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PMC:7048180 / 7571-8506 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T29 259-267 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T30 583-591 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T31 639-647 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T43 55-63 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T47 155-165 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T48 222-223 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 242-247 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T50 604-605 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T46 0-382 Sentence denotes Next, we expressed and purified several representative SARS-CoV-specific antibodies which have been reported to target RBD and possess potent neutralizing activities, including m396 [3], CR3014 [4], CR3022 [5], as well as a MERS-CoV-specific human monoclonal antibody m336 developed by our laboratory [15], and measured their binding ability to 2019-nCoV RBD by ELISA (Figure 1(e)).
T47 383-482 Sentence denotes Surprisingly, we found that most of these antibodies did not show evident binding to 2019-nCoV RBD.
T48 483-558 Sentence denotes To confirm this result, we further measured the binding kinetics using BLI.
T49 559-623 Sentence denotes An irrelevant anti-CD40 antibody was used as a negative control.
T50 624-785 Sentence denotes Similarly, the antibody m396, which was predicted to bind 2019-nCoV RBD (Figure 1(d)), only showed slight binding at the highest measured concentration (2.0 µM).
T51 786-935 Sentence denotes Further studies are needed to solve the high-resolution structure of 2019-nCoV RBD and understand why it could not be recognized by these antibodies.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
286 578-582 Gene denotes CD40 Gene:958
287 224-232 Species denotes MERS-CoV Tax:1335626
288 345-354 Species denotes 2019-nCoV Tax:2697049
289 468-477 Species denotes 2019-nCoV Tax:2697049
290 682-691 Species denotes 2019-nCoV Tax:2697049
291 855-864 Species denotes 2019-nCoV Tax:2697049
292 55-63 Species denotes SARS-CoV Tax:694009
293 242-247 Species denotes human Tax:9606
294 187-193 Chemical denotes CR3014
295 199-205 Chemical denotes CR3022