-72 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 288-289 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 517-518 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 723-728 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T39 824-826 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T40 832-834 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T41 840-842 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T42 840-842 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T43 848-850 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T44 868-870 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T45 868-870 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T46 914-921 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T47 959-962 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T48 1008-1010 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T49 1008-1010 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T50 1078-1085 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T51 1089-1095 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T52 1282-1283 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T53 1310-1312 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T54 1383-1388 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T55 1410-1415 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T56 1488-1490 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T57 1551-1556 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T58 1721-1726 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T59 1781-1782 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 1783-1788 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T61 1804-1805 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T62 2000-2001 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63 2112-2119 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkeys
T64 2172-2179 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkeys
T65 2358-2364 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T66 2424-2426 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T67 2517-2523 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T17 12-20 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T18 96-103 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T19 158-165 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20 300-307 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T21 348-355 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22 401-408 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T23 409-412 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T24 466-473 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T25 596-603 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T26 675-687 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T27 766-773 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T28 840-842 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T29 868-870 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T30 871-878 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T31 1008-1010 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T32 1011-1018 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T33 1048-1057 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T34 1433-1444 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T35 1491-1498 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T36 1604-1615 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T37 1604-1609 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T38 1610-1615 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T39 1930-1937 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T40 2143-2150 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T41 2258-2266 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T8 53-67 http://purl.obolibrary.org/obo/GO_0019068 denotes viral assembly
T9 180-189 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T10 180-189 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T11 372-387 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T12 1841-1856 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T37 0-143 Sentence denotes The E and M proteins have important functions in the viral assembly of a coronavirus, and the N protein is necessary for viral RNA synthesis13.
T38 144-341 Sentence denotes Deletion of E protein abrogated the virulence of CoVs, and several studies have explored the potential of recombinant SARS-CoV or MERS-CoV with a mutated E protein as live attenuated vaccines13,14.
T39 342-661 Sentence denotes The M protein can augment the immune response induced by N protein DNA vaccine against SARS-CoV;15 however, the conserved N protein across CoV families implies that it is not a suitable candidate for vaccine development, and the antibodies against the N protein of SARS-CoV-2 do not provide immunity to the infection16.
T40 662-749 Sentence denotes The critical glycoprotein S of SARS-CoV-2 is responsible for virus binding and entry16.
T41 750-863 Sentence denotes The S precursor protein of SARS-CoV-2 can be proteolytically cleaved into S1 (685 aa) and S2 (588 aa) subunits10.
T42 864-975 Sentence denotes The S2 protein is well conserved among SARS-CoV-2 viruses and shares 99% identity with that of bat SARS-CoVs10.
T43 976-1103 Sentence denotes The vaccine design based on the S2 protein may boost the broad-spectrum antiviral effect and is worth testing in animal models.
T44 1104-1292 Sentence denotes Antibodies against the conserved stem region of influenza hemagglutinin have been found to exhibit broadly cross-reactive immunity, but are less potent in neutralizing influenza A virus17.
T45 1293-1483 Sentence denotes In contrast, the S1 subunit consists of the receptor-binding domain (RBD), which mediates virus entry into sensitive cells through the host angiotensin-converting enzyme 2 (ACE2) receptor18.
T46 1484-1567 Sentence denotes The S1 protein of 2019-nCoV shares about 70% identity with that of human SARS-CoVs.
T47 1568-1750 Sentence denotes The highest number of variations of amino acids in the RBD is located in the external subdomain, which is responsible for the direct interaction between virus and host receptor10,18.
T48 1751-1857 Sentence denotes Blocking the initial entry of a virus is proposed as a successful strategy in controlling viral infection.
T49 1858-2051 Sentence denotes Based on SARS vaccine development, most vaccine candidates target the S protein, which induces neutralizing antibody responses and stimulates a protective cellular immunity against SARS-CoVs12.
T50 2052-2226 Sentence denotes Bukreyev et al.19 showed that immunization of African green monkeys with the full-length S protein of SARS-CoV protects monkeys from subsequent homologous SARS-CoV challenge.
T51 2227-2374 Sentence denotes Administration of SARS-CoV RBD proteins can also induce highly potent neutralizing antibodies and long-term protective immunity in animal models20.
T52 2375-2576 Sentence denotes Thus, the generation of antibodies targeting the S1 subunit of SARS-CoV-2 would be an important preventive and treatment strategy that can be tested further in suitable models before clinical trials10.