PMC:7029759 / 25055-25304 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"559","span":{"begin":75,"end":79},"obj":"Gene"},{"id":"560","span":{"begin":133,"end":137},"obj":"Gene"},{"id":"570","span":{"begin":175,"end":191},"obj":"Species"},{"id":"573","span":{"begin":114,"end":119},"obj":"Species"}],"attributes":[{"id":"A559","pred":"tao:has_database_id","subj":"559","obj":"Gene:59272"},{"id":"A560","pred":"tao:has_database_id","subj":"560","obj":"Gene:59272"},{"id":"A570","pred":"tao:has_database_id","subj":"570","obj":"Tax:694009"},{"id":"A573","pred":"tao:has_database_id","subj":"573","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"While not tested in an animal model, a previous study demonstrated that an ACE2 extracellular domain fused to the human IgG1 domain (ACE2-NN-Ig) was effective in neutralizing SARS coronavirus in vitro, with a 50% inhibitory concentration of 2 nM 56."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T589","span":{"begin":23,"end":29},"obj":"NCBITaxon:33208"},{"id":"T588","span":{"begin":75,"end":79},"obj":"G_3;PG_10;PR:000003622"},{"id":"T587","span":{"begin":80,"end":93},"obj":"GO:0005576"},{"id":"T586","span":{"begin":94,"end":100},"obj":"SO:0000417"},{"id":"T585","span":{"begin":114,"end":119},"obj":"SP_6;NCBITaxon:9606"},{"id":"T584","span":{"begin":125,"end":131},"obj":"SO:0000417"},{"id":"T583","span":{"begin":133,"end":137},"obj":"G_3;PG_10;PR:000003622"},{"id":"T582","span":{"begin":175,"end":179},"obj":"SP_10"},{"id":"T581","span":{"begin":180,"end":191},"obj":"NCBITaxon:11118"}],"text":"While not tested in an animal model, a previous study demonstrated that an ACE2 extracellular domain fused to the human IgG1 domain (ACE2-NN-Ig) was effective in neutralizing SARS coronavirus in vitro, with a 50% inhibitory concentration of 2 nM 56."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T79","span":{"begin":138,"end":140},"obj":"Disease"},{"id":"T80","span":{"begin":175,"end":179},"obj":"Disease"}],"attributes":[{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0009747"},{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"While not tested in an animal model, a previous study demonstrated that an ACE2 extracellular domain fused to the human IgG1 domain (ACE2-NN-Ig) was effective in neutralizing SARS coronavirus in vitro, with a 50% inhibitory concentration of 2 nM 56."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T226","span":{"begin":10,"end":16},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T227","span":{"begin":23,"end":29},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T228","span":{"begin":37,"end":38},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T229","span":{"begin":114,"end":119},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T230","span":{"begin":207,"end":208},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"While not tested in an animal model, a previous study demonstrated that an ACE2 extracellular domain fused to the human IgG1 domain (ACE2-NN-Ig) was effective in neutralizing SARS coronavirus in vitro, with a 50% inhibitory concentration of 2 nM 56."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T91","span":{"begin":138,"end":140},"obj":"Chemical"}],"attributes":[{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_73406"}],"text":"While not tested in an animal model, a previous study demonstrated that an ACE2 extracellular domain fused to the human IgG1 domain (ACE2-NN-Ig) was effective in neutralizing SARS coronavirus in vitro, with a 50% inhibitory concentration of 2 nM 56."}

{"project":"LitCovid-sentences","denotations":[{"id":"T161","span":{"begin":0,"end":249},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"While not tested in an animal model, a previous study demonstrated that an ACE2 extracellular domain fused to the human IgG1 domain (ACE2-NN-Ig) was effective in neutralizing SARS coronavirus in vitro, with a 50% inhibitory concentration of 2 nM 56."}