PMC:7060038 / 48668-50062 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"337","span":{"begin":545,"end":549},"obj":"Gene"},{"id":"338","span":{"begin":1236,"end":1240},"obj":"Gene"},{"id":"339","span":{"begin":168,"end":172},"obj":"Gene"},{"id":"340","span":{"begin":614,"end":623},"obj":"Disease"},{"id":"341","span":{"begin":818,"end":823},"obj":"Disease"},{"id":"342","span":{"begin":827,"end":832},"obj":"Disease"},{"id":"343","span":{"begin":1211,"end":1221},"obj":"Disease"}],"attributes":[{"id":"A337","pred":"tao:has_database_id","subj":"337","obj":"Gene:3635"},{"id":"A338","pred":"tao:has_database_id","subj":"338","obj":"Gene:3635"},{"id":"A339","pred":"tao:has_database_id","subj":"339","obj":"Gene:3635"},{"id":"A340","pred":"tao:has_database_id","subj":"340","obj":"MESH:D007239"},{"id":"A341","pred":"tao:has_database_id","subj":"341","obj":"MESH:D005334"},{"id":"A342","pred":"tao:has_database_id","subj":"342","obj":"MESH:D003371"},{"id":"A343","pred":"tao:has_database_id","subj":"343","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Fraction of subclinical cases\nTo estimate the upper-bound fraction of subclinical cases, we draw on data from active surveillance of passengers quarantined on a cruise ship off the coast of Japan, or passengers of repatriation flights. These data show that 50–70% of cases are asymptomatic at the time of diagnosis (Dorigatti et al., 2020; Nishiura et al., 2020; Schnirring, 2020c; Schnirring, 2020b). We estimate that 50% subclinical cases is a reasonable upper bound: due to intensive monitoring, cases in repatriated individuals or in cruise ship passengers will be detected earlier than usual in the course of infection--and possibly before the onset of symptoms. From clinical data (where severe cases are likely overrepresented), we estimate a lower bound of 5%: even among clinically attended cases, 2–15% lack fever or cough, and would be undetectable in symptom screening (Chan et al., 2020; Chen et al., 2020; The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, 2020; Huang et al., 2020). In addition to the upper and lower bound scenarios, we consider a plausible middle-case scenario in which 25% of cases are subclinical. A very recent delay-adjusted estimate indicates 30-40% of infections on the cruise ship quarantined off the coast of Japan are asymptomatic, so the truth may fall somewhere between our middle and worst-case scenarios (Mizumoto et al., 2020)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T51","span":{"begin":614,"end":623},"obj":"Disease"},{"id":"T52","span":{"begin":942,"end":951},"obj":"Disease"},{"id":"T53","span":{"begin":1211,"end":1221},"obj":"Disease"}],"attributes":[{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Fraction of subclinical cases\nTo estimate the upper-bound fraction of subclinical cases, we draw on data from active surveillance of passengers quarantined on a cruise ship off the coast of Japan, or passengers of repatriation flights. These data show that 50–70% of cases are asymptomatic at the time of diagnosis (Dorigatti et al., 2020; Nishiura et al., 2020; Schnirring, 2020c; Schnirring, 2020b). We estimate that 50% subclinical cases is a reasonable upper bound: due to intensive monitoring, cases in repatriated individuals or in cruise ship passengers will be detected earlier than usual in the course of infection--and possibly before the onset of symptoms. From clinical data (where severe cases are likely overrepresented), we estimate a lower bound of 5%: even among clinically attended cases, 2–15% lack fever or cough, and would be undetectable in symptom screening (Chan et al., 2020; Chen et al., 2020; The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, 2020; Huang et al., 2020). In addition to the upper and lower bound scenarios, we consider a plausible middle-case scenario in which 25% of cases are subclinical. A very recent delay-adjusted estimate indicates 30-40% of infections on the cruise ship quarantined off the coast of Japan are asymptomatic, so the truth may fall somewhere between our middle and worst-case scenarios (Mizumoto et al., 2020)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T171","span":{"begin":110,"end":116},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T172","span":{"begin":159,"end":160},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T173","span":{"begin":444,"end":445},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T174","span":{"begin":748,"end":749},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T175","span":{"begin":1081,"end":1082},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T176","span":{"begin":1153,"end":1154},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Fraction of subclinical cases\nTo estimate the upper-bound fraction of subclinical cases, we draw on data from active surveillance of passengers quarantined on a cruise ship off the coast of Japan, or passengers of repatriation flights. These data show that 50–70% of cases are asymptomatic at the time of diagnosis (Dorigatti et al., 2020; Nishiura et al., 2020; Schnirring, 2020c; Schnirring, 2020b). We estimate that 50% subclinical cases is a reasonable upper bound: due to intensive monitoring, cases in repatriated individuals or in cruise ship passengers will be detected earlier than usual in the course of infection--and possibly before the onset of symptoms. From clinical data (where severe cases are likely overrepresented), we estimate a lower bound of 5%: even among clinically attended cases, 2–15% lack fever or cough, and would be undetectable in symptom screening (Chan et al., 2020; Chen et al., 2020; The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, 2020; Huang et al., 2020). In addition to the upper and lower bound scenarios, we consider a plausible middle-case scenario in which 25% of cases are subclinical. A very recent delay-adjusted estimate indicates 30-40% of infections on the cruise ship quarantined off the coast of Japan are asymptomatic, so the truth may fall somewhere between our middle and worst-case scenarios (Mizumoto et al., 2020)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T48","span":{"begin":818,"end":823},"obj":"Phenotype"},{"id":"T49","span":{"begin":827,"end":832},"obj":"Phenotype"},{"id":"T50","span":{"begin":942,"end":951},"obj":"Phenotype"}],"attributes":[{"id":"A48","pred":"hp_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A49","pred":"hp_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/HP_0012735"},{"id":"A50","pred":"hp_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"Fraction of subclinical cases\nTo estimate the upper-bound fraction of subclinical cases, we draw on data from active surveillance of passengers quarantined on a cruise ship off the coast of Japan, or passengers of repatriation flights. These data show that 50–70% of cases are asymptomatic at the time of diagnosis (Dorigatti et al., 2020; Nishiura et al., 2020; Schnirring, 2020c; Schnirring, 2020b). We estimate that 50% subclinical cases is a reasonable upper bound: due to intensive monitoring, cases in repatriated individuals or in cruise ship passengers will be detected earlier than usual in the course of infection--and possibly before the onset of symptoms. From clinical data (where severe cases are likely overrepresented), we estimate a lower bound of 5%: even among clinically attended cases, 2–15% lack fever or cough, and would be undetectable in symptom screening (Chan et al., 2020; Chen et al., 2020; The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, 2020; Huang et al., 2020). In addition to the upper and lower bound scenarios, we consider a plausible middle-case scenario in which 25% of cases are subclinical. A very recent delay-adjusted estimate indicates 30-40% of infections on the cruise ship quarantined off the coast of Japan are asymptomatic, so the truth may fall somewhere between our middle and worst-case scenarios (Mizumoto et al., 2020)."}

{"project":"2_test","denotations":[{"id":"32091395-32064853-27032145","span":{"begin":990,"end":994},"obj":"32064853"}],"text":"Fraction of subclinical cases\nTo estimate the upper-bound fraction of subclinical cases, we draw on data from active surveillance of passengers quarantined on a cruise ship off the coast of Japan, or passengers of repatriation flights. These data show that 50–70% of cases are asymptomatic at the time of diagnosis (Dorigatti et al., 2020; Nishiura et al., 2020; Schnirring, 2020c; Schnirring, 2020b). We estimate that 50% subclinical cases is a reasonable upper bound: due to intensive monitoring, cases in repatriated individuals or in cruise ship passengers will be detected earlier than usual in the course of infection--and possibly before the onset of symptoms. From clinical data (where severe cases are likely overrepresented), we estimate a lower bound of 5%: even among clinically attended cases, 2–15% lack fever or cough, and would be undetectable in symptom screening (Chan et al., 2020; Chen et al., 2020; The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, 2020; Huang et al., 2020). In addition to the upper and lower bound scenarios, we consider a plausible middle-case scenario in which 25% of cases are subclinical. A very recent delay-adjusted estimate indicates 30-40% of infections on the cruise ship quarantined off the coast of Japan are asymptomatic, so the truth may fall somewhere between our middle and worst-case scenarios (Mizumoto et al., 2020)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T299","span":{"begin":0,"end":29},"obj":"Sentence"},{"id":"T300","span":{"begin":30,"end":235},"obj":"Sentence"},{"id":"T301","span":{"begin":236,"end":401},"obj":"Sentence"},{"id":"T302","span":{"begin":402,"end":667},"obj":"Sentence"},{"id":"T303","span":{"begin":668,"end":1016},"obj":"Sentence"},{"id":"T304","span":{"begin":1017,"end":1152},"obj":"Sentence"},{"id":"T305","span":{"begin":1153,"end":1394},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Fraction of subclinical cases\nTo estimate the upper-bound fraction of subclinical cases, we draw on data from active surveillance of passengers quarantined on a cruise ship off the coast of Japan, or passengers of repatriation flights. These data show that 50–70% of cases are asymptomatic at the time of diagnosis (Dorigatti et al., 2020; Nishiura et al., 2020; Schnirring, 2020c; Schnirring, 2020b). We estimate that 50% subclinical cases is a reasonable upper bound: due to intensive monitoring, cases in repatriated individuals or in cruise ship passengers will be detected earlier than usual in the course of infection--and possibly before the onset of symptoms. From clinical data (where severe cases are likely overrepresented), we estimate a lower bound of 5%: even among clinically attended cases, 2–15% lack fever or cough, and would be undetectable in symptom screening (Chan et al., 2020; Chen et al., 2020; The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, 2020; Huang et al., 2020). In addition to the upper and lower bound scenarios, we consider a plausible middle-case scenario in which 25% of cases are subclinical. A very recent delay-adjusted estimate indicates 30-40% of infections on the cruise ship quarantined off the coast of Japan are asymptomatic, so the truth may fall somewhere between our middle and worst-case scenarios (Mizumoto et al., 2020)."}

{"project":"MyTest","denotations":[{"id":"32091395-32064853-27032145","span":{"begin":990,"end":994},"obj":"32064853"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Fraction of subclinical cases\nTo estimate the upper-bound fraction of subclinical cases, we draw on data from active surveillance of passengers quarantined on a cruise ship off the coast of Japan, or passengers of repatriation flights. These data show that 50–70% of cases are asymptomatic at the time of diagnosis (Dorigatti et al., 2020; Nishiura et al., 2020; Schnirring, 2020c; Schnirring, 2020b). We estimate that 50% subclinical cases is a reasonable upper bound: due to intensive monitoring, cases in repatriated individuals or in cruise ship passengers will be detected earlier than usual in the course of infection--and possibly before the onset of symptoms. From clinical data (where severe cases are likely overrepresented), we estimate a lower bound of 5%: even among clinically attended cases, 2–15% lack fever or cough, and would be undetectable in symptom screening (Chan et al., 2020; Chen et al., 2020; The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, 2020; Huang et al., 2020). In addition to the upper and lower bound scenarios, we consider a plausible middle-case scenario in which 25% of cases are subclinical. A very recent delay-adjusted estimate indicates 30-40% of infections on the cruise ship quarantined off the coast of Japan are asymptomatic, so the truth may fall somewhere between our middle and worst-case scenarios (Mizumoto et al., 2020)."}