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PMC:7029759 / 36865-37703 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
969 109-113 Gene denotes ACE2 Gene:59272
970 193-197 Gene denotes IgG3 Gene:3502
971 338-342 Gene denotes ACE2 Gene:59272
972 370-374 Gene denotes ACE2 Gene:59272
973 737-741 Gene denotes ACE2 Gene:59272
974 70-79 Species denotes 2019-nCoV Tax:2697049
975 163-168 Species denotes human Tax:9606

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T659 70-79 SP_7 denotes 2019-nCoV
T658 109-113 G_3;PG_10;PR:000003622 denotes ACE2
T657 163-168 SP_6;NCBITaxon:9606 denotes human
T656 172-179 SO:0000417 denotes domains
T655 338-342 G_3;PG_10;PR:000003622 denotes ACE2
T654 370-374 G_3;PG_10;PR:000003622 denotes ACE2
T653 432-436 GO:0006412;SO:0000704 denotes gene
T652 437-446 GO:0071897 denotes synthesis
T651 496-500 SO:0000704 denotes gene
T650 528-535 BV_20 denotes protein
T649 536-546 BV_20;GO:0010467 denotes expression
T648 709-719 GO:0042571 denotes antibodies
T647 737-741 G_3;PG_10;PR:000003622 denotes ACE2
T646 782-790 GO:0042571 denotes antibody

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T229 85-92 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T230 432-436 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T231 496-500 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T232 528-535 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T233 596-603 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T234 644-651 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T235 782-790 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T378 114-116 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T379 163-168 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T380 169-171 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T381 259-262 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T382 343-345 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T383 363-369 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T384 432-436 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T385 484-485 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T386 496-500 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T387 652-653 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T388 742-744 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T161 85-92 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T162 528-535 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T163 596-603 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T164 644-651 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T23 437-446 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T228 0-152 Sentence denotes In an effort to help aide researchers and industry in China to combat 2019-nCoV, the protein sequence of the ACE2-Fc construct is provided ( Figure 2B).
T229 153-323 Sentence denotes Different human Fc domains (IgG1, IgG2, IgG3, or IgG4) could be contemplated, although IgG1 traditionally has the most potency for triggering anti-microbial responses 49.
T230 324-420 Sentence denotes Similarly, an ACE2-Fc biologic without active ACE2 peptidase function could be explored as well.
T231 421-623 Sentence denotes Given that gene synthesis of this sequence could happen within a week, the gene could be placed within the protein expression platform of choice shortly thereafter leading to protein production quickly.
T232 624-838 Sentence denotes The availability of protein A columns and other techniques in the industry to purify antibodies would facilitate ACE2-Fc to quickly be repurposed on existing antibody manufacturing infrastructure existing in China.