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PMC:7035340 / 4002-7503 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
115 76-79 Disease denotes NCP MESH:C000657245
131 3037-3040 Gene denotes CRP Gene:1401
132 2367-2375 Species denotes patients Tax:9606
133 2381-2390 Species denotes 2019-nCoV Tax:2697049
134 2439-2447 Species denotes patients Tax:9606
135 2462-2471 Species denotes 2019-nCoV Tax:2697049
136 2743-2751 Species denotes patients Tax:9606
137 2845-2849 Chemical denotes SaO2
138 2850-2856 Chemical denotes oxygen MESH:D010100
139 2869-2887 Chemical denotes CS corticosteroids
140 2954-2960 Chemical denotes oxygen MESH:D010100
141 2992-2998 Chemical denotes oxygen MESH:D010100
142 2448-2456 Disease denotes infected MESH:D007239
143 2505-2526 Disease denotes aOf the 14 infections MESH:D007239
144 2728-2742 Disease denotes critically ill MESH:D016638
145 2757-2776 Disease denotes 2019-nCoV infection MESH:C000657245
186 354-362 Species denotes patients Tax:9606
187 461-469 Species denotes patients Tax:9606
188 656-664 Species denotes patients Tax:9606
189 1053-1061 Species denotes patients Tax:9606
190 1195-1203 Species denotes patients Tax:9606
191 1309-1317 Species denotes patients Tax:9606
192 1444-1452 Species denotes patients Tax:9606
193 1833-1841 Species denotes patients Tax:9606
194 1911-1919 Species denotes patients Tax:9606
195 2307-2315 Species denotes patients Tax:9606
196 712-718 Chemical denotes oxygen MESH:D010100
197 905-926 Chemical denotes median hydrocortisone
198 1540-1546 Chemical denotes oxygen MESH:D010100
199 1559-1563 Chemical denotes SaO2
200 1578-1584 Chemical denotes oxygen MESH:D010100
201 1594-1598 Chemical denotes PaO2
202 1612-1618 Chemical denotes oxygen MESH:D010100
203 1629-1633 Chemical denotes FiO2
204 252-271 Disease denotes 2019-nCoV infection MESH:C000657245
205 350-353 Disease denotes NCP MESH:C000657245
206 500-509 Disease denotes pneumonia MESH:D011014
207 511-520 Disease denotes hypoxemia MESH:D000860
208 544-548 Disease denotes ARDS MESH:D012128
209 565-575 Disease denotes infections MESH:D007239
210 602-607 Disease denotes shock MESH:D012769
211 803-812 Disease denotes hypoxemia MESH:D000860
212 1156-1165 Disease denotes mortality MESH:D003643
213 1191-1194 Disease denotes NCP MESH:C000657245
214 1294-1308 Disease denotes critically ill MESH:D016638
215 1323-1327 Disease denotes MERS MESH:D018352
216 1418-1427 Disease denotes mortality MESH:D003643
217 1440-1443 Disease denotes NCP MESH:C000657245
218 1829-1832 Disease denotes NCP MESH:C000657245
219 1864-1868 Disease denotes ARDS MESH:D012128
220 1873-1878 Disease denotes shock MESH:D012769
221 1882-1903 Disease denotes multiple organ injury MESH:D009102
222 1988-1992 Disease denotes ARDS MESH:D012128
223 2095-2104 Disease denotes infection MESH:D007239
224 2152-2157 Disease denotes shock MESH:D012769
225 2303-2306 Disease denotes NCP MESH:C000657245
233 3227-3235 Species denotes patients Tax:9606
234 3241-3250 Species denotes 2019-nCoV Tax:2697049
235 3381-3389 Species denotes patients Tax:9606
236 3477-3485 Species denotes patients Tax:9606
237 3491-3500 Species denotes 2019-nCoV Tax:2697049
238 3377-3380 Disease denotes NCP MESH:C000657245
239 3462-3476 Disease denotes critically ill MESH:D016638

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T4 636-641 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T5 1891-1896 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T6 2869-2871 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T7 3019-3035 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T8 3031-3035 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 3052-3059 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 636-641 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T4 1891-1896 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T5 3025-3030 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T25 252-271 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T26 262-271 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 500-509 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T28 544-548 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T29 565-575 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T30 1864-1868 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T31 1897-1903 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T32 1988-1992 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T33 2095-2104 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 2516-2526 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T35 2757-2776 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T36 2767-2776 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T11 636-641 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T12 1517-1520 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3−5
T13 1559-1563 http://purl.obolibrary.org/obo/CLO_0008947 denotes SaO2
T14 1559-1563 http://purl.obolibrary.org/obo/CLO_0050140 denotes SaO2
T15 1569-1577 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T16 1569-1577 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T17 1891-1896 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T18 2392-2393 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 2655-2656 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 2704-2705 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T21 2845-2849 http://purl.obolibrary.org/obo/CLO_0008947 denotes SaO2
T22 2845-2849 http://purl.obolibrary.org/obo/CLO_0050140 denotes SaO2
T23 2945-2953 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T24 2945-2953 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T25 3025-3030 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T26 3031-3035 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T27 3117-3118 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T18 39-54 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T19 195-210 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T20 712-718 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T21 731-742 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T22 750-766 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T23 880-895 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T24 912-926 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T25 1336-1351 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T26 1380-1395 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T27 1480-1495 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T28 1540-1546 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T29 1578-1584 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T30 1612-1618 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T31 1946-1961 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T32 2178-2193 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T33 2784-2799 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T34 2850-2856 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T35 2869-2871 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T36 2872-2887 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T37 2954-2960 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T38 2992-2998 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T39 3052-3059 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T40 3135-3140 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T41 3208-3223 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T42 3411-3426 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T12 500-509 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 511-520 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T14 602-607 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T15 803-812 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T16 1873-1878 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T17 2152-2157 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T22 0-88 Sentence denotes Current evidence: clinical benefits of corticosteroids therapy for critical NCP patients
T23 89-281 Sentence denotes Over the past month, we collaborated with front-line ICU physicians and firstly evaluated the efficacy of corticosteroids treatment for severe or fatal cases with 2019-nCoV infection in Wuhan.
T24 282-450 Sentence denotes From January 1 to January 29, 2020, the first 15 confirmed critical NCP patients with an average age of 61.7 years were admitted to the ICU in Wuhan Pulmonary Hospital.
T25 451-651 Sentence denotes Of the 15 patients, 15 (100.0%) showed bilateral pneumonia, hypoxemia and moderate or severe ARDS, 14 (93.3%) had infections, 8 (53.3%) accompanied by shock and 9 (60.0%) with multiple organ injuries.
T26 652-850 Sentence denotes All patients had received treatments containing noninvasive oxygen therapy and antibiotics and/or antiviral agents before and after ICU admission, and hypoxemia was not improved by these treatments.
T27 851-1125 Sentence denotes According to the guidelines, corticosteroids therapy (median hydrocortisone-equivalent dose of 400.0 mg/day) was instantly initiated after ICU admission for an average of 9.5 days, and outcomes for all patients were followed up until February 9, 2020 (Fig. 1a and Fig. S1c).
T28 1126-1453 Sentence denotes Briefly, we observed that ICU mortality of these severe or fatal NCP patients was 46.7% (7/15), closer to that after adjustment for time-varying confounders induced by critically ill patients with MERS without corticosteroids treatment6, suggesting that corticosteroids might not improve ICU mortality in critical NCP patients.
T29 1454-1747 Sentence denotes But meanwhile, systematic corticosteroids therapy in the first 3−5 days could enhance oxygen saturation (SaO2) and arterial oxygen tension (PaO2)/inspiratory oxygen fraction (FiO2), both of which could be further augmented by collaborating with invasive mechanical ventilation (IMV) (Fig. 1b).
T30 1748-1931 Sentence denotes Corticosteroids did not exert any intervention efficacy on survival advantage of NCP patients complicated with both ARDS and shock or multiple organ injury (seven patients, all dead).
T31 1932-2316 Sentence denotes Nevertheless, corticosteroids treatment in the phase of ARDS would effectively inhibit furious inflammatory storm (Fig. 1b) and gain valuable time for controlling infection and preventing secondary multiorgan damage and shock, which implies that corticosteroids have synergistic biological effects when combined with other intensivists’ treatment against severe or fatal NCP patients.
T32 2317-2844 Sentence denotes Fig. 1 Corticosteroids treatment for severely ill patients with 2019-nCoV. a Demographics and baseline characteristics of patients infected with 2019-nCoV according to survival condition. aOf the 14 infections, 12 with identified pathogens, 2 diagnosed by characteristic clinical symptoms without identified pathogens; bN = 7. *P < 0.05, a significant difference between the two groups. b Part of indexes of 15 critically ill patients with 2019-nCoV infection during corticosteroids therapy. *P < 0.05 vs. the indexes on day 1.
T33 2845-3075 Sentence denotes SaO2 oxygen saturation, CS corticosteroids, IMV invasive mechanical ventilation, PaO2/FiO2 ratio of arterial oxygen tension to fractional inspired oxygen concentrations, WBC white blood cell, CRP C-reaction protein, FIB fibrinogen
T34 3076-3258 Sentence denotes Due to the deficiency of sample size and a matched control group, we could not easily draw an accurate conclusion about the role of corticosteroids in patients with 2019-nCoV by now.
T35 3259-3501 Sentence denotes However, our clinical experience and available descriptive data from the therapeutic process of the first 15 critical NCP patients are prone to support corticosteroids treatment for specific subgroup of critically ill patients with 2019-nCoV.

2_test

Id Subject Object Predicate Lexical cue
32296012-29161116-139944478 1361-1362 29161116 denotes 6