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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 22-26 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T2 514-521 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T3 626-633 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T4 749-753 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T5 754-757 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T6 770-773 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T7 1688-1692 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T8 1786-1793 Body_part denotes Genomes http://purl.org/sig/ont/fma/fma84116
T9 1917-1923 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T10 2025-2035 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T11 2133-2139 Body_part denotes lysine http://purl.org/sig/ont/fma/fma82758
T12 2148-2156 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T13 2230-2237 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 2529-2536 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 2629-2636 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 4417-4423 Body_part denotes intron http://purl.org/sig/ont/fma/fma84121
T17 4612-4616 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T18 4969-4975 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T19 5138-5145 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T20 5984-5991 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T21 6115-6121 Body_part denotes intron http://purl.org/sig/ont/fma/fma84121
T22 6130-6134 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T23 6359-6363 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T24 6497-6501 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T25 6502-6509 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T26 6583-6587 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T27 6588-6591 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T28 6667-6671 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T29 6771-6774 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T30 6816-6820 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T31 6821-6828 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T32 6948-6953 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T33 6979-6984 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T34 6988-6992 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T35 7051-7056 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T36 7336-7342 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T37 7368-7372 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T38 7373-7376 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T39 8028-8035 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T40 8227-8231 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T41 8243-8247 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T42 8371-8378 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1911-1916 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T2 4969-4975 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 6497-6501 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 6816-6820 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T5 6988-6992 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 7317-7322 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T7 7336-7342 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T8 8227-8231 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T9 8243-8247 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p6832s6 472-478 NegReg denotes reduce
p6832s12 512-513 Protein denotes S

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 126-142 Disease denotes SARS-coronavirus http://purl.obolibrary.org/obo/MONDO_0005091
T3 144-152 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 308-316 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 405-414 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T6 418-426 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 525-533 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 711-719 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 722-731 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 897-905 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 908-917 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 1415-1423 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 3339-3342 Disease denotes CHS http://purl.obolibrary.org/obo/MONDO_0008963
T14 8221-8238 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T16 8232-8238 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T17 8458-8466 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 22-26 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T2 78-81 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T3 162-167 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T4 440-441 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T5 602-607 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T6 733-734 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T7 749-753 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8 809-814 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T9 809-814 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T10 978-979 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T11 1676-1678 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T12 1688-1692 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T13 1971-1973 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T14 1971-1973 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T15 2157-2159 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T16 2183-2188 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T17 2346-2347 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 2473-2474 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 3523-3528 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T20 3523-3528 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T21 3558-3565 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T22 3621-3623 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T23 3621-3623 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T24 3903-3904 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 4131-4132 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T26 4612-4616 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T27 4859-4862 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAS
T28 5836-5838 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T29 5857-5859 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T30 6130-6134 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T31 6136-6139 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T32 6359-6363 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T33 6497-6501 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T34 6497-6501 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T35 6583-6587 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T36 6667-6671 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T37 6816-6820 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T38 6816-6820 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T39 6909-6913 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T40 6909-6913 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T41 6948-6953 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T42 6958-6959 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 6979-6984 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T44 6988-6992 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T45 6988-6992 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T46 7051-7056 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T47 7368-7372 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T48 8227-8231 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T49 8227-8231 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T50 8243-8247 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T51 8243-8247 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T52 8574-8576 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T53 8597-8599 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T54 8597-8599 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 39-50 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T2 514-521 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T3 1584-1586 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T4 1971-1973 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T5 2025-2035 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T6 2025-2030 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T7 2031-2035 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T8 2133-2139 Chemical denotes lysine http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094
T10 2148-2156 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T11 2230-2237 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 2529-2536 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13 2629-2636 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 3203-3205 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T15 3264-3266 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T16 3308-3310 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T17 3621-3623 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T18 5607-5609 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T19 5877-5879 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T20 6013-6015 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T21 6629-6634 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T22 6909-6913 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T23 7306-7308 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T24 8028-8035 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T25 8597-8599 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T26 8620-8622 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 8221-8238 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T2 0-12 Sentence denotes Dear Editor,
T3 13-197 Sentence denotes The ACE2 gene encodes the angiotensin-converting enzyme-2, which has been proved to be the receptor for both the SARS-coronavirus (SARS-CoV) and the human respiratory coronavirus NL63.
T4 198-322 Sentence denotes Recent studies and analyses indicate that ACE2 could be the host receptor for the novel coronavirus 2019-nCoV/SARS-CoV-21,2.
T5 323-439 Sentence denotes Previous studies demonstrated the positive correlation of ACE2 expression and the infection of SARS-CoV in vitro3,4.
T6 440-543 Sentence denotes A number of ACE2 variants could reduce the association between ACE2 and S-protein in SARS-CoV or NL635.
T7 544-732 Sentence denotes Therefore, the expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection.
T8 733-851 Sentence denotes A recent single-cell RNA-sequencing (RNA-seq) analysis indicated that Asian males may have higher expression of ACE26.
T9 852-977 Sentence denotes Currently, the clinical reports of 2019-nCoV/SARS-CoV-2 infection from non-Asian populations for comparison are very limited.
T10 978-1093 Sentence denotes A study from Munich reported four German cases, all of which showed mild clinical symptoms without severe illness7.
T11 1094-1203 Sentence denotes However, the genetic basis of ACE2 expression and function in different populations is still largely unknown.
T12 1204-1478 Sentence denotes Therefore, genetic analysis of expression quantitative trait loci (eQTLs)8 and potential functional coding variants in ACE2 among populations are required for further epidemiological investigations of 2019-nCoV/SARS-CoV-2 spreading in East Asian (EAS) and other populations.
T13 1479-1814 Sentence denotes To systematically investigate the candidate functional coding variants in ACE2 and the allele frequency (AF) differences between populations, we analyzed all the 1700 variants (Supplementary Table S1) in ACE2 gene region from the ChinaMAP (China Metabolic Analytics Project, under reviewing) and 1KGP (1000 Genomes Project)9 databases.
T14 1815-1975 Sentence denotes The AFs of 62 variants located in the coding regions of ACE2 in ChinaMAP, 1KGP, and other large-scale genome databases were summarized (Supplementary Table S2).
T15 1976-2087 Sentence denotes All of the 32 variants potentially affecting the amino acid sequence of ACE2 in databases were shown (Fig. 1a).
T16 2088-2254 Sentence denotes Previous study showed that the residues near lysine 31, and tyrosine 41, 82–84, and 353–357 in human ACE2 were important for the binding of S-protein in coronavirus5.
T17 2255-2340 Sentence denotes The mutations in these residues were not found in different populations in our study.
T18 2341-2436 Sentence denotes Only a singleton truncating variant of ACE2 (Gln300X) was identified in the ChinaMAP (Fig. 1a).
T19 2437-2560 Sentence denotes These data suggested that there was a lack of natural resistant mutations for coronavirus S-protein binding in populations.
T20 2561-2675 Sentence denotes The effects of low-frequency missense variants in populations for S-protein binding could be further investigated.
T21 2676-2857 Sentence denotes The distributions of seven hotspot variants (Lys26Arg, Ile468Val, Ala627Val, Asn638Ser, Ser692Pro, Asn720Asp, and Leu731Ile/Leu731Phe) in different populations were shown (Fig. 1b).
T22 2858-3074 Sentence denotes Six low-frequency loci (rs200180615, rs140473595, rs199951323, rs147311723, rs149039346, and rs73635825) were found to be specific in 1KGP database, the AFs of which were also low in the gnomAD and TopMed10 database.
T23 3075-3213 Sentence denotes Only two of these six variants (rs200180615 and rs140473595) could be found in CHB (Han Chinese in Beijing) population with the AF < 0.01.
T24 3214-3477 Sentence denotes Interestingly, the SNP rs2285666 with the highest AF in the 62 variants exhibited much higher AF in the ChinaMAP (0.556) and CHS (Han Chinese South, 0.557) populations compared to others (AMR, Ad Mixed American, 0.336; AFR, African, 0.2114; EUR, European, 0.235).
T25 3478-3625 Sentence denotes In addition, the homozygous mutation rate in males (0.550) was much higher than females (0.310) in the Chinese population (Supplementary Table S2).
T26 3626-3804 Sentence denotes Taken together, the differences in AFs of ACE2 coding variants among different populations suggested that the diverse genetic basis might affect ACE2 functions among populations.
T27 3805-3902 Sentence denotes Fig. 1 The coding-region variants and eQTL variants for ACE2 in East Asian and other populations.
T28 3903-3992 Sentence denotes a Schematics of 32 coding variants in ACE2 identified in the ChinaMAP and 1KGP databases.
T29 3993-4074 Sentence denotes Yellow stars indicate the nonsense variants; dots indicate the missense variants.
T30 4075-4213 Sentence denotes The number of samples with hotspot variants was marked. b The distribution of hotspot missense mutations of ACE2 in different populations.
T31 4214-4369 Sentence denotes The colors indicate different populations. c The distribution and the allele frequencies of representative eQTL variants for ACE2 in different populations.
T32 4370-4465 Sentence denotes Pie charts depict the allele frequencies of an intron variant of ACE2 (rs4646127) in the world.
T33 4466-4567 Sentence denotes Orange color denotes the frequency of alteration allele, and blue color denotes the reference allele.
T34 4568-4637 Sentence denotes The allele frequencies of 15 eQTLs for ACE2 gene are shown in tables.
T35 4638-4721 Sentence denotes The color gradient from blue to red indicates the increasing of allele frequencies.
T36 4722-4812 Sentence denotes The allele frequencies of INDEL variant rs200781818 were annotated by the gnomAD database.
T37 4813-4900 Sentence denotes EAS, East Asian; EUR, European; AFR, African; SAS, South Asian; AMR, Ad Mixed American.
T38 4901-5046 Sentence denotes To analyze the distribution of eQTLs for ACE2, we used the Genotype Tissue Expression (GTEx) database (https://www.gtexportal.org/home/datasets).
T39 5047-5344 Sentence denotes We found 15 unique eQTL variants (14 SNPs and 1 INDELs) for ACE2 with q value ≤ 0.05 in 20 tissues from the GTEx database (rs112171234, rs12010448, rs143695310, rs1996225, rs200781818, rs2158082, rs4060, rs4646127, rs4830974, rs4830983, rs5936011, rs5936029, rs6629110, rs6632704, and rs75979613).
T40 5345-5419 Sentence denotes The AFs of the 15 eQTL variants were compared among different populations.
T41 5420-5611 Sentence denotes Notably, our results showed most of the 15 eQTL variants had much higher AFs in the ChinaMAP dataset and EAS populations compared to European populations (Fig. 1c and Supplementary Table S3).
T42 5612-5845 Sentence denotes The AFs of the top 6 common variants (rs4646127, rs2158082, rs5936011, rs6629110, rs4830983, and rs5936029) were higher than 95% in EAS populations, whereas the AFs of these variants in European populations were much lower (52%–65%).
T43 5846-6017 Sentence denotes All of the 11 common variants (AF > 0.05) and 1 rare variant (rs143695310) in the 15 eQTLs are associated with high expression of ACE2 in tissues (Supplementary Table S3).
T44 6018-6216 Sentence denotes For instance, the eQTL variant rs4646127 (log allelic fold change = 0.314), which locates in the intron of ACE2 gene, has the highest AFs in both of the ChinaMAP (0.997) and EAS (0.994) populations.
T45 6217-6311 Sentence denotes Comparatively, the AFs of rs4646127 in EUR (0.651) and AMR (0.754) populations are much lower.
T46 6312-6446 Sentence denotes These findings suggested the genotypes of ACE2 gene polymorphism may be associated higher expression levels of ACE2 in EAS population.
T47 6447-6571 Sentence denotes Recent reports of the ACE2 expression analysis in lung tissues from Asian and Caucasian populations are still controversial.
T48 6572-6718 Sentence denotes The single-cell RNA-seq analysis reported that the Asian donor had much higher ACE2 expression cell ratio than white and African-American donors6.
T49 6719-6927 Sentence denotes In contrast, the ACE2 expression analysis using the RNA-seq and microarray datasets from control lung tissues indicated there were no significant differences between Asian and Caucasian, or male and female11.
T50 6928-7002 Sentence denotes The ACE2-expressing cells are a very small part of cells in lung tissues6.
T51 7003-7113 Sentence denotes The sample size and the purity of ACE2-positive cells in the selected samples would influence the conclusions.
T52 7114-7310 Sentence denotes Our analysis showed the differences in distribution and AFs of eQTLs for ACE2 in different populations, indicating the diversity of ACE2 expression pattern in populations (Supplementary Table S3).
T53 7311-7465 Sentence denotes Large-scale and multiple tissue-level analysis of single-cell RNA-seq would be more accurate for the expression analysis of ACE2 in different populations.
T54 7466-7678 Sentence denotes In addition, our data showed the moderate difference in AFs of eQTLs between South Asian and EAS, which suggests the potential difference of ACE2 expression in different populations and ethnics in Asia (Fig. 1c).
T55 7679-7911 Sentence denotes In summary, we systematically analyzed coding-region variants in ACE2 and the eQTL variants, which may affect the expression of ACE2 using the GTEx database to compare the genomic characteristics of ACE2 among different populations.
T56 7912-8102 Sentence denotes Our findings indicated that no direct evidence was identified genetically supporting the existence of coronavirus S-protein binding-resistant ACE2 mutants in different populations (Fig. 1a).
T57 8103-8259 Sentence denotes The data of variant distribution and AFs may contribute to the further investigations of ACE2, including its roles in acute lung injury and lung function12.
T58 8260-8525 Sentence denotes The East Asian populations have much higher AFs in the eQTL variants associated with higher ACE2 expression in tissues (Fig. 1c), which may suggest different susceptibility or response to 2019-nCoV/SARS-CoV-2 from different populations under the similar conditions.
T59 8527-8552 Sentence denotes Supplementary information
T60 8554-8576 Sentence denotes Supplementary Table S1
T61 8577-8599 Sentence denotes Supplementary Table S2
T62 8600-8622 Sentence denotes Supplementary Table S3

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
153 1823-1825 Gene denotes of Gene:6688
43 698-700 Gene denotes of Gene:6688
44 1124-1128 Gene denotes ACE2 Gene:59272
45 845-849 Gene denotes ACE2 Gene:59272
46 608-612 Gene denotes ACE2 Gene:59272
47 503-507 Gene denotes ACE2 Gene:59272
48 452-456 Gene denotes ACE2 Gene:59272
49 381-385 Gene denotes ACE2 Gene:59272
50 240-244 Gene denotes ACE2 Gene:59272
51 1402-1404 Gene denotes of Gene:6688
52 1121-1123 Gene denotes of Gene:6688
53 1030-1032 Gene denotes of Gene:6688
54 884-886 Gene denotes of Gene:6688
55 842-844 Gene denotes of Gene:6688
56 449-451 Gene denotes of Gene:6688
57 415-417 Gene denotes of Gene:6688
58 378-380 Gene denotes of Gene:6688
59 126-142 Species denotes SARS-coronavirus Tax:694009
60 144-152 Species denotes SARS-CoV Tax:694009
61 162-167 Species denotes human Tax:9606
62 180-196 Species denotes coronavirus NL63 Tax:277944
63 280-297 Species denotes novel coronavirus Tax:2697049
64 298-307 Species denotes 2019-nCoV Tax:2697049
65 308-318 Species denotes SARS-CoV-2 Tax:2697049
66 418-426 Species denotes SARS-CoV Tax:694009
67 525-533 Species denotes SARS-CoV Tax:694009
68 701-710 Species denotes 2019-nCoV Tax:2697049
69 887-896 Species denotes 2019-nCoV Tax:2697049
70 1405-1414 Species denotes 2019-nCoV Tax:2697049
71 1415-1425 Species denotes SARS-CoV-2 Tax:2697049
72 537-541 Species denotes NL63 Tax:277944
73 405-414 Disease denotes infection MESH:D007239
74 716-731 Disease denotes CoV-2 infection MESH:C000657245
75 902-917 Disease denotes CoV-2 infection MESH:C000657245
77 3861-3865 Gene denotes ACE2 Gene:59272
95 4086-4088 Gene denotes of Gene:6688
96 4607-4611 Gene denotes ACE2 Gene:59272
97 4435-4439 Gene denotes ACE2 Gene:59272
98 4339-4343 Gene denotes ACE2 Gene:59272
99 4183-4187 Gene denotes ACE2 Gene:59272
100 3941-3945 Gene denotes ACE2 Gene:59272
101 4745-4747 Gene denotes of Gene:6688
102 4699-4701 Gene denotes of Gene:6688
103 4591-4593 Gene denotes of Gene:6688
104 4501-4503 Gene denotes of Gene:6688
105 4432-4434 Gene denotes of Gene:6688
106 4411-4413 Gene denotes of Gene:6688
107 4303-4305 Gene denotes of Gene:6688
108 4180-4182 Gene denotes of Gene:6688
109 4150-4152 Gene denotes of Gene:6688
110 4441-4450 Mutation denotes rs4646127 rs4646127
111 4762-4773 Mutation denotes rs200781818 rs200781818
145 3668-3672 Gene denotes ACE2 Gene:59272
146 2380-2384 Gene denotes ACE2 Gene:59272
147 2189-2193 Gene denotes ACE2 Gene:59272
148 1683-1687 Gene denotes ACE2 Gene:59272
149 1553-1557 Gene denotes ACE2 Gene:59272
150 2225-2227 Gene denotes of Gene:6688
151 1980-1982 Gene denotes of Gene:6688
152 1868-1870 Gene denotes of Gene:6688
154 2183-2188 Species denotes human Tax:9606
155 2241-2252 Species denotes coronavirus Tax:11118
156 2515-2526 Species denotes coronavirus Tax:11118
157 3771-3775 Gene denotes ACE2 Gene:59272
158 1871-1875 Gene denotes ACE2 Gene:59272
159 2133-2139 Chemical denotes lysine MESH:D008239
160 2148-2156 Chemical denotes tyrosine MESH:D014443
161 2731-2740 Chemical denotes Ile468Val
162 2800-2809 Chemical denotes Leu731Phe
163 1584-1586 Disease denotes AF MESH:D001281
164 3154-3157 Disease denotes CHB
165 3203-3205 Disease denotes AF MESH:D001281
166 3264-3266 Disease denotes AF MESH:D001281
167 3308-3310 Disease denotes AF MESH:D001281
168 3339-3342 Disease denotes CHS MESH:D002609
169 3107-3118 Mutation denotes rs200180615 rs200180615
170 3123-3134 Mutation denotes rs140473595 rs140473595
171 2908-2919 Mutation denotes rs199951323 rs199951323
172 2921-2932 Mutation denotes rs147311723 rs147311723
173 2934-2945 Mutation denotes rs149039346 rs149039346
174 2951-2961 Mutation denotes rs73635825 rs73635825
175 2882-2893 Mutation denotes rs200180615 rs200180615
176 2895-2906 Mutation denotes rs140473595 rs140473595
177 3237-3246 Mutation denotes rs2285666 rs2285666
219 6423-6427 Gene denotes ACE2 Gene:59272
220 6354-6358 Gene denotes ACE2 Gene:59272
221 6125-6129 Gene denotes ACE2 Gene:59272
222 5976-5980 Gene denotes ACE2 Gene:59272
223 5107-5111 Gene denotes ACE2 Gene:59272
224 4942-4946 Gene denotes ACE2 Gene:59272
225 6420-6422 Gene denotes of Gene:6688
226 6351-6353 Gene denotes of Gene:6688
227 6164-6166 Gene denotes of Gene:6688
228 6122-6124 Gene denotes of Gene:6688
229 5777-5779 Gene denotes of Gene:6688
230 5620-5622 Gene denotes of Gene:6688
231 5453-5455 Gene denotes of Gene:6688
232 5353-5355 Gene denotes of Gene:6688
233 4929-4931 Gene denotes of Gene:6688
234 6431-6434 Chemical denotes EAS
235 5877-5879 Disease denotes AF MESH:D001281
236 5170-5181 Mutation denotes rs112171234 rs112171234
237 5183-5193 Mutation denotes rs12010448 rs12010448
238 5908-5919 Mutation denotes rs143695310 rs143695310
239 5208-5217 Mutation denotes rs1996225 rs1996225
240 5219-5230 Mutation denotes rs200781818 rs200781818
241 5661-5670 Mutation denotes rs2158082 rs2158082
242 5243-5249 Mutation denotes rs4060 rs4060
243 6243-6252 Mutation denotes rs4646127 rs4646127
244 5262-5271 Mutation denotes rs4830974 rs4830974
245 5694-5703 Mutation denotes rs4830983 rs4830983
246 5672-5681 Mutation denotes rs5936011 rs5936011
247 5709-5718 Mutation denotes rs5936029 rs5936029
248 5683-5692 Mutation denotes rs6629110 rs6629110
249 5317-5326 Mutation denotes rs6632704 rs6632704
250 5332-5342 Mutation denotes rs75979613 rs75979613
251 6049-6058 Mutation denotes rs4646127 rs4646127
252 5232-5241 Mutation denotes rs2158082 rs2158082
253 5284-5293 Mutation denotes rs5936011 rs5936011
254 5306-5315 Mutation denotes rs6629110 rs6629110
255 5273-5282 Mutation denotes rs4830983 rs4830983
256 5295-5304 Mutation denotes rs5936029 rs5936029
257 5195-5206 Mutation denotes rs143695310 rs143695310
258 5650-5659 Mutation denotes rs4646127 rs4646127
259 5251-5260 Mutation denotes rs4646127 rs4646127
276 7246-7250 Gene denotes ACE2 Gene:59272
277 7435-7439 Gene denotes ACE2 Gene:59272
278 7187-7191 Gene denotes ACE2 Gene:59272
279 7037-7041 Gene denotes ACE2 Gene:59272
280 6932-6936 Gene denotes ACE2 Gene:59272
281 6736-6740 Gene denotes ACE2 Gene:59272
282 6651-6655 Gene denotes ACE2 Gene:59272
283 6469-6473 Gene denotes ACE2 Gene:59272
284 7432-7434 Gene denotes of Gene:6688
285 7358-7360 Gene denotes of Gene:6688
286 7243-7245 Gene denotes of Gene:6688
287 7034-7036 Gene denotes of Gene:6688
288 6462-6464 Gene denotes of Gene:6688
289 7607-7611 Gene denotes ACE2 Gene:59272
290 7170-7182 Disease denotes AFs of eQTLs
291 7522-7534 Disease denotes AFs of eQTLs
305 7762-7777 Gene denotes variants, which
306 7878-7882 Gene denotes ACE2 Gene:59272
307 7807-7810 Gene denotes ACE Gene:1636
308 8352-8356 Gene denotes ACE2 Gene:59272
309 8192-8196 Gene denotes ACE2 Gene:59272
310 8054-8058 Gene denotes ACE2 Gene:59272
311 7744-7748 Gene denotes ACE2 Gene:59272
312 7875-7877 Gene denotes of Gene:6688
313 7804-7806 Gene denotes of Gene:6688
314 8014-8025 Species denotes coronavirus Tax:11118
315 8448-8457 Species denotes 2019-nCoV Tax:2697049
316 8458-8468 Species denotes SARS-CoV-2 Tax:2697049
317 8227-8238 Disease denotes lung injury MESH:D055370