> top > docs > PMC:7029759 > spans > 25424-26887 > annotations

PMC:7029759 / 25424-26887 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
615 33-37 Gene denotes ACE2 Gene:59272
616 90-94 Gene denotes ACE2 Gene:59272
617 396-400 Gene denotes ACE2 Gene:59272
618 422-426 Gene denotes ACE2 Gene:59272
619 539-543 Gene denotes ACE2 Gene:59272
620 615-629 Gene denotes angiotensin II Gene:183
621 724-728 Gene denotes ACE2 Gene:59272
622 888-892 Gene denotes ACE2 Gene:59272
623 1154-1160 Gene denotes Ang1-8 Gene:284
624 1397-1401 Gene denotes ACE2 Gene:59272
625 53-54 Gene denotes S Gene:43740568
626 43-52 Species denotes 2019-nCoV Tax:2697049
627 180-188 Species denotes patients Tax:9606
628 753-780 Species denotes respiratory syncytial virus Tax:12814
629 788-792 Species denotes H5N1 Tax:102793
630 882-887 Species denotes human Tax:9606
631 974-982 Species denotes patients Tax:9606
632 1444-1453 Species denotes 2019-nCoV Tax:2697049
633 1454-1462 Species denotes patients Tax:9606
634 793-802 Species denotes influenza Tax:11320
635 1220-1231 Species denotes respiratory Tax:12814
636 894-900 Chemical denotes rhACE2
637 1013-1019 Chemical denotes rhACE2
638 1277-1283 Chemical denotes rhACE2
639 140-149 Disease denotes pneumonia MESH:D011014
640 194-198 Disease denotes SARS MESH:D045169
641 203-222 Disease denotes 2019-nCoV infection MESH:C000657245
642 231-240 Disease denotes pneumonia MESH:D011014
643 268-283 Disease denotes pulmonary edema MESH:D011654
644 288-323 Disease denotes acute respiratory distress syndrome MESH:D012128
645 325-329 Disease denotes ARDS MESH:D012128
646 369-373 Disease denotes ARDS MESH:D012128
647 584-595 Disease denotes lung injury MESH:D055370
648 745-749 Disease denotes ARDS MESH:D012128
649 806-815 Disease denotes infection MESH:D007239
650 951-955 Disease denotes ARDS MESH:D012128
651 959-973 Disease denotes critically ill MESH:D016638
652 1342-1346 Disease denotes ARDS MESH:D012128
653 1436-1440 Disease denotes ARDS MESH:D012128

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T569 382-387 NCBITaxon:10239 denotes viral
T568 396-400 G_3;PG_10;PR:000003622 denotes ACE2
T567 422-426 G_3;PG_10;PR:000003622 denotes ACE2
T566 445-455 GO:0010467 denotes expression
T565 487-496 PG_1 denotes S protein
T564 539-543 G_3;PG_10;PR:000003622 denotes ACE2
T563 584-588 UBERON:0002048 denotes lung
T562 615-629 PR:000036009;DG_37 denotes angiotensin II
T561 676-690 DG_37;PR:000001251 denotes angiotensin II
T560 691-707 PR:000001251 denotes type 1a receptor
T559 724-728 G_3;PG_10;PR:000003622 denotes ACE2
T558 753-764 UBERON:0001004;NCBITaxon:12814 denotes respiratory
T557 765-774 NCBITaxon:12814 denotes syncytial
T556 775-780 NCBITaxon:10239 denotes virus
T555 882-887 SP_6;NCBITaxon:9606;PG_10 denotes human
T554 888-892 PG_10;PR:000003622 denotes ACE2
T553 1067-1088 UBERON:0004535 denotes cardiovascular system
T552 1154-1158 PR:000004020 denotes Ang1
T551 1206-1216 GO:0065007 denotes modulation
T550 1220-1231 UBERON:0001004 denotes respiratory
T549 1370-1376 NCBITaxon:33208 denotes animal
T548 1397-1401 G_3;PG_10;PR:000003622 denotes ACE2
T547 1444-1453 SP_7 denotes 2019-nCoV
T578 33-37 G_3;PG_10;PR:000003622 denotes ACE2
T577 43-52 SP_7 denotes 2019-nCoV
T576 53-62 PG_1 denotes S protein
T575 90-94 G_3;PG_10;PR:000003622 denotes ACE2
T574 194-198 SP_10 denotes SARS
T573 203-212 SP_7 denotes 2019-nCoV
T572 268-277 UBERON:0002048 denotes pulmonary
T571 294-305 UBERON:0001004 denotes respiratory
T570 341-348 NCBITaxon:10239 denotes viruses

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T152 55-62 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T153 401-408 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T154 427-434 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T155 489-496 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T156 544-551 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T157 584-588 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T158 645-653 Body_part denotes hormones http://purl.org/sig/ont/fma/fma12278
T159 1067-1088 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T17 584-588 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T18 1067-1088 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p4551s19 435-444 NegReg denotes decreased
p4551s20 445-455 MPA denotes expression

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T81 140-149 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T82 194-198 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T83 203-222 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T84 213-222 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T85 231-240 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T86 268-283 Disease denotes pulmonary edema http://purl.obolibrary.org/obo/MONDO_0006932
T87 288-323 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T88 294-323 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T89 325-329 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T90 369-373 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T91 578-595 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T93 589-595 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T94 745-749 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T95 793-802 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T96 806-815 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T97 951-955 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T98 1342-1346 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T99 1436-1440 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T232 41-42 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 167-168 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T234 341-348 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T235 552-555 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T236 584-588 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T237 584-588 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T238 775-780 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T239 882-887 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T240 984-985 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T241 1067-1088 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system
T242 1067-1088 http://www.ebi.ac.uk/efo/EFO_0000791 denotes cardiovascular system
T243 1093-1094 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T244 1161-1168 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T245 1299-1302 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T246 1370-1376 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T247 1402-1404 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T92 55-62 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T93 401-408 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T94 427-434 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T95 489-496 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T96 544-551 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T97 615-629 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T100 615-626 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T101 627-629 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T102 645-653 Chemical denotes hormones http://purl.obolibrary.org/obo/CHEBI_24621
T103 676-690 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T106 676-687 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T107 688-690 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T108 1101-1103 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T109 1161-1168 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T163 0-166 Sentence denotes An additional advantage of using ACE2 as a 2019-nCoV S protein neutralizing agent is that ACE2 administration could also directly treat the pneumonia pathophysiology.
T164 167-336 Sentence denotes A portion of patients with SARS and 2019-nCoV infection develop pneumonia, which is characterized by pulmonary edema and acute respiratory distress syndrome (ARDS) 1, 2.
T165 337-508 Sentence denotes The viruses may, in part, cause ARDS through viral-induced ACE2 protein shedding and ACE2 protein decreased expression, both of which are mediated by S protein binding 54.
T166 509-711 Sentence denotes Administration of recombinant ACE2 protein has been shown to improve acute lung injury through decreasing angiotensin II levels and the hormones subsequent binding to angiotensin II type 1a receptor 57.
T167 712-823 Sentence denotes Recombinant ACE2 can also reduce ARDS in respiratory syncytial virus 58 and H5N1 influenza 59 infection models.
T168 824-983 Sentence denotes Based on these promising preclinical studies, recombinant human ACE2 (rhACE2) was moved into clinical trials in order to treat ARDS in critically ill patients.
T169 984-1092 Sentence denotes A phase I trial demonstrated rhACE2 was well tolerated with no effects seen on the cardiovascular system 60.
T170 1093-1246 Sentence denotes A phase II trial demonstrated on-target efficacy in reducing Ang1-8 peptide levels, but did not show significant modulation of respiratory parameters 61.
T171 1247-1463 Sentence denotes It remains to be seen whether rhACE2 administration has the same clinical benefits in treating ARDS that have been seen in animal models, and whether ACE2-Fc administration could alleviate ARDS in 2019-nCoV patients.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T14 140-149 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T15 231-240 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T16 268-283 Phenotype denotes pulmonary edema http://purl.obolibrary.org/obo/HP_0100598
T17 294-314 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T18 578-595 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320