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PMC:7035340 / 4091-7077 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
131 2948-2951 Gene denotes CRP Gene:1401
132 2278-2286 Species denotes patients Tax:9606
133 2292-2301 Species denotes 2019-nCoV Tax:2697049
134 2350-2358 Species denotes patients Tax:9606
135 2373-2382 Species denotes 2019-nCoV Tax:2697049
136 2654-2662 Species denotes patients Tax:9606
137 2756-2760 Chemical denotes SaO2
138 2761-2767 Chemical denotes oxygen MESH:D010100
139 2780-2798 Chemical denotes CS corticosteroids
140 2865-2871 Chemical denotes oxygen MESH:D010100
141 2903-2909 Chemical denotes oxygen MESH:D010100
142 2359-2367 Disease denotes infected MESH:D007239
143 2416-2437 Disease denotes aOf the 14 infections MESH:D007239
144 2639-2653 Disease denotes critically ill MESH:D016638
145 2668-2687 Disease denotes 2019-nCoV infection MESH:C000657245
186 265-273 Species denotes patients Tax:9606
187 372-380 Species denotes patients Tax:9606
188 567-575 Species denotes patients Tax:9606
189 964-972 Species denotes patients Tax:9606
190 1106-1114 Species denotes patients Tax:9606
191 1220-1228 Species denotes patients Tax:9606
192 1355-1363 Species denotes patients Tax:9606
193 1744-1752 Species denotes patients Tax:9606
194 1822-1830 Species denotes patients Tax:9606
195 2218-2226 Species denotes patients Tax:9606
196 623-629 Chemical denotes oxygen MESH:D010100
197 816-837 Chemical denotes median hydrocortisone
198 1451-1457 Chemical denotes oxygen MESH:D010100
199 1470-1474 Chemical denotes SaO2
200 1489-1495 Chemical denotes oxygen MESH:D010100
201 1505-1509 Chemical denotes PaO2
202 1523-1529 Chemical denotes oxygen MESH:D010100
203 1540-1544 Chemical denotes FiO2
204 163-182 Disease denotes 2019-nCoV infection MESH:C000657245
205 261-264 Disease denotes NCP MESH:C000657245
206 411-420 Disease denotes pneumonia MESH:D011014
207 422-431 Disease denotes hypoxemia MESH:D000860
208 455-459 Disease denotes ARDS MESH:D012128
209 476-486 Disease denotes infections MESH:D007239
210 513-518 Disease denotes shock MESH:D012769
211 714-723 Disease denotes hypoxemia MESH:D000860
212 1067-1076 Disease denotes mortality MESH:D003643
213 1102-1105 Disease denotes NCP MESH:C000657245
214 1205-1219 Disease denotes critically ill MESH:D016638
215 1234-1238 Disease denotes MERS MESH:D018352
216 1329-1338 Disease denotes mortality MESH:D003643
217 1351-1354 Disease denotes NCP MESH:C000657245
218 1740-1743 Disease denotes NCP MESH:C000657245
219 1775-1779 Disease denotes ARDS MESH:D012128
220 1784-1789 Disease denotes shock MESH:D012769
221 1793-1814 Disease denotes multiple organ injury MESH:D009102
222 1899-1903 Disease denotes ARDS MESH:D012128
223 2006-2015 Disease denotes infection MESH:D007239
224 2063-2068 Disease denotes shock MESH:D012769
225 2214-2217 Disease denotes NCP MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T4 547-552 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T5 1802-1807 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T6 2780-2782 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T7 2930-2946 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T8 2942-2946 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 2963-2970 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 547-552 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T4 1802-1807 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T5 2936-2941 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T25 163-182 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T26 173-182 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 411-420 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T28 455-459 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T29 476-486 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T30 1775-1779 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T31 1808-1814 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T32 1899-1903 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T33 2006-2015 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 2427-2437 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T35 2668-2687 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T36 2678-2687 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T11 547-552 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T12 1428-1431 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3−5
T13 1470-1474 http://purl.obolibrary.org/obo/CLO_0008947 denotes SaO2
T14 1470-1474 http://purl.obolibrary.org/obo/CLO_0050140 denotes SaO2
T15 1480-1488 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T16 1480-1488 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T17 1802-1807 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T18 2303-2304 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 2566-2567 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 2615-2616 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T21 2756-2760 http://purl.obolibrary.org/obo/CLO_0008947 denotes SaO2
T22 2756-2760 http://purl.obolibrary.org/obo/CLO_0050140 denotes SaO2
T23 2856-2864 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T24 2856-2864 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T25 2936-2941 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T26 2942-2946 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T19 106-121 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T20 623-629 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T21 642-653 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T22 661-677 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T23 791-806 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T24 823-837 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T25 1247-1262 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T26 1291-1306 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T27 1391-1406 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T28 1451-1457 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T29 1489-1495 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T30 1523-1529 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T31 1857-1872 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T32 2089-2104 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T33 2695-2710 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T34 2761-2767 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T35 2780-2782 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T36 2783-2798 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T37 2865-2871 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T38 2903-2909 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T39 2963-2970 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T12 411-420 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 422-431 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T14 513-518 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T15 714-723 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T16 1784-1789 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T17 2063-2068 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T23 0-192 Sentence denotes Over the past month, we collaborated with front-line ICU physicians and firstly evaluated the efficacy of corticosteroids treatment for severe or fatal cases with 2019-nCoV infection in Wuhan.
T24 193-361 Sentence denotes From January 1 to January 29, 2020, the first 15 confirmed critical NCP patients with an average age of 61.7 years were admitted to the ICU in Wuhan Pulmonary Hospital.
T25 362-562 Sentence denotes Of the 15 patients, 15 (100.0%) showed bilateral pneumonia, hypoxemia and moderate or severe ARDS, 14 (93.3%) had infections, 8 (53.3%) accompanied by shock and 9 (60.0%) with multiple organ injuries.
T26 563-761 Sentence denotes All patients had received treatments containing noninvasive oxygen therapy and antibiotics and/or antiviral agents before and after ICU admission, and hypoxemia was not improved by these treatments.
T27 762-1036 Sentence denotes According to the guidelines, corticosteroids therapy (median hydrocortisone-equivalent dose of 400.0 mg/day) was instantly initiated after ICU admission for an average of 9.5 days, and outcomes for all patients were followed up until February 9, 2020 (Fig. 1a and Fig. S1c).
T28 1037-1364 Sentence denotes Briefly, we observed that ICU mortality of these severe or fatal NCP patients was 46.7% (7/15), closer to that after adjustment for time-varying confounders induced by critically ill patients with MERS without corticosteroids treatment6, suggesting that corticosteroids might not improve ICU mortality in critical NCP patients.
T29 1365-1658 Sentence denotes But meanwhile, systematic corticosteroids therapy in the first 3−5 days could enhance oxygen saturation (SaO2) and arterial oxygen tension (PaO2)/inspiratory oxygen fraction (FiO2), both of which could be further augmented by collaborating with invasive mechanical ventilation (IMV) (Fig. 1b).
T30 1659-1842 Sentence denotes Corticosteroids did not exert any intervention efficacy on survival advantage of NCP patients complicated with both ARDS and shock or multiple organ injury (seven patients, all dead).
T31 1843-2227 Sentence denotes Nevertheless, corticosteroids treatment in the phase of ARDS would effectively inhibit furious inflammatory storm (Fig. 1b) and gain valuable time for controlling infection and preventing secondary multiorgan damage and shock, which implies that corticosteroids have synergistic biological effects when combined with other intensivists’ treatment against severe or fatal NCP patients.
T32 2228-2755 Sentence denotes Fig. 1 Corticosteroids treatment for severely ill patients with 2019-nCoV. a Demographics and baseline characteristics of patients infected with 2019-nCoV according to survival condition. aOf the 14 infections, 12 with identified pathogens, 2 diagnosed by characteristic clinical symptoms without identified pathogens; bN = 7. *P < 0.05, a significant difference between the two groups. b Part of indexes of 15 critically ill patients with 2019-nCoV infection during corticosteroids therapy. *P < 0.05 vs. the indexes on day 1.
T33 2756-2986 Sentence denotes SaO2 oxygen saturation, CS corticosteroids, IMV invasive mechanical ventilation, PaO2/FiO2 ratio of arterial oxygen tension to fractional inspired oxygen concentrations, WBC white blood cell, CRP C-reaction protein, FIB fibrinogen

2_test

Id Subject Object Predicate Lexical cue
32296012-29161116-139944478 1272-1273 29161116 denotes 6