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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 65-84 Disease denotes 2019-nCoV pneumonia MESH:C000657245
19 136-145 Species denotes 2019-nCoV Tax:2697049
20 260-268 Species denotes patients Tax:9606
21 402-411 Species denotes 2019-nCoV Tax:2697049
22 472-480 Species denotes patients Tax:9606
23 598-606 Species denotes patients Tax:9606
24 877-885 Species denotes patients Tax:9606
25 891-900 Species denotes 2019-nCoV Tax:2697049
26 958-966 Species denotes patients Tax:9606
27 293-312 Disease denotes 2019-nCoV infection MESH:C000657245
28 359-365 Disease denotes deaths MESH:D003643
29 387-391 Disease denotes SARS MESH:D045169
30 396-400 Disease denotes MERS MESH:D018352
31 612-631 Disease denotes 2019-nCoV infection MESH:C000657245
32 734-769 Disease denotes acute respiratory distress syndrome MESH:D012128
33 771-775 Disease denotes ARDS MESH:D012128
34 780-792 Disease denotes septic shock MESH:D012772
35 943-957 Disease denotes critically ill MESH:D016638
43 1138-1146 Species denotes patients Tax:9606
44 1683-1691 Species denotes patients Tax:9606
45 1711-1728 Species denotes novel coronavirus Tax:2697049
46 1529-1547 Chemical denotes methylprednisolone MESH:D008775
47 1113-1132 Disease denotes 2019-nCoV infection MESH:C000657245
48 1395-1414 Disease denotes 2019-nCoV Infection MESH:C000657245
49 1692-1700 Disease denotes infected MESH:D007239
52 1823-1831 Species denotes patients Tax:9606
53 1837-1846 Species denotes 2019-nCoV Tax:2697049
64 2363-2367 Species denotes H1N1 Tax:114727
65 2617-2625 Species denotes patients Tax:9606
66 1891-1902 Disease denotes lung injury MESH:D055370
67 1939-1948 Disease denotes pneumonia MESH:D011014
68 2039-2076 Disease denotes dysfunctional systematic inflammation MESH:D007249
69 2143-2170 Disease denotes novel coronavirus pneumonia MESH:C000657245
70 2172-2175 Disease denotes NCP MESH:C000657245
71 2322-2338 Disease denotes viral pneumonias
72 2348-2352 Disease denotes SARS MESH:D045169
73 2354-2358 Disease denotes MERS MESH:D018352
94 3564-3568 Gene denotes HIN1 Gene:54726
95 3249-3257 Species denotes patients Tax:9606
96 3435-3443 Species denotes patients Tax:9606
97 3786-3794 Species denotes patients Tax:9606
98 3800-3809 Species denotes 2019-nCoV Tax:2697049
99 3866-3874 Species denotes patients Tax:9606
100 2971-2980 Disease denotes mortality MESH:D003643
101 2986-2998 Disease denotes septic shock MESH:D012772
102 3017-3032 Disease denotes lung infections MESH:D012141
103 3122-3127 Disease denotes shock MESH:D012769
104 3272-3276 Disease denotes ARDS MESH:D012128
105 3297-3315 Disease denotes pulmonary fibrosis MESH:D011658
106 3449-3453 Disease denotes SARS MESH:D045169
107 3454-3463 Disease denotes infection MESH:D007239
108 3527-3536 Disease denotes mortality MESH:D003643
109 3771-3785 Disease denotes critically ill MESH:D016638
110 3862-3865 Disease denotes NCP MESH:C000657245
111 3930-3934 Disease denotes ARDS MESH:D012128
112 3936-3942 Disease denotes sepsis MESH:D018805
113 3946-3958 Disease denotes septic shock MESH:D012772
115 4078-4081 Disease denotes NCP MESH:C000657245
131 7039-7042 Gene denotes CRP Gene:1401
132 6369-6377 Species denotes patients Tax:9606
133 6383-6392 Species denotes 2019-nCoV Tax:2697049
134 6441-6449 Species denotes patients Tax:9606
135 6464-6473 Species denotes 2019-nCoV Tax:2697049
136 6745-6753 Species denotes patients Tax:9606
137 6847-6851 Chemical denotes SaO2
138 6852-6858 Chemical denotes oxygen MESH:D010100
139 6871-6889 Chemical denotes CS corticosteroids
140 6956-6962 Chemical denotes oxygen MESH:D010100
141 6994-7000 Chemical denotes oxygen MESH:D010100
142 6450-6458 Disease denotes infected MESH:D007239
143 6507-6528 Disease denotes aOf the 14 infections MESH:D007239
144 6730-6744 Disease denotes critically ill MESH:D016638
145 6759-6778 Disease denotes 2019-nCoV infection MESH:C000657245
186 4356-4364 Species denotes patients Tax:9606
187 4463-4471 Species denotes patients Tax:9606
188 4658-4666 Species denotes patients Tax:9606
189 5055-5063 Species denotes patients Tax:9606
190 5197-5205 Species denotes patients Tax:9606
191 5311-5319 Species denotes patients Tax:9606
192 5446-5454 Species denotes patients Tax:9606
193 5835-5843 Species denotes patients Tax:9606
194 5913-5921 Species denotes patients Tax:9606
195 6309-6317 Species denotes patients Tax:9606
196 4714-4720 Chemical denotes oxygen MESH:D010100
197 4907-4928 Chemical denotes median hydrocortisone
198 5542-5548 Chemical denotes oxygen MESH:D010100
199 5561-5565 Chemical denotes SaO2
200 5580-5586 Chemical denotes oxygen MESH:D010100
201 5596-5600 Chemical denotes PaO2
202 5614-5620 Chemical denotes oxygen MESH:D010100
203 5631-5635 Chemical denotes FiO2
204 4254-4273 Disease denotes 2019-nCoV infection MESH:C000657245
205 4352-4355 Disease denotes NCP MESH:C000657245
206 4502-4511 Disease denotes pneumonia MESH:D011014
207 4513-4522 Disease denotes hypoxemia MESH:D000860
208 4546-4550 Disease denotes ARDS MESH:D012128
209 4567-4577 Disease denotes infections MESH:D007239
210 4604-4609 Disease denotes shock MESH:D012769
211 4805-4814 Disease denotes hypoxemia MESH:D000860
212 5158-5167 Disease denotes mortality MESH:D003643
213 5193-5196 Disease denotes NCP MESH:C000657245
214 5296-5310 Disease denotes critically ill MESH:D016638
215 5325-5329 Disease denotes MERS MESH:D018352
216 5420-5429 Disease denotes mortality MESH:D003643
217 5442-5445 Disease denotes NCP MESH:C000657245
218 5831-5834 Disease denotes NCP MESH:C000657245
219 5866-5870 Disease denotes ARDS MESH:D012128
220 5875-5880 Disease denotes shock MESH:D012769
221 5884-5905 Disease denotes multiple organ injury MESH:D009102
222 5990-5994 Disease denotes ARDS MESH:D012128
223 6097-6106 Disease denotes infection MESH:D007239
224 6154-6159 Disease denotes shock MESH:D012769
225 6305-6308 Disease denotes NCP MESH:C000657245
233 7229-7237 Species denotes patients Tax:9606
234 7243-7252 Species denotes 2019-nCoV Tax:2697049
235 7383-7391 Species denotes patients Tax:9606
236 7479-7487 Species denotes patients Tax:9606
237 7493-7502 Species denotes 2019-nCoV Tax:2697049
238 7379-7382 Disease denotes NCP MESH:C000657245
239 7464-7478 Disease denotes critically ill MESH:D016638
241 7549-7557 Species denotes patients Tax:9606
266 7659-7667 Species denotes patients Tax:9606
267 8578-8586 Species denotes patients Tax:9606
268 9113-9121 Species denotes patients Tax:9606
269 9127-9136 Species denotes 2019-nCoV Tax:2697049
270 9253-9261 Species denotes patients Tax:9606
271 9337-9344 Species denotes patient Tax:9606
272 8672-8686 Chemical denotes hydrocortisone MESH:D006854
273 8944-8962 Chemical denotes methylprednisolone MESH:D008775
274 7644-7658 Disease denotes critically ill MESH:D016638
275 7706-7710 Disease denotes SARS MESH:D045169
276 7784-7787 Disease denotes NCP MESH:C000657245
277 8067-8071 Disease denotes ARDS MESH:D012128
278 8073-8079 Disease denotes sepsis MESH:D018805
279 8083-8095 Disease denotes septic shock MESH:D012772
280 8267-8271 Disease denotes ARDS MESH:D012128
281 8363-8372 Disease denotes mortality MESH:D003643
282 8430-8442 Disease denotes inflammation MESH:D007249
283 8452-8463 Disease denotes lung injury MESH:D055370
284 8518-8522 Disease denotes ARDS MESH:D012128
285 8573-8577 Disease denotes SARS MESH:D045169
286 8802-8815 Disease denotes hyperglycemia MESH:D006943
287 8817-8826 Disease denotes psychosis MESH:D011605
288 8832-8851 Disease denotes secondary infection MESH:D060085
289 8853-8871 Disease denotes avascular necrosis MESH:D010020
298 9484-9493 Species denotes 2019-nCoV Tax:2697049
299 9557-9565 Species denotes patients Tax:9606
300 9711-9719 Species denotes patients Tax:9606
301 9725-9734 Species denotes 2019-nCoV Tax:2697049
302 10069-10078 Species denotes 2019-nCoV Tax:2697049
303 9553-9556 Disease denotes NCP MESH:C000657245
304 9696-9710 Disease denotes critically ill MESH:D016638
305 10052-10063 Disease denotes lung injury MESH:D055370

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1564-1568 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T2 1891-1895 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T3 3017-3021 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T4 4638-4643 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T5 5893-5898 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T6 6871-6873 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T7 7021-7037 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T8 7033-7037 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 7054-7061 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T10 8452-8456 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T11 8973-8977 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T12 9601-9605 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T13 10052-10056 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1891-1895 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 3017-3021 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 4638-4643 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T4 5893-5898 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T5 7027-7032 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T6 8452-8456 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 9601-9605 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T8 10052-10056 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 75-84 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T2 293-312 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T3 303-312 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T4 387-391 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 612-631 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T6 622-631 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 734-769 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T8 740-769 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T9 771-775 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T10 1113-1132 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T11 1123-1132 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 1378-1389 Disease denotes Pneumonitis http://purl.obolibrary.org/obo/MONDO_0043905
T13 1395-1414 Disease denotes 2019-nCoV Infection http://purl.obolibrary.org/obo/MONDO_0100096
T14 1896-1902 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T15 1939-1948 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T16 2161-2170 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T17 2322-2338 Disease denotes viral pneumonias http://purl.obolibrary.org/obo/MONDO_0006012
T18 2348-2352 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T19 3022-3032 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T20 3272-3276 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T21 3297-3315 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T22 3449-3453 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T23 3454-3463 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T24 3930-3934 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T25 4254-4273 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T26 4264-4273 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 4502-4511 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T28 4546-4550 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T29 4567-4577 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T30 5866-5870 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T31 5899-5905 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T32 5990-5994 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T33 6097-6106 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 6518-6528 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T35 6759-6778 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T36 6769-6778 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 7706-7710 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T38 8067-8071 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T39 8267-8271 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T40 8430-8442 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T41 8457-8463 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T42 8573-8577 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T43 8802-8815 Disease denotes hyperglycemia http://purl.obolibrary.org/obo/MONDO_0002909
T44 8817-8826 Disease denotes psychosis http://purl.obolibrary.org/obo/MONDO_0005485
T45 8842-8851 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46 10057-10063 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 155-158 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T2 1010-1020 http://purl.obolibrary.org/obo/UBERON_0001456 denotes are facing
T3 1429-1430 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 1581-1584 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3–5
T5 1891-1895 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T6 1891-1895 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T7 2857-2858 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 3017-3021 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T9 3017-3021 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T10 3385-3386 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 4638-4643 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T12 5519-5522 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3−5
T13 5561-5565 http://purl.obolibrary.org/obo/CLO_0008947 denotes SaO2
T14 5561-5565 http://purl.obolibrary.org/obo/CLO_0050140 denotes SaO2
T15 5571-5579 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T16 5571-5579 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T17 5893-5898 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T18 6394-6395 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 6657-6658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 6706-6707 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T21 6847-6851 http://purl.obolibrary.org/obo/CLO_0008947 denotes SaO2
T22 6847-6851 http://purl.obolibrary.org/obo/CLO_0050140 denotes SaO2
T23 6947-6955 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T24 6947-6955 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T25 7027-7032 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T26 7033-7037 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T27 7119-7120 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 8173-8185 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T29 8344-8349 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T30 8452-8456 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T31 8452-8456 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T32 9151-9152 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 9411-9414 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T34 9451-9452 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 9601-9605 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T36 9684-9685 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 10052-10056 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T38 10052-10056 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 30-45 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T2 1065-1074 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T3 1502-1517 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T4 1529-1547 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T5 1616-1624 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T6 1748-1763 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T7 1784-1799 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T8 2113-2128 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T9 2294-2309 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T10 2447-2462 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T11 2580-2595 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T12 2805-2820 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T13 2930-2945 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T14 3212-3227 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T15 3484-3499 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T16 3605-3610 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T17 3721-3736 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T18 4041-4056 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T19 4197-4212 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T20 4714-4720 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T21 4733-4744 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T22 4752-4768 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T23 4882-4897 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T24 4914-4928 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T25 5338-5353 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T26 5382-5397 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T27 5482-5497 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T28 5542-5548 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T29 5580-5586 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T30 5614-5620 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T31 5948-5963 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T32 6180-6195 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T33 6786-6801 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T34 6852-6858 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T35 6871-6873 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T36 6874-6889 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T37 6956-6962 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T38 6994-7000 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T39 7054-7061 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T40 7137-7142 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T41 7210-7225 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T42 7413-7428 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T43 7520-7535 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T44 7625-7640 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T45 7754-7769 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T46 7802-7810 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T47 7936-7951 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T48 7981-7996 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T49 8227-8242 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T50 8287-8302 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T51 8303-8314 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T52 8383-8398 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T53 8592-8607 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T54 8672-8686 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T55 8917-8932 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T56 8944-8962 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T57 9027-9031 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T58 9655-9670 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T59 10015-10030 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 75-84 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 740-760 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T3 787-792 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T4 1939-1948 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T5 2161-2170 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T6 2328-2338 Phenotype denotes pneumonias http://purl.obolibrary.org/obo/HP_0002090
T7 2993-2998 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T8 3122-3127 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T9 3297-3315 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T10 3936-3942 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T11 3953-3958 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T12 4502-4511 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 4513-4522 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T14 4604-4609 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T15 4805-4814 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T16 5875-5880 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T17 6154-6159 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T18 8073-8079 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T19 8090-8095 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T20 8802-8815 Phenotype denotes hyperglycemia http://purl.obolibrary.org/obo/HP_0003074
T21 8817-8826 Phenotype denotes psychosis http://purl.obolibrary.org/obo/HP_0000709
T22 9019-9040 Phenotype denotes adverse drug reaction http://purl.obolibrary.org/obo/HP_0020172

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 8430-8442 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-84 Sentence denotes Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia
T2 86-98 Sentence denotes Dear Editor,
T3 99-228 Sentence denotes Since last December, the outbreak of 2019-nCoV in Wuhan has caused ever-increasing attention and public panic all over the world.
T4 229-374 Sentence denotes Up to February 9, 2020, 40,171 patients had been diagnosed with 2019-nCoV infection, including 6484 (16.14%) severe cases and 908 deaths (2.27%).
T5 375-522 Sentence denotes Compared to SARS and MERS, 2019-nCoV appears to be much more contagious but less lethal, as most patients have mild symptoms and good prognosis1,2.
T6 523-793 Sentence denotes However, according to the Chinese government’s daily report, 13.2–21.3% of patients with 2019-nCoV infection developed into severe or fatal illness (Fig. S1a), which is characterized by the rapid development to acute respiratory distress syndrome (ARDS) or septic shock.
T7 794-923 Sentence denotes Along with an increasing number of confirmed cases, the cumulative total of severe patients with 2019-nCoV is growing (Fig. S1b).
T8 924-1021 Sentence denotes Treatment of these critically ill patients is becoming one of the major challenges we are facing.
T9 1022-1133 Sentence denotes Unfortunately, there are still no specific antiviral medicines or vaccines recommended for 2019-nCoV infection.
T10 1134-1246 Sentence denotes For patients with severe clinical manifestations, an effective clinical treatment scheme is of great importance.
T11 1247-1478 Sentence denotes On February 7, 2020, the China’s National Health Commission released the fifth trial version of Diagnosis and Treatment Scheme for Pneumonitis with 2019-nCoV Infection, and provided a systematic treatment strategy for severe cases.
T12 1479-1774 Sentence denotes Remarkably, systematic corticosteroids treatment (methylprednisolone, <1–2 mg per kg body weight, for 3–5 days) was recommended to be an adjuvant therapy3, which immediately raised concerns about whether patients infected with this novel coronavirus could benefit from corticosteroids therapy 4.
T13 1776-1847 Sentence denotes Salvage corticosteroids treatment for critical patients with 2019-nCoV?
T14 1848-2078 Sentence denotes Corticosteroids are widely used to prevent lung injury caused by severe community-acquired pneumonia (sCAP) due to their excellent pharmacological effects on the suppression of exuberant and dysfunctional systematic inflammation5.
T15 2079-2369 Sentence denotes Some scholars may not support the corticosteroids treatment for novel coronavirus pneumonia (NCP), because observational studies and systematic reviews have indicated inconclusive clinical evidence on the effect of corticosteroids therapy for viral pneumonias (such as SARS, MERS and H1N1).
T16 2370-2518 Sentence denotes Additionally, pulse-dose therapy or long-term administration to high dose of corticosteroids in early stage were reported to be possibly harmful6–8.
T17 2519-2830 Sentence denotes However, these conclusions obscured the clinical benefits of corticosteroids on some subgroups of patients, particularly those with severe symptoms, as the clinical effects might be related to the indication (severities of illness), the timing of intervention, the dose and duration of corticosteroids therapy9.
T18 2831-3194 Sentence denotes Of note, as documented in a series of randomized clinical trials (RCT), low or physiologic dose of corticosteroids treatment did not reduce mortality from septic shock caused by primary lung infections, but it could bring clinical benefits to secondary outcomes, such as earlier reversal of shock, shorter duration to exit from ICU and mechanical ventilation9,10.
T19 3195-3508 Sentence denotes Besides, salvage corticosteroids treatment for severe patients with advanced ARDS could alleviate the pulmonary fibrosis and prevent progressive pathological deterioration11, which provides a good framework for explaining why some critical patients with SARS infection benefit from rescue corticosteroids therapy.
T20 3509-3646 Sentence denotes More importantly, mortality benefit favored the severe HIN1-illness in the adjunctive treatment group with low dose of corticosteroids12.
T21 3647-4000 Sentence denotes Evidently, all these results strongly suggest that proper use of low-dose corticosteroids may bring survival advantages for critically ill patients with 2019-nCoV, but this treatment should be strictly performed on NCP patients with definite clinical indications (such as refractory ARDS, sepsis or septic shock) according to the recommended guidelines.
T22 4002-4090 Sentence denotes Current evidence: clinical benefits of corticosteroids therapy for critical NCP patients
T23 4091-4283 Sentence denotes Over the past month, we collaborated with front-line ICU physicians and firstly evaluated the efficacy of corticosteroids treatment for severe or fatal cases with 2019-nCoV infection in Wuhan.
T24 4284-4452 Sentence denotes From January 1 to January 29, 2020, the first 15 confirmed critical NCP patients with an average age of 61.7 years were admitted to the ICU in Wuhan Pulmonary Hospital.
T25 4453-4653 Sentence denotes Of the 15 patients, 15 (100.0%) showed bilateral pneumonia, hypoxemia and moderate or severe ARDS, 14 (93.3%) had infections, 8 (53.3%) accompanied by shock and 9 (60.0%) with multiple organ injuries.
T26 4654-4852 Sentence denotes All patients had received treatments containing noninvasive oxygen therapy and antibiotics and/or antiviral agents before and after ICU admission, and hypoxemia was not improved by these treatments.
T27 4853-5127 Sentence denotes According to the guidelines, corticosteroids therapy (median hydrocortisone-equivalent dose of 400.0 mg/day) was instantly initiated after ICU admission for an average of 9.5 days, and outcomes for all patients were followed up until February 9, 2020 (Fig. 1a and Fig. S1c).
T28 5128-5455 Sentence denotes Briefly, we observed that ICU mortality of these severe or fatal NCP patients was 46.7% (7/15), closer to that after adjustment for time-varying confounders induced by critically ill patients with MERS without corticosteroids treatment6, suggesting that corticosteroids might not improve ICU mortality in critical NCP patients.
T29 5456-5749 Sentence denotes But meanwhile, systematic corticosteroids therapy in the first 3−5 days could enhance oxygen saturation (SaO2) and arterial oxygen tension (PaO2)/inspiratory oxygen fraction (FiO2), both of which could be further augmented by collaborating with invasive mechanical ventilation (IMV) (Fig. 1b).
T30 5750-5933 Sentence denotes Corticosteroids did not exert any intervention efficacy on survival advantage of NCP patients complicated with both ARDS and shock or multiple organ injury (seven patients, all dead).
T31 5934-6318 Sentence denotes Nevertheless, corticosteroids treatment in the phase of ARDS would effectively inhibit furious inflammatory storm (Fig. 1b) and gain valuable time for controlling infection and preventing secondary multiorgan damage and shock, which implies that corticosteroids have synergistic biological effects when combined with other intensivists’ treatment against severe or fatal NCP patients.
T32 6319-6846 Sentence denotes Fig. 1 Corticosteroids treatment for severely ill patients with 2019-nCoV. a Demographics and baseline characteristics of patients infected with 2019-nCoV according to survival condition. aOf the 14 infections, 12 with identified pathogens, 2 diagnosed by characteristic clinical symptoms without identified pathogens; bN = 7. *P < 0.05, a significant difference between the two groups. b Part of indexes of 15 critically ill patients with 2019-nCoV infection during corticosteroids therapy. *P < 0.05 vs. the indexes on day 1.
T33 6847-7077 Sentence denotes SaO2 oxygen saturation, CS corticosteroids, IMV invasive mechanical ventilation, PaO2/FiO2 ratio of arterial oxygen tension to fractional inspired oxygen concentrations, WBC white blood cell, CRP C-reaction protein, FIB fibrinogen
T34 7078-7260 Sentence denotes Due to the deficiency of sample size and a matched control group, we could not easily draw an accurate conclusion about the role of corticosteroids in patients with 2019-nCoV by now.
T35 7261-7503 Sentence denotes However, our clinical experience and available descriptive data from the therapeutic process of the first 15 critical NCP patients are prone to support corticosteroids treatment for specific subgroup of critically ill patients with 2019-nCoV.
T36 7505-7572 Sentence denotes Precautions of corticosteroids treatment in patients with 2019-nCoV
T37 7573-7675 Sentence denotes There is no fixed clinical guideline for the use of corticosteroids in critically ill patients in ICU.
T38 7676-7788 Sentence denotes The anecdotal experience from SARS and sCAP therapy strongly supports precise corticosteroids management of NCP.
T39 7789-7960 Sentence denotes Personalized medicine strategy should contain, but not limited to, specific indications, timing and duration, as well as therapeutic monitoring of corticosteroids therapy.
T40 7961-8192 Sentence denotes As mentioned above, corticosteroids should be avoided unless there are indications for moderate or severe ARDS, sepsis or septic shock, in part consistent with the recommended clinical guidance from World Health Organization (WHO).
T41 8193-8525 Sentence denotes We also do not suggest the use of corticosteroids for mild or early-stage ARDS, because early corticosteroids application could delay the clearance of virus and increase mortality risk, and corticosteroids are more likely to function on inflammation-mediated lung injury and interstitial fibro-proliferation at late-stage of ARDS11.
T42 8526-8656 Sentence denotes Furthermore, clinical adverse complications in SARS patients with corticosteroids treatment have been reported to be dose-related.
T43 8657-8876 Sentence denotes Over 240 mg of hydrocortisone-equivalent dose or an excessive cumulative dose was considered to be able to generate some side effects, including hyperglycemia, psychosis, and secondary infection, avascular necrosis9,10.
T44 8877-9137 Sentence denotes Hence, lower dose and short duration of corticosteroids treatment (methylprednisolone, <1 mg/kg body weight, no more than 7 days), along with adverse drug reaction monitoring, would be more beneficial in clinical management of critical patients with 2019-nCoV.
T45 9138-9262 Sentence denotes In addition, a long-term follow-up (6 months to 3 years) is essential to identify delayed adverse effects in these patients.
T46 9263-9376 Sentence denotes Of course, the optimal treatment strategy requires constant adjustment as patient’s clinical performance changes.
T47 9377-9503 Sentence denotes In conclusion, Chinese government has taken effective measures to prevent a possible national or worldwide 2019-nCoV pandemic.
T48 9504-9606 Sentence denotes Offering the most reasonable treatment to severe NCP patients could be another challenge we will face.
T49 9607-9850 Sentence denotes We endorse the potential benefits from low-dose corticosteroids treatment in a subset of critically ill patients with 2019-nCoV based on existing studies and clinical experience, despite there is no significant improvement in overall survival.
T50 9851-10099 Sentence denotes Certainly, our ongoing well-designed prospective cohort study with sufficient samples may provide systematic answers to this clinical dilemma—“to use or not to use corticosteroids for the treatment of lung injury with 2019-nCoV”—in the near future.
T51 10101-10126 Sentence denotes Supplementary information
T52 10128-10150 Sentence denotes Supplementary Material
T53 10152-10186 Sentence denotes These authors contributed equally:
T54 10187-10232 Sentence denotes Wei Zhou, Yisi Liu, Dongdong Tian, Cheng Wang
T55 10234-10259 Sentence denotes Supplementary information
T56 10260-10395 Sentence denotes The online version of this article (10.1038/s41392-020-0127-9) contains supplementary material, which is available to authorized users.
T57 10397-10413 Sentence denotes Acknowledgements
T58 10414-10556 Sentence denotes We thank all medical staff working in the Intensive Care Unit of Wuhan Pulmonary Hospital for their essential assistance with case collection.
T59 10557-10660 Sentence denotes The authors acknowledge the National Natural Science Foundation of China for the financial support (no.
T60 10661-10677 Sentence denotes 81630102 and no.
T61 10678-10688 Sentence denotes 81803833).
T62 10690-10709 Sentence denotes Competing interests
T63 10710-10753 Sentence denotes The authors declare no competing interests.

2_test

Id Subject Object Predicate Lexical cue
32296012-31261585-139944471 2076-2077 31261585 denotes 5
32296012-29161116-139944472 2514-2515 29161116 denotes 6
32296012-16968120-139944472 2514-2515 16968120 denotes 6
32296012-30074052-139944472 2514-2515 30074052 denotes 6
32296012-29849191-139944473 2828-2829 29849191 denotes 9
32296012-29849191-139944474 3189-3190 29849191 denotes 9
32296012-28098591-139944475 3191-3193 28098591 denotes 10
32296012-7492007-139944476 3366-3368 7492007 denotes 11
32296012-28464462-139944477 3643-3645 28464462 denotes 12
32296012-29161116-139944478 5363-5364 29161116 denotes 6
32296012-7492007-139944479 8522-8524 7492007 denotes 11
32296012-29849191-139944480 8871-8872 29849191 denotes 9
32296012-28098591-139944481 8873-8875 28098591 denotes 10