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PMC:7035340 / 7505-10099 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
241 44-52 Species denotes patients Tax:9606
266 154-162 Species denotes patients Tax:9606
267 1073-1081 Species denotes patients Tax:9606
268 1608-1616 Species denotes patients Tax:9606
269 1622-1631 Species denotes 2019-nCoV Tax:2697049
270 1748-1756 Species denotes patients Tax:9606
271 1832-1839 Species denotes patient Tax:9606
272 1167-1181 Chemical denotes hydrocortisone MESH:D006854
273 1439-1457 Chemical denotes methylprednisolone MESH:D008775
274 139-153 Disease denotes critically ill MESH:D016638
275 201-205 Disease denotes SARS MESH:D045169
276 279-282 Disease denotes NCP MESH:C000657245
277 562-566 Disease denotes ARDS MESH:D012128
278 568-574 Disease denotes sepsis MESH:D018805
279 578-590 Disease denotes septic shock MESH:D012772
280 762-766 Disease denotes ARDS MESH:D012128
281 858-867 Disease denotes mortality MESH:D003643
282 925-937 Disease denotes inflammation MESH:D007249
283 947-958 Disease denotes lung injury MESH:D055370
284 1013-1017 Disease denotes ARDS MESH:D012128
285 1068-1072 Disease denotes SARS MESH:D045169
286 1297-1310 Disease denotes hyperglycemia MESH:D006943
287 1312-1321 Disease denotes psychosis MESH:D011605
288 1327-1346 Disease denotes secondary infection MESH:D060085
289 1348-1366 Disease denotes avascular necrosis MESH:D010020
298 1979-1988 Species denotes 2019-nCoV Tax:2697049
299 2052-2060 Species denotes patients Tax:9606
300 2206-2214 Species denotes patients Tax:9606
301 2220-2229 Species denotes 2019-nCoV Tax:2697049
302 2564-2573 Species denotes 2019-nCoV Tax:2697049
303 2048-2051 Disease denotes NCP MESH:C000657245
304 2191-2205 Disease denotes critically ill MESH:D016638
305 2547-2558 Disease denotes lung injury MESH:D055370

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T10 947-951 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T11 1468-1472 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T12 2096-2100 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T13 2547-2551 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 947-951 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 2096-2100 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T8 2547-2551 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T37 201-205 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T38 562-566 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T39 762-766 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T40 925-937 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T41 952-958 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T42 1068-1072 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T43 1297-1310 Disease denotes hyperglycemia http://purl.obolibrary.org/obo/MONDO_0002909
T44 1312-1321 Disease denotes psychosis http://purl.obolibrary.org/obo/MONDO_0005485
T45 1337-1346 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46 2552-2558 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T28 668-680 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T29 839-844 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T30 947-951 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T31 947-951 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T32 1646-1647 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 1906-1909 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T34 1946-1947 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 2096-2100 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T36 2179-2180 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 2547-2551 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T38 2547-2551 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T43 15-30 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T44 120-135 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T45 249-264 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T46 297-305 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T47 431-446 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T48 476-491 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T49 722-737 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T50 782-797 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T51 798-809 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T52 878-893 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T53 1087-1102 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T54 1167-1181 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T55 1412-1427 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T56 1439-1457 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T57 1522-1526 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T58 2150-2165 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T59 2510-2525 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T18 568-574 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T19 585-590 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T20 1297-1310 Phenotype denotes hyperglycemia http://purl.obolibrary.org/obo/HP_0003074
T21 1312-1321 Phenotype denotes psychosis http://purl.obolibrary.org/obo/HP_0000709
T22 1514-1535 Phenotype denotes adverse drug reaction http://purl.obolibrary.org/obo/HP_0020172

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 925-937 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T36 0-67 Sentence denotes Precautions of corticosteroids treatment in patients with 2019-nCoV
T37 68-170 Sentence denotes There is no fixed clinical guideline for the use of corticosteroids in critically ill patients in ICU.
T38 171-283 Sentence denotes The anecdotal experience from SARS and sCAP therapy strongly supports precise corticosteroids management of NCP.
T39 284-455 Sentence denotes Personalized medicine strategy should contain, but not limited to, specific indications, timing and duration, as well as therapeutic monitoring of corticosteroids therapy.
T40 456-687 Sentence denotes As mentioned above, corticosteroids should be avoided unless there are indications for moderate or severe ARDS, sepsis or septic shock, in part consistent with the recommended clinical guidance from World Health Organization (WHO).
T41 688-1020 Sentence denotes We also do not suggest the use of corticosteroids for mild or early-stage ARDS, because early corticosteroids application could delay the clearance of virus and increase mortality risk, and corticosteroids are more likely to function on inflammation-mediated lung injury and interstitial fibro-proliferation at late-stage of ARDS11.
T42 1021-1151 Sentence denotes Furthermore, clinical adverse complications in SARS patients with corticosteroids treatment have been reported to be dose-related.
T43 1152-1371 Sentence denotes Over 240 mg of hydrocortisone-equivalent dose or an excessive cumulative dose was considered to be able to generate some side effects, including hyperglycemia, psychosis, and secondary infection, avascular necrosis9,10.
T44 1372-1632 Sentence denotes Hence, lower dose and short duration of corticosteroids treatment (methylprednisolone, <1 mg/kg body weight, no more than 7 days), along with adverse drug reaction monitoring, would be more beneficial in clinical management of critical patients with 2019-nCoV.
T45 1633-1757 Sentence denotes In addition, a long-term follow-up (6 months to 3 years) is essential to identify delayed adverse effects in these patients.
T46 1758-1871 Sentence denotes Of course, the optimal treatment strategy requires constant adjustment as patient’s clinical performance changes.
T47 1872-1998 Sentence denotes In conclusion, Chinese government has taken effective measures to prevent a possible national or worldwide 2019-nCoV pandemic.
T48 1999-2101 Sentence denotes Offering the most reasonable treatment to severe NCP patients could be another challenge we will face.
T49 2102-2345 Sentence denotes We endorse the potential benefits from low-dose corticosteroids treatment in a subset of critically ill patients with 2019-nCoV based on existing studies and clinical experience, despite there is no significant improvement in overall survival.
T50 2346-2594 Sentence denotes Certainly, our ongoing well-designed prospective cohort study with sufficient samples may provide systematic answers to this clinical dilemma—“to use or not to use corticosteroids for the treatment of lung injury with 2019-nCoV”—in the near future.

2_test

Id Subject Object Predicate Lexical cue
32296012-7492007-139944479 1017-1019 7492007 denotes 11
32296012-29849191-139944480 1366-1367 29849191 denotes 9
32296012-28098591-139944481 1368-1370 28098591 denotes 10