PMC:7029759 / 37704-38734
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
991 | 28-32 | Gene | denotes | ACE2 | Gene:59272 |
992 | 240-244 | Gene | denotes | ACE2 | Gene:59272 |
993 | 658-662 | Gene | denotes | DPP4 | Gene:1803 |
994 | 725-729 | Gene | denotes | DPP4 | Gene:1803 |
995 | 872-876 | Gene | denotes | ACE2 | Gene:59272 |
996 | 138-147 | Species | denotes | 2019-nCoV | Tax:2697049 |
997 | 157-172 | Species | denotes | new coronavirus | Tax:2697049 |
998 | 275-288 | Species | denotes | coronaviruses | Tax:11118 |
999 | 761-774 | Species | denotes | coronaviruses | Tax:11118 |
1000 | 129-133 | Disease | denotes | SARS | MESH:D045169 |
1001 | 193-201 | Disease | denotes | zoonotic | MESH:D015047 |
1002 | 526-534 | Disease | denotes | zoonotic | MESH:D015047 |
1003 | 691-695 | Disease | denotes | MERS | MESH:D018352 |
1004 | 912-916 | Disease | denotes | ARDS | MESH:D012128 |
1005 | 959-976 | Disease | denotes | acute lung injury | MESH:D055371 |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T645 | 28-32 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T644 | 90-94 | CHEBI:23888;CHEBI:23888 | denotes | drug |
T643 | 129-133 | SP_10 | denotes | SARS |
T642 | 138-147 | SP_7 | denotes | 2019-nCoV |
T641 | 161-172 | NCBITaxon:11118 | denotes | coronavirus |
T640 | 240-244 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T639 | 275-288 | NCBITaxon:11118 | denotes | coronaviruses |
T638 | 294-303 | GO:0006260 | denotes | replicate |
T637 | 307-314 | NCBITaxon:33208 | denotes | animals |
T636 | 446-453 | NCBITaxon:33208 | denotes | animals |
T635 | 594-602 | CHEBI:36357;CHEBI:36357 | denotes | molecule |
T634 | 658-662 | PG_7;PR:000001341 | denotes | DPP4 |
T633 | 691-695 | SP_9 | denotes | MERS |
T632 | 709-714 | NCBITaxon:10239 | denotes | viral |
T631 | 725-729 | PG_7;PR:000001341 | denotes | DPP4 |
T630 | 744-749 | NCBITaxon:10239 | denotes | virus |
T629 | 761-774 | NCBITaxon:11118 | denotes | coronaviruses |
T628 | 818-825 | NCBITaxon:10239 | denotes | viruses |
T627 | 872-876 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T626 | 937-944 | NCBITaxon:10239 | denotes | viruses |
T625 | 965-969 | UBERON:0002048 | denotes | lung |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T236 | 965-969 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T23 | 965-969 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T125 | 129-133 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T126 | 912-916 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
T127 | 959-976 | Disease | denotes | acute lung injury | http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796 |
T129 | 970-976 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T389 | 0-1 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T390 | 33-35 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T391 | 76-77 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T392 | 191-192 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T393 | 307-314 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animals |
T394 | 446-453 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animals |
T395 | 485-486 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T396 | 565-566 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T397 | 633-634 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T398 | 663-665 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T399 | 744-749 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T400 | 818-825 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T401 | 877-879 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T402 | 937-944 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T403 | 965-969 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T404 | 965-969 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T165 | 90-94 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T166 | 594-602 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T233 | 0-264 | Sentence | denotes | A final benefit of pursuing ACE2-Fc is that it could effectively be used as a therapeutic drug stockpile for future outbreaks of SARS and 2019-nCoV, and any new coronavirus that emerges from a zoonotic reservoir in the future that uses the ACE2 receptor for entry. |
T234 | 265-407 | Sentence | denotes | Moreover, coronaviruses that replicate in animals across China and other countries could be studied in order to assess their entry mechanisms. |
T235 | 408-617 | Sentence | denotes | By understanding entry in these other animals, one could effectively predict a receptor that could be utilized in any zoonotic transmission event, and build a new receptor immunoadhesin molecule in the future. |
T236 | 618-753 | Sentence | denotes | As an example, a similar immunoadhesin, DPP4-Fc, could be envisioned for MERS based on the viral receptor, DPP4, used by that virus 74. |
T237 | 754-871 | Sentence | denotes | Beyond coronaviruses, this strategy could be utilized for other viruses where the risk of outbreak potential is high. |
T238 | 872-1030 | Sentence | denotes | ACE2-Fc could also find use in treating ARDS for other unrelated viruses and causes of acute lung injury, building on the previous clinical trial work 60, 61. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T23 | 959-976 | Phenotype | denotes | acute lung injury | http://www.orpha.net/ORDO/Orphanet_178320 |