PMC:7029759 / 27840-28493 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"694","span":{"begin":25,"end":29},"obj":"Gene"},{"id":"695","span":{"begin":69,"end":90},"obj":"Species"},{"id":"705","span":{"begin":125,"end":129},"obj":"Gene"},{"id":"706","span":{"begin":257,"end":261},"obj":"Gene"},{"id":"707","span":{"begin":307,"end":311},"obj":"Gene"},{"id":"708","span":{"begin":347,"end":351},"obj":"Gene"},{"id":"709","span":{"begin":403,"end":407},"obj":"Gene"},{"id":"710","span":{"begin":151,"end":156},"obj":"Species"},{"id":"711","span":{"begin":397,"end":402},"obj":"Species"},{"id":"712","span":{"begin":464,"end":469},"obj":"Species"},{"id":"713","span":{"begin":580,"end":585},"obj":"Species"}],"attributes":[{"id":"A694","pred":"tao:has_database_id","subj":"694","obj":"Gene:59272"},{"id":"A695","pred":"tao:has_database_id","subj":"695","obj":"Tax:2697049"},{"id":"A705","pred":"tao:has_database_id","subj":"705","obj":"Gene:59272"},{"id":"A706","pred":"tao:has_database_id","subj":"706","obj":"Gene:59272"},{"id":"A707","pred":"tao:has_database_id","subj":"707","obj":"Gene:59272"},{"id":"A708","pred":"tao:has_database_id","subj":"708","obj":"Gene:59272"},{"id":"A709","pred":"tao:has_database_id","subj":"709","obj":"Gene:59272"},{"id":"A710","pred":"tao:has_database_id","subj":"710","obj":"Tax:9606"},{"id":"A711","pred":"tao:has_database_id","subj":"711","obj":"Tax:9606"},{"id":"A712","pred":"tao:has_database_id","subj":"712","obj":"Tax:9606"},{"id":"A713","pred":"tao:has_database_id","subj":"713","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T757","span":{"begin":25,"end":29},"obj":"G_3;PG_10;PR:000003622"},{"id":"T756","span":{"begin":69,"end":78},"obj":"SP_7"},{"id":"T755","span":{"begin":79,"end":90},"obj":"NCBITaxon:11118"},{"id":"T754","span":{"begin":101,"end":114},"obj":"GO:0005576"},{"id":"T753","span":{"begin":115,"end":121},"obj":"SO:0000417"},{"id":"T752","span":{"begin":125,"end":129},"obj":"G_3;PG_10;PR:000003622"},{"id":"T751","span":{"begin":151,"end":156},"obj":"SP_6;NCBITaxon:9606"},{"id":"T750","span":{"begin":157,"end":171},"obj":"GO:0019814"},{"id":"T749","span":{"begin":175,"end":181},"obj":"SO:0000417"},{"id":"T748","span":{"begin":218,"end":224},"obj":"SO:0000417"},{"id":"T747","span":{"begin":237,"end":249},"obj":"GO:0046983"},{"id":"T746","span":{"begin":257,"end":261},"obj":"G_3;PG_10"},{"id":"T745","span":{"begin":262,"end":269},"obj":"SO:0000417"},{"id":"T744","span":{"begin":307,"end":311},"obj":"G_3;PG_10;PR:000003622"},{"id":"T743","span":{"begin":347,"end":351},"obj":"G_3;PG_10"},{"id":"T742","span":{"begin":352,"end":358},"obj":"SO:0000417"},{"id":"T741","span":{"begin":397,"end":402},"obj":"SP_6;NCBITaxon:9606;PG_10"},{"id":"T740","span":{"begin":403,"end":407},"obj":"PG_10;PR:000003622"},{"id":"T739","span":{"begin":464,"end":469},"obj":"SP_6;NCBITaxon:9606"},{"id":"T738","span":{"begin":470,"end":484},"obj":"GO:0019814"},{"id":"T737","span":{"begin":580,"end":585},"obj":"SP_6;NCBITaxon:9606"},{"id":"T736","span":{"begin":586,"end":598},"obj":"CHEBI:60816;CHEBI:60816"}],"text":"TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T171","span":{"begin":40,"end":47},"obj":"Body_part"},{"id":"T172","span":{"begin":157,"end":171},"obj":"Body_part"},{"id":"T173","span":{"begin":280,"end":290},"obj":"Body_part"},{"id":"T174","span":{"begin":322,"end":329},"obj":"Body_part"},{"id":"T175","span":{"begin":371,"end":382},"obj":"Body_part"},{"id":"T176","span":{"begin":408,"end":415},"obj":"Body_part"},{"id":"T177","span":{"begin":470,"end":486},"obj":"Body_part"}],"attributes":[{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma62872"}],"text":"TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T261","span":{"begin":30,"end":32},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T262","span":{"begin":51,"end":52},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T263","span":{"begin":94,"end":95},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T264","span":{"begin":151,"end":156},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T265","span":{"begin":172,"end":174},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T266","span":{"begin":215,"end":217},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T267","span":{"begin":273,"end":274},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T268","span":{"begin":312,"end":314},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T269","span":{"begin":383,"end":385},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T270","span":{"begin":397,"end":402},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T271","span":{"begin":464,"end":469},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T272","span":{"begin":554,"end":555},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T273","span":{"begin":566,"end":572},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T274","span":{"begin":578,"end":579},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T275","span":{"begin":580,"end":585},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"text":"TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T120","span":{"begin":40,"end":47},"obj":"Chemical"},{"id":"T121","span":{"begin":280,"end":290},"obj":"Chemical"},{"id":"T122","span":{"begin":280,"end":285},"obj":"Chemical"},{"id":"T123","span":{"begin":286,"end":290},"obj":"Chemical"},{"id":"T124","span":{"begin":322,"end":329},"obj":"Chemical"},{"id":"T125","span":{"begin":371,"end":382},"obj":"Chemical"},{"id":"T126","span":{"begin":371,"end":376},"obj":"Chemical"},{"id":"T127","span":{"begin":377,"end":382},"obj":"Chemical"},{"id":"T128","span":{"begin":408,"end":415},"obj":"Chemical"}],"attributes":[{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T18","span":{"begin":556,"end":565},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T178","span":{"begin":0,"end":91},"obj":"Sentence"},{"id":"T179","span":{"begin":92,"end":210},"obj":"Sentence"},{"id":"T180","span":{"begin":211,"end":342},"obj":"Sentence"},{"id":"T181","span":{"begin":343,"end":443},"obj":"Sentence"},{"id":"T182","span":{"begin":444,"end":553},"obj":"Sentence"},{"id":"T183","span":{"begin":554,"end":653},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}