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PMC:7029759 / 28494-30525 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
763 1888-1897 Species denotes 2019-nCoV Tax:2697049
745 235-239 Gene denotes ACE2 Gene:70008
746 335-339 Gene denotes ACE2 Gene:70008
747 635-639 Gene denotes CD16 Gene:2214
748 1012-1016 Gene denotes ACE2 Gene:59272
749 1485-1489 Gene denotes ACE2 Gene:59272
750 1532-1536 Gene denotes ACE2 Gene:59272
751 1619-1623 Gene denotes ACE2 Gene:59272
752 1805-1809 Gene denotes ACE2 Gene:59272
753 1969-1973 Gene denotes ACE2 Gene:59272
754 188-196 Species denotes patients Tax:9606
755 298-302 Species denotes mice Tax:10090
756 830-835 Species denotes mouse Tax:10090
757 1227-1236 Species denotes 2019-nCoV Tax:2697049
758 1412-1434 Species denotes human coronavirus NL63 Tax:277944
759 1479-1484 Species denotes human Tax:9606
760 1587-1596 Species denotes 2019-nCoV Tax:2697049
761 1745-1755 Species denotes SARS virus Tax:694009
762 1799-1804 Species denotes human Tax:9606
764 1470-1474 Species denotes NL63 Tax:277944
765 1508-1512 Species denotes NL63 Tax:277944
766 179-187 Disease denotes infected MESH:D007239
767 387-399 Disease denotes hypertension MESH:D006973
768 676-684 Disease denotes infected MESH:D007239
769 825-829 Disease denotes SARS MESH:D045169
770 903-907 Disease denotes SARS MESH:D045169
771 1155-1164 Disease denotes infection MESH:D007239
772 1386-1390 Disease denotes SARS MESH:D045169
773 1497-1501 Disease denotes SARS MESH:D045169
774 1554-1558 Disease denotes SARS MESH:D045169
775 1838-1847 Disease denotes infection MESH:D007239

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T515 24-30 SO:0000417 denotes domain
T514 69-73 CHEBI:23888;CHEBI:23888 denotes drug
T513 137-141 CHEBI:23888;CHEBI:23888 denotes drug
T512 235-239 G_3;PG_10;PR:000003622 denotes ACE2
T511 298-302 NCBITaxon:10088 denotes mice
T510 335-339 G_3;PG_10;PR:000003622 denotes ACE2
T509 472-480 CHEBI:35224;CHEBI:35224 denotes effector
T508 501-507 SO:0000417 denotes domain
T507 534-542 CHEBI:36357;CHEBI:36357 denotes molecule
T506 568-577 GO:0030425;CL:0000451 denotes dendritic
T505 578-583 CL:0000451 denotes cells
T504 585-596 CL:0000235 denotes macrophages
T503 602-622 CL:0000623 denotes natural killer cells
T502 635-639 PR:000001483 denotes CD16
T501 657-662 NCBITaxon:10239 denotes viral
T500 752-758 UBERON:0002405;GO:0006955 denotes immune
T499 759-767 GO:0006955 denotes response
T498 791-796 NCBITaxon:10239 denotes virus
T497 825-829 SP_10 denotes SARS
T496 830-835 NCBITaxon:10088 denotes mouse
T495 860-870 GO:0042571 denotes antibodies
T494 903-907 SP_10 denotes SARS
T493 912-925 GO:0001775 denotes activation of
T492 926-936 GO:0006909;CL:0000234 denotes phagocytic
T491 937-942 CL:0000234 denotes cells
T490 955-965 GO:0042571 denotes antibodies
T489 983-988 NCBITaxon:10239 denotes virus
T488 1012-1016 G_3;PG_10;PR:000003622 denotes ACE2
T487 1102-1110 GO:0042571 denotes antibody
T486 1227-1236 SP_7 denotes 2019-nCoV
T485 1369-1382 BV_19 denotes pathogenicity
T484 1386-1390 SP_10 denotes SARS
T483 1412-1417 SP_6;NCBITaxon:9606 denotes human
T482 1418-1429 NCBITaxon:11118 denotes coronavirus
T481 1479-1484 SP_6;NCBITaxon:9606;PG_10 denotes human
T480 1485-1489 PG_10;PR:000003622 denotes ACE2
T479 1497-1501 SP_10 denotes SARS
T478 1513-1522 PG_1 denotes S protein
T477 1532-1536 G_3;PG_10;PR:000003622 denotes ACE2
T476 1554-1558 SP_10;PG_9 denotes SARS
T475 1559-1560 PG_9;PG_1 denotes S
T474 1561-1568 PG_1 denotes protein
T473 1587-1596 SP_7 denotes 2019-nCoV
T472 1619-1623 G_3;PG_10;PR:000003622 denotes ACE2
T471 1703-1708 NCBITaxon:10239 denotes virus
T470 1745-1749 SP_10;NCBITaxon:10633 denotes SARS
T469 1750-1755 NCBITaxon:10239 denotes virus
T468 1799-1804 SP_6;NCBITaxon:9606;PG_10 denotes human
T467 1805-1809 PG_10;PR:000003622 denotes ACE2
T466 1888-1897 SP_7 denotes 2019-nCoV
T465 1969-1973 G_3;PG_10;PR:000003622 denotes ACE2

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T178 568-583 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T179 578-583 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T180 585-596 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T181 602-622 Body_part denotes natural killer cells http://purl.org/sig/ont/fma/fma63147
T182 617-622 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T183 685-690 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T184 937-942 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T185 1027-1034 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 1102-1110 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T187 1289-1296 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T188 1322-1326 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T189 1515-1522 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T190 1561-1568 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p4580s38 1537-1543 MPA denotes levels

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T103 387-399 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T104 825-829 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 903-907 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T106 1155-1164 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T107 1386-1390 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T108 1497-1501 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T109 1554-1558 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T110 1745-1749 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T111 1838-1847 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T276 21-23 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T277 43-44 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 321-322 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 340-342 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T280 354-355 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T281 498-500 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T282 568-583 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T283 602-622 http://purl.obolibrary.org/obo/CL_0000623 denotes natural killer cells
T284 685-690 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T285 719-729 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T286 791-796 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T287 823-824 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T288 830-835 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T289 848-850 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T290 912-922 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T291 926-936 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytic
T292 937-942 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T293 983-988 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T294 1017-1019 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T295 1075-1076 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T296 1135-1136 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T297 1322-1326 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T298 1345-1348 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T299 1412-1417 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T300 1450-1451 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T301 1479-1484 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T302 1685-1686 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T303 1703-1708 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T304 1750-1755 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T305 1799-1804 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T306 1948-1953 http://purl.obolibrary.org/obo/UBERON_0001456 denotes faced
T307 1974-1976 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T308 2001-2002 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T129 69-73 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T130 137-141 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T131 472-480 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T132 534-542 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T133 742-751 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T134 1027-1034 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T135 1289-1296 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T136 1515-1522 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T137 1561-1568 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T19 752-767 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T184 0-197 Sentence denotes The advantage of the Fc domain is endowing a longer-half life of the drug, which could enable healthcare workers to potentially be given drug doses prophylactically before seeing infected patients.
T185 198-403 Sentence denotes Indeed, the half-life of recombinant ACE2 was extended from less than two hours to over one week in mice when formatted as a recombinant ACE2-Fc therapy in a study evaluating treatment for hypertension 63.
T186 404-691 Sentence denotes One difference from the prior blocking agent strategies is that the effector functions of the Fc domain could be retained in this molecule, allowing recruitment of dendritic cells, macrophages, and natural killer cells through the CD16 receptor against viral particles or infected cells.
T187 692-998 Sentence denotes This may facilitate faster activation of the host antiviral immune response and elimination of the virus, which was illustrated in a SARS mouse model where Fc engaging antibodies were more potent in eliminating SARS via activation of phagocytic cells compared to antibodies that neutralized virus alone 64.
T188 999-1333 Sentence denotes Overall, the ACE2-Fc fusion protein would have many of the same benefits of a traditional neutralizing antibody that would be sought as a treatment for the infection, but represent one with maximal breadth and potency since the 2019-nCoV could not escape its neutralization, given the same protein is also its receptor for cell entry.
T189 1334-1572 Sentence denotes Indeed, it has been shown that the pathogenicity of SARS versus the more mild human coronavirus NL63 was related to a lower affinity of NL63 for human ACE2 versus SARS, with NL63 S protein reducing ACE2 levels less than SARS S protein 65.
T190 1573-1709 Sentence denotes Therefore, if 2019-nCoV were to try to escape ACE2 neutralization via decreasing affinity, it would mutate into a less pathogenic virus.
T191 1710-1881 Sentence denotes This is similar to the re-emergent SARS virus in 2003-2004, which had lower affinity for human ACE2 and resulted in less severe infection and no secondary transmission 66.
T192 1882-2031 Sentence denotes Thus, 2019-nCoV could be presented with an evolutionary trap when faced with potential ACE2-Fc therapy, leading toward a more benign clinical course.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T19 387-399 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T20 1831-1847 Phenotype denotes severe infection http://purl.obolibrary.org/obo/HP_0032169