PMC:7029759 / 27932-28493 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"705","span":{"begin":33,"end":37},"obj":"Gene"},{"id":"706","span":{"begin":165,"end":169},"obj":"Gene"},{"id":"707","span":{"begin":215,"end":219},"obj":"Gene"},{"id":"708","span":{"begin":255,"end":259},"obj":"Gene"},{"id":"709","span":{"begin":311,"end":315},"obj":"Gene"},{"id":"710","span":{"begin":59,"end":64},"obj":"Species"},{"id":"711","span":{"begin":305,"end":310},"obj":"Species"},{"id":"712","span":{"begin":372,"end":377},"obj":"Species"},{"id":"713","span":{"begin":488,"end":493},"obj":"Species"}],"attributes":[{"id":"A705","pred":"tao:has_database_id","subj":"705","obj":"Gene:59272"},{"id":"A706","pred":"tao:has_database_id","subj":"706","obj":"Gene:59272"},{"id":"A707","pred":"tao:has_database_id","subj":"707","obj":"Gene:59272"},{"id":"A708","pred":"tao:has_database_id","subj":"708","obj":"Gene:59272"},{"id":"A709","pred":"tao:has_database_id","subj":"709","obj":"Gene:59272"},{"id":"A710","pred":"tao:has_database_id","subj":"710","obj":"Tax:9606"},{"id":"A711","pred":"tao:has_database_id","subj":"711","obj":"Tax:9606"},{"id":"A712","pred":"tao:has_database_id","subj":"712","obj":"Tax:9606"},{"id":"A713","pred":"tao:has_database_id","subj":"713","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T754","span":{"begin":9,"end":22},"obj":"GO:0005576"},{"id":"T753","span":{"begin":23,"end":29},"obj":"SO:0000417"},{"id":"T752","span":{"begin":33,"end":37},"obj":"G_3;PG_10;PR:000003622"},{"id":"T751","span":{"begin":59,"end":64},"obj":"SP_6;NCBITaxon:9606"},{"id":"T750","span":{"begin":65,"end":79},"obj":"GO:0019814"},{"id":"T749","span":{"begin":83,"end":89},"obj":"SO:0000417"},{"id":"T748","span":{"begin":126,"end":132},"obj":"SO:0000417"},{"id":"T747","span":{"begin":145,"end":157},"obj":"GO:0046983"},{"id":"T746","span":{"begin":165,"end":169},"obj":"G_3;PG_10"},{"id":"T745","span":{"begin":170,"end":177},"obj":"SO:0000417"},{"id":"T744","span":{"begin":215,"end":219},"obj":"G_3;PG_10;PR:000003622"},{"id":"T743","span":{"begin":255,"end":259},"obj":"G_3;PG_10"},{"id":"T742","span":{"begin":260,"end":266},"obj":"SO:0000417"},{"id":"T741","span":{"begin":305,"end":310},"obj":"SP_6;NCBITaxon:9606;PG_10"},{"id":"T740","span":{"begin":311,"end":315},"obj":"PG_10;PR:000003622"},{"id":"T739","span":{"begin":372,"end":377},"obj":"SP_6;NCBITaxon:9606"},{"id":"T738","span":{"begin":378,"end":392},"obj":"GO:0019814"},{"id":"T737","span":{"begin":488,"end":493},"obj":"SP_6;NCBITaxon:9606"},{"id":"T736","span":{"begin":494,"end":506},"obj":"CHEBI:60816;CHEBI:60816"}],"text":"( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T172","span":{"begin":65,"end":79},"obj":"Body_part"},{"id":"T173","span":{"begin":188,"end":198},"obj":"Body_part"},{"id":"T174","span":{"begin":230,"end":237},"obj":"Body_part"},{"id":"T175","span":{"begin":279,"end":290},"obj":"Body_part"},{"id":"T176","span":{"begin":316,"end":323},"obj":"Body_part"},{"id":"T177","span":{"begin":378,"end":394},"obj":"Body_part"}],"attributes":[{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma62872"}],"text":"( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T263","span":{"begin":2,"end":3},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T264","span":{"begin":59,"end":64},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T265","span":{"begin":80,"end":82},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T266","span":{"begin":123,"end":125},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T267","span":{"begin":181,"end":182},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T268","span":{"begin":220,"end":222},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T269","span":{"begin":291,"end":293},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T270","span":{"begin":305,"end":310},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T271","span":{"begin":372,"end":377},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T272","span":{"begin":462,"end":463},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T273","span":{"begin":474,"end":480},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T274","span":{"begin":486,"end":487},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T275","span":{"begin":488,"end":493},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"text":"( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T121","span":{"begin":188,"end":198},"obj":"Chemical"},{"id":"T122","span":{"begin":188,"end":193},"obj":"Chemical"},{"id":"T123","span":{"begin":194,"end":198},"obj":"Chemical"},{"id":"T124","span":{"begin":230,"end":237},"obj":"Chemical"},{"id":"T125","span":{"begin":279,"end":290},"obj":"Chemical"},{"id":"T126","span":{"begin":279,"end":284},"obj":"Chemical"},{"id":"T127","span":{"begin":285,"end":290},"obj":"Chemical"},{"id":"T128","span":{"begin":316,"end":323},"obj":"Chemical"}],"attributes":[{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T18","span":{"begin":464,"end":473},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T179","span":{"begin":0,"end":118},"obj":"Sentence"},{"id":"T180","span":{"begin":119,"end":250},"obj":"Sentence"},{"id":"T181","span":{"begin":251,"end":351},"obj":"Sentence"},{"id":"T182","span":{"begin":352,"end":461},"obj":"Sentence"},{"id":"T183","span":{"begin":462,"end":561},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}