PMC:7029759 / 27829-28493 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"694","span":{"begin":36,"end":40},"obj":"Gene"},{"id":"695","span":{"begin":80,"end":101},"obj":"Species"},{"id":"705","span":{"begin":136,"end":140},"obj":"Gene"},{"id":"706","span":{"begin":268,"end":272},"obj":"Gene"},{"id":"707","span":{"begin":318,"end":322},"obj":"Gene"},{"id":"708","span":{"begin":358,"end":362},"obj":"Gene"},{"id":"709","span":{"begin":414,"end":418},"obj":"Gene"},{"id":"710","span":{"begin":162,"end":167},"obj":"Species"},{"id":"711","span":{"begin":408,"end":413},"obj":"Species"},{"id":"712","span":{"begin":475,"end":480},"obj":"Species"},{"id":"713","span":{"begin":591,"end":596},"obj":"Species"}],"attributes":[{"id":"A694","pred":"tao:has_database_id","subj":"694","obj":"Gene:59272"},{"id":"A695","pred":"tao:has_database_id","subj":"695","obj":"Tax:2697049"},{"id":"A705","pred":"tao:has_database_id","subj":"705","obj":"Gene:59272"},{"id":"A706","pred":"tao:has_database_id","subj":"706","obj":"Gene:59272"},{"id":"A707","pred":"tao:has_database_id","subj":"707","obj":"Gene:59272"},{"id":"A708","pred":"tao:has_database_id","subj":"708","obj":"Gene:59272"},{"id":"A709","pred":"tao:has_database_id","subj":"709","obj":"Gene:59272"},{"id":"A710","pred":"tao:has_database_id","subj":"710","obj":"Tax:9606"},{"id":"A711","pred":"tao:has_database_id","subj":"711","obj":"Tax:9606"},{"id":"A712","pred":"tao:has_database_id","subj":"712","obj":"Tax:9606"},{"id":"A713","pred":"tao:has_database_id","subj":"713","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Figure 2. TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T757","span":{"begin":36,"end":40},"obj":"G_3;PG_10;PR:000003622"},{"id":"T756","span":{"begin":80,"end":89},"obj":"SP_7"},{"id":"T755","span":{"begin":90,"end":101},"obj":"NCBITaxon:11118"},{"id":"T754","span":{"begin":112,"end":125},"obj":"GO:0005576"},{"id":"T753","span":{"begin":126,"end":132},"obj":"SO:0000417"},{"id":"T752","span":{"begin":136,"end":140},"obj":"G_3;PG_10;PR:000003622"},{"id":"T751","span":{"begin":162,"end":167},"obj":"SP_6;NCBITaxon:9606"},{"id":"T750","span":{"begin":168,"end":182},"obj":"GO:0019814"},{"id":"T749","span":{"begin":186,"end":192},"obj":"SO:0000417"},{"id":"T748","span":{"begin":229,"end":235},"obj":"SO:0000417"},{"id":"T747","span":{"begin":248,"end":260},"obj":"GO:0046983"},{"id":"T746","span":{"begin":268,"end":272},"obj":"G_3;PG_10"},{"id":"T745","span":{"begin":273,"end":280},"obj":"SO:0000417"},{"id":"T744","span":{"begin":318,"end":322},"obj":"G_3;PG_10;PR:000003622"},{"id":"T743","span":{"begin":358,"end":362},"obj":"G_3;PG_10"},{"id":"T742","span":{"begin":363,"end":369},"obj":"SO:0000417"},{"id":"T741","span":{"begin":408,"end":413},"obj":"SP_6;NCBITaxon:9606;PG_10"},{"id":"T740","span":{"begin":414,"end":418},"obj":"PG_10;PR:000003622"},{"id":"T739","span":{"begin":475,"end":480},"obj":"SP_6;NCBITaxon:9606"},{"id":"T738","span":{"begin":481,"end":495},"obj":"GO:0019814"},{"id":"T737","span":{"begin":591,"end":596},"obj":"SP_6;NCBITaxon:9606"},{"id":"T736","span":{"begin":597,"end":609},"obj":"CHEBI:60816;CHEBI:60816"}],"text":"Figure 2. TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T171","span":{"begin":51,"end":58},"obj":"Body_part"},{"id":"T172","span":{"begin":168,"end":182},"obj":"Body_part"},{"id":"T173","span":{"begin":291,"end":301},"obj":"Body_part"},{"id":"T174","span":{"begin":333,"end":340},"obj":"Body_part"},{"id":"T175","span":{"begin":382,"end":393},"obj":"Body_part"},{"id":"T176","span":{"begin":419,"end":426},"obj":"Body_part"},{"id":"T177","span":{"begin":481,"end":497},"obj":"Body_part"}],"attributes":[{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma62872"}],"text":"Figure 2. TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T261","span":{"begin":41,"end":43},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T262","span":{"begin":62,"end":63},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T263","span":{"begin":105,"end":106},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T264","span":{"begin":162,"end":167},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T265","span":{"begin":183,"end":185},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T266","span":{"begin":226,"end":228},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T267","span":{"begin":284,"end":285},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T268","span":{"begin":323,"end":325},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T269","span":{"begin":394,"end":396},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T270","span":{"begin":408,"end":413},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T271","span":{"begin":475,"end":480},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T272","span":{"begin":565,"end":566},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T273","span":{"begin":577,"end":583},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T274","span":{"begin":589,"end":590},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T275","span":{"begin":591,"end":596},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"text":"Figure 2. TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T120","span":{"begin":51,"end":58},"obj":"Chemical"},{"id":"T121","span":{"begin":291,"end":301},"obj":"Chemical"},{"id":"T122","span":{"begin":291,"end":296},"obj":"Chemical"},{"id":"T123","span":{"begin":297,"end":301},"obj":"Chemical"},{"id":"T124","span":{"begin":333,"end":340},"obj":"Chemical"},{"id":"T125","span":{"begin":382,"end":393},"obj":"Chemical"},{"id":"T126","span":{"begin":382,"end":387},"obj":"Chemical"},{"id":"T127","span":{"begin":388,"end":393},"obj":"Chemical"},{"id":"T128","span":{"begin":419,"end":426},"obj":"Chemical"}],"attributes":[{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Figure 2. TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T18","span":{"begin":567,"end":576},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"Figure 2. TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T177","span":{"begin":0,"end":9},"obj":"Sentence"},{"id":"T178","span":{"begin":11,"end":102},"obj":"Sentence"},{"id":"T179","span":{"begin":103,"end":221},"obj":"Sentence"},{"id":"T180","span":{"begin":222,"end":353},"obj":"Sentence"},{"id":"T181","span":{"begin":354,"end":454},"obj":"Sentence"},{"id":"T182","span":{"begin":455,"end":564},"obj":"Sentence"},{"id":"T183","span":{"begin":565,"end":664},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 2. TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.\n( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region. The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided. The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1). The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857). A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39)."}