PMC:7029759 / 31079-31417 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"805","span":{"begin":29,"end":32},"obj":"Gene"},{"id":"806","span":{"begin":126,"end":130},"obj":"Gene"},{"id":"808","span":{"begin":246,"end":261},"obj":"Species"},{"id":"809","span":{"begin":284,"end":319},"obj":"Species"},{"id":"816","span":{"begin":222,"end":225},"obj":"Species"}],"attributes":[{"id":"A805","pred":"tao:has_database_id","subj":"805","obj":"Gene:920"},{"id":"A806","pred":"tao:has_database_id","subj":"806","obj":"Gene:1234"},{"id":"A808","pred":"tao:has_database_id","subj":"808","obj":"Tax:9544"},{"id":"A809","pred":"tao:has_database_id","subj":"809","obj":"Tax:57667"},{"id":"A816","pred":"tao:has_database_id","subj":"816","obj":"Tax:12721"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T455","span":{"begin":29,"end":32},"obj":"PR:000001004"},{"id":"T454","span":{"begin":33,"end":36},"obj":"GO:0071735"},{"id":"T453","span":{"begin":126,"end":130},"obj":"PR:000001201"},{"id":"T452","span":{"begin":226,"end":234},"obj":"SO:0001060"},{"id":"T451","span":{"begin":246,"end":252},"obj":"NCBITaxon:9654"},{"id":"T450","span":{"begin":253,"end":261},"obj":"NCBITaxon:9539"},{"id":"T449","span":{"begin":284,"end":290},"obj":"NCBITaxon:10633"},{"id":"T448","span":{"begin":290,"end":291},"obj":"NCBITaxon:57667"},{"id":"T447","span":{"begin":291,"end":296},"obj":"SP_6;NCBITaxon:9606"},{"id":"T446","span":{"begin":314,"end":319},"obj":"NCBITaxon:10633"}],"text":"Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T199","span":{"begin":33,"end":36},"obj":"Body_part"},{"id":"T200","span":{"begin":222,"end":225},"obj":"Body_part"}],"attributes":[{"id":"A199","pred":"fma_id","subj":"T199","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A200","pred":"fma_id","subj":"T200","obj":"http://purl.org/sig/ont/fma/fma278683"}],"text":"Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p4588s25","span":{"begin":132,"end":141},"obj":"PosReg"},{"id":"p4588s26","span":{"begin":142,"end":150},"obj":"MPA"}],"text":"Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T113","span":{"begin":297,"end":313},"obj":"Disease"}],"attributes":[{"id":"A113","pred":"mondo_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/MONDO_0021094"}],"text":"Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T318","span":{"begin":29,"end":32},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T319","span":{"begin":80,"end":81},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T320","span":{"begin":88,"end":95},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T321","span":{"begin":192,"end":200},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T322","span":{"begin":246,"end":261},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9544"},{"id":"T323","span":{"begin":291,"end":296},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T324","span":{"begin":314,"end":319},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T325","span":{"begin":335,"end":337},"obj":"http://purl.obolibrary.org/obo/CLO_0054055"}],"text":"Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T141","span":{"begin":88,"end":95},"obj":"Chemical"}],"attributes":[{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"}],"text":"Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71."}

{"project":"LitCovid-sentences","denotations":[{"id":"T197","span":{"begin":0,"end":338},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T21","span":{"begin":297,"end":313},"obj":"Phenotype"}],"attributes":[{"id":"A21","pred":"hp_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/HP_0002721"}],"text":"Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71."}