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PMC:7029759 / 9688-11523 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
236 41-50 Species denotes 2019-nCoV Tax:2697049
237 141-150 Species denotes 2019-nCoV Tax:2697049
238 470-478 Species denotes CoV-2019 Tax:2697049
239 669-678 Species denotes 2019-nCoV Tax:2697049
240 686-696 Species denotes SARS virus Tax:694009
241 1425-1430 Species denotes Ebola Tax:1570291
242 302-318 Chemical denotes oligonucleotides MESH:D009841
243 606-621 Chemical denotes oligonucleotide MESH:D009841
244 801-817 Chemical denotes oligonucleotides MESH:D009841
245 908-913 Chemical denotes lipid MESH:D008055
246 1089-1098 Disease denotes infection MESH:D007239
247 1344-1359 Disease denotes viral infection MESH:D001102
248 1661-1669 Disease denotes infected MESH:D007239
249 184-194 CellLine denotes MN908947.3 CVCL:U508

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T182 21-28 GO:0009986 denotes surface
T181 41-50 SP_7 denotes 2019-nCoV
T180 82-88 SO:0001026 denotes genome
T179 122-128 SO:0001026 denotes genome
T178 141-150 SP_7 denotes 2019-nCoV
T177 259-280 SO:0000646 denotes small interfering RNA
T176 282-287 SO:0000646 denotes siRNA
T175 292-301 SO:0000077 denotes antisense
T174 339-344 NCBITaxon:10239 denotes virus
T173 366-372 SO:0001026 denotes genome
T172 459-466 SO:0000417 denotes domains
T171 560-565 SO:0000646 denotes siRNA
T170 586-591 NCBITaxon:10239 denotes viral
T169 650-656 SO:0001026 denotes genome
T168 657-665 SO:0000853 denotes homology
T167 669-678 SP_7 denotes 2019-nCoV
T166 686-696 NCBITaxon:10633 denotes SARS virus
T165 846-851 UBERON:0000170 denotes lungs
T164 908-913 CHEBI:18059;CHEBI:18059 denotes lipid
T163 968-973 UBERON:0000170 denotes lungs
T162 1012-1017 SO:0000646 denotes siRNA
T161 1071-1076 UBERON:0000170 denotes lungs
T160 1167-1175 UBERON:0004821;CL:0000322 denotes alveolar
T159 1176-1186 CL:0000322;UBERON:0004821 denotes epithelial
T158 1187-1192 CL:0000322 denotes cells
T157 1200-1204 UBERON:0002048 denotes lung
T156 1209-1214 SO:0000646 denotes siRNA
T155 1288-1292 SO:0000704 denotes gene
T154 1344-1349 NCBITaxon:10239 denotes viral
T153 1400-1405 SO:0000646 denotes siRNA
T152 1495-1501 NCBITaxon:33208 denotes animal
T151 1550-1555 SO:0000646 denotes siRNA
T150 1638-1643 SO:0000646 denotes siRNA
T149 1644-1649 CHEBI:23888;CHEBI:23888 denotes drugs
T148 1690-1695 SO:0000646 denotes siRNA
T147 1815-1826 CHEBI:23888;CHEBI:23888 denotes medications

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T41 29-37 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T42 78-81 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T43 82-88 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T44 118-121 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T45 122-128 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T46 277-280 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T47 362-365 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T48 366-372 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T49 446-449 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T50 650-656 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T51 846-851 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T52 908-913 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T53 968-973 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T54 1071-1076 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T55 1167-1192 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T56 1187-1192 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T57 1200-1204 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T58 1288-1292 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T4 1200-1204 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T5 1612-1617 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T25 686-690 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T26 1089-1098 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 1344-1359 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T28 1350-1359 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 1425-1430 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T86 339-344 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T87 691-696 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T88 771-772 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T89 846-851 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T90 968-973 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T91 1071-1076 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T92 1107-1108 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 1176-1204 http://purl.obolibrary.org/obo/CL_0000082 denotes epithelial cells in the lung
T94 1256-1257 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 1288-1292 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T96 1342-1343 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 1495-1501 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T98 1513-1515 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T99 1591-1592 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 1653-1654 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T24 29-37 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T25 302-318 Chemical denotes oligonucleotides http://purl.obolibrary.org/obo/CHEBI_7754
T26 606-621 Chemical denotes oligonucleotide http://purl.obolibrary.org/obo/CHEBI_7754
T27 801-817 Chemical denotes oligonucleotides http://purl.obolibrary.org/obo/CHEBI_7754
T28 908-913 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T29 914-927 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T30 1644-1649 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T4 100-111 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T5 1344-1359 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T59 0-112 Sentence denotes Beyond targeting the surface proteins of 2019-nCoV, one could also target the RNA genome itself for degradation.
T60 113-376 Sentence denotes This RNA genome sequence of 2019-nCoV was recently published (GenBank: MN908947.3), and one strategy that could be considered then, is the use of small interfering RNA (siRNA) or antisense oligonucleotides (ASO) to combat the virus by targeting its RNA genome 23.
T61 377-424 Sentence denotes The challenge with this strategy is multi-fold.
T62 425-493 Sentence denotes First, the conserved RNA sequence domains of CoV-2019 are not known.
T63 494-631 Sentence denotes Identifying conserved sequences is essential in order to optimize siRNA targeting and avoid viral escape of the oligonucleotide strategy.
T64 632-770 Sentence denotes One could look at genome homology of 2019-nCoV to the SARS virus for comparison of conserved sequences, but this would still be guesswork.
T65 771-852 Sentence denotes A second challenge is how the oligonucleotides would be delivered into the lungs.
T66 853-977 Sentence denotes Advances have been made into delivery vehicles such as lipid nanoparticles that can mediate some delivery into the lungs 24.
T67 978-1143 Sentence denotes It is unknown, however, if enough siRNA’s or ASO’s would be effectively delivered within the lungs to stop the infection or make a difference in its clinical course.
T68 1144-1360 Sentence denotes For example, if 25% of alveolar epithelial cells in the lung had siRNA or ASO in them, that efficiency might be a great success for traditional gene therapy, but would hardly make any difference in a viral infection.
T69 1361-1516 Sentence denotes Such an explanation is also likely why siRNA candidates against Ebola failed in trials 25, despite significant success in preclinical animal models 26, 27.
T70 1517-1681 Sentence denotes Lastly, even if one assumed that siRNA was effective clinically, there is a limited ability to scale up manufacturing of siRNA drugs to a large infected population.
T71 1682-1835 Sentence denotes Current siRNA and ASO therapies are manufactured for rare diseases, and there are no available resources existing to manufacture the medications quickly.