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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7039910","sourcedb":"PMC","sourceid":"7039910","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7039910","text":"The reproduction number, R, measures the transmissibility of a virus, representing the average number of new infections generated by each infected person, the initial constant of which is called the basic reproduction number, R09, and the actual average number of secondary cases per infected case at time t is called effective reproduction number, Rt10–12. Rt shows time-dependent variation with the implementation of control measures. R \u003e 1 indicates that the outbreak is self-sustaining unless effective control measures are implemented, while R \u003c 1 indicates that the number of new cases decreases over time and, eventually, the outbreak will stop9. Over the past month, several groups reported estimated R0 of COVID-19 and generated valuable prediction for the early phase of this outbreak. In particular, Imai et al.9 provided the first estimation, using R0 of 2.6 and based on the number of cases in China and those detected in other countries. Other authors estimated R0 to be 3.813, 6.4714, 2.215, and 2.6816. These predictions were very alerting and suggestions have been made for very strict public health measures to contain the epidemics.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"72","span":{"begin":109,"end":119},"obj":"Disease"},{"id":"73","span":{"begin":138,"end":146},"obj":"Disease"},{"id":"74","span":{"begin":284,"end":292},"obj":"Disease"},{"id":"75","span":{"begin":715,"end":723},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"MESH:D007239"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:D007239"},{"id":"A74","pred":"tao:has_database_id","subj":"74","obj":"MESH:D007239"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"MESH:C000657245"},{"subj":"72","pred":"source","obj":"LitCovid-PubTator"},{"subj":"73","pred":"source","obj":"LitCovid-PubTator"},{"subj":"74","pred":"source","obj":"LitCovid-PubTator"},{"subj":"75","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T22","span":{"begin":109,"end":119},"obj":"Disease"},{"id":"T23","span":{"begin":715,"end":723},"obj":"Disease"}],"attributes":[{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T14","span":{"begin":61,"end":62},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T15","span":{"begin":63,"end":68},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T16","span":{"begin":437,"end":442},"obj":"http://purl.obolibrary.org/obo/CLO_0008697"},{"id":"T17","span":{"begin":437,"end":442},"obj":"http://purl.obolibrary.org/obo/CLO_0052381"},{"id":"T18","span":{"begin":547,"end":552},"obj":"http://purl.obolibrary.org/obo/CLO_0008697"},{"id":"T19","span":{"begin":547,"end":552},"obj":"http://purl.obolibrary.org/obo/CLO_0052381"}],"attributes":[{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":4,"end":16},"obj":"http://purl.obolibrary.org/obo/GO_0000003"},{"id":"T2","span":{"begin":205,"end":217},"obj":"http://purl.obolibrary.org/obo/GO_0000003"},{"id":"T3","span":{"begin":328,"end":340},"obj":"http://purl.obolibrary.org/obo/GO_0000003"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T22","span":{"begin":0,"end":357},"obj":"Sentence"},{"id":"T23","span":{"begin":358,"end":436},"obj":"Sentence"},{"id":"T24","span":{"begin":437,"end":653},"obj":"Sentence"},{"id":"T25","span":{"begin":654,"end":795},"obj":"Sentence"},{"id":"T26","span":{"begin":796,"end":951},"obj":"Sentence"},{"id":"T27","span":{"begin":952,"end":1018},"obj":"Sentence"},{"id":"T28","span":{"begin":1019,"end":1151},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T22","pred":"source","obj":"LitCovid-sentences"},{"subj":"T23","pred":"source","obj":"LitCovid-sentences"},{"subj":"T24","pred":"source","obj":"LitCovid-sentences"},{"subj":"T25","pred":"source","obj":"LitCovid-sentences"},{"subj":"T26","pred":"source","obj":"LitCovid-sentences"},{"subj":"T27","pred":"source","obj":"LitCovid-sentences"},{"subj":"T28","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32133152-12590749-19616452","span":{"begin":351,"end":353},"obj":"12590749"}],"attributes":[{"subj":"32133152-12590749-19616452","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ece593","default":true},{"id":"LitCovid-PD-MONDO","color":"#cb93ec"},{"id":"LitCovid-PD-CLO","color":"#93ecb1"},{"id":"LitCovid-PD-GO-BP","color":"#ec9793"},{"id":"LitCovid-sentences","color":"#93a8ec"},{"id":"2_test","color":"#c2ec93"}]}]}}