PMC:7040011 / 6564-7795 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T24","span":{"begin":50,"end":54},"obj":"Body_part"},{"id":"T25","span":{"begin":55,"end":62},"obj":"Body_part"},{"id":"T26","span":{"begin":136,"end":140},"obj":"Body_part"},{"id":"T27","span":{"begin":141,"end":144},"obj":"Body_part"},{"id":"T28","span":{"begin":220,"end":224},"obj":"Body_part"},{"id":"T29","span":{"begin":324,"end":327},"obj":"Body_part"},{"id":"T30","span":{"begin":369,"end":373},"obj":"Body_part"},{"id":"T31","span":{"begin":374,"end":381},"obj":"Body_part"},{"id":"T32","span":{"begin":501,"end":506},"obj":"Body_part"},{"id":"T33","span":{"begin":532,"end":537},"obj":"Body_part"},{"id":"T34","span":{"begin":541,"end":545},"obj":"Body_part"},{"id":"T35","span":{"begin":604,"end":609},"obj":"Body_part"},{"id":"T36","span":{"begin":889,"end":895},"obj":"Body_part"},{"id":"T37","span":{"begin":921,"end":925},"obj":"Body_part"},{"id":"T38","span":{"begin":926,"end":929},"obj":"Body_part"}],"attributes":[{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"Recent reports of the ACE2 expression analysis in lung tissues from Asian and Caucasian populations are still controversial. The single-cell RNA-seq analysis reported that the Asian donor had much higher ACE2 expression cell ratio than white and African-American donors6. In contrast, the ACE2 expression analysis using the RNA-seq and microarray datasets from control lung tissues indicated there were no significant differences between Asian and Caucasian, or male and female11. The ACE2-expressing cells are a very small part of cells in lung tissues6. The sample size and the purity of ACE2-positive cells in the selected samples would influence the conclusions. Our analysis showed the differences in distribution and AFs of eQTLs for ACE2 in different populations, indicating the diversity of ACE2 expression pattern in populations (Supplementary Table S3). Large-scale and multiple tissue-level analysis of single-cell RNA-seq would be more accurate for the expression analysis of ACE2 in different populations. In addition, our data showed the moderate difference in AFs of eQTLs between South Asian and EAS, which suggests the potential difference of ACE2 expression in different populations and ethnics in Asia (Fig. 1c)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T3","span":{"begin":50,"end":54},"obj":"Body_part"},{"id":"T4","span":{"begin":369,"end":373},"obj":"Body_part"},{"id":"T5","span":{"begin":541,"end":545},"obj":"Body_part"},{"id":"T6","span":{"begin":870,"end":875},"obj":"Body_part"},{"id":"T7","span":{"begin":889,"end":895},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Recent reports of the ACE2 expression analysis in lung tissues from Asian and Caucasian populations are still controversial. The single-cell RNA-seq analysis reported that the Asian donor had much higher ACE2 expression cell ratio than white and African-American donors6. In contrast, the ACE2 expression analysis using the RNA-seq and microarray datasets from control lung tissues indicated there were no significant differences between Asian and Caucasian, or male and female11. The ACE2-expressing cells are a very small part of cells in lung tissues6. The sample size and the purity of ACE2-positive cells in the selected samples would influence the conclusions. Our analysis showed the differences in distribution and AFs of eQTLs for ACE2 in different populations, indicating the diversity of ACE2 expression pattern in populations (Supplementary Table S3). Large-scale and multiple tissue-level analysis of single-cell RNA-seq would be more accurate for the expression analysis of ACE2 in different populations. In addition, our data showed the moderate difference in AFs of eQTLs between South Asian and EAS, which suggests the potential difference of ACE2 expression in different populations and ethnics in Asia (Fig. 1c)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T33","span":{"begin":50,"end":54},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T34","span":{"begin":50,"end":54},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T35","span":{"begin":136,"end":140},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T36","span":{"begin":220,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T37","span":{"begin":369,"end":373},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T38","span":{"begin":369,"end":373},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T39","span":{"begin":462,"end":466},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T40","span":{"begin":462,"end":466},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T41","span":{"begin":501,"end":506},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T42","span":{"begin":511,"end":512},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T43","span":{"begin":532,"end":537},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T44","span":{"begin":541,"end":545},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T45","span":{"begin":541,"end":545},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T46","span":{"begin":604,"end":609},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T47","span":{"begin":921,"end":925},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Recent reports of the ACE2 expression analysis in lung tissues from Asian and Caucasian populations are still controversial. The single-cell RNA-seq analysis reported that the Asian donor had much higher ACE2 expression cell ratio than white and African-American donors6. In contrast, the ACE2 expression analysis using the RNA-seq and microarray datasets from control lung tissues indicated there were no significant differences between Asian and Caucasian, or male and female11. The ACE2-expressing cells are a very small part of cells in lung tissues6. The sample size and the purity of ACE2-positive cells in the selected samples would influence the conclusions. Our analysis showed the differences in distribution and AFs of eQTLs for ACE2 in different populations, indicating the diversity of ACE2 expression pattern in populations (Supplementary Table S3). Large-scale and multiple tissue-level analysis of single-cell RNA-seq would be more accurate for the expression analysis of ACE2 in different populations. In addition, our data showed the moderate difference in AFs of eQTLs between South Asian and EAS, which suggests the potential difference of ACE2 expression in different populations and ethnics in Asia (Fig. 1c)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T21","span":{"begin":182,"end":187},"obj":"Chemical"},{"id":"T22","span":{"begin":462,"end":466},"obj":"Chemical"},{"id":"T23","span":{"begin":859,"end":861},"obj":"Chemical"}],"attributes":[{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_17891"},{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"}],"text":"Recent reports of the ACE2 expression analysis in lung tissues from Asian and Caucasian populations are still controversial. The single-cell RNA-seq analysis reported that the Asian donor had much higher ACE2 expression cell ratio than white and African-American donors6. In contrast, the ACE2 expression analysis using the RNA-seq and microarray datasets from control lung tissues indicated there were no significant differences between Asian and Caucasian, or male and female11. The ACE2-expressing cells are a very small part of cells in lung tissues6. The sample size and the purity of ACE2-positive cells in the selected samples would influence the conclusions. Our analysis showed the differences in distribution and AFs of eQTLs for ACE2 in different populations, indicating the diversity of ACE2 expression pattern in populations (Supplementary Table S3). Large-scale and multiple tissue-level analysis of single-cell RNA-seq would be more accurate for the expression analysis of ACE2 in different populations. In addition, our data showed the moderate difference in AFs of eQTLs between South Asian and EAS, which suggests the potential difference of ACE2 expression in different populations and ethnics in Asia (Fig. 1c)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T47","span":{"begin":0,"end":124},"obj":"Sentence"},{"id":"T48","span":{"begin":125,"end":271},"obj":"Sentence"},{"id":"T49","span":{"begin":272,"end":480},"obj":"Sentence"},{"id":"T50","span":{"begin":481,"end":555},"obj":"Sentence"},{"id":"T51","span":{"begin":556,"end":666},"obj":"Sentence"},{"id":"T52","span":{"begin":667,"end":863},"obj":"Sentence"},{"id":"T53","span":{"begin":864,"end":1018},"obj":"Sentence"},{"id":"T54","span":{"begin":1019,"end":1231},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Recent reports of the ACE2 expression analysis in lung tissues from Asian and Caucasian populations are still controversial. The single-cell RNA-seq analysis reported that the Asian donor had much higher ACE2 expression cell ratio than white and African-American donors6. In contrast, the ACE2 expression analysis using the RNA-seq and microarray datasets from control lung tissues indicated there were no significant differences between Asian and Caucasian, or male and female11. The ACE2-expressing cells are a very small part of cells in lung tissues6. The sample size and the purity of ACE2-positive cells in the selected samples would influence the conclusions. Our analysis showed the differences in distribution and AFs of eQTLs for ACE2 in different populations, indicating the diversity of ACE2 expression pattern in populations (Supplementary Table S3). Large-scale and multiple tissue-level analysis of single-cell RNA-seq would be more accurate for the expression analysis of ACE2 in different populations. In addition, our data showed the moderate difference in AFs of eQTLs between South Asian and EAS, which suggests the potential difference of ACE2 expression in different populations and ethnics in Asia (Fig. 1c)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"276","span":{"begin":799,"end":803},"obj":"Gene"},{"id":"277","span":{"begin":988,"end":992},"obj":"Gene"},{"id":"278","span":{"begin":740,"end":744},"obj":"Gene"},{"id":"279","span":{"begin":590,"end":594},"obj":"Gene"},{"id":"280","span":{"begin":485,"end":489},"obj":"Gene"},{"id":"281","span":{"begin":289,"end":293},"obj":"Gene"},{"id":"282","span":{"begin":204,"end":208},"obj":"Gene"},{"id":"283","span":{"begin":22,"end":26},"obj":"Gene"},{"id":"284","span":{"begin":985,"end":987},"obj":"Gene"},{"id":"285","span":{"begin":911,"end":913},"obj":"Gene"},{"id":"286","span":{"begin":796,"end":798},"obj":"Gene"},{"id":"287","span":{"begin":587,"end":589},"obj":"Gene"},{"id":"288","span":{"begin":15,"end":17},"obj":"Gene"},{"id":"289","span":{"begin":1160,"end":1164},"obj":"Gene"},{"id":"290","span":{"begin":723,"end":735},"obj":"Disease"},{"id":"291","span":{"begin":1075,"end":1087},"obj":"Disease"}],"attributes":[{"id":"A276","pred":"tao:has_database_id","subj":"276","obj":"Gene:59272"},{"id":"A277","pred":"tao:has_database_id","subj":"277","obj":"Gene:59272"},{"id":"A278","pred":"tao:has_database_id","subj":"278","obj":"Gene:59272"},{"id":"A279","pred":"tao:has_database_id","subj":"279","obj":"Gene:59272"},{"id":"A280","pred":"tao:has_database_id","subj":"280","obj":"Gene:59272"},{"id":"A281","pred":"tao:has_database_id","subj":"281","obj":"Gene:59272"},{"id":"A282","pred":"tao:has_database_id","subj":"282","obj":"Gene:59272"},{"id":"A283","pred":"tao:has_database_id","subj":"283","obj":"Gene:59272"},{"id":"A284","pred":"tao:has_database_id","subj":"284","obj":"Gene:6688"},{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"Gene:6688"},{"id":"A286","pred":"tao:has_database_id","subj":"286","obj":"Gene:6688"},{"id":"A287","pred":"tao:has_database_id","subj":"287","obj":"Gene:6688"},{"id":"A288","pred":"tao:has_database_id","subj":"288","obj":"Gene:6688"},{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"Gene:59272"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Recent reports of the ACE2 expression analysis in lung tissues from Asian and Caucasian populations are still controversial. The single-cell RNA-seq analysis reported that the Asian donor had much higher ACE2 expression cell ratio than white and African-American donors6. In contrast, the ACE2 expression analysis using the RNA-seq and microarray datasets from control lung tissues indicated there were no significant differences between Asian and Caucasian, or male and female11. The ACE2-expressing cells are a very small part of cells in lung tissues6. The sample size and the purity of ACE2-positive cells in the selected samples would influence the conclusions. Our analysis showed the differences in distribution and AFs of eQTLs for ACE2 in different populations, indicating the diversity of ACE2 expression pattern in populations (Supplementary Table S3). Large-scale and multiple tissue-level analysis of single-cell RNA-seq would be more accurate for the expression analysis of ACE2 in different populations. In addition, our data showed the moderate difference in AFs of eQTLs between South Asian and EAS, which suggests the potential difference of ACE2 expression in different populations and ethnics in Asia (Fig. 1c)."}