PMC:7033348 / 105-2412 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7033348","sourcedb":"PMC","sourceid":"7033348","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7033348","text":"The initial cluster of severe pneumonia cases that triggered the COVID-19 epidemic was identified in Wuhan, China in December 2019. While early cases of the disease were linked to a wet market, human-to-human transmission has driven the rapid spread of the virus throughout China. The Chinese government has implemented containment strategies of city-wide lockdowns, screening at airports and train stations, and isolation of suspected patients; however, the cumulative case count keeps growing every day. The ongoing outbreak presents a challenge for modelers, as limited data are available on the early growth trajectory, and the epidemiological characteristics of the novel coronavirus are yet to be fully elucidated.\nWe use phenomenological models that have been validated during previous outbreaks to generate and assess short-term forecasts of the cumulative number of confirmed reported cases in Hubei province, the epicenter of the epidemic, and for the overall trajectory in China, excluding the province of Hubei. We collect daily reported cumulative confirmed cases for the 2019-nCoV outbreak for each Chinese province from the National Health Commission of China. Here, we provide 5, 10, and 15 day forecasts for five consecutive days, February 5th through February 9th, with quantified uncertainty based on a generalized logistic growth model, the Richards growth model, and a sub-epidemic wave model.\nOur most recent forecasts reported here, based on data up until February 9, 2020, largely agree across the three models presented and suggest an average range of 7409–7496 additional confirmed cases in Hubei and 1128–1929 additional cases in other provinces within the next five days. Models also predict an average total cumulative case count between 37,415 and 38,028 in Hubei and 11,588–13,499 in other provinces by February 24, 2020.\nMean estimates and uncertainty bounds for both Hubei and other provinces have remained relatively stable in the last three reporting dates (February 7th – 9th). We also observe that each of the models predicts that the epidemic has reached saturation in both Hubei and other provinces. Our findings suggest that the containment strategies implemented in China are successfully reducing transmission and that the epidemic growth has slowed in recent days.","divisions":[{"label":"p","span":{"begin":0,"end":720}},{"label":"p","span":{"begin":721,"end":1414}},{"label":"p","span":{"begin":1415,"end":1852}}],"tracks":[{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T2","span":{"begin":30,"end":39},"obj":"Disease"},{"id":"T3","span":{"begin":65,"end":73},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":180,"end":181},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":194,"end":199},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T3","span":{"begin":203,"end":208},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T4","span":{"begin":222,"end":225},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T5","span":{"begin":257,"end":262},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T6","span":{"begin":304,"end":307},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T7","span":{"begin":536,"end":537},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":1320,"end":1321},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T9","span":{"begin":1388,"end":1389},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T10","span":{"begin":2081,"end":2084},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T11","span":{"begin":2281,"end":2284},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":30,"end":39},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":605,"end":611},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T2","span":{"begin":1343,"end":1349},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T3","span":{"begin":1370,"end":1376},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T4","span":{"begin":2274,"end":2280},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T3","span":{"begin":0,"end":131},"obj":"Sentence"},{"id":"T4","span":{"begin":132,"end":280},"obj":"Sentence"},{"id":"T5","span":{"begin":281,"end":505},"obj":"Sentence"},{"id":"T6","span":{"begin":506,"end":720},"obj":"Sentence"},{"id":"T7","span":{"begin":721,"end":1023},"obj":"Sentence"},{"id":"T8","span":{"begin":1024,"end":1175},"obj":"Sentence"},{"id":"T9","span":{"begin":1176,"end":1414},"obj":"Sentence"},{"id":"T10","span":{"begin":1415,"end":1699},"obj":"Sentence"},{"id":"T11","span":{"begin":1700,"end":1852},"obj":"Sentence"},{"id":"T12","span":{"begin":1853,"end":2013},"obj":"Sentence"},{"id":"T13","span":{"begin":2014,"end":2138},"obj":"Sentence"},{"id":"T14","span":{"begin":2139,"end":2307},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"},{"subj":"T13","pred":"source","obj":"LitCovid-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"4","span":{"begin":30,"end":39},"obj":"Disease"},{"id":"5","span":{"begin":65,"end":73},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"MESH:D011014"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"MESH:C000657245"},{"subj":"4","pred":"source","obj":"LitCovid-PubTator"},{"subj":"5","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-MONDO","color":"#93ebec","default":true},{"id":"LitCovid-PD-CLO","color":"#ecd293"},{"id":"LitCovid-PD-HP","color":"#b893ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ec9e"},{"id":"LitCovid-sentences","color":"#ec93a1"},{"id":"LitCovid-PubTator","color":"#93bbec"}]}]}}