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PMC:7054935 / 3182-4596 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
135 138-142 Gene denotes ACE2 Gene:59272
136 450-454 Gene denotes ACE2 Gene:59272
137 566-570 Gene denotes ACE2 Gene:59272
138 644-648 Gene denotes ACE2 Gene:59272
139 1078-1082 Gene denotes ACE2 Gene:59272
140 49-52 Species denotes CoV Tax:11118
141 71-76 Species denotes human Tax:9606
142 77-85 Species denotes patients Tax:9606
143 132-137 Species denotes human Tax:9606
144 172-177 Species denotes human Tax:9606
145 252-256 Species denotes CoVs Tax:11118
146 279-287 Species denotes SARS CoV Tax:694009
147 291-297 Species denotes humans Tax:9606
148 341-354 Species denotes coronaviruses Tax:11118
149 382-396 Species denotes horseshoe bats Tax:49442
150 425-428 Species denotes CoV Tax:11118
151 460-466 Species denotes humans Tax:9606
152 487-501 Species denotes horseshoe bats Tax:49442
153 638-643 Species denotes human Tax:9606
154 675-683 Species denotes SARS CoV Tax:694009
155 774-778 Species denotes CoVs Tax:11118
156 810-815 Species denotes human Tax:9606
157 883-898 Species denotes bat coronavirus Tax:1508220
158 970-975 Species denotes mouse Tax:10090
159 989-997 Species denotes SARS-CoV Tax:694009
160 1072-1077 Species denotes human Tax:9606
161 1108-1113 Species denotes human Tax:9606
162 1168-1176 Species denotes SARS-CoV Tax:694009
163 1243-1248 Species denotes mouse Tax:10090
164 1405-1409 Species denotes mice Tax:10090
165 1256-1265 Disease denotes infection MESH:D007239

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T157 27-31 SO:0000704 denotes gene
T156 37-40 SP_2 denotes bat
T155 71-76 SP_6;NCBITaxon:9606 denotes human
T154 105-112 NCBITaxon:10239 denotes viruses
T153 132-137 SP_6;NCBITaxon:9606;PG_10 denotes human
T152 138-142 PG_10;PR:000003622 denotes ACE2
T151 172-177 SP_6;NCBITaxon:9606 denotes human
T150 248-251 SP_2 denotes bat
T149 279-287 SP_10 denotes SARS CoV
T148 291-297 NCBITaxon:9606 denotes humans
T147 337-340 SP_2 denotes bat
T146 341-354 NCBITaxon:11118 denotes coronaviruses
T145 382-396 SP_2 denotes horseshoe bats
T144 405-408 SP_2 denotes bat
T143 409-413 SP_10 denotes SARS
T142 450-454 G_3;PG_10;PR:000003622 denotes ACE2
T141 460-466 NCBITaxon:9606 denotes humans
T140 487-501 SP_2 denotes horseshoe bats
T139 562-565 SP_2 denotes bat
T138 566-570 G_3;PG_10;PR:000003622 denotes ACE2
T137 571-575 SO:0000704 denotes gene
T136 617-630 SO:0000409 denotes contact sites
T135 638-643 SP_6;NCBITaxon:9606;PG_10 denotes human
T134 644-648 PG_10;PR:000003622 denotes ACE2
T133 649-653 SO:0000704 denotes gene
T132 675-683 SP_10 denotes SARS CoV
T131 767-770 SP_2 denotes bat
T130 810-815 SP_6;NCBITaxon:9606 denotes human
T129 873-877 SO:0000704 denotes gene
T128 883-886 SP_2 denotes bat
T127 887-898 NCBITaxon:11118 denotes coronavirus
T126 957-962 NCBITaxon:10239 denotes virus
T125 970-975 NCBITaxon:10088 denotes mouse
T124 989-997 SP_10 denotes SARS-CoV
T123 1037-1042 NCBITaxon:10239 denotes virus
T122 1072-1077 SP_6;NCBITaxon:9606;PG_10 denotes human
T121 1078-1082 PG_10;PR:000003622 denotes ACE2
T120 1087-1096 GO:0006260 denotes replicate
T119 1108-1113 SP_6;NCBITaxon:9606 denotes human
T118 1114-1120 UBERON:0001005 denotes airway
T117 1168-1176 SP_10 denotes SARS-CoV
T116 1203-1212 GO:0006260 denotes replicate
T115 1243-1248 NCBITaxon:10088 denotes mouse
T114 1249-1254 UBERON:0000170 denotes lungs
T113 1291-1296 NCBITaxon:10239 denotes virus
T112 1297-1304 CHEBI:59132;CHEBI:59132 denotes antigen
T111 1324-1330 UBERON:0001005 denotes airway
T110 1331-1341 UBERON:0000483 denotes epithelium
T109 1357-1361 SP_10 denotes SARS
T108 1405-1409 NCBITaxon:10088 denotes mice

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T15 27-31 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T16 178-183 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17 571-575 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T18 649-653 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T19 873-877 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T20 998-1006 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T21 1121-1126 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22 1249-1254 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T23 1331-1341 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 1331-1341 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T43 279-283 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T44 409-413 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T45 675-679 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T46 989-997 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 989-993 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T48 1168-1176 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 1168-1172 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T50 1256-1265 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T51 1357-1361 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T43 27-31 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T44 37-40 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T45 71-76 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T46 105-112 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T47 132-137 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T48 146-147 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 172-183 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T50 248-251 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T51 291-297 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T52 337-340 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T53 392-396 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T54 405-408 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T55 460-466 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T56 497-501 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T57 562-565 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T58 571-575 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T59 576-579 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T60 638-643 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T61 649-653 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T62 767-770 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T63 810-815 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T64 873-877 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T65 883-886 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T66 946-947 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 957-962 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T68 970-975 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T69 1037-1042 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T70 1072-1077 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T71 1108-1113 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T72 1114-1120 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T73 1121-1126 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T74 1243-1248 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T75 1249-1254 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T76 1291-1296 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T77 1324-1330 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T78 1331-1341 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T6 422-424 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T7 771-773 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T8 899-901 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T9 1022-1024 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T10 1184-1186 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T11 1297-1304 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T22 0-192 Sentence denotes It was proposed that the S gene from bat-derived CoV, unlike that from human patients- or civets-derived viruses, was unable to use human ACE2 as a receptor for entry into human cells [10,11].
T23 193-305 Sentence denotes Civets were proposed to be an intermediate host of the bat-CoVs, capable of spreading SARS CoV to humans [6,12].
T24 306-516 Sentence denotes However, in 2013 several novel bat coronaviruses were isolated from Chinese horseshoe bats and the bat SARS-like or SL-CoV-WIV1 was able to use ACE2 from humans, civets and Chinese horseshoe bats for entry [8].
T25 517-822 Sentence denotes Combined with evolutionary evidence that the bat ACE2 gene has been positively selected at the same contact sites as the human ACE2 gene for interacting with SARS CoV [13], it was proposed that an intermediate host may not be necessary and that some bat SL-CoVs may be able to directly infect human hosts.
T26 823-1007 Sentence denotes To directly address this possibility, the exact S gene from bat coronavirus SL-SHC014 was synthesized and used to generate a chimeric virus in the mouse adapted MA15 SARS-CoV backbone.
T27 1008-1177 Sentence denotes The resultant SL-SHC014-MA15 virus could indeed efficiently use human ACE2 and replicate in primary human airway cells to similar titres as epidemic strains of SARS-CoV.
T28 1178-1414 Sentence denotes While SL-SHC014-MA15 can replicate efficiently in young and aged mouse lungs, infection was attenuated, and less virus antigen was present in the airway epithelium as compared to SARS MA15, which causes lethal outcomes in aged mice [7].