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PMC:7048180 / 168-1659 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T3 462-469 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T4 668-676 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T5 1225-1232 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 120-130 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T3 359-367 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 421-425 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 633-641 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 1025-1045 Disease denotes 2019-nCoV infections http://purl.obolibrary.org/obo/MONDO_0100096
T7 1086-1094 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 1185-1193 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1277-1285 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T3 65-68 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 114-119 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T5 161-162 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 181-186 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T7 631-632 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 651-656 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T9 1300-1303 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T10 1304-1305 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T2 236-245 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T3 462-469 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T4 726-728 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T5 745-752 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T6 1225-1232 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T6 0-8 Sentence denotes ABSTRACT
T7 9-194 Sentence denotes The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health.
T8 195-267 Sentence denotes Currently, however, there is no specific antiviral treatment or vaccine.
T9 268-590 Sentence denotes Considering the relatively high identity of receptor-binding domain (RBD) in 2019-nCoV and SARS-CoV, it is urgent to assess the cross-reactivity of anti-SARS CoV antibodies with 2019-nCoV spike protein, which could have important implications for rapid development of vaccines and therapeutic antibodies against 2019-nCoV.
T10 591-740 Sentence denotes Here, we report for the first time that a SARS-CoV-specific human monoclonal antibody, CR3022, could bind potently with 2019-nCoV RBD (KD of 6.3 nM).
T11 741-828 Sentence denotes The epitope of CR3022 does not overlap with the ACE2 binding site within 2019-nCoV RBD.
T12 829-1046 Sentence denotes These results suggest that CR3022 may have the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections.
T13 1047-1491 Sentence denotes Interestingly, some of the most potent SARS-CoV-specific neutralizing antibodies (e.g. m396, CR3014) that target the ACE2 binding site of SARS-CoV failed to bind 2019-nCoV spike protein, implying that the difference in the RBD of SARS-CoV and 2019-nCoV has a critical impact for the cross-reactivity of neutralizing antibodies, and that it is still necessary to develop novel monoclonal antibodies that could bind specifically to 2019-nCoV RBD.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
34 789-793 Gene denotes ACE2 Gene:59272
35 1164-1168 Gene denotes ACE2 Gene:59272
36 30-52 Species denotes 2019 novel coronavirus Tax:2697049
37 54-63 Species denotes 2019-nCoV Tax:2697049
38 114-119 Species denotes human Tax:9606
39 181-186 Species denotes human Tax:9606
40 345-354 Species denotes 2019-nCoV Tax:2697049
41 359-367 Species denotes SARS-CoV Tax:694009
42 446-455 Species denotes 2019-nCoV Tax:2697049
43 580-589 Species denotes 2019-nCoV Tax:2697049
44 633-641 Species denotes SARS-CoV Tax:694009
45 711-720 Species denotes 2019-nCoV Tax:2697049
46 814-823 Species denotes 2019-nCoV Tax:2697049
47 1086-1094 Species denotes SARS-CoV Tax:694009
48 1185-1193 Species denotes SARS-CoV Tax:694009
49 1209-1218 Species denotes 2019-nCoV Tax:2697049
50 1277-1285 Species denotes SARS-CoV Tax:694009
51 1290-1299 Species denotes 2019-nCoV Tax:2697049
52 1477-1486 Species denotes 2019-nCoV Tax:2697049
53 421-429 Species denotes SARS CoV Tax:694009
54 651-656 Species denotes human Tax:9606
55 678-684 Chemical denotes CR3022
56 756-762 Chemical denotes CR3022
57 856-862 Chemical denotes CR3022
58 1140-1146 Chemical denotes CR3014
59 120-130 Disease denotes infections MESH:D007239
60 146-152 Disease denotes deaths MESH:D003643
61 1025-1045 Disease denotes 2019-nCoV infections MESH:C000657245