PMC:7045880 / 3166-7857 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7045880","sourcedb":"PMC","sourceid":"7045880","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7045880","text":"Materials and Methods\n\n1. Clinical specimens and RNA extraction\nNasopharyngeal and oropharyngeal swab and sputum samples were collected from symptomatic patients to detect SARS-CoV-2 by real-time reverse transcriptase (RT)-PCR. RNA was extracted from clinical samples with a QIAamp viral RNA mini kit (QIAGEN, Hilden, Germany) following the manufacturer’s instructions. All specimens were handled under a biosafety cabinet according to laboratory biosafety guidelines of Korea Centers for Disease Control and Prevention for COVID-19.\n\n2. Real-time RT-PCR\nThe optimal concentration of primers and probes, which were synthesized using a published sequence [12], was determined with the RNA transcripts of SARS-CoV. The primer and probe sequences used for RNA-dependent RNA polymerase gene detection were: 5′-GTGARATGGTCATGTGTGGCGG-3′ (Forward), 5′-CARATGTTAAASACACTATTAGCATA-3′ (Reverse) and 5′-CAGGTGGAACCTCATCAGGAGATGC-3′ (Probe in 5-FAM/3′-BHQ format) and the primer and probe sequences used for E gene detection were: 5′-ACAGGTACGTTAATAGTTAATAGCGT-3′ (Forward), 5′-ATATTGCAGCAGTACGCACACA-3′ (Reverse) and 5′-ACACTAGCCATCCTTACTGCGCTTCG-3′ (Probe in 5-FAM/3′-BHQ format). A 25-μL reaction was setup that contained 5 μL of RNA, 12.5 μL of 2 × reaction buffer provided with the Agpath IDTM 1 step RT-PCR system (Thermo Fisher Scientific, Waltham, USA), 1 μL of 25 × enzyme mixture, 1 μL of forward and reverse primers at 10 pM, and 0.5 μL of each probe at 10 pM. Reverse transcription was performed at 50°C for 30 minutes, followed by inactivation of the reverse transcriptase at 95°C for 10 minutes. PCR amplification was performed with 40 cycles at 95°C for 15 seconds and 60°C for 1 minute using an ABI 7500 Fast instrument (Thermo Fisher Scientific).\n\n3. Virus isolation\nThe virus was isolated from nasopharyngeal and oropharyngeal samples from putative COVID-19 patients. Oropharyngeal samples were diluted with viral transfer medium containing nasopharyngeal swabs and antibiotics (Nystadin, penicillin-streptomycin 1:1 dilution) at 1:4 ratio and incubated for 1 hour at 4°C, before being inoculated onto Vero cells. Inoculated Vero cells were cultured at 37°C, 5% CO2 in 1× Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 2% fetal bovine serum and penicillin-streptomycin. Virus replication and isolation were confirmed through cytopathic effects, gene detection, and electron microscopy. Viral culture of SARS-CoV-2 was conducted in a biosafety Level-3 facility according to laboratory biosafety guidelines of Korea Centers for Disease Control and Prevention.\n\n4. Next generation sequencing of viral full-length genome\nUsing reverse transcriptase, cDNA was synthesized from RNA extracted from the cultured cell medium in which the virus was replicated. A next generation sequencing (NGS) library was constructed after amplifying the full-length genes of the isolates using the synthesized cDNA and primers designed based on published SARS-CoV-2 DNA sequence. The prepared library was purified and analyzed with Miseq 150 PE. De novo assembly was performed on the sequenced product using Megahit to secure a full-length genome.\n\n5. Sequencing analysis\nGene sequencing was performed using CLC Main Workbench 7.9.1. Alignment was conducted using human and animal coronavirus sequences registered in Global Initiative on Sharing All Influenza Data (GISAID) and NCBI GenBank. The phylogenetic tree was analyzed using MEGA6 with the neighbor-joining method, maximum composite likelihood-parameter distance matrix, and bootstrap values of 1,000 replicates.\n\n6. Transmission electron microscopy\nFor transmission electron microscopy, the inoculated cells were prefixed by incubating in 2% paraformaldehyde and 2.5% glutaraldehyde in 0.1 M phosphate buffer (pH 7.4) to prevent the autolysis of the cells infected with virus. To minimize the chemical reaction between pre- and post-fixation, the slides were washed 3 times using the same buffer as in the fixative solution and post-fixed with 1% osmium tetroxide. After washing 3 times with deionized water, en bloc staining was performed using 0.5% uranyl acetate. Thereafter, 30%, 50%, 70%, 80%, 90%, and 100% ethanol were used sequentially in ascending concentration for dehydration, which was substituted with propylene oxide. The slides were then embedded in Epon812 plastic resin, and polymerized at 70°C for 48 hours. The prepared plastic block was cut to 70-nm thick sections using an ultramicrotome and mounted on a 100-mesh nickel grid, and electrostained with 5% uranyl acetate. The sections were observed with a transmission electron microscope (Libra120, Carl Zeiss, Germany) at an acceleration voltage of 120 kV [13–15].","divisions":[{"label":"title","span":{"begin":0,"end":21}},{"label":"sec","span":{"begin":23,"end":533}},{"label":"title","span":{"begin":23,"end":63}},{"label":"p","span":{"begin":64,"end":533}},{"label":"sec","span":{"begin":535,"end":1752}},{"label":"title","span":{"begin":535,"end":554}},{"label":"p","span":{"begin":555,"end":1752}},{"label":"sec","span":{"begin":1754,"end":2577}},{"label":"title","span":{"begin":1754,"end":1772}},{"label":"p","span":{"begin":1773,"end":2577}},{"label":"sec","span":{"begin":2579,"end":3144}},{"label":"title","span":{"begin":2579,"end":2636}},{"label":"p","span":{"begin":2637,"end":3144}},{"label":"sec","span":{"begin":3146,"end":3567}},{"label":"title","span":{"begin":3146,"end":3168}},{"label":"p","span":{"begin":3169,"end":3567}},{"label":"title","span":{"begin":3569,"end":3604}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"115","span":{"begin":153,"end":161},"obj":"Species"},{"id":"116","span":{"begin":172,"end":182},"obj":"Species"},{"id":"117","span":{"begin":524,"end":532},"obj":"Disease"},{"id":"119","span":{"begin":703,"end":711},"obj":"Species"},{"id":"131","span":{"begin":1865,"end":1873},"obj":"Species"},{"id":"132","span":{"begin":2423,"end":2433},"obj":"Species"},{"id":"133","span":{"begin":1986,"end":1994},"obj":"Chemical"},{"id":"134","span":{"begin":1996,"end":2006},"obj":"Chemical"},{"id":"135","span":{"begin":2007,"end":2019},"obj":"Chemical"},{"id":"136","span":{"begin":2169,"end":2172},"obj":"Chemical"},{"id":"137","span":{"begin":2179,"end":2213},"obj":"Chemical"},{"id":"138","span":{"begin":2215,"end":2219},"obj":"Chemical"},{"id":"139","span":{"begin":2265,"end":2275},"obj":"Chemical"},{"id":"140","span":{"begin":2276,"end":2288},"obj":"Chemical"},{"id":"141","span":{"begin":1856,"end":1864},"obj":"Disease"},{"id":"143","span":{"begin":2952,"end":2962},"obj":"Species"},{"id":"146","span":{"begin":3261,"end":3266},"obj":"Species"},{"id":"147","span":{"begin":3278,"end":3289},"obj":"Species"},{"id":"159","span":{"begin":3698,"end":3714},"obj":"Chemical"},{"id":"160","span":{"begin":3724,"end":3738},"obj":"Chemical"},{"id":"161","span":{"begin":3748,"end":3757},"obj":"Chemical"},{"id":"162","span":{"begin":4003,"end":4019},"obj":"Chemical"},{"id":"163","span":{"begin":4058,"end":4063},"obj":"Chemical"},{"id":"164","span":{"begin":4169,"end":4176},"obj":"Chemical"},{"id":"165","span":{"begin":4271,"end":4286},"obj":"Chemical"},{"id":"166","span":{"begin":4491,"end":4497},"obj":"Chemical"},{"id":"167","span":{"begin":4531,"end":4545},"obj":"Chemical"},{"id":"168","span":{"begin":3812,"end":3820},"obj":"Disease"},{"id":"169","span":{"begin":4231,"end":4242},"obj":"Disease"}],"attributes":[{"id":"A115","pred":"tao:has_database_id","subj":"115","obj":"Tax:9606"},{"id":"A116","pred":"tao:has_database_id","subj":"116","obj":"Tax:2697049"},{"id":"A117","pred":"tao:has_database_id","subj":"117","obj":"MESH:C000657245"},{"id":"A119","pred":"tao:has_database_id","subj":"119","obj":"Tax:694009"},{"id":"A131","pred":"tao:has_database_id","subj":"131","obj":"Tax:9606"},{"id":"A132","pred":"tao:has_database_id","subj":"132","obj":"Tax:2697049"},{"id":"A134","pred":"tao:has_database_id","subj":"134","obj":"MESH:D010406"},{"id":"A135","pred":"tao:has_database_id","subj":"135","obj":"MESH:D013307"},{"id":"A136","pred":"tao:has_database_id","subj":"136","obj":"MESH:D002245"},{"id":"A139","pred":"tao:has_database_id","subj":"139","obj":"MESH:D010406"},{"id":"A140","pred":"tao:has_database_id","subj":"140","obj":"MESH:D013307"},{"id":"A141","pred":"tao:has_database_id","subj":"141","obj":"MESH:C000657245"},{"id":"A143","pred":"tao:has_database_id","subj":"143","obj":"Tax:2697049"},{"id":"A146","pred":"tao:has_database_id","subj":"146","obj":"Tax:9606"},{"id":"A147","pred":"tao:has_database_id","subj":"147","obj":"Tax:11118"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"MESH:C003043"},{"id":"A160","pred":"tao:has_database_id","subj":"160","obj":"MESH:D005976"},{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"MESH:D010710"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"MESH:D009993"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"MESH:D014867"},{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"MESH:D000431"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"MESH:C009068"},{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"MESH:D009532"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"MESH:C005460"},{"id":"A168","pred":"tao:has_database_id","subj":"168","obj":"MESH:D007239"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"MESH:D003681"},{"subj":"115","pred":"source","obj":"LitCovid-PubTator"},{"subj":"116","pred":"source","obj":"LitCovid-PubTator"},{"subj":"117","pred":"source","obj":"LitCovid-PubTator"},{"subj":"119","pred":"source","obj":"LitCovid-PubTator"},{"subj":"131","pred":"source","obj":"LitCovid-PubTator"},{"subj":"132","pred":"source","obj":"LitCovid-PubTator"},{"subj":"133","pred":"source","obj":"LitCovid-PubTator"},{"subj":"134","pred":"source","obj":"LitCovid-PubTator"},{"subj":"135","pred":"source","obj":"LitCovid-PubTator"},{"subj":"136","pred":"source","obj":"LitCovid-PubTator"},{"subj":"137","pred":"source","obj":"LitCovid-PubTator"},{"subj":"138","pred":"source","obj":"LitCovid-PubTator"},{"subj":"139","pred":"source","obj":"LitCovid-PubTator"},{"subj":"140","pred":"source","obj":"LitCovid-PubTator"},{"subj":"141","pred":"source","obj":"LitCovid-PubTator"},{"subj":"143","pred":"source","obj":"LitCovid-PubTator"},{"subj":"146","pred":"source","obj":"LitCovid-PubTator"},{"subj":"147","pred":"source","obj":"LitCovid-PubTator"},{"subj":"159","pred":"source","obj":"LitCovid-PubTator"},{"subj":"160","pred":"source","obj":"LitCovid-PubTator"},{"subj":"161","pred":"source","obj":"LitCovid-PubTator"},{"subj":"162","pred":"source","obj":"LitCovid-PubTator"},{"subj":"163","pred":"source","obj":"LitCovid-PubTator"},{"subj":"164","pred":"source","obj":"LitCovid-PubTator"},{"subj":"165","pred":"source","obj":"LitCovid-PubTator"},{"subj":"166","pred":"source","obj":"LitCovid-PubTator"},{"subj":"167","pred":"source","obj":"LitCovid-PubTator"},{"subj":"168","pred":"source","obj":"LitCovid-PubTator"},{"subj":"169","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T13","span":{"begin":49,"end":52},"obj":"Body_part"},{"id":"T14","span":{"begin":106,"end":112},"obj":"Body_part"},{"id":"T15","span":{"begin":228,"end":231},"obj":"Body_part"},{"id":"T16","span":{"begin":288,"end":291},"obj":"Body_part"},{"id":"T17","span":{"begin":684,"end":687},"obj":"Body_part"},{"id":"T18","span":{"begin":753,"end":756},"obj":"Body_part"},{"id":"T19","span":{"begin":767,"end":770},"obj":"Body_part"},{"id":"T20","span":{"begin":782,"end":786},"obj":"Body_part"},{"id":"T21","span":{"begin":999,"end":1003},"obj":"Body_part"},{"id":"T22","span":{"begin":1222,"end":1225},"obj":"Body_part"},{"id":"T23","span":{"begin":2114,"end":2119},"obj":"Body_part"},{"id":"T24","span":{"begin":2137,"end":2142},"obj":"Body_part"},{"id":"T25","span":{"begin":2255,"end":2260},"obj":"Body_part"},{"id":"T26","span":{"begin":2365,"end":2369},"obj":"Body_part"},{"id":"T27","span":{"begin":2630,"end":2636},"obj":"Body_part"},{"id":"T28","span":{"begin":2692,"end":2695},"obj":"Body_part"},{"id":"T29","span":{"begin":2724,"end":2728},"obj":"Body_part"},{"id":"T30","span":{"begin":2963,"end":2966},"obj":"Body_part"},{"id":"T31","span":{"begin":3137,"end":3143},"obj":"Body_part"},{"id":"T32","span":{"begin":3169,"end":3173},"obj":"Body_part"},{"id":"T33","span":{"begin":3658,"end":3663},"obj":"Body_part"},{"id":"T34","span":{"begin":3806,"end":3811},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma312401"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T4","span":{"begin":106,"end":112},"obj":"Body_part"},{"id":"T5","span":{"begin":2255,"end":2260},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0007311"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T23","span":{"begin":172,"end":180},"obj":"Disease"},{"id":"T24","span":{"begin":524,"end":532},"obj":"Disease"},{"id":"T25","span":{"begin":703,"end":711},"obj":"Disease"},{"id":"T26","span":{"begin":1856,"end":1864},"obj":"Disease"},{"id":"T27","span":{"begin":2423,"end":2431},"obj":"Disease"},{"id":"T28","span":{"begin":2952,"end":2960},"obj":"Disease"},{"id":"T29","span":{"begin":3205,"end":3208},"obj":"Disease"},{"id":"T30","span":{"begin":3347,"end":3356},"obj":"Disease"}],"attributes":[{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0004315"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T33","span":{"begin":273,"end":274},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T34","span":{"begin":403,"end":404},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T35","span":{"begin":633,"end":634},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T36","span":{"begin":782,"end":786},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T37","span":{"begin":999,"end":1003},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T38","span":{"begin":1172,"end":1173},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T39","span":{"begin":1714,"end":1724},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T40","span":{"begin":1757,"end":1762},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T41","span":{"begin":1777,"end":1782},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T42","span":{"begin":2020,"end":2023},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T43","span":{"begin":2034,"end":2038},"obj":"http://purl.obolibrary.org/obo/CLO_0001757"},{"id":"T44","span":{"begin":2075,"end":2078},"obj":"http://purl.obolibrary.org/obo/CLO_0001387"},{"id":"T45","span":{"begin":2109,"end":2113},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T46","span":{"begin":2109,"end":2113},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T47","span":{"begin":2114,"end":2119},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T48","span":{"begin":2132,"end":2136},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T49","span":{"begin":2132,"end":2136},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T50","span":{"begin":2137,"end":2142},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T51","span":{"begin":2163,"end":2167},"obj":"http://purl.obolibrary.org/obo/CLO_0002131"},{"id":"T52","span":{"begin":2290,"end":2295},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T53","span":{"begin":2365,"end":2369},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T54","span":{"begin":2451,"end":2452},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T55","span":{"begin":2715,"end":2728},"obj":"http://purl.obolibrary.org/obo/CL_0000010"},{"id":"T56","span":{"begin":2749,"end":2754},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T57","span":{"begin":2771,"end":2772},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T58","span":{"begin":2863,"end":2868},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T59","span":{"begin":3123,"end":3124},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T60","span":{"begin":3169,"end":3173},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T61","span":{"begin":3205,"end":3208},"obj":"http://purl.obolibrary.org/obo/CLO_0002494"},{"id":"T62","span":{"begin":3261,"end":3266},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T63","span":{"begin":3271,"end":3277},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T64","span":{"begin":3658,"end":3663},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T65","span":{"begin":3806,"end":3811},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T66","span":{"begin":3826,"end":3831},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T67","span":{"begin":4065,"end":4067},"obj":"http://purl.obolibrary.org/obo/CLO_0037161"},{"id":"T68","span":{"begin":4372,"end":4374},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T69","span":{"begin":4480,"end":4481},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T70","span":{"begin":4579,"end":4580},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T33","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T9","span":{"begin":728,"end":733},"obj":"Chemical"},{"id":"T10","span":{"begin":932,"end":937},"obj":"Chemical"},{"id":"T11","span":{"begin":972,"end":977},"obj":"Chemical"},{"id":"T12","span":{"begin":1150,"end":1155},"obj":"Chemical"},{"id":"T13","span":{"begin":1251,"end":1257},"obj":"Chemical"},{"id":"T14","span":{"begin":1371,"end":1378},"obj":"Chemical"},{"id":"T15","span":{"begin":1445,"end":1450},"obj":"Chemical"},{"id":"T16","span":{"begin":1973,"end":1984},"obj":"Chemical"},{"id":"T17","span":{"begin":1996,"end":2006},"obj":"Chemical"},{"id":"T19","span":{"begin":2007,"end":2019},"obj":"Chemical"},{"id":"T21","span":{"begin":2169,"end":2172},"obj":"Chemical"},{"id":"T22","span":{"begin":2265,"end":2275},"obj":"Chemical"},{"id":"T24","span":{"begin":2276,"end":2288},"obj":"Chemical"},{"id":"T26","span":{"begin":2385,"end":2393},"obj":"Chemical"},{"id":"T27","span":{"begin":2963,"end":2966},"obj":"Chemical"},{"id":"T28","span":{"begin":3039,"end":3041},"obj":"Chemical"},{"id":"T31","span":{"begin":3585,"end":3593},"obj":"Chemical"},{"id":"T32","span":{"begin":3622,"end":3630},"obj":"Chemical"},{"id":"T33","span":{"begin":3724,"end":3738},"obj":"Chemical"},{"id":"T34","span":{"begin":3748,"end":3757},"obj":"Chemical"},{"id":"T38","span":{"begin":3758,"end":3764},"obj":"Chemical"},{"id":"T39","span":{"begin":3945,"end":3951},"obj":"Chemical"},{"id":"T40","span":{"begin":3962,"end":3970},"obj":"Chemical"},{"id":"T41","span":{"begin":3971,"end":3979},"obj":"Chemical"},{"id":"T42","span":{"begin":4003,"end":4019},"obj":"Chemical"},{"id":"T43","span":{"begin":4003,"end":4009},"obj":"Chemical"},{"id":"T44","span":{"begin":4058,"end":4063},"obj":"Chemical"},{"id":"T45","span":{"begin":4065,"end":4067},"obj":"Chemical"},{"id":"T46","span":{"begin":4114,"end":4121},"obj":"Chemical"},{"id":"T48","span":{"begin":4169,"end":4176},"obj":"Chemical"},{"id":"T49","span":{"begin":4271,"end":4286},"obj":"Chemical"},{"id":"T50","span":{"begin":4271,"end":4280},"obj":"Chemical"},{"id":"T51","span":{"begin":4281,"end":4286},"obj":"Chemical"},{"id":"T53","span":{"begin":4491,"end":4497},"obj":"Chemical"},{"id":"T54","span":{"begin":4538,"end":4545},"obj":"Chemical"},{"id":"T56","span":{"begin":4594,"end":4602},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_50406"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_51617"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_50406"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_51617"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_35225"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_60004"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_50406"},{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_33281"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_17334"},{"id":"A18","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_51356"},{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_17076"},{"id":"A20","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_58007"},{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_16526"},{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_17334"},{"id":"A23","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_51356"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_17076"},{"id":"A25","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_58007"},{"id":"A26","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_16038"},{"id":"A29","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_17553"},{"id":"A30","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_74762"},{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A33","pred":"chebi_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_64276"},{"id":"A34","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_18367"},{"id":"A35","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_26020"},{"id":"A36","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_35780"},{"id":"A37","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_43474"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_35225"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_35225"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_50913"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_75958"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_88215"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_30687"},{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_30347"},{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_30089"},{"id":"A47","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_47622"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_16236"},{"id":"A49","pred":"chebi_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/CHEBI_38685"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_16052"},{"id":"A51","pred":"chebi_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/CHEBI_25741"},{"id":"A52","pred":"chebi_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/CHEBI_29356"},{"id":"A53","pred":"chebi_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/CHEBI_28112"},{"id":"A54","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_30089"},{"id":"A55","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_47622"},{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":204,"end":217},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T3","span":{"begin":204,"end":217},"obj":"http://purl.obolibrary.org/obo/GO_0003899"},{"id":"T4","span":{"begin":1461,"end":1482},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T5","span":{"begin":1469,"end":1482},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T6","span":{"begin":1561,"end":1574},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T7","span":{"begin":1561,"end":1574},"obj":"http://purl.obolibrary.org/obo/GO_0003899"},{"id":"T8","span":{"begin":2651,"end":2664},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T9","span":{"begin":2651,"end":2664},"obj":"http://purl.obolibrary.org/obo/GO_0003899"},{"id":"T10","span":{"begin":3789,"end":3798},"obj":"http://purl.obolibrary.org/obo/GO_0097264"},{"id":"T11","span":{"begin":3789,"end":3798},"obj":"http://purl.obolibrary.org/obo/GO_0001896"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"2_test","denotations":[{"id":"32149036-26235643-81764452","span":{"begin":4684,"end":4686},"obj":"26235643"},{"id":"32149036-19844604-81764452","span":{"begin":4684,"end":4686},"obj":"19844604"}],"attributes":[{"subj":"32149036-26235643-81764452","pred":"source","obj":"2_test"},{"subj":"32149036-19844604-81764452","pred":"source","obj":"2_test"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T31","span":{"begin":0,"end":21},"obj":"Sentence"},{"id":"T32","span":{"begin":23,"end":25},"obj":"Sentence"},{"id":"T33","span":{"begin":26,"end":63},"obj":"Sentence"},{"id":"T34","span":{"begin":64,"end":227},"obj":"Sentence"},{"id":"T35","span":{"begin":228,"end":369},"obj":"Sentence"},{"id":"T36","span":{"begin":370,"end":533},"obj":"Sentence"},{"id":"T37","span":{"begin":535,"end":537},"obj":"Sentence"},{"id":"T38","span":{"begin":538,"end":554},"obj":"Sentence"},{"id":"T39","span":{"begin":555,"end":712},"obj":"Sentence"},{"id":"T40","span":{"begin":713,"end":802},"obj":"Sentence"},{"id":"T41","span":{"begin":803,"end":1019},"obj":"Sentence"},{"id":"T42","span":{"begin":1020,"end":1171},"obj":"Sentence"},{"id":"T43","span":{"begin":1172,"end":1460},"obj":"Sentence"},{"id":"T44","span":{"begin":1461,"end":1598},"obj":"Sentence"},{"id":"T45","span":{"begin":1599,"end":1752},"obj":"Sentence"},{"id":"T46","span":{"begin":1754,"end":1756},"obj":"Sentence"},{"id":"T47","span":{"begin":1757,"end":1772},"obj":"Sentence"},{"id":"T48","span":{"begin":1773,"end":1874},"obj":"Sentence"},{"id":"T49","span":{"begin":1875,"end":2120},"obj":"Sentence"},{"id":"T50","span":{"begin":2121,"end":2289},"obj":"Sentence"},{"id":"T51","span":{"begin":2290,"end":2405},"obj":"Sentence"},{"id":"T52","span":{"begin":2406,"end":2577},"obj":"Sentence"},{"id":"T53","span":{"begin":2579,"end":2581},"obj":"Sentence"},{"id":"T54","span":{"begin":2582,"end":2636},"obj":"Sentence"},{"id":"T55","span":{"begin":2637,"end":2770},"obj":"Sentence"},{"id":"T56","span":{"begin":2771,"end":2976},"obj":"Sentence"},{"id":"T57","span":{"begin":2977,"end":3042},"obj":"Sentence"},{"id":"T58","span":{"begin":3043,"end":3144},"obj":"Sentence"},{"id":"T59","span":{"begin":3146,"end":3148},"obj":"Sentence"},{"id":"T60","span":{"begin":3149,"end":3168},"obj":"Sentence"},{"id":"T61","span":{"begin":3169,"end":3230},"obj":"Sentence"},{"id":"T62","span":{"begin":3231,"end":3388},"obj":"Sentence"},{"id":"T63","span":{"begin":3389,"end":3567},"obj":"Sentence"},{"id":"T64","span":{"begin":3569,"end":3571},"obj":"Sentence"},{"id":"T65","span":{"begin":3572,"end":3604},"obj":"Sentence"},{"id":"T66","span":{"begin":3605,"end":3832},"obj":"Sentence"},{"id":"T67","span":{"begin":3833,"end":4020},"obj":"Sentence"},{"id":"T68","span":{"begin":4021,"end":4122},"obj":"Sentence"},{"id":"T69","span":{"begin":4123,"end":4287},"obj":"Sentence"},{"id":"T70","span":{"begin":4288,"end":4381},"obj":"Sentence"},{"id":"T71","span":{"begin":4382,"end":4546},"obj":"Sentence"},{"id":"T72","span":{"begin":4547,"end":4691},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T31","pred":"source","obj":"LitCovid-sentences"},{"subj":"T32","pred":"source","obj":"LitCovid-sentences"},{"subj":"T33","pred":"source","obj":"LitCovid-sentences"},{"subj":"T34","pred":"source","obj":"LitCovid-sentences"},{"subj":"T35","pred":"source","obj":"LitCovid-sentences"},{"subj":"T36","pred":"source","obj":"LitCovid-sentences"},{"subj":"T37","pred":"source","obj":"LitCovid-sentences"},{"subj":"T38","pred":"source","obj":"LitCovid-sentences"},{"subj":"T39","pred":"source","obj":"LitCovid-sentences"},{"subj":"T40","pred":"source","obj":"LitCovid-sentences"},{"subj":"T41","pred":"source","obj":"LitCovid-sentences"},{"subj":"T42","pred":"source","obj":"LitCovid-sentences"},{"subj":"T43","pred":"source","obj":"LitCovid-sentences"},{"subj":"T44","pred":"source","obj":"LitCovid-sentences"},{"subj":"T45","pred":"source","obj":"LitCovid-sentences"},{"subj":"T46","pred":"source","obj":"LitCovid-sentences"},{"subj":"T47","pred":"source","obj":"LitCovid-sentences"},{"subj":"T48","pred":"source","obj":"LitCovid-sentences"},{"subj":"T49","pred":"source","obj":"LitCovid-sentences"},{"subj":"T50","pred":"source","obj":"LitCovid-sentences"},{"subj":"T51","pred":"source","obj":"LitCovid-sentences"},{"subj":"T52","pred":"source","obj":"LitCovid-sentences"},{"subj":"T53","pred":"source","obj":"LitCovid-sentences"},{"subj":"T54","pred":"source","obj":"LitCovid-sentences"},{"subj":"T55","pred":"source","obj":"LitCovid-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sentences"},{"subj":"T57","pred":"source","obj":"LitCovid-sentences"},{"subj":"T58","pred":"source","obj":"LitCovid-sentences"},{"subj":"T59","pred":"source","obj":"LitCovid-sentences"},{"subj":"T60","pred":"source","obj":"LitCovid-sentences"},{"subj":"T61","pred":"source","obj":"LitCovid-sentences"},{"subj":"T62","pred":"source","obj":"LitCovid-sentences"},{"subj":"T63","pred":"source","obj":"LitCovid-sentences"},{"subj":"T64","pred":"source","obj":"LitCovid-sentences"},{"subj":"T65","pred":"source","obj":"LitCovid-sentences"},{"subj":"T66","pred":"source","obj":"LitCovid-sentences"},{"subj":"T67","pred":"source","obj":"LitCovid-sentences"},{"subj":"T68","pred":"source","obj":"LitCovid-sentences"},{"subj":"T69","pred":"source","obj":"LitCovid-sentences"},{"subj":"T70","pred":"source","obj":"LitCovid-sentences"},{"subj":"T71","pred":"source","obj":"LitCovid-sentences"},{"subj":"T72","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T8","span":{"begin":4231,"end":4242},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0001944"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93a8ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#c2ec93"},{"id":"LitCovid-PD-UBERON","color":"#ec93dc"},{"id":"LitCovid-PD-MONDO","color":"#93ece2"},{"id":"LitCovid-PD-CLO","color":"#ecc893"},{"id":"LitCovid-PD-CHEBI","color":"#ae93ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ec94"},{"id":"2_test","color":"#ec93ac"},{"id":"LitCovid-sentences","color":"#93c6ec"},{"id":"LitCovid-PD-HP","color":"#e0ec93"}]}]}}