PMC:7039956 / 3915-4611 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7039956","sourcedb":"PMC","sourceid":"7039956","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7039956","text":"In order to investigated the potential routes of 2019-nCov infection on the mucosa of oral cavity, we explored whether the ACE2 is expressed and the ACE2-expressing cell composition and proportion in oral cavity based on the public bulk RNA-seq profiles from two public databases and single-cell transcriptomes from an independent data generated in-house. The result showed that the ACE2 could be expressed in the oral cavity, and was highly enriched in epithelial cells. Moreover, among different oral sites, ACE2 expression was higher in tongue than buccal and gingival tissues. These findings indicate that the mucosa of oral cavity may be a potentially high risk route of 2019-nCov 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