PMC:7033706 / 4980-5284 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"101","span":{"begin":61,"end":65},"obj":"Gene"},{"id":"114","span":{"begin":41,"end":49},"obj":"Species"}],"attributes":[{"id":"A101","pred":"tao:has_database_id","subj":"101","obj":"Gene:6941"},{"id":"A114","pred":"tao:has_database_id","subj":"114","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A peptide derived from the HR2 domain of SARS-CoV S protein (SC-1) can interact with HR1 region in viral S protein to form heterologous 6-HB, resulting in the inhibition of homologous 6-HB formation between HR1 and HR2 domains in viral S protein and thus blocking the viral fusion with the host cell [6]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T15","span":{"begin":52,"end":59},"obj":"Body_part"},{"id":"T16","span":{"begin":107,"end":114},"obj":"Body_part"},{"id":"T17","span":{"begin":238,"end":245},"obj":"Body_part"},{"id":"T18","span":{"begin":295,"end":299},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"A peptide derived from the HR2 domain of SARS-CoV S protein (SC-1) can interact with HR1 region in viral S protein to form heterologous 6-HB, resulting in the inhibition of homologous 6-HB formation between HR1 and HR2 domains in viral S protein and thus blocking the viral fusion with the host cell [6]."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p5527s40","span":{"begin":184,"end":198},"obj":"MPA"}],"text":"A peptide derived from the HR2 domain of SARS-CoV S protein (SC-1) can interact with HR1 region in viral S protein to form heterologous 6-HB, resulting in the inhibition of homologous 6-HB formation between HR1 and HR2 domains in viral S protein and thus blocking the viral fusion with the host cell [6]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T16","span":{"begin":41,"end":49},"obj":"Disease"}],"attributes":[{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"A peptide derived from the HR2 domain of SARS-CoV S protein (SC-1) can interact with HR1 region in viral S protein to form heterologous 6-HB, resulting in the inhibition of homologous 6-HB formation between HR1 and HR2 domains in viral S protein and thus blocking the viral fusion with the host cell [6]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T62","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T63","span":{"begin":2,"end":9},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T64","span":{"begin":61,"end":65},"obj":"http://purl.obolibrary.org/obo/CLO_0008956"},{"id":"T65","span":{"begin":61,"end":65},"obj":"http://purl.obolibrary.org/obo/CLO_0008957"},{"id":"T66","span":{"begin":61,"end":65},"obj":"http://purl.obolibrary.org/obo/CLO_0008958"},{"id":"T67","span":{"begin":61,"end":65},"obj":"http://purl.obolibrary.org/obo/CLO_0050606"},{"id":"T68","span":{"begin":138,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0003622"},{"id":"T69","span":{"begin":186,"end":188},"obj":"http://purl.obolibrary.org/obo/CLO_0003622"},{"id":"T70","span":{"begin":295,"end":299},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"A peptide derived from the HR2 domain of SARS-CoV S protein (SC-1) can interact with HR1 region in viral S protein to form heterologous 6-HB, resulting in the inhibition of homologous 6-HB formation between HR1 and HR2 domains in viral S protein and thus blocking the viral fusion with the host cell [6]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T28","span":{"begin":2,"end":9},"obj":"Chemical"},{"id":"T29","span":{"begin":52,"end":59},"obj":"Chemical"},{"id":"T30","span":{"begin":61,"end":65},"obj":"Chemical"},{"id":"T31","span":{"begin":107,"end":114},"obj":"Chemical"},{"id":"T32","span":{"begin":238,"end":245},"obj":"Chemical"}],"attributes":[{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_136542"},{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"A peptide derived from the HR2 domain of SARS-CoV S protein (SC-1) can interact with HR1 region in viral S protein to form heterologous 6-HB, resulting in the inhibition of homologous 6-HB formation between HR1 and HR2 domains in viral S protein and thus blocking the viral fusion with the host cell [6]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":189,"end":198},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"A peptide derived from the HR2 domain of SARS-CoV S protein (SC-1) can interact with HR1 region in viral S protein to form heterologous 6-HB, resulting in the inhibition of homologous 6-HB formation between HR1 and HR2 domains in viral S protein and thus blocking the viral fusion with the host cell [6]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T29","span":{"begin":0,"end":304},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A peptide derived from the HR2 domain of SARS-CoV S protein (SC-1) can interact with HR1 region in viral S protein to form heterologous 6-HB, resulting in the inhibition of homologous 6-HB formation between HR1 and HR2 domains in viral S protein and thus blocking the viral fusion with the host cell [6]."}