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PMC:7039956 / 1416-4611 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
51 58-66 Species denotes patients Tax:9606
52 396-400 Species denotes ncov Tax:2697049
53 547-555 Species denotes patients Tax:9606
54 72-81 Disease denotes pneumonia MESH:D011014
55 212-221 Disease denotes pneumonia MESH:D011014
56 235-258 Disease denotes Corona Virus Disease 19 MESH:C000657245
57 260-268 Disease denotes COVID-19 MESH:C000657245
58 448-456 Disease denotes COVID-19 MESH:C000657245
59 479-484 Disease denotes fever MESH:D005334
60 486-493 Disease denotes fatigue MESH:D005221
61 495-504 Disease denotes dry cough MESH:D003371
62 506-513 Disease denotes myalgia MESH:D063806
63 519-526 Disease denotes dyspnea MESH:D004417
64 574-582 Disease denotes headache MESH:D006261
65 584-593 Disease denotes dizziness MESH:D004244
66 595-609 Disease denotes abdominal pain MESH:D015746
67 611-619 Disease denotes diarrhea MESH:D003967
68 621-627 Disease denotes nausea MESH:D009325
69 633-641 Disease denotes vomiting MESH:D014839
70 685-704 Disease denotes respiratory failure MESH:D012131
71 737-742 Disease denotes death MESH:D003643
92 1204-1208 Gene denotes ACE2 Gene:59272
93 1556-1560 Gene denotes ACE2 Gene:59272
94 1604-1608 Gene denotes ACE2 Gene:59272
95 1657-1661 Gene denotes ACE2 Gene:59272
96 1507-1516 Gene denotes S-protein Gene:43740568
97 772-789 Species denotes novel coronavirus Tax:2697049
98 795-800 Species denotes human Tax:9606
99 842-851 Species denotes 2019-nCoV Tax:2697049
100 876-885 Species denotes 2019-nCoV Tax:2697049
101 996-1005 Species denotes 2019-nCoV Tax:2697049
102 1064-1116 Species denotes severe acute respiratory syndrome (SARS) coronavirus Tax:694009
103 1118-1126 Species denotes SARS-CoV Tax:694009
104 1241-1250 Species denotes 2019-nCoV Tax:2697049
105 1285-1293 Species denotes SARS-CoV Tax:694009
106 1298-1307 Species denotes HCoV-NL63 Tax:277944
107 1342-1351 Species denotes 2019-nCoV Tax:2697049
108 1371-1382 Species denotes coronavirus Tax:11118
109 1497-1506 Species denotes 2019-nCoV Tax:2697049
110 1550-1555 Species denotes human Tax:9606
111 1726-1745 Disease denotes 2019-nCoV infection MESH:C000657245
120 1788-1792 Gene denotes ACE2 Gene:59272
121 2022-2026 Gene denotes ACE2 Gene:59272
122 2082-2086 Gene denotes ACE2 Gene:59272
123 2406-2410 Gene denotes ACE2 Gene:59272
124 1796-1801 Species denotes human Tax:9606
125 1854-1863 Species denotes 2019-nCoV Tax:2697049
126 1834-1843 Disease denotes infection MESH:D007239
127 2476-2495 Disease denotes 2019-nCoV infection MESH:C000657245
134 2622-2626 Gene denotes ACE2 Gene:59272
135 2648-2652 Gene denotes ACE2 Gene:59272
136 2882-2886 Gene denotes ACE2 Gene:59272
137 3009-3013 Gene denotes ACE2 Gene:59272
138 2548-2567 Disease denotes 2019-nCov infection MESH:C000657245
139 3175-3194 Disease denotes 2019-nCov infection MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T29 712-720 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T30 808-824 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T31 819-824 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 948-954 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T33 1224-1228 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T34 1509-1516 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T35 1673-1678 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T36 1697-1702 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T37 1796-1806 Body_part denotes human body http://purl.org/sig/ont/fma/fma305853
T38 1894-1898 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T39 1899-1902 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T40 1947-1951 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T41 2027-2030 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T42 2060-2064 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T43 2116-2138 Body_part denotes type II alveolar cells http://purl.org/sig/ont/fma/fma62501
T44 2133-2138 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T45 2159-2168 Body_part denotes esophagus http://purl.org/sig/ont/fma/fma7131
T46 2190-2206 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T47 2201-2206 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T48 2219-2230 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T49 2236-2241 Body_part denotes ileum http://purl.org/sig/ont/fma/fma7208
T50 2284-2289 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T51 2291-2297 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T52 2314-2319 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T53 2325-2332 Body_part denotes bladder http://purl.org/sig/ont/fma/fma15900
T54 2422-2427 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T55 2575-2581 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T56 2585-2596 Body_part denotes oral cavity http://purl.org/sig/ont/fma/fma20292
T57 2664-2668 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T58 2699-2710 Body_part denotes oral cavity http://purl.org/sig/ont/fma/fma20292
T59 2736-2739 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T60 2790-2794 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T61 2913-2924 Body_part denotes oral cavity http://purl.org/sig/ont/fma/fma20292
T62 2953-2969 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T63 2964-2969 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T64 3039-3045 Body_part denotes tongue http://purl.org/sig/ont/fma/fma54640
T65 3071-3078 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T66 3113-3119 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T67 3123-3134 Body_part denotes oral cavity http://purl.org/sig/ont/fma/fma20292

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T13 2159-2168 Body_part denotes esophagus http://purl.obolibrary.org/obo/UBERON_0001043
T14 2236-2241 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T15 2291-2297 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T16 2298-2313 Body_part denotes proximal tubule http://purl.obolibrary.org/obo/UBERON_0004134
T17 2325-2332 Body_part denotes bladder http://purl.obolibrary.org/obo/UBERON_0001255
T18 2389-2395 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T19 2575-2581 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T20 2585-2596 Body_part denotes oral cavity http://purl.obolibrary.org/obo/UBERON_0000167
T21 2699-2710 Body_part denotes oral cavity http://purl.obolibrary.org/obo/UBERON_0000167
T22 2913-2924 Body_part denotes oral cavity http://purl.obolibrary.org/obo/UBERON_0000167
T23 3039-3045 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723
T24 3113-3119 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T25 3123-3134 Body_part denotes oral cavity http://purl.obolibrary.org/obo/UBERON_0000167

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 72-81 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T4 212-221 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T5 479-484 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T6 486-493 Phenotype denotes fatigue http://purl.obolibrary.org/obo/HP_0012378
T7 495-504 Phenotype denotes dry cough http://purl.obolibrary.org/obo/HP_0031246
T8 506-513 Phenotype denotes myalgia http://purl.obolibrary.org/obo/HP_0003326
T9 574-582 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T10 584-593 Phenotype denotes dizziness http://purl.obolibrary.org/obo/HP_0002321
T11 595-609 Phenotype denotes abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T12 611-619 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T13 621-627 Phenotype denotes nausea http://purl.obolibrary.org/obo/HP_0002018
T14 673-704 Phenotype denotes progressive respiratory failure http://purl.obolibrary.org/obo/HP_0002093

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T7 72-81 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T8 212-221 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T9 260-268 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 448-456 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 611-619 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T12 685-704 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T13 1064-1097 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T14 1099-1103 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T15 1118-1126 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 1118-1122 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T17 1285-1293 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 1285-1289 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T19 1834-1843 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T20 2548-2567 Disease denotes 2019-nCov infection http://purl.obolibrary.org/obo/MONDO_0100096
T21 2558-2567 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T22 3175-3194 Disease denotes 2019-nCov infection http://purl.obolibrary.org/obo/MONDO_0100096
T23 3185-3194 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T32 242-247 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T33 286-298 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T34 393-395 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T35 770-771 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 795-800 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T37 801-807 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T38 808-818 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T39 819-824 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T40 900-903 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T41 919-922 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T42 1224-1228 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T43 1550-1555 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T44 1673-1678 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T45 1697-1702 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T46 1796-1801 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T47 1894-1898 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T48 1947-1951 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T49 2060-2064 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T50 2133-2138 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T51 2159-2168 http://purl.obolibrary.org/obo/UBERON_0001043 denotes esophagus
T52 2179-2206 http://purl.obolibrary.org/obo/CL_0000079 denotes stratified epithelial cells
T53 2236-2241 http://purl.obolibrary.org/obo/UBERON_0002116 denotes ileum
T54 2284-2289 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T55 2291-2297 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T56 2291-2297 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T57 2291-2297 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T58 2298-2313 http://purl.obolibrary.org/obo/UBERON_0004134 denotes proximal tubule
T59 2314-2319 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T60 2389-2395 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T61 2422-2427 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T62 2575-2581 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T63 2585-2596 http://purl.obolibrary.org/obo/UBERON_0000167 denotes oral cavity
T64 2585-2596 http://www.ebi.ac.uk/efo/EFO_0000825 denotes oral cavity
T65 2664-2668 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T66 2699-2710 http://purl.obolibrary.org/obo/UBERON_0000167 denotes oral cavity
T67 2699-2710 http://www.ebi.ac.uk/efo/EFO_0000825 denotes oral cavity
T68 2790-2794 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T69 2913-2924 http://purl.obolibrary.org/obo/UBERON_0000167 denotes oral cavity
T70 2913-2924 http://www.ebi.ac.uk/efo/EFO_0000825 denotes oral cavity
T71 2953-2963 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T72 2964-2969 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T73 3039-3045 http://purl.obolibrary.org/obo/UBERON_0001723 denotes tongue
T74 3113-3119 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T75 3123-3134 http://purl.obolibrary.org/obo/UBERON_0000167 denotes oral cavity
T76 3123-3134 http://www.ebi.ac.uk/efo/EFO_0000825 denotes oral cavity
T77 3142-3143 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 854-856 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T2 904-906 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T3 923-925 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T4 1170-1181 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T5 1200-1202 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T6 1509-1516 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T7 1561-1570 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T8 2121-2123 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T10 0-12 Sentence denotes Introduction
T11 13-201 Sentence denotes Since December 2019, an increasing number of patients with pneumonia occurred in Wuhan, Hubei province, China, which attracted much attention not only within China but across the world1,2.
T12 202-528 Sentence denotes The novel pneumonia was named as Corona Virus Disease 19 (COVID-19) by World Health Organization (WHO) (https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200211-sitrep-22-ncov.pdf?sfvrsn=fb6d49b1_2), the common symptoms of COVID-19 at illness onset were fever, fatigue, dry cough, myalgia, and dyspnea3.
T13 529-643 Sentence denotes In addition, some patients might suffer from headache, dizziness, abdominal pain, diarrhea, nausea, and vomiting3.
T14 644-744 Sentence denotes Onset of disease may lead to progressive respiratory failure due to alveolar damage and even death4.
T15 745-853 Sentence denotes Scientists then isolated a novel coronavirus from human airway epithelial cells, which was named 2019-nCoV5.
T16 854-1128 Sentence denotes Lu et al.6 found that 2019-nCoV was closer to bat-SL-CoVZC45 and bat-SL-CoVZXC21 at the whole-genome level, and the external subdomain of the 2019-nCoV receptor-binding domain (RBD) was more similar to that of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV).
T17 1129-1311 Sentence denotes Study of Zhou et al.4 indicated that the angiotensin-converting enzyme II (ACE2) is likely the cell receptor of 2019-nCoV, which were also the receptor for SARS-CoV and HCoV-NL637,8.
T18 1312-1439 Sentence denotes Zhou et al.4 also proved that 2019-nCoV does not use other coronavirus receptors, aminopeptidase N, and dipeptidyl peptidase 4.
T19 1440-1571 Sentence denotes The study of Xu et al.9 found that the RBD domain of the 2019-nCoV S-protein supports strong interaction with human ACE2 molecules.
T20 1572-1748 Sentence denotes These findings suggest that the ACE2 plays an important role in cellular entry, thus ACE2-expressing cells may act as target cells and are susceptible to 2019-nCoV infection10.
T21 1749-1864 Sentence denotes The expression and distribution of the ACE2 in human body may indicate the potential infection routes of 2019-nCoV.
T22 1865-2076 Sentence denotes Through the developed single-cell RNA sequencing (scRNA-Seq) technique and single-cell transcriptomes based on the public database, researchers analyzed the ACE2 RNA expression profile at single-cell resolution.
T23 2077-2352 Sentence denotes High ACE2 expression was identified in type II alveolar cells (AT2) of lung10–12, esophagus upper and stratified epithelial cells, absorptive enterocytes from ileum and colon12, cholangiocytes13, myocardial cells, kidney proximal tubule cells, and bladder urothelial cells10.
T24 2353-2498 Sentence denotes These findings indicated that those organs with high ACE2-expressing cells should be considered as potential high risk for 2019-nCoV infection10.
T25 2499-2854 Sentence denotes In order to investigated the potential routes of 2019-nCov infection on the mucosa of oral cavity, we explored whether the ACE2 is expressed and the ACE2-expressing cell composition and proportion in oral cavity based on the public bulk RNA-seq profiles from two public databases and single-cell transcriptomes from an independent data generated in-house.
T26 2855-2970 Sentence denotes The result showed that the ACE2 could be expressed in the oral cavity, and was highly enriched in epithelial cells.
T27 2971-3079 Sentence denotes Moreover, among different oral sites, ACE2 expression was higher in tongue than buccal and gingival tissues.
T28 3080-3195 Sentence denotes These findings indicate that the mucosa of oral cavity may be a potentially high risk route of 2019-nCov infection.

2_test

Id Subject Object Predicate Lexical cue
32094336-31986257-53457423 197-198 31986257 denotes 1
32094336-23329690-53457424 199-200 23329690 denotes 2
32094336-32365354-53457425 742-743 32365354 denotes 4
32094336-32334705-53457426 863-864 32334705 denotes 6
32094336-32365354-53457427 1149-1150 32365354 denotes 4
32094336-14647384-53457428 1305-1308 14647384 denotes 637
32094336-15897467-53457429 1309-1310 15897467 denotes 8
32094336-32365354-53457430 1323-1324 32365354 denotes 4
32094336-32318909-53457431 1462-1463 32318909 denotes 9
T41652 197-198 31986257 denotes 1
T61985 199-200 23329690 denotes 2
T2908 742-743 32365354 denotes 4
T24209 863-864 32334705 denotes 6
T45122 1149-1150 32365354 denotes 4
T45703 1305-1308 14647384 denotes 637
T29939 1309-1310 15897467 denotes 8
T46737 1323-1324 32365354 denotes 4
T74693 1462-1463 32318909 denotes 9