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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4 40-47 Species denotes Patient Tax:9606
5 138-157 Chemical denotes Lopinavir/Ritonavir MESH:C558899
6 84-108 Disease denotes Coronavirus Disease 2019 MESH:C000657245
7 179-197 Disease denotes COVID-19 Pneumonia MESH:C000657245
11 255-258 Gene denotes Lim Gene:10611
12 297-305 Disease denotes COVID-19 MESH:C000657245
13 387-405 Disease denotes infectious disease MESH:D003141
24 923-933 Species denotes SARS-CoV-2 Tax:2697049
25 986-994 Species denotes patients Tax:9606
26 1102-1109 Species denotes patient Tax:9606
27 671-680 Chemical denotes Lopinavir MESH:D061466
28 696-701 Chemical denotes LPV/r MESH:C558899
29 955-960 Chemical denotes LPV/r MESH:C558899
30 750-758 Disease denotes COVID-19 MESH:C000657245
31 1000-1009 Disease denotes pneumonia MESH:D011014
32 1020-1028 Disease denotes COVID-19 MESH:C000657245
33 1132-1151 Disease denotes respiratory failure MESH:D012131
37 1348-1358 Species denotes SARS-CoV-2 Tax:2697049
38 1648-1653 Chemical denotes LPV/r MESH:C558899
39 1268-1287 Disease denotes Infectious Diseases MESH:D003141
48 2480-2488 Species denotes patients Tax:9606
49 2220-2225 Chemical denotes LPV/r MESH:C558899
50 2292-2297 Chemical denotes LPV/r MESH:C558899
51 2461-2466 Chemical denotes LPV/r MESH:C558899
52 2746-2751 Chemical denotes LPV/r MESH:C558899
53 2363-2368 Disease denotes fever MESH:D005334
54 2423-2428 Disease denotes cough MESH:D003371
55 2820-2828 Disease denotes COVID-19 MESH:C000657245
58 2924-2929 Chemical denotes LPV/r MESH:C558899
59 2982-2990 Disease denotes COVID-19 MESH:C000657245

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T57 297-305 SP_7 denotes COVID-19
T56 463-468 NCBITaxon:10239 denotes viral
T55 671-680 DG_23 denotes Lopinavir
T54 685-694 DG_30 denotes ritonavir
T53 750-758 SP_7 denotes COVID-19
T52 777-781 SP_10 denotes SARS
T51 916-921 NCBITaxon:10239 denotes virus
T50 923-933 SP_7 denotes SARS-CoV-2
T49 1020-1028 SP_7 denotes COVID-19
T48 1132-1143 UBERON:0001004 denotes respiratory
T47 1202-1211 CHEBI:67079;CHEBI:67079 denotes antiviral
T46 1212-1216 CHEBI:36044;CHEBI:36044 denotes drug
T45 1348-1358 SP_7 denotes SARS-CoV-2
T44 1594-1599 NCBITaxon:10239 denotes virus
T43 1682-1687 NCBITaxon:10239 denotes virus
T42 2030-2046 CHEBI:22587;CHEBI:22587 denotes antiviral agents
T41 2105-2110 NCBITaxon:10239 denotes virus
T40 2249-2254 NCBITaxon:10239 denotes viral
T39 2423-2428 UBERON:0002048 denotes cough
T38 2763-2768 NCBITaxon:10239 denotes virus
T37 2820-2828 SP_7 denotes COVID-19
T36 2982-2990 SP_7 denotes COVID-19
T35 3133-3139 CHEBI:52217;CHEBI:52217 denotes agents
T5 179-187 SP_7 denotes COVID-19
T6 148-157 DG_30 denotes Ritonavir
T7 138-147 DG_23 denotes Lopinavir
T8 84-95 NCBITaxon:11118 denotes Coronavirus

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 84-108 Disease denotes Coronavirus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T2 179-187 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 188-197 Disease denotes Pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T4 297-305 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 387-405 Disease denotes infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T6 750-758 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 777-781 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T8 923-931 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1000-1009 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T10 1020-1028 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 1126-1151 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T13 1268-1278 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T14 1348-1356 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 2820-2828 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 2982-2990 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 287-288 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 717-718 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 916-921 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T4 1053-1056 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T5 1362-1364 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T6 1478-1482 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T7 1592-1593 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 1594-1599 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T9 1624-1625 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1682-1687 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T11 2105-2110 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T12 2120-2121 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 2199-2200 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 2313-2316 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T15 2369-2372 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T16 2763-2768 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T17 2933-2934 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 3153-3154 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 3319-3320 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 3406-3409 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 0-6 Chemical denotes Letter http://purl.obolibrary.org/obo/CHEBI_6446
T2 138-147 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T3 497-506 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T4 671-680 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T5 685-694 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T6 967-982 Chemical denotes antiviral agent http://purl.obolibrary.org/obo/CHEBI_22587
T7 1202-1216 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T8 1202-1211 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T9 1212-1216 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T10 1558-1567 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T11 1855-1871 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T12 2030-2046 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T13 2140-2149 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T14 2615-2625 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T15 2945-2960 Chemical denotes antiviral agent http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-21 Sentence denotes Letter to the Editor:
T2 22-230 Sentence denotes Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
T3 232-522 Sentence denotes I am grateful that Dr. Lim and his colleagues reported a case of COVID-19 that caused tertiary transmission in Korea and added information about the novel infectious disease.1 In this report, the authors emphasized the decrease in viral titer due to the effects of antiviral administration.
T4 523-670 Sentence denotes However, I would like to discuss what to look out for when interpreting the causal relationship between laboratory results and therapeutic effects.
T5 671-934 Sentence denotes Lopinavir and ritonavir (LPV/r) is considered a promising treatment option for COVID-19 based on the 2003 SARS treatment experience.23 However, care should be taken when administering because there are no or little clinical evidence for the new virus, SARS-CoV-2.
T6 935-1217 Sentence denotes I have treated with LPV/r as an antiviral agent in patients with pneumonia caused by COVID-19, but the disease course has not improved dramatically.4 Fortunately, the patient did not develop acute respiratory failure, but it was not clear whether it was an effect of antiviral drug.
T7 1218-1418 Sentence denotes According to the Center for Laboratory Control of Infectious Diseases in KCDC, the upper limit of Ct value for positive RT-PCR of SARS-CoV-2 is 35, and the negative criterion is Ct value 37 or higher.
T8 1419-1578 Sentence denotes In this case report, it is difficult to determine that the test result is positive because the Ct value is 35.66 on day 10, the day of the antiviral treatment.
T9 1579-1641 Sentence denotes If there was a virus, it would have remained a very low titer.
T10 1642-1872 Sentence denotes Since LPV/r was administered during the virus titer reduction from 30.71 (day 9) to 35.66 (day 10), I think two consecutive negative results are more likely to be due to the natural history of the disease than to antiviral agents.
T11 1873-2047 Sentence denotes Furthermore, the authors did not explain why Ct values are consistently detected near positive criteria from day 4 of treatment despite the continued use of antiviral agents.
T12 2048-2166 Sentence denotes The authors say they do not know whether the decrease in virus titer is a natural course or antiviral effect, or both.
T13 2167-2260 Sentence denotes However, the authors are making a leap of logic that LPV/r administration reduces viral load.
T14 2261-2349 Sentence denotes Also, the authors explain that LPV/r administration has also improved clinical symptoms.
T15 2350-2454 Sentence denotes However, The fever has already been falling from the day before, and the cough lasted for few more days.
T16 2455-2582 Sentence denotes Since LPV/r was given to patients on day 10, it could not be regarded as being administered in the early stages of the disease.
T17 2583-2683 Sentence denotes However, the authors argue that antivirals should be given early in the disease, based on this case.
T18 2684-2871 Sentence denotes For the reasons described so far, it is difficult to say that LPV/r lowers the virus level or improves symptoms or is "recommended" for COVID-19 treatment based on this case report alone.
T19 2872-2991 Sentence denotes Regardless of the case report, I still believe that LPV/r is a promising antiviral agent for the treatment of COVID-19.
T20 2992-3140 Sentence denotes However, it is clear that well-designed studies have to be carried out to build more evidence so that they can be recommended as therapeutic agents.
T21 3141-3215 Sentence denotes Research is a very important component of the response during an outbreak.
T22 3216-3381 Sentence denotes But even if the epidemic is underway, we should reiterate that we should try to find evidence based on a scientific background, and be careful to advise what is not.
T23 3383-3394 Sentence denotes Disclosure:
T24 3395-3457 Sentence denotes The author has no potential conflicts of interest to disclose.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 188-197 Phenotype denotes Pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 1000-1009 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T3 1132-1151 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T4 2363-2368 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T5 2423-2428 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735