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PMC:7039956 / 6867-8928 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
185 1169-1173 Gene denotes ACE2 Gene:59272
186 1203-1207 Gene denotes ACE2 Gene:59272
187 1265-1269 Gene denotes ACE2 Gene:59272
188 1358-1362 Gene denotes ACE2 Gene:59272
189 1250-1256 Gene denotes Violin
217 204-208 Gene denotes ACE2 Gene:59272
218 405-408 Gene denotes SFN Gene:104444
219 410-415 Gene denotes KRT6A Gene:16687
220 421-426 Gene denotes KRT10 Gene:16661
221 465-468 Gene denotes FAP Gene:14089
222 470-474 Gene denotes PDPN Gene:14726
223 476-482 Gene denotes COL1A2 Gene:12843
224 484-487 Gene denotes DCN Gene:13179
225 489-495 Gene denotes COL3A1 Gene:1281
226 497-503 Gene denotes COL6A1 Gene:1291
227 538-541 Gene denotes CD2 Gene:914
228 543-547 Gene denotes CD3D Gene:915
229 549-553 Gene denotes CD3E Gene:916
230 559-563 Gene denotes CD3G Gene:917
231 602-607 Gene denotes CD163 Gene:9332
232 609-614 Gene denotes CSF1R Gene:1436
233 626-632 Gene denotes FCGR2A Gene:2212
234 670-674 Gene denotes CMA1 Gene:1215
235 676-681 Gene denotes MS4A2 Gene:2206
236 683-689 Gene denotes TPSAB1 Gene:100503895
237 691-696 Gene denotes TPSB2 Gene:17229
238 731-737 Gene denotes SLAMF7 Gene:75345
239 739-744 Gene denotes FCRL5 Gene:329693
240 750-755 Gene denotes CD79A Gene:12518
241 803-809 Gene denotes PECAM1 Gene:18613
242 811-814 Gene denotes VWF Gene:22371
243 820-823 Gene denotes ENG Gene:13805
252 1416-1420 Gene denotes ACE2 Gene:59272
253 1458-1462 Gene denotes ACE2 Gene:59272
254 1547-1551 Gene denotes ACE2 Gene:59272
255 1617-1621 Gene denotes ACE2 Gene:59272
256 1702-1706 Gene denotes ACE2 Gene:59272
257 1790-1794 Gene denotes ACE2 Gene:59272
258 1852-1856 Gene denotes ACE2 Gene:59272
259 1947-1951 Gene denotes ACE2 Gene:59272

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T109 7-11 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T110 12-15 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T111 37-44 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T112 52-56 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T113 57-60 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T114 92-99 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T115 171-175 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T116 290-295 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T117 316-320 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T118 364-380 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T119 375-380 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T120 429-440 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T121 508-513 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T122 566-577 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T123 635-645 Body_part denotes mast cells http://purl.org/sig/ont/fma/fma66784
T124 640-645 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T125 701-706 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T126 761-778 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T127 773-778 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T128 846-850 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T129 870-874 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T130 920-924 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T131 925-928 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T132 950-957 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T133 992-996 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T134 1026-1030 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T135 1040-1045 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T136 1090-1094 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T137 1119-1123 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T138 1158-1163 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T139 1298-1302 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T140 1329-1335 Body_part denotes tongue http://purl.org/sig/ont/fma/fma54640
T141 1336-1352 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T142 1347-1352 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T143 1443-1450 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T144 1472-1477 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T145 1499-1505 Body_part denotes tongue http://purl.org/sig/ont/fma/fma54640
T146 1531-1538 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T147 1561-1566 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T148 1583-1589 Body_part denotes tongue http://purl.org/sig/ont/fma/fma54640
T149 1631-1636 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T150 1660-1667 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T151 1678-1694 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T152 1689-1694 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T153 1716-1721 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T154 1726-1731 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T155 1743-1748 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T156 1762-1772 Body_part denotes fibroblast http://purl.org/sig/ont/fma/fma63877
T157 1818-1834 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T158 1829-1834 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T159 1866-1871 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T160 1882-1898 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T161 1893-1898 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T162 1978-1994 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T163 1989-1994 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T164 2002-2013 Body_part denotes oral mucosa http://purl.org/sig/ont/fma/fma59660
T165 2007-2013 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T166 2037-2043 Body_part denotes tongue http://purl.org/sig/ont/fma/fma54640
T167 2044-2060 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T168 2055-2060 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T57 1329-1335 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723
T58 1499-1505 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723
T59 1583-1589 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723
T60 2007-2013 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T61 2037-2043 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T28 465-468 Disease denotes FAP http://purl.obolibrary.org/obo/MONDO_0021055
T29 543-547 Disease denotes CD3D http://purl.obolibrary.org/obo/MONDO_0014280

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T122 7-11 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T123 52-56 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T124 171-180 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T125 283-285 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T126 290-295 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T127 316-326 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T128 349-351 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2a
T129 364-374 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T130 375-380 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T131 389-394 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T132 429-440 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T133 449-454 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T134 506-513 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T135 522-527 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T136 586-591 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T137 609-614 http://purl.obolibrary.org/obo/PR_000002062 denotes CSF1R
T138 616-620 http://purl.obolibrary.org/obo/PR_000002064 denotes CD68
T139 640-645 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T140 654-659 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T141 699-706 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T142 715-720 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T143 761-778 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T144 787-792 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T145 846-850 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T146 870-880 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T147 920-924 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T148 984-985 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T149 992-1002 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T150 1026-1030 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T151 1040-1045 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T152 1077-1078 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T153 1090-1094 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T154 1119-1129 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T155 1158-1163 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T156 1298-1308 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T157 1329-1335 http://purl.obolibrary.org/obo/UBERON_0001723 denotes tongue
T158 1336-1346 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T159 1347-1352 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T160 1472-1477 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T161 1499-1505 http://purl.obolibrary.org/obo/UBERON_0001723 denotes tongue
T162 1561-1566 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T163 1583-1589 http://purl.obolibrary.org/obo/UBERON_0001723 denotes tongue
T164 1631-1636 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T165 1678-1688 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T166 1689-1694 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T167 1716-1721 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T168 1724-1731 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T169 1741-1748 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T170 1762-1772 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblast
T171 1818-1828 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T172 1829-1834 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T173 1866-1871 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T174 1882-1892 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T175 1893-1898 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T176 1978-1988 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T177 1989-1994 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T178 2007-2013 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T179 2037-2043 http://purl.obolibrary.org/obo/UBERON_0001723 denotes tongue
T180 2044-2054 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T181 2055-2060 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T13 465-468 Chemical denotes FAP http://purl.obolibrary.org/obo/CHEBI_73617

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T53 0-44 Sentence denotes Single cell RNA-seq analysis of oral tissues
T54 45-209 Sentence denotes Single cell RNA-seq was utilized for four oral tissues, and the data was analyzed to confirm the above results and assess the cell type-specific expression of ACE2.
T55 210-825 Sentence denotes After the data preprocessing (shown in section “Materials and methods”), 22 969 cells were acquired and 7 cell types were identified (Fig. 2a), including epithelial cells (marker genes including SFN, KRT6A, and KRT10), fibroblasts (marker genes including FAP, PDPN, COL1A2, DCN, COL3A1, COL6A1), T cells (marker genes including CD2, CD3D, CD3E, and CD3G), macrophages (marker genes including CD163, CSF1R, CD68, and FCGR2A), mast cells (marker genes including CMA1, MS4A2, TPSAB1, TPSB2), B cells (marker genes including SLAMF7, FCRL5, and CD79A) and endothelial cells (marker genes including PECAM1, VWF, and ENG).
T56 826-905 Sentence denotes The heatmap of main cell markers across the cell types can be found in Fig. 2b.
T57 906-1373 Sentence denotes Fig. 2 Single cell RNA-seq analysis of oral tissues from independent dataset. a Seven-cell types were identified by the cell markers; cells were clustered by UMAP method. b Heatmap of cell markers for identifying cell types. c Scatter plots of all the cells with ACE2 expression. d Violin plot of ACE2 expression across different oral sites. e Violin plot of ACE2 expression across different cell types. f Scatter plots of tongue epithelial cells with ACE2 expression
T58 1374-1591 Sentence denotes According to Fig. 2c, d, we confirmed the ACE2 was expressed in oral tissues (0.52% ACE2-positive cells), and higher in oral tongue than buccal and gingival tissues (95.86% ACE2-positive cells located in oral tongue).
T59 1592-1909 Sentence denotes Figure 2e shows that the ACE2-positive cells could be found in oral tissues including epithelial cells (1.19% ACE2-positive cells), T cells (<0.5%), B cells (<0.5%), and fibroblast (<0.5%), and the ACE2 was highly enriched in epithelial cells, of which 93.38% ACE2-positive cells belong to epithelial cells (Fig. 2f).
T60 1910-2061 Sentence denotes The above results indicated that the ACE2 could be expressed on the epithelial cells of the oral mucosa and highly enriched in tongue epithelial cells.