PMC:7036338 / 2488-4971 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7036338","sourcedb":"PMC","sourceid":"7036338","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7036338","text":"A 35-year-old Chinese woman from Wuhan, China was confirmed to be first SARS-CoV-2 infected case in Korea. The detailed exposure history and a clinical course of this patient is described in previous report.7 Viral load kinetics of Patient 1 is shown in Fig. 1A (viral RNA copies) and Supplementary Fig. 1 (reverse Ct value). Briefly, she was quarantined at the airport due to fever (38.3°C) at the entry inspection on January 19, 2020. She had no significant exposure history and developed fever, chills, and myalgia one day before the entry to Korea (January 18, 2020, day 1 of symptom onset). The virus was detected from URT specimens on day 2 of symptom onset. As she did not have significant respiratory symptoms, LRT specimen (spontaneous sputum) was obtained with airway clearance techniques of percussion on day 3. Although any infiltration was not noticed on her chest X-ray (CXR) on the same day, LRT specimen was positive for SARS-CoV-2. On day 4, high resolution computed tomography (HRCT) was taken and multiple ground-glass opacities were observed in both sub-pleural spaces.7 On day 5, the viral load was increased from day 3 in LRT specimen and she required oxygen supplement via nasal cannula (3 L/min). She eventually developed cough on day 7, and infiltration was observed on CXR from the next day. However, it appeared that the viral loads already started to decrease from around day 7 in both URT and LRT specimens. rRT-PCR continued to be positive at low level until day 13 (LRT specimens) and 14 (URT specimens). On day 12, her CXR was worsened with increase in oxygen requirement up to 10 L/min, while the viral loads dropped significantly from the initial values. Therefore, by the time when the significant infiltration was visible on a plain chest radiography, the viral load might be already on its lower end of detection. From day 14 (LRT specimen) and day 15 (URT specimen), rRT-PCR became undetectable for two consecutive days, respectively. She had mild loose stool from day 4 to day 19. Although RdRp and/or E gene were detected occasionally from urine and stool specimens collected from day 5 to 12, none of specimen satisfied conditions for positivity. Only one serum sample collected on day 8 showed positive rRT-PCR result, but the Ct value was adjacent to the cut-off value for positivity. Her symptoms, oxygen requirement, and CXR findings significantly improved from day 17 and she was discharged on day 20 of symptom onset (February 6, 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