PMC:7054964 / 152-1093 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"10","span":{"begin":237,"end":241},"obj":"Species"},{"id":"11","span":{"begin":289,"end":297},"obj":"Species"},{"id":"12","span":{"begin":328,"end":336},"obj":"Species"},{"id":"13","span":{"begin":365,"end":373},"obj":"Species"},{"id":"14","span":{"begin":576,"end":584},"obj":"Species"},{"id":"15","span":{"begin":779,"end":786},"obj":"Species"},{"id":"16","span":{"begin":19,"end":52},"obj":"Disease"},{"id":"17","span":{"begin":60,"end":69},"obj":"Disease"}],"attributes":[{"id":"A10","pred":"tao:has_database_id","subj":"10","obj":"Tax:2697049"},{"id":"A11","pred":"tao:has_database_id","subj":"11","obj":"Tax:9606"},{"id":"A12","pred":"tao:has_database_id","subj":"12","obj":"Tax:9606"},{"id":"A13","pred":"tao:has_database_id","subj":"13","obj":"Tax:9606"},{"id":"A14","pred":"tao:has_database_id","subj":"14","obj":"Tax:9606"},{"id":"A15","pred":"tao:has_database_id","subj":"15","obj":"Tax:9606"},{"id":"A16","pred":"tao:has_database_id","subj":"16","obj":"MESH:C000657245"},{"id":"A17","pred":"tao:has_database_id","subj":"17","obj":"MESH:D011014"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ABSTRACT\nThe novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T3","span":{"begin":142,"end":147},"obj":"Body_part"},{"id":"T4","span":{"begin":242,"end":245},"obj":"Body_part"},{"id":"T5","span":{"begin":274,"end":279},"obj":"Body_part"},{"id":"T6","span":{"begin":396,"end":399},"obj":"Body_part"},{"id":"T7","span":{"begin":407,"end":412},"obj":"Body_part"},{"id":"T8","span":{"begin":491,"end":496},"obj":"Body_part"},{"id":"T9","span":{"begin":503,"end":506},"obj":"Body_part"},{"id":"T10","span":{"begin":682,"end":685},"obj":"Body_part"},{"id":"T11","span":{"begin":747,"end":752},"obj":"Body_part"},{"id":"T12","span":{"begin":839,"end":854},"obj":"Body_part"},{"id":"T13","span":{"begin":912,"end":915},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma317863"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"ABSTRACT\nThe novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T2","span":{"begin":142,"end":147},"obj":"Body_part"},{"id":"T3","span":{"begin":274,"end":279},"obj":"Body_part"},{"id":"T4","span":{"begin":407,"end":412},"obj":"Body_part"},{"id":"T5","span":{"begin":491,"end":496},"obj":"Body_part"},{"id":"T6","span":{"begin":747,"end":752},"obj":"Body_part"},{"id":"T7","span":{"begin":839,"end":854},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"}],"text":"ABSTRACT\nThe novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":31,"end":52},"obj":"Disease"},{"id":"T2","span":{"begin":43,"end":52},"obj":"Disease"},{"id":"T3","span":{"begin":60,"end":69},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"}],"text":"ABSTRACT\nThe novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T4","span":{"begin":103,"end":108},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T5","span":{"begin":142,"end":147},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T6","span":{"begin":142,"end":147},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T7","span":{"begin":274,"end":279},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T8","span":{"begin":274,"end":279},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T9","span":{"begin":319,"end":321},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T10","span":{"begin":407,"end":412},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T11","span":{"begin":407,"end":412},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T12","span":{"begin":467,"end":468},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T13","span":{"begin":573,"end":575},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T14","span":{"begin":601,"end":606},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T15","span":{"begin":747,"end":752},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T16","span":{"begin":747,"end":752},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T17","span":{"begin":765,"end":767},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T18","span":{"begin":810,"end":815},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T19","span":{"begin":839,"end":854},"obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"T20","span":{"begin":906,"end":911},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"ABSTRACT\nThe novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":60,"end":69},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"ABSTRACT\nThe novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites."}

{"project":"LitCovid-sentences","denotations":[{"id":"T6","span":{"begin":0,"end":8},"obj":"Sentence"},{"id":"T7","span":{"begin":9,"end":213},"obj":"Sentence"},{"id":"T8","span":{"begin":214,"end":338},"obj":"Sentence"},{"id":"T9","span":{"begin":339,"end":552},"obj":"Sentence"},{"id":"T10","span":{"begin":553,"end":645},"obj":"Sentence"},{"id":"T11","span":{"begin":646,"end":855},"obj":"Sentence"},{"id":"T12","span":{"begin":856,"end":941},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ABSTRACT\nThe novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites."}