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PMC:7054527 / 4974-6327
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
219 | 64-69 | Gene | denotes | spike | Gene:43740568 |
220 | 564-595 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
221 | 597-601 | Gene | denotes | ACE2 | Gene:59272 |
222 | 670-674 | Gene | denotes | ACE2 | Gene:59272 |
223 | 776-780 | Gene | denotes | ACE2 | Gene:100144303 |
224 | 804-808 | Gene | denotes | ACE2 | Gene:59272 |
225 | 972-976 | Gene | denotes | ACE2 | Gene:59272 |
226 | 1044-1048 | Gene | denotes | ACE2 | Gene:59272 |
227 | 1134-1138 | Gene | denotes | ACE2 | Gene:59272 |
228 | 1213-1220 | Gene | denotes | TMPRSS2 | Gene:7113 |
229 | 1297-1304 | Gene | denotes | TMPRSS2 | Gene:7113 |
230 | 711-714 | Gene | denotes | bat | Gene:570 |
231 | 0-9 | Species | denotes | 2019-nCoV | Tax:2697049 |
232 | 32-43 | Species | denotes | coronavirus | Tax:11118 |
233 | 336-347 | Species | denotes | coronavirus | Tax:11118 |
234 | 503-512 | Species | denotes | 2019-nCoV | Tax:2697049 |
235 | 517-525 | Species | denotes | SARS-CoV | Tax:694009 |
236 | 527-536 | Species | denotes | 2019-nCoV | Tax:2697049 |
237 | 558-563 | Species | denotes | human | Tax:9606 |
238 | 631-639 | Species | denotes | SARS-CoV | Tax:694009 |
239 | 644-653 | Species | denotes | 2019-nCoV | Tax:2697049 |
240 | 704-709 | Species | denotes | human | Tax:9606 |
241 | 731-734 | Species | denotes | pig | Tax:9823 |
242 | 824-832 | Species | denotes | SARS-CoV | Tax:694009 |
243 | 921-928 | Species | denotes | patient | Tax:9606 |
244 | 951-960 | Species | denotes | 2019-nCoV | Tax:2697049 |
245 | 1002-1011 | Species | denotes | 2019-nCoV | Tax:2697049 |
246 | 1053-1062 | Species | denotes | 2019-nCoV | Tax:2697049 |
247 | 1168-1177 | Species | denotes | 2019-nCoV | Tax:2697049 |
248 | 1266-1275 | Species | denotes | 2019-nCoV | Tax:2697049 |
249 | 842-847 | Species | denotes | human | Tax:9606 |
250 | 1197-1203 | Chemical | denotes | serine | MESH:D012694 |
251 | 903-920 | Disease | denotes | SARS-CoV-infected | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T22 | 70-77 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T23 | 175-183 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T24 | 193-196 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T25 | 271-283 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
T26 | 323-330 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T27 | 460-470 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
T28 | 487-494 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T29 | 693-698 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T30 | 762-767 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T31 | 812-820 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T32 | 859-867 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T33 | 877-882 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
T34 | 1065-1072 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T35 | 1197-1203 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
T36 | 1247-1254 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T12 | 877-882 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T39 | 517-525 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T40 | 517-521 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T41 | 631-639 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T42 | 631-635 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T43 | 824-832 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T44 | 824-828 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T45 | 903-911 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T46 | 903-907 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T43 | 86-94 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T44 | 166-174 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T45 | 558-563 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T46 | 693-698 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T47 | 704-709 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T48 | 711-714 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bat |
T49 | 762-767 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T50 | 786-788 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
T51 | 790-791 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T52 | 822-823 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T53 | 842-847 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T54 | 888-889 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T55 | 1332-1333 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T5 | 70-77 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T6 | 175-183 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T7 | 271-283 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
T8 | 323-330 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T9 | 460-470 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
T10 | 460-465 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T11 | 466-470 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T12 | 487-494 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T13 | 564-575 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T14 | 722-725 | Chemical | denotes | cat | http://purl.obolibrary.org/obo/CHEBI_32402 |
T15 | 1065-1072 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T16 | 1197-1203 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
T17 | 1247-1254 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T18 | 1305-1314 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T34 | 0-316 | Sentence | denotes | 2019-nCoV possessed the typical coronavirus structure with the “spike protein” in the membrane envelope30, and also expressed other polyproteins, nucleoproteins, and membrane proteins, such as RNA polymerase, 3-chymotrypsin-like protease, papain-like protease, helicase, glycoprotein, and accessory proteins10,11,30. |
T35 | 317-435 | Sentence | denotes | The S protein from coronavirus can bind to the receptors of the host to facilitate viral entry into target cells31,32. |
T36 | 436-789 | Sentence | denotes | Although there are four amino acid variations of S protein between 2019-nCoV and SARS-CoV, 2019-nCoV can also bind to the human angiotensin-converting enzyme 2 (ACE2), the same host receptor for SARS-CoV, as 2019-nCoV can bind to the ACE2 receptor from the cells from human, bat, civet cat, and pig, but it cannot bind to the cells without ACE211,33–35. |
T37 | 790-1017 | Sentence | denotes | A recombinant ACE2-Ig antibody, a SARS-CoV-specific human monoclonal antibody, and the serum from a convalescent SARS-CoV-infected patient, which can neutralize 2019-nCoV, confirmed ACE2 as the host receptor for 2019-nCoV36–39. |
T38 | 1018-1183 | Sentence | denotes | The high affinity between ACE2 and 2019-nCoV S protein also suggested that the population with higher expression of ACE2 might be more susceptible to 2019-nCoV40,41. |
T39 | 1184-1353 | Sentence | denotes | The cellular serine protease TMPRSS2 also contributed to the S-protein priming of 2019-nCoV, indicating that the TMPRSS2 inhibitor might constitute a treatment option36. |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32127517-27578435-53455635 | 103-105 | 27578435 | denotes | 30 |
32127517-27578435-53455636 | 313-315 | 27578435 | denotes | 30 |
32127517-30567993-53455637 | 429-431 | 30567993 | denotes | 31 |
32127517-22816037-53455638 | 432-434 | 22816037 | denotes | 32 |
32127517-32065055-53455639 | 1011-1013 | 32065055 | denotes | 36 |
T63019 | 103-105 | 27578435 | denotes | 30 |
T4951 | 313-315 | 27578435 | denotes | 30 |
T6721 | 429-431 | 30567993 | denotes | 31 |
T53119 | 432-434 | 22816037 | denotes | 32 |
T24045 | 1011-1013 | 32065055 | denotes | 36 |