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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 139-143 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T2 631-638 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T3 743-750 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T4 866-870 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T5 871-874 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T6 887-890 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T7 1805-1809 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T8 1903-1910 Body_part denotes Genomes http://purl.org/sig/ont/fma/fma84116
T9 2034-2040 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T10 2142-2152 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T11 2250-2256 Body_part denotes lysine http://purl.org/sig/ont/fma/fma82758
T12 2265-2273 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T13 2347-2354 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 2646-2653 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 2746-2753 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 4534-4540 Body_part denotes intron http://purl.org/sig/ont/fma/fma84121
T17 4729-4733 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T18 5086-5092 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T19 5255-5262 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T20 6101-6108 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T21 6232-6238 Body_part denotes intron http://purl.org/sig/ont/fma/fma84121
T22 6247-6251 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T23 6476-6480 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T24 6614-6618 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T25 6619-6626 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T26 6700-6704 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T27 6705-6708 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T28 6784-6788 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T29 6888-6891 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T30 6933-6937 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T31 6938-6945 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T32 7065-7070 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T33 7096-7101 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T34 7105-7109 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T35 7168-7173 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T36 7453-7459 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T37 7485-7489 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T38 7490-7493 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T39 8145-8152 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T40 8344-8348 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T41 8360-8364 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T42 8488-8495 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 2028-2033 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T2 5086-5092 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 6614-6618 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 6933-6937 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T5 7105-7109 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 7434-7439 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T7 7453-7459 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T8 8344-8348 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T9 8360-8364 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p6832s6 589-595 NegReg denotes reduce
p6832s12 629-630 Protein denotes S

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 65-73 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 243-259 Disease denotes SARS-coronavirus http://purl.obolibrary.org/obo/MONDO_0005091
T3 261-269 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 425-433 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 522-531 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T6 535-543 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 642-650 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 828-836 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 839-848 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 1014-1022 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 1025-1034 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 1532-1540 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 3456-3459 Disease denotes CHS http://purl.obolibrary.org/obo/MONDO_0008963
T14 8338-8355 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T16 8349-8355 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T17 8575-8583 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 139-143 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T2 195-198 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T3 279-284 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T4 557-558 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T5 719-724 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T6 850-851 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T7 866-870 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8 926-931 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T9 926-931 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T10 1095-1096 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T11 1793-1795 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T12 1805-1809 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T13 2088-2090 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T14 2088-2090 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T15 2274-2276 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T16 2300-2305 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T17 2463-2464 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 2590-2591 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 3640-3645 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T20 3640-3645 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T21 3675-3682 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T22 3738-3740 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T23 3738-3740 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T24 4020-4021 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 4248-4249 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T26 4729-4733 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T27 4976-4979 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAS
T28 5953-5955 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T29 5974-5976 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T30 6247-6251 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T31 6253-6256 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T32 6476-6480 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T33 6614-6618 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T34 6614-6618 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T35 6700-6704 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T36 6784-6788 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T37 6933-6937 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T38 6933-6937 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T39 7026-7030 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T40 7026-7030 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T41 7065-7070 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T42 7075-7076 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 7096-7101 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T44 7105-7109 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T45 7105-7109 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T46 7168-7173 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T47 7485-7489 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T48 8344-8348 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T49 8344-8348 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T50 8360-8364 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T51 8360-8364 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T52 8691-8693 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T53 8714-8716 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T54 8714-8716 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T55 8927-8929 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T56 8927-8929 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 156-167 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T2 631-638 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T3 1701-1703 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T4 2088-2090 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T5 2142-2152 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T6 2142-2147 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T7 2148-2152 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T8 2250-2256 Chemical denotes lysine http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094
T10 2265-2273 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T11 2347-2354 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 2646-2653 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13 2746-2753 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 3320-3322 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T15 3381-3383 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T16 3425-3427 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T17 3738-3740 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T18 5724-5726 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T19 5994-5996 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T20 6130-6132 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T21 6746-6751 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T22 7026-7030 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T23 7423-7425 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T24 8145-8152 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T25 8714-8716 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T26 8737-8739 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T27 8923-8926 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T28 8927-8929 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 8338-8355 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations
T2 117-129 Sentence denotes Dear Editor,
T3 130-314 Sentence denotes The ACE2 gene encodes the angiotensin-converting enzyme-2, which has been proved to be the receptor for both the SARS-coronavirus (SARS-CoV) and the human respiratory coronavirus NL63.
T4 315-439 Sentence denotes Recent studies and analyses indicate that ACE2 could be the host receptor for the novel coronavirus 2019-nCoV/SARS-CoV-21,2.
T5 440-556 Sentence denotes Previous studies demonstrated the positive correlation of ACE2 expression and the infection of SARS-CoV in vitro3,4.
T6 557-660 Sentence denotes A number of ACE2 variants could reduce the association between ACE2 and S-protein in SARS-CoV or NL635.
T7 661-849 Sentence denotes Therefore, the expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection.
T8 850-968 Sentence denotes A recent single-cell RNA-sequencing (RNA-seq) analysis indicated that Asian males may have higher expression of ACE26.
T9 969-1094 Sentence denotes Currently, the clinical reports of 2019-nCoV/SARS-CoV-2 infection from non-Asian populations for comparison are very limited.
T10 1095-1210 Sentence denotes A study from Munich reported four German cases, all of which showed mild clinical symptoms without severe illness7.
T11 1211-1320 Sentence denotes However, the genetic basis of ACE2 expression and function in different populations is still largely unknown.
T12 1321-1595 Sentence denotes Therefore, genetic analysis of expression quantitative trait loci (eQTLs)8 and potential functional coding variants in ACE2 among populations are required for further epidemiological investigations of 2019-nCoV/SARS-CoV-2 spreading in East Asian (EAS) and other populations.
T13 1596-1931 Sentence denotes To systematically investigate the candidate functional coding variants in ACE2 and the allele frequency (AF) differences between populations, we analyzed all the 1700 variants (Supplementary Table S1) in ACE2 gene region from the ChinaMAP (China Metabolic Analytics Project, under reviewing) and 1KGP (1000 Genomes Project)9 databases.
T14 1932-2092 Sentence denotes The AFs of 62 variants located in the coding regions of ACE2 in ChinaMAP, 1KGP, and other large-scale genome databases were summarized (Supplementary Table S2).
T15 2093-2204 Sentence denotes All of the 32 variants potentially affecting the amino acid sequence of ACE2 in databases were shown (Fig. 1a).
T16 2205-2371 Sentence denotes Previous study showed that the residues near lysine 31, and tyrosine 41, 82–84, and 353–357 in human ACE2 were important for the binding of S-protein in coronavirus5.
T17 2372-2457 Sentence denotes The mutations in these residues were not found in different populations in our study.
T18 2458-2553 Sentence denotes Only a singleton truncating variant of ACE2 (Gln300X) was identified in the ChinaMAP (Fig. 1a).
T19 2554-2677 Sentence denotes These data suggested that there was a lack of natural resistant mutations for coronavirus S-protein binding in populations.
T20 2678-2792 Sentence denotes The effects of low-frequency missense variants in populations for S-protein binding could be further investigated.
T21 2793-2974 Sentence denotes The distributions of seven hotspot variants (Lys26Arg, Ile468Val, Ala627Val, Asn638Ser, Ser692Pro, Asn720Asp, and Leu731Ile/Leu731Phe) in different populations were shown (Fig. 1b).
T22 2975-3191 Sentence denotes Six low-frequency loci (rs200180615, rs140473595, rs199951323, rs147311723, rs149039346, and rs73635825) were found to be specific in 1KGP database, the AFs of which were also low in the gnomAD and TopMed10 database.
T23 3192-3330 Sentence denotes Only two of these six variants (rs200180615 and rs140473595) could be found in CHB (Han Chinese in Beijing) population with the AF < 0.01.
T24 3331-3594 Sentence denotes Interestingly, the SNP rs2285666 with the highest AF in the 62 variants exhibited much higher AF in the ChinaMAP (0.556) and CHS (Han Chinese South, 0.557) populations compared to others (AMR, Ad Mixed American, 0.336; AFR, African, 0.2114; EUR, European, 0.235).
T25 3595-3742 Sentence denotes In addition, the homozygous mutation rate in males (0.550) was much higher than females (0.310) in the Chinese population (Supplementary Table S2).
T26 3743-3921 Sentence denotes Taken together, the differences in AFs of ACE2 coding variants among different populations suggested that the diverse genetic basis might affect ACE2 functions among populations.
T27 3922-4019 Sentence denotes Fig. 1 The coding-region variants and eQTL variants for ACE2 in East Asian and other populations.
T28 4020-4109 Sentence denotes a Schematics of 32 coding variants in ACE2 identified in the ChinaMAP and 1KGP databases.
T29 4110-4191 Sentence denotes Yellow stars indicate the nonsense variants; dots indicate the missense variants.
T30 4192-4330 Sentence denotes The number of samples with hotspot variants was marked. b The distribution of hotspot missense mutations of ACE2 in different populations.
T31 4331-4486 Sentence denotes The colors indicate different populations. c The distribution and the allele frequencies of representative eQTL variants for ACE2 in different populations.
T32 4487-4582 Sentence denotes Pie charts depict the allele frequencies of an intron variant of ACE2 (rs4646127) in the world.
T33 4583-4684 Sentence denotes Orange color denotes the frequency of alteration allele, and blue color denotes the reference allele.
T34 4685-4754 Sentence denotes The allele frequencies of 15 eQTLs for ACE2 gene are shown in tables.
T35 4755-4838 Sentence denotes The color gradient from blue to red indicates the increasing of allele frequencies.
T36 4839-4929 Sentence denotes The allele frequencies of INDEL variant rs200781818 were annotated by the gnomAD database.
T37 4930-5017 Sentence denotes EAS, East Asian; EUR, European; AFR, African; SAS, South Asian; AMR, Ad Mixed American.
T38 5018-5163 Sentence denotes To analyze the distribution of eQTLs for ACE2, we used the Genotype Tissue Expression (GTEx) database (https://www.gtexportal.org/home/datasets).
T39 5164-5461 Sentence denotes We found 15 unique eQTL variants (14 SNPs and 1 INDELs) for ACE2 with q value ≤ 0.05 in 20 tissues from the GTEx database (rs112171234, rs12010448, rs143695310, rs1996225, rs200781818, rs2158082, rs4060, rs4646127, rs4830974, rs4830983, rs5936011, rs5936029, rs6629110, rs6632704, and rs75979613).
T40 5462-5536 Sentence denotes The AFs of the 15 eQTL variants were compared among different populations.
T41 5537-5728 Sentence denotes Notably, our results showed most of the 15 eQTL variants had much higher AFs in the ChinaMAP dataset and EAS populations compared to European populations (Fig. 1c and Supplementary Table S3).
T42 5729-5962 Sentence denotes The AFs of the top 6 common variants (rs4646127, rs2158082, rs5936011, rs6629110, rs4830983, and rs5936029) were higher than 95% in EAS populations, whereas the AFs of these variants in European populations were much lower (52%–65%).
T43 5963-6134 Sentence denotes All of the 11 common variants (AF > 0.05) and 1 rare variant (rs143695310) in the 15 eQTLs are associated with high expression of ACE2 in tissues (Supplementary Table S3).
T44 6135-6333 Sentence denotes For instance, the eQTL variant rs4646127 (log allelic fold change = 0.314), which locates in the intron of ACE2 gene, has the highest AFs in both of the ChinaMAP (0.997) and EAS (0.994) populations.
T45 6334-6428 Sentence denotes Comparatively, the AFs of rs4646127 in EUR (0.651) and AMR (0.754) populations are much lower.
T46 6429-6563 Sentence denotes These findings suggested the genotypes of ACE2 gene polymorphism may be associated higher expression levels of ACE2 in EAS population.
T47 6564-6688 Sentence denotes Recent reports of the ACE2 expression analysis in lung tissues from Asian and Caucasian populations are still controversial.
T48 6689-6835 Sentence denotes The single-cell RNA-seq analysis reported that the Asian donor had much higher ACE2 expression cell ratio than white and African-American donors6.
T49 6836-7044 Sentence denotes In contrast, the ACE2 expression analysis using the RNA-seq and microarray datasets from control lung tissues indicated there were no significant differences between Asian and Caucasian, or male and female11.
T50 7045-7119 Sentence denotes The ACE2-expressing cells are a very small part of cells in lung tissues6.
T51 7120-7230 Sentence denotes The sample size and the purity of ACE2-positive cells in the selected samples would influence the conclusions.
T52 7231-7427 Sentence denotes Our analysis showed the differences in distribution and AFs of eQTLs for ACE2 in different populations, indicating the diversity of ACE2 expression pattern in populations (Supplementary Table S3).
T53 7428-7582 Sentence denotes Large-scale and multiple tissue-level analysis of single-cell RNA-seq would be more accurate for the expression analysis of ACE2 in different populations.
T54 7583-7795 Sentence denotes In addition, our data showed the moderate difference in AFs of eQTLs between South Asian and EAS, which suggests the potential difference of ACE2 expression in different populations and ethnics in Asia (Fig. 1c).
T55 7796-8028 Sentence denotes In summary, we systematically analyzed coding-region variants in ACE2 and the eQTL variants, which may affect the expression of ACE2 using the GTEx database to compare the genomic characteristics of ACE2 among different populations.
T56 8029-8219 Sentence denotes Our findings indicated that no direct evidence was identified genetically supporting the existence of coronavirus S-protein binding-resistant ACE2 mutants in different populations (Fig. 1a).
T57 8220-8376 Sentence denotes The data of variant distribution and AFs may contribute to the further investigations of ACE2, including its roles in acute lung injury and lung function12.
T58 8377-8642 Sentence denotes The East Asian populations have much higher AFs in the eQTL variants associated with higher ACE2 expression in tissues (Fig. 1c), which may suggest different susceptibility or response to 2019-nCoV/SARS-CoV-2 from different populations under the similar conditions.
T59 8644-8669 Sentence denotes Supplementary information
T60 8671-8693 Sentence denotes Supplementary Table S1
T61 8694-8716 Sentence denotes Supplementary Table S2
T62 8717-8739 Sentence denotes Supplementary Table S3
T63 8741-8876 Sentence denotes Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
T64 8877-8911 Sentence denotes These authors contributed equally:
T65 8912-8929 Sentence denotes Yanan Cao, Lin Li
T66 8931-8956 Sentence denotes Supplementary information
T67 8957-9036 Sentence denotes Supplementary Information accompanies the paper at (10.1038/s41421-020-0147-1).
T68 9038-9054 Sentence denotes Acknowledgements
T69 9055-9225 Sentence denotes This work is supported by the National Basic Research Program of China (973 Program, 2015CB553601); the National Natural Science Foundation of China (81530020, 81522032).
T70 9227-9247 Sentence denotes Author contributions
T71 9248-9371 Sentence denotes Y.C. and W.W. conceived the study; L.L., Z.F, S.W., P.H., X.S., F.W., X.H., and Y.C. performed the bioinformatics analysis.
T72 9372-9422 Sentence denotes G.N. contributed to the discussion of the results.
T73 9423-9496 Sentence denotes Y.C. and L.L. wrote the manuscript; Y.C. and W.W. revised the manuscript.
T74 9498-9518 Sentence denotes Conflict of interest
T75 9519-9578 Sentence denotes The authors declare that they have no conflict of interest.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
153 1940-1942 Gene denotes of Gene:6688
5 29-31 Gene denotes of Gene:6688
6 36-53 Species denotes novel coronavirus Tax:2697049
7 55-64 Species denotes 2019-nCoV Tax:2697049
8 65-75 Species denotes SARS-CoV-2 Tax:2697049
9 86-90 Gene denotes ACE2 Gene:59272
43 815-817 Gene denotes of Gene:6688
44 1241-1245 Gene denotes ACE2 Gene:59272
45 962-966 Gene denotes ACE2 Gene:59272
46 725-729 Gene denotes ACE2 Gene:59272
47 620-624 Gene denotes ACE2 Gene:59272
48 569-573 Gene denotes ACE2 Gene:59272
49 498-502 Gene denotes ACE2 Gene:59272
50 357-361 Gene denotes ACE2 Gene:59272
51 1519-1521 Gene denotes of Gene:6688
52 1238-1240 Gene denotes of Gene:6688
53 1147-1149 Gene denotes of Gene:6688
54 1001-1003 Gene denotes of Gene:6688
55 959-961 Gene denotes of Gene:6688
56 566-568 Gene denotes of Gene:6688
57 532-534 Gene denotes of Gene:6688
58 495-497 Gene denotes of Gene:6688
59 243-259 Species denotes SARS-coronavirus Tax:694009
60 261-269 Species denotes SARS-CoV Tax:694009
61 279-284 Species denotes human Tax:9606
62 297-313 Species denotes coronavirus NL63 Tax:277944
63 397-414 Species denotes novel coronavirus Tax:2697049
64 415-424 Species denotes 2019-nCoV Tax:2697049
65 425-435 Species denotes SARS-CoV-2 Tax:2697049
66 535-543 Species denotes SARS-CoV Tax:694009
67 642-650 Species denotes SARS-CoV Tax:694009
68 818-827 Species denotes 2019-nCoV Tax:2697049
69 1004-1013 Species denotes 2019-nCoV Tax:2697049
70 1522-1531 Species denotes 2019-nCoV Tax:2697049
71 1532-1542 Species denotes SARS-CoV-2 Tax:2697049
72 654-658 Species denotes NL63 Tax:277944
73 522-531 Disease denotes infection MESH:D007239
74 833-848 Disease denotes CoV-2 infection MESH:C000657245
75 1019-1034 Disease denotes CoV-2 infection MESH:C000657245
77 3978-3982 Gene denotes ACE2 Gene:59272
95 4203-4205 Gene denotes of Gene:6688
96 4724-4728 Gene denotes ACE2 Gene:59272
97 4552-4556 Gene denotes ACE2 Gene:59272
98 4456-4460 Gene denotes ACE2 Gene:59272
99 4300-4304 Gene denotes ACE2 Gene:59272
100 4058-4062 Gene denotes ACE2 Gene:59272
101 4862-4864 Gene denotes of Gene:6688
102 4816-4818 Gene denotes of Gene:6688
103 4708-4710 Gene denotes of Gene:6688
104 4618-4620 Gene denotes of Gene:6688
105 4549-4551 Gene denotes of Gene:6688
106 4528-4530 Gene denotes of Gene:6688
107 4420-4422 Gene denotes of Gene:6688
108 4297-4299 Gene denotes of Gene:6688
109 4267-4269 Gene denotes of Gene:6688
110 4558-4567 Mutation denotes rs4646127 rs4646127
111 4879-4890 Mutation denotes rs200781818 rs200781818
145 3785-3789 Gene denotes ACE2 Gene:59272
146 2497-2501 Gene denotes ACE2 Gene:59272
147 2306-2310 Gene denotes ACE2 Gene:59272
148 1800-1804 Gene denotes ACE2 Gene:59272
149 1670-1674 Gene denotes ACE2 Gene:59272
150 2342-2344 Gene denotes of Gene:6688
151 2097-2099 Gene denotes of Gene:6688
152 1985-1987 Gene denotes of Gene:6688
154 2300-2305 Species denotes human Tax:9606
155 2358-2369 Species denotes coronavirus Tax:11118
156 2632-2643 Species denotes coronavirus Tax:11118
157 3888-3892 Gene denotes ACE2 Gene:59272
158 1988-1992 Gene denotes ACE2 Gene:59272
159 2250-2256 Chemical denotes lysine MESH:D008239
160 2265-2273 Chemical denotes tyrosine MESH:D014443
161 2848-2857 Chemical denotes Ile468Val
162 2917-2926 Chemical denotes Leu731Phe
163 1701-1703 Disease denotes AF MESH:D001281
164 3271-3274 Disease denotes CHB
165 3320-3322 Disease denotes AF MESH:D001281
166 3381-3383 Disease denotes AF MESH:D001281
167 3425-3427 Disease denotes AF MESH:D001281
168 3456-3459 Disease denotes CHS MESH:D002609
169 3224-3235 Mutation denotes rs200180615 rs200180615
170 3240-3251 Mutation denotes rs140473595 rs140473595
171 3025-3036 Mutation denotes rs199951323 rs199951323
172 3038-3049 Mutation denotes rs147311723 rs147311723
173 3051-3062 Mutation denotes rs149039346 rs149039346
174 3068-3078 Mutation denotes rs73635825 rs73635825
175 2999-3010 Mutation denotes rs200180615 rs200180615
176 3012-3023 Mutation denotes rs140473595 rs140473595
177 3354-3363 Mutation denotes rs2285666 rs2285666
219 6540-6544 Gene denotes ACE2 Gene:59272
220 6471-6475 Gene denotes ACE2 Gene:59272
221 6242-6246 Gene denotes ACE2 Gene:59272
222 6093-6097 Gene denotes ACE2 Gene:59272
223 5224-5228 Gene denotes ACE2 Gene:59272
224 5059-5063 Gene denotes ACE2 Gene:59272
225 6537-6539 Gene denotes of Gene:6688
226 6468-6470 Gene denotes of Gene:6688
227 6281-6283 Gene denotes of Gene:6688
228 6239-6241 Gene denotes of Gene:6688
229 5894-5896 Gene denotes of Gene:6688
230 5737-5739 Gene denotes of Gene:6688
231 5570-5572 Gene denotes of Gene:6688
232 5470-5472 Gene denotes of Gene:6688
233 5046-5048 Gene denotes of Gene:6688
234 6548-6551 Chemical denotes EAS
235 5994-5996 Disease denotes AF MESH:D001281
236 5287-5298 Mutation denotes rs112171234 rs112171234
237 5300-5310 Mutation denotes rs12010448 rs12010448
238 6025-6036 Mutation denotes rs143695310 rs143695310
239 5325-5334 Mutation denotes rs1996225 rs1996225
240 5336-5347 Mutation denotes rs200781818 rs200781818
241 5778-5787 Mutation denotes rs2158082 rs2158082
242 5360-5366 Mutation denotes rs4060 rs4060
243 6360-6369 Mutation denotes rs4646127 rs4646127
244 5379-5388 Mutation denotes rs4830974 rs4830974
245 5811-5820 Mutation denotes rs4830983 rs4830983
246 5789-5798 Mutation denotes rs5936011 rs5936011
247 5826-5835 Mutation denotes rs5936029 rs5936029
248 5800-5809 Mutation denotes rs6629110 rs6629110
249 5434-5443 Mutation denotes rs6632704 rs6632704
250 5449-5459 Mutation denotes rs75979613 rs75979613
251 6166-6175 Mutation denotes rs4646127 rs4646127
252 5349-5358 Mutation denotes rs2158082 rs2158082
253 5401-5410 Mutation denotes rs5936011 rs5936011
254 5423-5432 Mutation denotes rs6629110 rs6629110
255 5390-5399 Mutation denotes rs4830983 rs4830983
256 5412-5421 Mutation denotes rs5936029 rs5936029
257 5312-5323 Mutation denotes rs143695310 rs143695310
258 5767-5776 Mutation denotes rs4646127 rs4646127
259 5368-5377 Mutation denotes rs4646127 rs4646127
276 7363-7367 Gene denotes ACE2 Gene:59272
277 7552-7556 Gene denotes ACE2 Gene:59272
278 7304-7308 Gene denotes ACE2 Gene:59272
279 7154-7158 Gene denotes ACE2 Gene:59272
280 7049-7053 Gene denotes ACE2 Gene:59272
281 6853-6857 Gene denotes ACE2 Gene:59272
282 6768-6772 Gene denotes ACE2 Gene:59272
283 6586-6590 Gene denotes ACE2 Gene:59272
284 7549-7551 Gene denotes of Gene:6688
285 7475-7477 Gene denotes of Gene:6688
286 7360-7362 Gene denotes of Gene:6688
287 7151-7153 Gene denotes of Gene:6688
288 6579-6581 Gene denotes of Gene:6688
289 7724-7728 Gene denotes ACE2 Gene:59272
290 7287-7299 Disease denotes AFs of eQTLs
291 7639-7651 Disease denotes AFs of eQTLs
305 7879-7894 Gene denotes variants, which
306 7995-7999 Gene denotes ACE2 Gene:59272
307 7924-7927 Gene denotes ACE Gene:1636
308 8469-8473 Gene denotes ACE2 Gene:59272
309 8309-8313 Gene denotes ACE2 Gene:59272
310 8171-8175 Gene denotes ACE2 Gene:59272
311 7861-7865 Gene denotes ACE2 Gene:59272
312 7992-7994 Gene denotes of Gene:6688
313 7921-7923 Gene denotes of Gene:6688
314 8131-8142 Species denotes coronavirus Tax:11118
315 8565-8574 Species denotes 2019-nCoV Tax:2697049
316 8575-8585 Species denotes SARS-CoV-2 Tax:2697049
317 8344-8355 Disease denotes lung injury MESH:D055370
319 8750-8752 Gene denotes ’s Gene:43740568
321 9407-9409 Gene denotes of Gene:6688