PMC:7049657 / 7765-8849 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"240","span":{"begin":447,"end":463},"obj":"Gene"},{"id":"241","span":{"begin":465,"end":468},"obj":"Gene"},{"id":"242","span":{"begin":512,"end":543},"obj":"Gene"},{"id":"243","span":{"begin":545,"end":549},"obj":"Gene"},{"id":"244","span":{"begin":621,"end":625},"obj":"Gene"},{"id":"245","span":{"begin":677,"end":681},"obj":"Gene"},{"id":"246","span":{"begin":790,"end":812},"obj":"Gene"},{"id":"247","span":{"begin":955,"end":959},"obj":"Gene"},{"id":"248","span":{"begin":129,"end":144},"obj":"Species"},{"id":"249","span":{"begin":191,"end":196},"obj":"Species"},{"id":"250","span":{"begin":197,"end":210},"obj":"Species"},{"id":"251","span":{"begin":284,"end":299},"obj":"Species"},{"id":"252","span":{"begin":327,"end":340},"obj":"Species"},{"id":"253","span":{"begin":598,"end":606},"obj":"Species"},{"id":"254","span":{"begin":753,"end":761},"obj":"Species"},{"id":"255","span":{"begin":939,"end":949},"obj":"Species"},{"id":"256","span":{"begin":734,"end":741},"obj":"Species"},{"id":"257","span":{"begin":898,"end":905},"obj":"Species"}],"attributes":[{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"Gene:290"},{"id":"A241","pred":"tao:has_database_id","subj":"241","obj":"Gene:290"},{"id":"A242","pred":"tao:has_database_id","subj":"242","obj":"Gene:59272"},{"id":"A243","pred":"tao:has_database_id","subj":"243","obj":"Gene:59272"},{"id":"A244","pred":"tao:has_database_id","subj":"244","obj":"Gene:59272"},{"id":"A245","pred":"tao:has_database_id","subj":"245","obj":"Gene:59272"},{"id":"A246","pred":"tao:has_database_id","subj":"246","obj":"Gene:1803"},{"id":"A247","pred":"tao:has_database_id","subj":"247","obj":"Gene:59272"},{"id":"A248","pred":"tao:has_database_id","subj":"248","obj":"Tax:2697049"},{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"Tax:9606"},{"id":"A250","pred":"tao:has_database_id","subj":"250","obj":"Tax:11118"},{"id":"A251","pred":"tao:has_database_id","subj":"251","obj":"Tax:2697049"},{"id":"A252","pred":"tao:has_database_id","subj":"252","obj":"Tax:11118"},{"id":"A253","pred":"tao:has_database_id","subj":"253","obj":"Tax:694009"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"Tax:1335626"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"Tax:2697049"},{"id":"A256","pred":"tao:has_database_id","subj":"256","obj":"Tax:28293"},{"id":"A257","pred":"tao:has_database_id","subj":"257","obj":"Tax:28293"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Given the sudden rapid superspreading event currently at play in China, it is imperative to learn as much as possible about this new coronavirus and to compare it to what we know about other human coronaviruses. One important area of research is determining the cell receptor for the new coronavirus. The previously recognised coronaviruses enter host cells by attaching their Spike (S) protein to a cellular receptor. Most Alphacoronaviruses use aminopeptidase-N (APN) [15], but one Alphacoronavirus, NL6, uses Angiotensin-converting enzyme 2 (ACE2) as its receptor for entry into host cells. The SARS-CoV also uses the ACE2 receptor as its entry method into cells [16], this ACE2 is commonly present on cells of the respiratory and enteric tract. The MERS-CoV uses the host cell receptor dipeptidyl peptidase 4 (DPPR or CD26) [17,18] a cell receptor that is similarly abundant in respiratory and enteric tracts. Recent evidence suggests SARS-CoV-2 uses ACE2 as its entry point; data that should speed the development of an effective drug and eventually a safe and effective vaccine."}

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{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T57","span":{"begin":598,"end":606},"obj":"Disease"},{"id":"T58","span":{"begin":598,"end":602},"obj":"Disease"},{"id":"T59","span":{"begin":939,"end":947},"obj":"Disease"},{"id":"T60","span":{"begin":939,"end":943},"obj":"Disease"}],"attributes":[{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Given the sudden rapid superspreading event currently at play in China, it is imperative to learn as much as possible about this new coronavirus and to compare it to what we know about other human coronaviruses. One important area of research is determining the cell receptor for the new coronavirus. The previously recognised coronaviruses enter host cells by attaching their Spike (S) protein to a cellular receptor. Most Alphacoronaviruses use aminopeptidase-N (APN) [15], but one Alphacoronavirus, NL6, uses Angiotensin-converting enzyme 2 (ACE2) as its receptor for entry into host cells. The SARS-CoV also uses the ACE2 receptor as its entry method into cells [16], this ACE2 is commonly present on cells of the respiratory and enteric tract. The MERS-CoV uses the host cell receptor dipeptidyl peptidase 4 (DPPR or CD26) [17,18] a cell receptor that is similarly abundant in respiratory and enteric tracts. Recent evidence suggests SARS-CoV-2 uses ACE2 as its entry point; data that should speed the development of an effective drug and eventually a safe and effective vaccine."}

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{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":387,"end":394},"obj":"Chemical"},{"id":"T2","span":{"begin":512,"end":523},"obj":"Chemical"},{"id":"T3","span":{"begin":1035,"end":1039},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Given the sudden rapid superspreading event currently at play in China, it is imperative to learn as much as possible about this new coronavirus and to compare it to what we know about other human coronaviruses. One important area of research is determining the cell receptor for the new coronavirus. The previously recognised coronaviruses enter host cells by attaching their Spike (S) protein to a cellular receptor. Most Alphacoronaviruses use aminopeptidase-N (APN) [15], but one Alphacoronavirus, NL6, uses Angiotensin-converting enzyme 2 (ACE2) as its receptor for entry into host cells. The SARS-CoV also uses the ACE2 receptor as its entry method into cells [16], this ACE2 is commonly present on cells of the respiratory and enteric tract. The MERS-CoV uses the host cell receptor dipeptidyl peptidase 4 (DPPR or CD26) [17,18] a cell receptor that is similarly abundant in respiratory and enteric tracts. Recent evidence suggests SARS-CoV-2 uses ACE2 as its entry point; data that should speed the development of an effective drug and eventually a safe and effective vaccine."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":571,"end":586},"obj":"http://purl.obolibrary.org/obo/GO_0044409"}],"text":"Given the sudden rapid superspreading event currently at play in China, it is imperative to learn as much as possible about this new coronavirus and to compare it to what we know about other human coronaviruses. One important area of research is determining the cell receptor for the new coronavirus. The previously recognised coronaviruses enter host cells by attaching their Spike (S) protein to a cellular receptor. Most Alphacoronaviruses use aminopeptidase-N (APN) [15], but one Alphacoronavirus, NL6, uses Angiotensin-converting enzyme 2 (ACE2) as its receptor for entry into host cells. The SARS-CoV also uses the ACE2 receptor as its entry method into cells [16], this ACE2 is commonly present on cells of the respiratory and enteric tract. The MERS-CoV uses the host cell receptor dipeptidyl peptidase 4 (DPPR or CD26) [17,18] a cell receptor that is similarly abundant in respiratory and enteric tracts. Recent evidence suggests SARS-CoV-2 uses ACE2 as its entry point; data that should speed the development of an effective drug and eventually a safe and effective vaccine."}

{"project":"LitCovid-sentences","denotations":[{"id":"T42","span":{"begin":0,"end":211},"obj":"Sentence"},{"id":"T43","span":{"begin":212,"end":300},"obj":"Sentence"},{"id":"T44","span":{"begin":301,"end":418},"obj":"Sentence"},{"id":"T45","span":{"begin":419,"end":593},"obj":"Sentence"},{"id":"T46","span":{"begin":594,"end":748},"obj":"Sentence"},{"id":"T47","span":{"begin":749,"end":913},"obj":"Sentence"},{"id":"T48","span":{"begin":914,"end":1084},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Given the sudden rapid superspreading event currently at play in China, it is imperative to learn as much as possible about this new coronavirus and to compare it to what we know about other human coronaviruses. One important area of research is determining the cell receptor for the new coronavirus. The previously recognised coronaviruses enter host cells by attaching their Spike (S) protein to a cellular receptor. Most Alphacoronaviruses use aminopeptidase-N (APN) [15], but one Alphacoronavirus, NL6, uses Angiotensin-converting enzyme 2 (ACE2) as its receptor for entry into host cells. The SARS-CoV also uses the ACE2 receptor as its entry method into cells [16], this ACE2 is commonly present on cells of the respiratory and enteric tract. The MERS-CoV uses the host cell receptor dipeptidyl peptidase 4 (DPPR or CD26) [17,18] a cell receptor that is similarly abundant in respiratory and enteric tracts. Recent evidence suggests SARS-CoV-2 uses ACE2 as its entry point; data that should speed the development of an effective drug and eventually a safe and effective vaccine."}