PMC:7055038 / 6984-7489 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"150","span":{"begin":220,"end":224},"obj":"Gene"},{"id":"151","span":{"begin":66,"end":74},"obj":"Species"},{"id":"152","span":{"begin":100,"end":110},"obj":"Species"},{"id":"153","span":{"begin":414,"end":422},"obj":"Species"}],"attributes":[{"id":"A150","pred":"tao:has_database_id","subj":"150","obj":"Gene:59272"},{"id":"A151","pred":"tao:has_database_id","subj":"151","obj":"Tax:694009"},{"id":"A152","pred":"tao:has_database_id","subj":"152","obj":"Tax:2697049"},{"id":"A153","pred":"tao:has_database_id","subj":"153","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T32","span":{"begin":45,"end":57},"obj":"Body_part"},{"id":"T33","span":{"begin":156,"end":163},"obj":"Body_part"},{"id":"T34","span":{"begin":196,"end":203},"obj":"Body_part"},{"id":"T35","span":{"begin":376,"end":380},"obj":"Body_part"}],"attributes":[{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15]."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p9941s12","span":{"begin":371,"end":399},"obj":"MPA"},{"id":"p9941s27","span":{"begin":460,"end":469},"obj":"MPA"},{"id":"p9941s29","span":{"begin":474,"end":496},"obj":"MPA"}],"text":"Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T46","span":{"begin":66,"end":70},"obj":"Disease"},{"id":"T47","span":{"begin":100,"end":108},"obj":"Disease"},{"id":"T48","span":{"begin":100,"end":104},"obj":"Disease"},{"id":"T49","span":{"begin":414,"end":422},"obj":"Disease"},{"id":"T50","span":{"begin":414,"end":418},"obj":"Disease"}],"attributes":[{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T63","span":{"begin":263,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T64","span":{"begin":376,"end":380},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6","span":{"begin":45,"end":57},"obj":"Chemical"},{"id":"T7","span":{"begin":156,"end":163},"obj":"Chemical"},{"id":"T8","span":{"begin":196,"end":203},"obj":"Chemical"}],"attributes":[{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T4","span":{"begin":279,"end":294},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T5","span":{"begin":460,"end":469},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T6","span":{"begin":460,"end":469},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15]."}

{"project":"2_test","denotations":[{"id":"32127124-30102747-29320643","span":{"begin":296,"end":298},"obj":"30102747"},{"id":"32127124-19198616-29320644","span":{"begin":299,"end":301},"obj":"19198616"},{"id":"32127124-32015507-29320645","span":{"begin":498,"end":500},"obj":"32015507"},{"id":"32127124-31996437-29320646","span":{"begin":501,"end":503},"obj":"31996437"}],"text":"Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T63","span":{"begin":0,"end":182},"obj":"Sentence"},{"id":"T64","span":{"begin":183,"end":303},"obj":"Sentence"},{"id":"T65","span":{"begin":304,"end":505},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15]."}

{"project":"MyTest","denotations":[{"id":"32127124-30102747-29320643","span":{"begin":296,"end":298},"obj":"30102747"},{"id":"32127124-19198616-29320644","span":{"begin":299,"end":301},"obj":"19198616"},{"id":"32127124-32015507-29320645","span":{"begin":498,"end":500},"obj":"32015507"},{"id":"32127124-31996437-29320646","span":{"begin":501,"end":503},"obj":"31996437"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15]."}