PMC:7033706 / 2447-3065 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"46","span":{"begin":58,"end":63},"obj":"Gene"},{"id":"47","span":{"begin":548,"end":549},"obj":"Gene"},{"id":"48","span":{"begin":302,"end":303},"obj":"Gene"},{"id":"49","span":{"begin":115,"end":116},"obj":"Gene"},{"id":"50","span":{"begin":48,"end":57},"obj":"Species"},{"id":"51","span":{"begin":125,"end":134},"obj":"Species"},{"id":"52","span":{"begin":183,"end":191},"obj":"Species"},{"id":"53","span":{"begin":202,"end":215},"obj":"Species"},{"id":"54","span":{"begin":315,"end":324},"obj":"Species"},{"id":"55","span":{"begin":538,"end":547},"obj":"Species"}],"attributes":[{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"Gene:43740568"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"Gene:43740568"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"Gene:43740568"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"Gene:43740568"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Tax:2697049"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"Tax:2697049"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Tax:694009"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:11118"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Tax:2697049"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Figure 1. Analysis of the functional domains in 2019-nCoV spike protein and its gene. (A) Phylogenetic analysis of S gene of 2019-nCoV (Wuhan-Hu-1), bat-SL-CoVZXC21, bat-SL-CoVZXC45, SARS-CoV and other coronaviruses using Neighbor-Joining method. (B) The representative scheme of functional domains in S protein of 2019-nCoV. SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; FP, fusion peptide, HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain; CP, cytoplasmic domain. (C) The target sites in 2019-nCoV S for development of vaccines, antibodies and fusion/entry inhibitors."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":64,"end":71},"obj":"Body_part"},{"id":"T3","span":{"begin":80,"end":84},"obj":"Body_part"},{"id":"T4","span":{"begin":117,"end":121},"obj":"Body_part"},{"id":"T5","span":{"begin":304,"end":311},"obj":"Body_part"},{"id":"T6","span":{"begin":494,"end":505},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma66835"}],"text":"Figure 1. Analysis of the functional domains in 2019-nCoV spike protein and its gene. (A) Phylogenetic analysis of S gene of 2019-nCoV (Wuhan-Hu-1), bat-SL-CoVZXC21, bat-SL-CoVZXC45, SARS-CoV and other coronaviruses using Neighbor-Joining method. (B) The representative scheme of functional domains in S protein of 2019-nCoV. SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; FP, fusion peptide, HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain; CP, cytoplasmic domain. (C) The target sites in 2019-nCoV S for development of vaccines, antibodies and fusion/entry inhibitors."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T7","span":{"begin":183,"end":191},"obj":"Disease"},{"id":"T8","span":{"begin":346,"end":349},"obj":"Disease"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A9","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"}],"text":"Figure 1. Analysis of the functional domains in 2019-nCoV spike protein and its gene. (A) Phylogenetic analysis of S gene of 2019-nCoV (Wuhan-Hu-1), bat-SL-CoVZXC21, bat-SL-CoVZXC45, SARS-CoV and other coronaviruses using Neighbor-Joining method. (B) The representative scheme of functional domains in S protein of 2019-nCoV. SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; FP, fusion peptide, HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain; CP, cytoplasmic domain. (C) The target sites in 2019-nCoV S for development of vaccines, antibodies and fusion/entry inhibitors."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T26","span":{"begin":80,"end":84},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T27","span":{"begin":87,"end":88},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T28","span":{"begin":117,"end":121},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T29","span":{"begin":149,"end":152},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T30","span":{"begin":166,"end":169},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T31","span":{"begin":248,"end":249},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T32","span":{"begin":330,"end":336},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T33","span":{"begin":337,"end":344},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T34","span":{"begin":411,"end":418},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T35","span":{"begin":490,"end":492},"obj":"http://purl.obolibrary.org/obo/PR_000005794"}],"text":"Figure 1. Analysis of the functional domains in 2019-nCoV spike protein and its gene. (A) Phylogenetic analysis of S gene of 2019-nCoV (Wuhan-Hu-1), bat-SL-CoVZXC21, bat-SL-CoVZXC45, SARS-CoV and other coronaviruses using Neighbor-Joining method. (B) The representative scheme of functional domains in S protein of 2019-nCoV. SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; FP, fusion peptide, HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain; CP, cytoplasmic domain. (C) The target sites in 2019-nCoV S for development of vaccines, antibodies and fusion/entry inhibitors."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T5","span":{"begin":64,"end":71},"obj":"Chemical"},{"id":"T6","span":{"begin":153,"end":155},"obj":"Chemical"},{"id":"T7","span":{"begin":170,"end":172},"obj":"Chemical"},{"id":"T8","span":{"begin":304,"end":311},"obj":"Chemical"},{"id":"T9","span":{"begin":326,"end":328},"obj":"Chemical"},{"id":"T10","span":{"begin":337,"end":344},"obj":"Chemical"},{"id":"T11","span":{"begin":400,"end":402},"obj":"Chemical"},{"id":"T12","span":{"begin":411,"end":418},"obj":"Chemical"},{"id":"T13","span":{"begin":464,"end":466},"obj":"Chemical"},{"id":"T15","span":{"begin":490,"end":492},"obj":"Chemical"},{"id":"T17","span":{"begin":607,"end":617},"obj":"Chemical"}],"attributes":[{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_74815"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_74815"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_74820"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_74750"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_55460"},{"id":"A14","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_74861"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_3380"},{"id":"A16","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_73461"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"Figure 1. Analysis of the functional domains in 2019-nCoV spike protein and its gene. (A) Phylogenetic analysis of S gene of 2019-nCoV (Wuhan-Hu-1), bat-SL-CoVZXC21, bat-SL-CoVZXC45, SARS-CoV and other coronaviruses using Neighbor-Joining method. (B) The representative scheme of functional domains in S protein of 2019-nCoV. SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; FP, fusion peptide, HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain; CP, cytoplasmic domain. (C) The target sites in 2019-nCoV S for development of vaccines, antibodies and fusion/entry inhibitors."}

{"project":"LitCovid-sentences","denotations":[{"id":"T17","span":{"begin":0,"end":9},"obj":"Sentence"},{"id":"T18","span":{"begin":10,"end":325},"obj":"Sentence"},{"id":"T19","span":{"begin":326,"end":618},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 1. Analysis of the functional domains in 2019-nCoV spike protein and its gene. (A) Phylogenetic analysis of S gene of 2019-nCoV (Wuhan-Hu-1), bat-SL-CoVZXC21, bat-SL-CoVZXC45, SARS-CoV and other coronaviruses using Neighbor-Joining method. (B) The representative scheme of functional domains in S protein of 2019-nCoV. SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; FP, fusion peptide, HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain; CP, cytoplasmic domain. (C) The target sites in 2019-nCoV S for development of vaccines, antibodies and fusion/entry inhibitors."}