PMC:7047369 / 9147-9783 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"121","span":{"begin":224,"end":234},"obj":"Chemical"},{"id":"122","span":{"begin":249,"end":259},"obj":"Chemical"},{"id":"123","span":{"begin":261,"end":270},"obj":"Chemical"},{"id":"124","span":{"begin":303,"end":322},"obj":"Chemical"},{"id":"125","span":{"begin":392,"end":403},"obj":"Chemical"}],"attributes":[{"id":"A121","pred":"tao:has_database_id","subj":"121","obj":"MESH:D009705"},{"id":"A122","pred":"tao:has_database_id","subj":"122","obj":"MESH:C000606551"},{"id":"A123","pred":"tao:has_database_id","subj":"123","obj":"MESH:D012254"},{"id":"A124","pred":"tao:has_database_id","subj":"124","obj":"MESH:C558899"},{"id":"A125","pred":"tao:has_database_id","subj":"125","obj":"MESH:D002738"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In terms of therapeutics there is no known effective pharmaceutical agent. There are over 200 registered clinical trials registered in China alone. Putative agents include antivirals; Griffithsin, a spike protein inhibitor, nucleoside analogues eg. remdesivir, ribavirin and protease inhibitors such as lopinavir/ritonavir. Immunomodulatory and other host targeted agents include interferon, chloroquine and immunoglobulins. Corticosteroids will potentially have benefit for immune mediated lung damage late in the course of disease [6]. Much of the theory stems from what we have learnt from limited trials in other corona viruses [7]."}

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{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T7","span":{"begin":205,"end":212},"obj":"Body_part"},{"id":"T8","span":{"begin":408,"end":423},"obj":"Body_part"},{"id":"T9","span":{"begin":491,"end":495},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"In terms of therapeutics there is no known effective pharmaceutical agent. There are over 200 registered clinical trials registered in China alone. Putative agents include antivirals; Griffithsin, a spike protein inhibitor, nucleoside analogues eg. remdesivir, ribavirin and protease inhibitors such as lopinavir/ritonavir. Immunomodulatory and other host targeted agents include interferon, chloroquine and immunoglobulins. Corticosteroids will potentially have benefit for immune mediated lung damage late in the course of disease [6]. Much of the theory stems from what we have learnt from limited trials in other corona viruses [7]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T6","span":{"begin":491,"end":495},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"In terms of therapeutics there is no known effective pharmaceutical agent. There are over 200 registered clinical trials registered in China alone. Putative agents include antivirals; Griffithsin, a spike protein inhibitor, nucleoside analogues eg. remdesivir, ribavirin and protease inhibitors such as lopinavir/ritonavir. Immunomodulatory and other host targeted agents include interferon, chloroquine and immunoglobulins. Corticosteroids will potentially have benefit for immune mediated lung damage late in the course of disease [6]. Much of the theory stems from what we have learnt from limited trials in other corona viruses [7]."}

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