> top > docs > PMC:7048180 > spans > 177-1659 > annotations

PMC:7048180 / 177-1659 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T3 453-460 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T4 659-667 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T5 1216-1223 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 111-121 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T3 350-358 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 412-416 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 624-632 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 1016-1036 Disease denotes 2019-nCoV infections http://purl.obolibrary.org/obo/MONDO_0100096
T7 1077-1085 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 1176-1184 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1268-1276 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T3 56-59 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 105-110 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T5 152-153 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 172-177 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T7 622-623 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 642-647 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T9 1291-1294 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T10 1295-1296 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T2 227-236 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T3 453-460 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T4 717-719 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T5 736-743 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T6 1216-1223 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T7 0-185 Sentence denotes The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health.
T8 186-258 Sentence denotes Currently, however, there is no specific antiviral treatment or vaccine.
T9 259-581 Sentence denotes Considering the relatively high identity of receptor-binding domain (RBD) in 2019-nCoV and SARS-CoV, it is urgent to assess the cross-reactivity of anti-SARS CoV antibodies with 2019-nCoV spike protein, which could have important implications for rapid development of vaccines and therapeutic antibodies against 2019-nCoV.
T10 582-731 Sentence denotes Here, we report for the first time that a SARS-CoV-specific human monoclonal antibody, CR3022, could bind potently with 2019-nCoV RBD (KD of 6.3 nM).
T11 732-819 Sentence denotes The epitope of CR3022 does not overlap with the ACE2 binding site within 2019-nCoV RBD.
T12 820-1037 Sentence denotes These results suggest that CR3022 may have the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections.
T13 1038-1482 Sentence denotes Interestingly, some of the most potent SARS-CoV-specific neutralizing antibodies (e.g. m396, CR3014) that target the ACE2 binding site of SARS-CoV failed to bind 2019-nCoV spike protein, implying that the difference in the RBD of SARS-CoV and 2019-nCoV has a critical impact for the cross-reactivity of neutralizing antibodies, and that it is still necessary to develop novel monoclonal antibodies that could bind specifically to 2019-nCoV RBD.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
34 780-784 Gene denotes ACE2 Gene:59272
35 1155-1159 Gene denotes ACE2 Gene:59272
36 21-43 Species denotes 2019 novel coronavirus Tax:2697049
37 45-54 Species denotes 2019-nCoV Tax:2697049
38 105-110 Species denotes human Tax:9606
39 172-177 Species denotes human Tax:9606
40 336-345 Species denotes 2019-nCoV Tax:2697049
41 350-358 Species denotes SARS-CoV Tax:694009
42 437-446 Species denotes 2019-nCoV Tax:2697049
43 571-580 Species denotes 2019-nCoV Tax:2697049
44 624-632 Species denotes SARS-CoV Tax:694009
45 702-711 Species denotes 2019-nCoV Tax:2697049
46 805-814 Species denotes 2019-nCoV Tax:2697049
47 1077-1085 Species denotes SARS-CoV Tax:694009
48 1176-1184 Species denotes SARS-CoV Tax:694009
49 1200-1209 Species denotes 2019-nCoV Tax:2697049
50 1268-1276 Species denotes SARS-CoV Tax:694009
51 1281-1290 Species denotes 2019-nCoV Tax:2697049
52 1468-1477 Species denotes 2019-nCoV Tax:2697049
53 412-420 Species denotes SARS CoV Tax:694009
54 642-647 Species denotes human Tax:9606
55 669-675 Chemical denotes CR3022
56 747-753 Chemical denotes CR3022
57 847-853 Chemical denotes CR3022
58 1131-1137 Chemical denotes CR3014
59 111-121 Disease denotes infections MESH:D007239
60 137-143 Disease denotes deaths MESH:D003643
61 1016-1036 Disease denotes 2019-nCoV infections MESH:C000657245