PMC:7048180 / 7571-8506
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T29 | 259-267 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T30 | 583-591 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T31 | 639-647 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T43 | 55-63 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T47 | 155-165 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
T48 | 222-223 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T49 | 242-247 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T50 | 604-605 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T46 | 0-382 | Sentence | denotes | Next, we expressed and purified several representative SARS-CoV-specific antibodies which have been reported to target RBD and possess potent neutralizing activities, including m396 [3], CR3014 [4], CR3022 [5], as well as a MERS-CoV-specific human monoclonal antibody m336 developed by our laboratory [15], and measured their binding ability to 2019-nCoV RBD by ELISA (Figure 1(e)). |
T47 | 383-482 | Sentence | denotes | Surprisingly, we found that most of these antibodies did not show evident binding to 2019-nCoV RBD. |
T48 | 483-558 | Sentence | denotes | To confirm this result, we further measured the binding kinetics using BLI. |
T49 | 559-623 | Sentence | denotes | An irrelevant anti-CD40 antibody was used as a negative control. |
T50 | 624-785 | Sentence | denotes | Similarly, the antibody m396, which was predicted to bind 2019-nCoV RBD (Figure 1(d)), only showed slight binding at the highest measured concentration (2.0 µM). |
T51 | 786-935 | Sentence | denotes | Further studies are needed to solve the high-resolution structure of 2019-nCoV RBD and understand why it could not be recognized by these antibodies. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
286 | 578-582 | Gene | denotes | CD40 | Gene:958 |
287 | 224-232 | Species | denotes | MERS-CoV | Tax:1335626 |
288 | 345-354 | Species | denotes | 2019-nCoV | Tax:2697049 |
289 | 468-477 | Species | denotes | 2019-nCoV | Tax:2697049 |
290 | 682-691 | Species | denotes | 2019-nCoV | Tax:2697049 |
291 | 855-864 | Species | denotes | 2019-nCoV | Tax:2697049 |
292 | 55-63 | Species | denotes | SARS-CoV | Tax:694009 |
293 | 242-247 | Species | denotes | human | Tax:9606 |
294 | 187-193 | Chemical | denotes | CR3014 | |
295 | 199-205 | Chemical | denotes | CR3022 |