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PMC:7029759 / 33665-34936 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
897 425-429 Gene denotes ACE2 Gene:59272
898 490-494 Gene denotes ACE2 Gene:59272
899 612-616 Gene denotes ACE2 Gene:59272
900 829-833 Gene denotes ACE2 Gene:59272
901 1107-1111 Gene denotes ACE2 Gene:59272
902 53-62 Species denotes 2019-nCoV Tax:2697049
903 97-105 Species denotes patients Tax:9606
904 273-281 Species denotes patients Tax:9606
905 375-384 Species denotes 2019-nCoV Tax:2697049
906 602-610 Species denotes patients Tax:9606
907 972-977 Species denotes yeast Tax:4932
908 1262-1270 Species denotes patients Tax:9606
909 140-148 Disease denotes infected MESH:D007239
910 264-272 Disease denotes infected MESH:D007239
911 342-347 Disease denotes death MESH:D003643
912 495-505 Disease denotes deficiency MESH:D007153
913 510-521 Disease denotes lung injury MESH:D055370
914 593-601 Disease denotes infected MESH:D007239
915 959-962 CellLine denotes CHO CVCL:0213

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T708 53-62 SP_7 denotes 2019-nCoV
T707 117-128 NCBITaxon:1 denotes individuals
T706 284-294 CHEBI:23888;CHEBI:23888 denotes medication
T705 342-347 GO:0016265 denotes death
T704 375-384 SP_7 denotes 2019-nCoV
T703 425-429 G_3;PG_10;PR:000003622 denotes ACE2
T702 490-494 G_3;PG_10;PR:000003622 denotes ACE2
T701 510-514 UBERON:0002048 denotes lung
T700 527-532 NCBITaxon:10239 denotes virus
T699 557-563 UBERON:0002405 denotes immune
T698 564-572 CHEBI:35224;CHEBI:35224 denotes effector
T697 612-616 G_3;PG_10;PR:000003622 denotes ACE2
T696 829-833 G_3;PG_10;PR:000003622 denotes ACE2
T695 929-936 BV_20 denotes protein
T694 937-947 BV_20;GO:0010467 denotes expression
T693 964-970 NCBITaxon:6960 denotes insect
T692 1061-1065 SO:0000704 denotes Gene
T691 1107-1111 G_3;PG_10;PR:000003622 denotes ACE2

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T218 510-514 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T219 929-936 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T220 1061-1065 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T221 1122-1125 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T222 1129-1133 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T22 510-514 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T120 515-521 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T347 10-19 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T348 171-180 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T349 282-283 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T350 430-432 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T351 443-444 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T352 510-514 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T353 510-514 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T354 527-532 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T355 617-619 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T356 834-836 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T357 906-907 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T358 959-962 http://purl.obolibrary.org/obo/CLO_0002421 denotes CHO
T359 959-962 http://purl.obolibrary.org/obo/CLO_0052479 denotes CHO
T360 959-962 http://purl.obolibrary.org/obo/CLO_0052480 denotes CHO
T361 959-962 http://purl.obolibrary.org/obo/CLO_0052483 denotes CHO
T362 959-962 http://purl.obolibrary.org/obo/CLO_0052484 denotes CHO
T363 959-962 http://purl.obolibrary.org/obo/CLO_0052485 denotes CHO
T364 1061-1065 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T365 1112-1114 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T366 1120-1121 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T153 564-572 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T154 929-936 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T155 1122-1125 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T210 0-165 Sentence denotes The chief objective of global health efforts against 2019-nCoV remains to effectively quarantine patients and screen individuals who may be infected to limit spread.
T211 166-211 Sentence denotes That objective should continue going forward.
T212 212-394 Sentence denotes What is proposed here is an option to at least give infected patients a medication quickly to help alleviate symptoms and prevent death, while vaccine efforts for 2019-nCoV continue.
T213 395-585 Sentence denotes This could be enabled through ACE2-Fc providing a triple mechanism of action: (1) Treatment of ACE2 deficiency and lung injury, (2) virus neutralization, and (3) immune effector recruitment.
T214 586-698 Sentence denotes Beyond infected patients, ACE2-Fc could provide passive immunity to healthcare works at risk as another benefit.
T215 699-905 Sentence denotes Going forward, it is recommended that physicians, scientists, and biotech industry in China and elsewhere pursue manufacturing an ACE2-Fc biologic agent right now, which can immediately advance into trials.
T216 906-1060 Sentence denotes A variety of different protein expression platforms (CHO, insect, yeast) could be utilized, depending on the particular contract manufacturer’s expertise.
T217 1061-1271 Sentence denotes Gene therapy could even be considered to make ACE2-Fc from a DNA or mRNA platform, but would have additional risk of uncertain delivery strategies and ultimately may slow down progress toward treating patients.