PMC:7033263 / 2827-3744
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7033263","sourcedb":"PMC","sourceid":"7033263","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7033263","text":"Coronaviruses are enveloped, positive-sense, single stranded RNA viruses that are distributed broadly among humans, other mammals, and birds, which cause respiratory, enteric, hepatic, and neurologic diseases [5]. Six coronavirus species are known to cause human disease. Four viruses including hCoV-229E, OC43, NL63, and HKU1 are prevalent and typically cause mild respiratory diseases [6]. The two novel fatal coronaviruses emerge periodically in different areas, severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012. Given the high prevalence and wide distribution of coronaviruses, the genetic diversity and frequent recombination of genomes, and increasing human and animal activities, novel coronaviruses are likely to emerge periodically in humans owing to frequent cross-species infections and occasional spillover events [7, 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