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PMC:7029759 / 26888-27828 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
673 93-97 Gene denotes ACE2 Gene:59272
674 192-196 Gene denotes ACE2 Gene:59272
675 326-330 Gene denotes ACE2 Gene:59272
676 405-409 Gene denotes ACE2 Gene:59272
677 597-601 Gene denotes ACE2 Gene:59272
678 677-681 Gene denotes ACE2 Gene:59272
679 780-784 Gene denotes ACE2 Gene:59272
680 848-852 Gene denotes ACE2 Gene:59272
681 747-748 Gene denotes S Gene:43740568
682 633-634 Gene denotes S Gene:43740568
683 25-34 Species denotes 2019-nCoV Tax:2697049
684 35-43 Species denotes patients Tax:9606
685 117-122 Species denotes human Tax:9606
686 623-632 Species denotes 2019-nCoV Tax:2697049
687 737-746 Species denotes 2019-nCoV Tax:2697049
688 885-895 Species denotes SARS virus Tax:694009
689 914-923 Species denotes 2019-nCoV Tax:2697049
690 246-250 Disease denotes SARS MESH:D045169
691 535-546 Disease denotes lung injury MESH:D055370

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T546 25-34 SP_7 denotes 2019-nCoV
T545 65-78 GO:0005576 denotes extracellular
T544 79-85 SO:0000417 denotes domain
T543 93-97 G_3;PG_10;PR:000003622 denotes ACE2
T542 117-122 SP_6;NCBITaxon:9606 denotes human
T541 123-137 GO:0019814 denotes immunoglobulin
T540 143-149 SO:0000417 denotes domain
T539 192-196 G_3;PG_10;PR:000003622 denotes ACE2
T538 246-250 SP_10;PG_9 denotes SARS
T537 251-252 PG_9;PG_1 denotes S
T536 253-260 PG_1 denotes protein
T535 305-311 SO:0000417 denotes domain
T534 326-330 G_3;PG_10;PR:000003622 denotes ACE2
T533 391-404 GO:0005576 denotes extracellular
T532 405-409 G_3;PG_10 denotes ACE2
T531 410-416 SO:0000417 denotes domain
T530 439-448 PG_1 denotes S protein
T529 535-539 UBERON:0002048 denotes lung
T528 597-601 G_3;PG_10 denotes ACE2
T527 602-608 SO:0000417 denotes domain
T526 623-632 SP_7 denotes 2019-nCoV
T525 633-642 PG_1 denotes S protein
T524 677-681 G_3;PG_10;PR:000003622 denotes ACE2
T523 737-746 SP_7 denotes 2019-nCoV
T522 747-756 PG_1 denotes S protein
T521 780-784 G_3;PG_10;PR:000003622 denotes ACE2
T520 848-852 G_3;PG_10;PR:000003622 denotes ACE2
T519 861-868 SO:0000417 denotes domains
T518 885-889 SP_10;NCBITaxon:10633 denotes SARS
T517 890-895 NCBITaxon:10239 denotes virus
T516 914-923 SP_7 denotes 2019-nCoV

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T160 98-105 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T161 123-139 Body_part denotes immunoglobulin G http://purl.org/sig/ont/fma/fma62872
T162 197-208 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T163 253-260 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T164 441-448 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T165 535-539 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T166 635-642 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T167 685-693 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T168 749-756 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T169 853-860 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T170 934-939 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T19 535-539 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T100 246-250 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 540-546 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T102 885-889 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T248 115-116 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T249 117-122 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T250 140-142 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T251 159-161 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2A
T252 209-211 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T253 366-367 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T254 467-468 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T255 503-511 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T256 535-539 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T257 535-539 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T258 682-684 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T259 890-895 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T260 934-939 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T110 98-105 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T111 197-208 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T112 197-202 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T113 203-208 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T114 253-260 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T115 441-448 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T116 635-642 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T117 685-693 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T118 749-756 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T119 853-860 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T172 0-163 Sentence denotes The proposed therapy for 2019-nCoV patients would consist of the extracellular domain of the ACE2 protein fused to a human immunoglobulin G Fc domain ( Figure 2A).
T173 164-350 Sentence denotes Studies have shown that the ACE2 amino acids 18 – 615 appear to be sufficient for SARS S protein binding 62, which also covers the peptidase domain necessary for ACE2 enzymatic function.
T174 351-547 Sentence denotes It is possible a smaller portion of the extracellular ACE2 domain would be adequate for S protein binding, although a smaller version would lack enzyme activity beneficial in treating lung injury.
T175 548-694 Sentence denotes Further studies are needed to define the minimal ACE2 domain necessary for 2019-nCoV S protein binding to construct even smaller ACE2-Fc proteins.
T176 695-940 Sentence denotes While we do not know the structure of the 2019-nCoV S protein or how it binds to the ACE2 receptor yet, it is reasonable for now to assume that the same ACE2 protein domains utilized by the SARS virus are also bound by 2019-nCoV to infect cells.