PMC:7048180 / 9570-10945
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T38 | 466-473 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T39 | 633-641 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T47 | 46-54 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T48 | 323-331 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T49 | 426-434 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T50 | 691-699 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T51 | 886-894 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T52 | 1157-1177 | Disease | denotes | 2019-nCoV infections | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T53 | 1242-1250 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T65 | 127-128 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T66 | 229-230 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T67 | 722-729 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T68 | 733-734 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T69 | 898-899 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T70 | 1000-1003 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T51 | 466-473 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T52 | 845-852 | Chemical | denotes | mixture | http://purl.obolibrary.org/obo/CHEBI_60004 |
| T53 | 1339-1348 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T59 | 0-96 | Sentence | denotes | The RBD of 2019-nCoV differs largely from the SARS-CoV at the C-terminus residues (Figure 1(c)). |
| T60 | 97-298 | Sentence | denotes | Our results implied that such a difference did not result in drastic changes in the capability to engage the ACE2 receptor, but had a critical impact on the cross-reactivity of neutralizing antibodies. |
| T61 | 299-592 | Sentence | denotes | Some of the most potent SARS-CoV-specific neutralizing antibodies (e.g. m396, CR3014) that target the receptor binding site of SARS-CoV failed to bind 2019-nCoV spike protein, indicating that it is necessary to develop novel monoclonal antibodies that could bind specifically to 2019-nCoV RBD. |
| T62 | 593-827 | Sentence | denotes | Interestingly, it was reported that the antibody CR3022 completely neutralized both the wild-type SARS-CoV and the CR3014 escape viruses at a concentration of 23.5 μg/ml, and that no escape variants could be generated with CR3022 [5]. |
| T63 | 828-965 | Sentence | denotes | Furthermore, the mixture of CR3022 and CR3014 neutralized SARS-CoV in a synergistic fashion by recognizing different epitopes on RBD [5]. |
| T64 | 966-1178 | Sentence | denotes | These results suggest that CR3022 has the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections. |
| T65 | 1179-1375 | Sentence | denotes | We expect more cross-reactive antibodies against 2019-nCoV and SARS-CoV or other coronaviruses to be identified soon, facilitating the development of effective antiviral therapeutics and vaccines. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 357 | 206-210 | Gene | denotes | ACE2 | Gene:59272 |
| 358 | 11-20 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 359 | 46-54 | Species | denotes | SARS-CoV | Tax:694009 |
| 360 | 323-331 | Species | denotes | SARS-CoV | Tax:694009 |
| 361 | 426-434 | Species | denotes | SARS-CoV | Tax:694009 |
| 362 | 450-459 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 363 | 578-587 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 364 | 691-699 | Species | denotes | SARS-CoV | Tax:694009 |
| 365 | 886-894 | Species | denotes | SARS-CoV | Tax:694009 |
| 366 | 1228-1237 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 367 | 1242-1250 | Species | denotes | SARS-CoV | Tax:694009 |
| 368 | 1260-1273 | Species | denotes | coronaviruses | Tax:11118 |
| 369 | 642-648 | Chemical | denotes | CR3022 | |
| 370 | 708-714 | Chemical | denotes | CR3014 | |
| 371 | 816-822 | Chemical | denotes | CR3022 | |
| 372 | 856-862 | Chemical | denotes | CR3022 | |
| 373 | 867-873 | Chemical | denotes | CR3014 | |
| 374 | 993-999 | Chemical | denotes | CR3022 | |
| 375 | 1157-1177 | Disease | denotes | 2019-nCoV infections | MESH:C000657245 |