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PMC:7035340 / 86-10150 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
19 50-59 Species denotes 2019-nCoV Tax:2697049
20 174-182 Species denotes patients Tax:9606
21 316-325 Species denotes 2019-nCoV Tax:2697049
22 386-394 Species denotes patients Tax:9606
23 512-520 Species denotes patients Tax:9606
24 791-799 Species denotes patients Tax:9606
25 805-814 Species denotes 2019-nCoV Tax:2697049
26 872-880 Species denotes patients Tax:9606
27 207-226 Disease denotes 2019-nCoV infection MESH:C000657245
28 273-279 Disease denotes deaths MESH:D003643
29 301-305 Disease denotes SARS MESH:D045169
30 310-314 Disease denotes MERS MESH:D018352
31 526-545 Disease denotes 2019-nCoV infection MESH:C000657245
32 648-683 Disease denotes acute respiratory distress syndrome MESH:D012128
33 685-689 Disease denotes ARDS MESH:D012128
34 694-706 Disease denotes septic shock MESH:D012772
35 857-871 Disease denotes critically ill MESH:D016638
43 1052-1060 Species denotes patients Tax:9606
44 1597-1605 Species denotes patients Tax:9606
45 1625-1642 Species denotes novel coronavirus Tax:2697049
46 1443-1461 Chemical denotes methylprednisolone MESH:D008775
47 1027-1046 Disease denotes 2019-nCoV infection MESH:C000657245
48 1309-1328 Disease denotes 2019-nCoV Infection MESH:C000657245
49 1606-1614 Disease denotes infected MESH:D007239
52 1737-1745 Species denotes patients Tax:9606
53 1751-1760 Species denotes 2019-nCoV Tax:2697049
64 2277-2281 Species denotes H1N1 Tax:114727
65 2531-2539 Species denotes patients Tax:9606
66 1805-1816 Disease denotes lung injury MESH:D055370
67 1853-1862 Disease denotes pneumonia MESH:D011014
68 1953-1990 Disease denotes dysfunctional systematic inflammation MESH:D007249
69 2057-2084 Disease denotes novel coronavirus pneumonia MESH:C000657245
70 2086-2089 Disease denotes NCP MESH:C000657245
71 2236-2252 Disease denotes viral pneumonias
72 2262-2266 Disease denotes SARS MESH:D045169
73 2268-2272 Disease denotes MERS MESH:D018352
94 3478-3482 Gene denotes HIN1 Gene:54726
95 3163-3171 Species denotes patients Tax:9606
96 3349-3357 Species denotes patients Tax:9606
97 3700-3708 Species denotes patients Tax:9606
98 3714-3723 Species denotes 2019-nCoV Tax:2697049
99 3780-3788 Species denotes patients Tax:9606
100 2885-2894 Disease denotes mortality MESH:D003643
101 2900-2912 Disease denotes septic shock MESH:D012772
102 2931-2946 Disease denotes lung infections MESH:D012141
103 3036-3041 Disease denotes shock MESH:D012769
104 3186-3190 Disease denotes ARDS MESH:D012128
105 3211-3229 Disease denotes pulmonary fibrosis MESH:D011658
106 3363-3367 Disease denotes SARS MESH:D045169
107 3368-3377 Disease denotes infection MESH:D007239
108 3441-3450 Disease denotes mortality MESH:D003643
109 3685-3699 Disease denotes critically ill MESH:D016638
110 3776-3779 Disease denotes NCP MESH:C000657245
111 3844-3848 Disease denotes ARDS MESH:D012128
112 3850-3856 Disease denotes sepsis MESH:D018805
113 3860-3872 Disease denotes septic shock MESH:D012772
115 3992-3995 Disease denotes NCP MESH:C000657245
131 6953-6956 Gene denotes CRP Gene:1401
132 6283-6291 Species denotes patients Tax:9606
133 6297-6306 Species denotes 2019-nCoV Tax:2697049
134 6355-6363 Species denotes patients Tax:9606
135 6378-6387 Species denotes 2019-nCoV Tax:2697049
136 6659-6667 Species denotes patients Tax:9606
137 6761-6765 Chemical denotes SaO2
138 6766-6772 Chemical denotes oxygen MESH:D010100
139 6785-6803 Chemical denotes CS corticosteroids
140 6870-6876 Chemical denotes oxygen MESH:D010100
141 6908-6914 Chemical denotes oxygen MESH:D010100
142 6364-6372 Disease denotes infected MESH:D007239
143 6421-6442 Disease denotes aOf the 14 infections MESH:D007239
144 6644-6658 Disease denotes critically ill MESH:D016638
145 6673-6692 Disease denotes 2019-nCoV infection MESH:C000657245
186 4270-4278 Species denotes patients Tax:9606
187 4377-4385 Species denotes patients Tax:9606
188 4572-4580 Species denotes patients Tax:9606
189 4969-4977 Species denotes patients Tax:9606
190 5111-5119 Species denotes patients Tax:9606
191 5225-5233 Species denotes patients Tax:9606
192 5360-5368 Species denotes patients Tax:9606
193 5749-5757 Species denotes patients Tax:9606
194 5827-5835 Species denotes patients Tax:9606
195 6223-6231 Species denotes patients Tax:9606
196 4628-4634 Chemical denotes oxygen MESH:D010100
197 4821-4842 Chemical denotes median hydrocortisone
198 5456-5462 Chemical denotes oxygen MESH:D010100
199 5475-5479 Chemical denotes SaO2
200 5494-5500 Chemical denotes oxygen MESH:D010100
201 5510-5514 Chemical denotes PaO2
202 5528-5534 Chemical denotes oxygen MESH:D010100
203 5545-5549 Chemical denotes FiO2
204 4168-4187 Disease denotes 2019-nCoV infection MESH:C000657245
205 4266-4269 Disease denotes NCP MESH:C000657245
206 4416-4425 Disease denotes pneumonia MESH:D011014
207 4427-4436 Disease denotes hypoxemia MESH:D000860
208 4460-4464 Disease denotes ARDS MESH:D012128
209 4481-4491 Disease denotes infections MESH:D007239
210 4518-4523 Disease denotes shock MESH:D012769
211 4719-4728 Disease denotes hypoxemia MESH:D000860
212 5072-5081 Disease denotes mortality MESH:D003643
213 5107-5110 Disease denotes NCP MESH:C000657245
214 5210-5224 Disease denotes critically ill MESH:D016638
215 5239-5243 Disease denotes MERS MESH:D018352
216 5334-5343 Disease denotes mortality MESH:D003643
217 5356-5359 Disease denotes NCP MESH:C000657245
218 5745-5748 Disease denotes NCP MESH:C000657245
219 5780-5784 Disease denotes ARDS MESH:D012128
220 5789-5794 Disease denotes shock MESH:D012769
221 5798-5819 Disease denotes multiple organ injury MESH:D009102
222 5904-5908 Disease denotes ARDS MESH:D012128
223 6011-6020 Disease denotes infection MESH:D007239
224 6068-6073 Disease denotes shock MESH:D012769
225 6219-6222 Disease denotes NCP MESH:C000657245
233 7143-7151 Species denotes patients Tax:9606
234 7157-7166 Species denotes 2019-nCoV Tax:2697049
235 7297-7305 Species denotes patients Tax:9606
236 7393-7401 Species denotes patients Tax:9606
237 7407-7416 Species denotes 2019-nCoV Tax:2697049
238 7293-7296 Disease denotes NCP MESH:C000657245
239 7378-7392 Disease denotes critically ill MESH:D016638
241 7463-7471 Species denotes patients Tax:9606
266 7573-7581 Species denotes patients Tax:9606
267 8492-8500 Species denotes patients Tax:9606
268 9027-9035 Species denotes patients Tax:9606
269 9041-9050 Species denotes 2019-nCoV Tax:2697049
270 9167-9175 Species denotes patients Tax:9606
271 9251-9258 Species denotes patient Tax:9606
272 8586-8600 Chemical denotes hydrocortisone MESH:D006854
273 8858-8876 Chemical denotes methylprednisolone MESH:D008775
274 7558-7572 Disease denotes critically ill MESH:D016638
275 7620-7624 Disease denotes SARS MESH:D045169
276 7698-7701 Disease denotes NCP MESH:C000657245
277 7981-7985 Disease denotes ARDS MESH:D012128
278 7987-7993 Disease denotes sepsis MESH:D018805
279 7997-8009 Disease denotes septic shock MESH:D012772
280 8181-8185 Disease denotes ARDS MESH:D012128
281 8277-8286 Disease denotes mortality MESH:D003643
282 8344-8356 Disease denotes inflammation MESH:D007249
283 8366-8377 Disease denotes lung injury MESH:D055370
284 8432-8436 Disease denotes ARDS MESH:D012128
285 8487-8491 Disease denotes SARS MESH:D045169
286 8716-8729 Disease denotes hyperglycemia MESH:D006943
287 8731-8740 Disease denotes psychosis MESH:D011605
288 8746-8765 Disease denotes secondary infection MESH:D060085
289 8767-8785 Disease denotes avascular necrosis MESH:D010020
298 9398-9407 Species denotes 2019-nCoV Tax:2697049
299 9471-9479 Species denotes patients Tax:9606
300 9625-9633 Species denotes patients Tax:9606
301 9639-9648 Species denotes 2019-nCoV Tax:2697049
302 9983-9992 Species denotes 2019-nCoV Tax:2697049
303 9467-9470 Disease denotes NCP MESH:C000657245
304 9610-9624 Disease denotes critically ill MESH:D016638
305 9966-9977 Disease denotes lung injury MESH:D055370

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1478-1482 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T2 1805-1809 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T3 2931-2935 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T4 4552-4557 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T5 5807-5812 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T6 6785-6787 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T7 6935-6951 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T8 6947-6951 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 6968-6975 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T10 8366-8370 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T11 8887-8891 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T12 9515-9519 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T13 9966-9970 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1805-1809 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 2931-2935 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 4552-4557 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T4 5807-5812 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T5 6941-6946 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T6 8366-8370 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 9515-9519 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T8 9966-9970 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 207-226 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T3 217-226 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T4 301-305 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 526-545 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T6 536-545 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 648-683 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T8 654-683 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T9 685-689 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T10 1027-1046 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T11 1037-1046 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 1292-1303 Disease denotes Pneumonitis http://purl.obolibrary.org/obo/MONDO_0043905
T13 1309-1328 Disease denotes 2019-nCoV Infection http://purl.obolibrary.org/obo/MONDO_0100096
T14 1810-1816 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T15 1853-1862 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T16 2075-2084 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T17 2236-2252 Disease denotes viral pneumonias http://purl.obolibrary.org/obo/MONDO_0006012
T18 2262-2266 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T19 2936-2946 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T20 3186-3190 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T21 3211-3229 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T22 3363-3367 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T23 3368-3377 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T24 3844-3848 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T25 4168-4187 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T26 4178-4187 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 4416-4425 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T28 4460-4464 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T29 4481-4491 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T30 5780-5784 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T31 5813-5819 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T32 5904-5908 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T33 6011-6020 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 6432-6442 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T35 6673-6692 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T36 6683-6692 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 7620-7624 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T38 7981-7985 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T39 8181-8185 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T40 8344-8356 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T41 8371-8377 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T42 8487-8491 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T43 8716-8729 Disease denotes hyperglycemia http://purl.obolibrary.org/obo/MONDO_0002909
T44 8731-8740 Disease denotes psychosis http://purl.obolibrary.org/obo/MONDO_0005485
T45 8756-8765 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46 9971-9977 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 69-72 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T2 924-934 http://purl.obolibrary.org/obo/UBERON_0001456 denotes are facing
T3 1343-1344 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 1495-1498 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3–5
T5 1805-1809 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T6 1805-1809 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T7 2771-2772 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 2931-2935 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T9 2931-2935 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T10 3299-3300 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 4552-4557 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T12 5433-5436 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3−5
T13 5475-5479 http://purl.obolibrary.org/obo/CLO_0008947 denotes SaO2
T14 5475-5479 http://purl.obolibrary.org/obo/CLO_0050140 denotes SaO2
T15 5485-5493 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T16 5485-5493 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T17 5807-5812 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T18 6308-6309 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 6571-6572 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 6620-6621 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T21 6761-6765 http://purl.obolibrary.org/obo/CLO_0008947 denotes SaO2
T22 6761-6765 http://purl.obolibrary.org/obo/CLO_0050140 denotes SaO2
T23 6861-6869 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T24 6861-6869 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T25 6941-6946 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T26 6947-6951 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T27 7033-7034 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 8087-8099 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T29 8258-8263 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T30 8366-8370 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T31 8366-8370 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T32 9065-9066 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 9325-9328 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T34 9365-9366 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 9515-9519 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T36 9598-9599 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 9966-9970 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T38 9966-9970 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T2 979-988 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T3 1416-1431 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T4 1443-1461 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T5 1530-1538 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T6 1662-1677 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T7 1698-1713 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T8 2027-2042 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T9 2208-2223 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T10 2361-2376 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T11 2494-2509 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T12 2719-2734 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T13 2844-2859 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T14 3126-3141 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T15 3398-3413 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T16 3519-3524 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T17 3635-3650 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T18 3955-3970 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T19 4111-4126 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T20 4628-4634 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T21 4647-4658 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T22 4666-4682 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T23 4796-4811 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T24 4828-4842 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T25 5252-5267 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T26 5296-5311 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T27 5396-5411 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T28 5456-5462 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T29 5494-5500 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T30 5528-5534 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T31 5862-5877 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T32 6094-6109 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T33 6700-6715 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T34 6766-6772 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T35 6785-6787 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T36 6788-6803 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T37 6870-6876 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T38 6908-6914 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T39 6968-6975 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T40 7051-7056 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T41 7124-7139 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T42 7327-7342 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T43 7434-7449 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T44 7539-7554 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T45 7668-7683 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T46 7716-7724 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T47 7850-7865 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T48 7895-7910 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T49 8141-8156 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T50 8201-8216 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T51 8217-8228 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T52 8297-8312 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T53 8506-8521 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T54 8586-8600 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T55 8831-8846 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T56 8858-8876 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T57 8941-8945 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T58 9569-9584 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T59 9929-9944 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 654-674 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T3 701-706 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T4 1853-1862 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T5 2075-2084 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T6 2242-2252 Phenotype denotes pneumonias http://purl.obolibrary.org/obo/HP_0002090
T7 2907-2912 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T8 3036-3041 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T9 3211-3229 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T10 3850-3856 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T11 3867-3872 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T12 4416-4425 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 4427-4436 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T14 4518-4523 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T15 4719-4728 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T16 5789-5794 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T17 6068-6073 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T18 7987-7993 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T19 8004-8009 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T20 8716-8729 Phenotype denotes hyperglycemia http://purl.obolibrary.org/obo/HP_0003074
T21 8731-8740 Phenotype denotes psychosis http://purl.obolibrary.org/obo/HP_0000709
T22 8933-8954 Phenotype denotes adverse drug reaction http://purl.obolibrary.org/obo/HP_0020172

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 8344-8356 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T2 0-12 Sentence denotes Dear Editor,
T3 13-142 Sentence denotes Since last December, the outbreak of 2019-nCoV in Wuhan has caused ever-increasing attention and public panic all over the world.
T4 143-288 Sentence denotes Up to February 9, 2020, 40,171 patients had been diagnosed with 2019-nCoV infection, including 6484 (16.14%) severe cases and 908 deaths (2.27%).
T5 289-436 Sentence denotes Compared to SARS and MERS, 2019-nCoV appears to be much more contagious but less lethal, as most patients have mild symptoms and good prognosis1,2.
T6 437-707 Sentence denotes However, according to the Chinese government’s daily report, 13.2–21.3% of patients with 2019-nCoV infection developed into severe or fatal illness (Fig. S1a), which is characterized by the rapid development to acute respiratory distress syndrome (ARDS) or septic shock.
T7 708-837 Sentence denotes Along with an increasing number of confirmed cases, the cumulative total of severe patients with 2019-nCoV is growing (Fig. S1b).
T8 838-935 Sentence denotes Treatment of these critically ill patients is becoming one of the major challenges we are facing.
T9 936-1047 Sentence denotes Unfortunately, there are still no specific antiviral medicines or vaccines recommended for 2019-nCoV infection.
T10 1048-1160 Sentence denotes For patients with severe clinical manifestations, an effective clinical treatment scheme is of great importance.
T11 1161-1392 Sentence denotes On February 7, 2020, the China’s National Health Commission released the fifth trial version of Diagnosis and Treatment Scheme for Pneumonitis with 2019-nCoV Infection, and provided a systematic treatment strategy for severe cases.
T12 1393-1688 Sentence denotes Remarkably, systematic corticosteroids treatment (methylprednisolone, <1–2 mg per kg body weight, for 3–5 days) was recommended to be an adjuvant therapy3, which immediately raised concerns about whether patients infected with this novel coronavirus could benefit from corticosteroids therapy 4.
T13 1690-1761 Sentence denotes Salvage corticosteroids treatment for critical patients with 2019-nCoV?
T14 1762-1992 Sentence denotes Corticosteroids are widely used to prevent lung injury caused by severe community-acquired pneumonia (sCAP) due to their excellent pharmacological effects on the suppression of exuberant and dysfunctional systematic inflammation5.
T15 1993-2283 Sentence denotes Some scholars may not support the corticosteroids treatment for novel coronavirus pneumonia (NCP), because observational studies and systematic reviews have indicated inconclusive clinical evidence on the effect of corticosteroids therapy for viral pneumonias (such as SARS, MERS and H1N1).
T16 2284-2432 Sentence denotes Additionally, pulse-dose therapy or long-term administration to high dose of corticosteroids in early stage were reported to be possibly harmful6–8.
T17 2433-2744 Sentence denotes However, these conclusions obscured the clinical benefits of corticosteroids on some subgroups of patients, particularly those with severe symptoms, as the clinical effects might be related to the indication (severities of illness), the timing of intervention, the dose and duration of corticosteroids therapy9.
T18 2745-3108 Sentence denotes Of note, as documented in a series of randomized clinical trials (RCT), low or physiologic dose of corticosteroids treatment did not reduce mortality from septic shock caused by primary lung infections, but it could bring clinical benefits to secondary outcomes, such as earlier reversal of shock, shorter duration to exit from ICU and mechanical ventilation9,10.
T19 3109-3422 Sentence denotes Besides, salvage corticosteroids treatment for severe patients with advanced ARDS could alleviate the pulmonary fibrosis and prevent progressive pathological deterioration11, which provides a good framework for explaining why some critical patients with SARS infection benefit from rescue corticosteroids therapy.
T20 3423-3560 Sentence denotes More importantly, mortality benefit favored the severe HIN1-illness in the adjunctive treatment group with low dose of corticosteroids12.
T21 3561-3914 Sentence denotes Evidently, all these results strongly suggest that proper use of low-dose corticosteroids may bring survival advantages for critically ill patients with 2019-nCoV, but this treatment should be strictly performed on NCP patients with definite clinical indications (such as refractory ARDS, sepsis or septic shock) according to the recommended guidelines.
T22 3916-4004 Sentence denotes Current evidence: clinical benefits of corticosteroids therapy for critical NCP patients
T23 4005-4197 Sentence denotes Over the past month, we collaborated with front-line ICU physicians and firstly evaluated the efficacy of corticosteroids treatment for severe or fatal cases with 2019-nCoV infection in Wuhan.
T24 4198-4366 Sentence denotes From January 1 to January 29, 2020, the first 15 confirmed critical NCP patients with an average age of 61.7 years were admitted to the ICU in Wuhan Pulmonary Hospital.
T25 4367-4567 Sentence denotes Of the 15 patients, 15 (100.0%) showed bilateral pneumonia, hypoxemia and moderate or severe ARDS, 14 (93.3%) had infections, 8 (53.3%) accompanied by shock and 9 (60.0%) with multiple organ injuries.
T26 4568-4766 Sentence denotes All patients had received treatments containing noninvasive oxygen therapy and antibiotics and/or antiviral agents before and after ICU admission, and hypoxemia was not improved by these treatments.
T27 4767-5041 Sentence denotes According to the guidelines, corticosteroids therapy (median hydrocortisone-equivalent dose of 400.0 mg/day) was instantly initiated after ICU admission for an average of 9.5 days, and outcomes for all patients were followed up until February 9, 2020 (Fig. 1a and Fig. S1c).
T28 5042-5369 Sentence denotes Briefly, we observed that ICU mortality of these severe or fatal NCP patients was 46.7% (7/15), closer to that after adjustment for time-varying confounders induced by critically ill patients with MERS without corticosteroids treatment6, suggesting that corticosteroids might not improve ICU mortality in critical NCP patients.
T29 5370-5663 Sentence denotes But meanwhile, systematic corticosteroids therapy in the first 3−5 days could enhance oxygen saturation (SaO2) and arterial oxygen tension (PaO2)/inspiratory oxygen fraction (FiO2), both of which could be further augmented by collaborating with invasive mechanical ventilation (IMV) (Fig. 1b).
T30 5664-5847 Sentence denotes Corticosteroids did not exert any intervention efficacy on survival advantage of NCP patients complicated with both ARDS and shock or multiple organ injury (seven patients, all dead).
T31 5848-6232 Sentence denotes Nevertheless, corticosteroids treatment in the phase of ARDS would effectively inhibit furious inflammatory storm (Fig. 1b) and gain valuable time for controlling infection and preventing secondary multiorgan damage and shock, which implies that corticosteroids have synergistic biological effects when combined with other intensivists’ treatment against severe or fatal NCP patients.
T32 6233-6760 Sentence denotes Fig. 1 Corticosteroids treatment for severely ill patients with 2019-nCoV. a Demographics and baseline characteristics of patients infected with 2019-nCoV according to survival condition. aOf the 14 infections, 12 with identified pathogens, 2 diagnosed by characteristic clinical symptoms without identified pathogens; bN = 7. *P < 0.05, a significant difference between the two groups. b Part of indexes of 15 critically ill patients with 2019-nCoV infection during corticosteroids therapy. *P < 0.05 vs. the indexes on day 1.
T33 6761-6991 Sentence denotes SaO2 oxygen saturation, CS corticosteroids, IMV invasive mechanical ventilation, PaO2/FiO2 ratio of arterial oxygen tension to fractional inspired oxygen concentrations, WBC white blood cell, CRP C-reaction protein, FIB fibrinogen
T34 6992-7174 Sentence denotes Due to the deficiency of sample size and a matched control group, we could not easily draw an accurate conclusion about the role of corticosteroids in patients with 2019-nCoV by now.
T35 7175-7417 Sentence denotes However, our clinical experience and available descriptive data from the therapeutic process of the first 15 critical NCP patients are prone to support corticosteroids treatment for specific subgroup of critically ill patients with 2019-nCoV.
T36 7419-7486 Sentence denotes Precautions of corticosteroids treatment in patients with 2019-nCoV
T37 7487-7589 Sentence denotes There is no fixed clinical guideline for the use of corticosteroids in critically ill patients in ICU.
T38 7590-7702 Sentence denotes The anecdotal experience from SARS and sCAP therapy strongly supports precise corticosteroids management of NCP.
T39 7703-7874 Sentence denotes Personalized medicine strategy should contain, but not limited to, specific indications, timing and duration, as well as therapeutic monitoring of corticosteroids therapy.
T40 7875-8106 Sentence denotes As mentioned above, corticosteroids should be avoided unless there are indications for moderate or severe ARDS, sepsis or septic shock, in part consistent with the recommended clinical guidance from World Health Organization (WHO).
T41 8107-8439 Sentence denotes We also do not suggest the use of corticosteroids for mild or early-stage ARDS, because early corticosteroids application could delay the clearance of virus and increase mortality risk, and corticosteroids are more likely to function on inflammation-mediated lung injury and interstitial fibro-proliferation at late-stage of ARDS11.
T42 8440-8570 Sentence denotes Furthermore, clinical adverse complications in SARS patients with corticosteroids treatment have been reported to be dose-related.
T43 8571-8790 Sentence denotes Over 240 mg of hydrocortisone-equivalent dose or an excessive cumulative dose was considered to be able to generate some side effects, including hyperglycemia, psychosis, and secondary infection, avascular necrosis9,10.
T44 8791-9051 Sentence denotes Hence, lower dose and short duration of corticosteroids treatment (methylprednisolone, <1 mg/kg body weight, no more than 7 days), along with adverse drug reaction monitoring, would be more beneficial in clinical management of critical patients with 2019-nCoV.
T45 9052-9176 Sentence denotes In addition, a long-term follow-up (6 months to 3 years) is essential to identify delayed adverse effects in these patients.
T46 9177-9290 Sentence denotes Of course, the optimal treatment strategy requires constant adjustment as patient’s clinical performance changes.
T47 9291-9417 Sentence denotes In conclusion, Chinese government has taken effective measures to prevent a possible national or worldwide 2019-nCoV pandemic.
T48 9418-9520 Sentence denotes Offering the most reasonable treatment to severe NCP patients could be another challenge we will face.
T49 9521-9764 Sentence denotes We endorse the potential benefits from low-dose corticosteroids treatment in a subset of critically ill patients with 2019-nCoV based on existing studies and clinical experience, despite there is no significant improvement in overall survival.
T50 9765-10013 Sentence denotes Certainly, our ongoing well-designed prospective cohort study with sufficient samples may provide systematic answers to this clinical dilemma—“to use or not to use corticosteroids for the treatment of lung injury with 2019-nCoV”—in the near future.
T51 10015-10040 Sentence denotes Supplementary information
T52 10042-10064 Sentence denotes Supplementary Material

2_test

Id Subject Object Predicate Lexical cue
32296012-31261585-139944471 1990-1991 31261585 denotes 5
32296012-29161116-139944472 2428-2429 29161116 denotes 6
32296012-16968120-139944472 2428-2429 16968120 denotes 6
32296012-30074052-139944472 2428-2429 30074052 denotes 6
32296012-29849191-139944473 2742-2743 29849191 denotes 9
32296012-29849191-139944474 3103-3104 29849191 denotes 9
32296012-28098591-139944475 3105-3107 28098591 denotes 10
32296012-7492007-139944476 3280-3282 7492007 denotes 11
32296012-28464462-139944477 3557-3559 28464462 denotes 12
32296012-29161116-139944478 5277-5278 29161116 denotes 6
32296012-7492007-139944479 8436-8438 7492007 denotes 11
32296012-29849191-139944480 8785-8786 29849191 denotes 9
32296012-28098591-139944481 8787-8789 28098591 denotes 10