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PMC:7029759 / 24007-25423 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
552 241-245 Gene denotes ACE2 Gene:59272
553 440-444 Gene denotes ACE2 Gene:59272
554 564-568 Gene denotes ACE2 Gene:59272
555 725-729 Gene denotes ACE2 Gene:59272
556 747-751 Gene denotes ACE2 Gene:59272
557 825-829 Gene denotes ACE2 Gene:59272
558 897-901 Gene denotes ACE2 Gene:59272
559 1123-1127 Gene denotes ACE2 Gene:59272
560 1181-1185 Gene denotes ACE2 Gene:59272
561 1337-1341 Gene denotes ACE2 Gene:59272
562 582-583 Gene denotes S Gene:43740568
563 278-279 Gene denotes S Gene:43740568
564 106-117 Species denotes coronavirus Tax:11118
565 291-300 Species denotes 2019-nCoV Tax:2697049
566 372-382 Species denotes SARS virus Tax:694009
567 484-494 Species denotes SARS virus Tax:694009
568 690-699 Species denotes 2019-nCoV Tax:2697049
569 774-782 Species denotes patients Tax:9606
570 1223-1239 Species denotes SARS coronavirus Tax:694009
571 1369-1378 Species denotes 2019-nCoV Tax:2697049
572 1407-1415 Species denotes patients Tax:9606
573 1162-1167 Species denotes human Tax:9606
574 165-173 Disease denotes infected MESH:D007239
575 577-581 Disease denotes SARS MESH:D045169

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T618 60-68 GO:0042571 denotes antibody
T617 74-82 CHEBI:36357;CHEBI:36357 denotes molecule
T616 106-117 NCBITaxon:11118 denotes coronavirus
T615 241-245 G_3;PG_10;PR:000003622 denotes ACE2
T614 278-287 PG_1 denotes S protein
T613 291-300 SP_7 denotes 2019-nCoV
T612 326-331 NCBITaxon:10239 denotes virus
T611 372-376 SP_10;NCBITaxon:10633 denotes SARS
T610 377-382 NCBITaxon:10239 denotes virus
T609 440-444 G_3;PG_10;PR:000003622 denotes ACE2
T608 484-488 SP_10;NCBITaxon:10633 denotes SARS
T607 489-494 NCBITaxon:10239 denotes virus
T606 564-568 G_3;PG_10;PR:000003622 denotes ACE2
T605 577-581 SP_10;PG_9 denotes SARS
T604 582-583 PG_9;PG_1 denotes S
T603 584-591 PG_1 denotes protein
T602 657-667 GO:0042571 denotes antibodies
T601 690-699 SP_7 denotes 2019-nCoV
T600 725-729 G_3;PG_10;PR:000003622 denotes ACE2
T599 747-751 G_3;PG_10;PR:000003622 denotes ACE2
T598 825-829 G_3;PG_10;PR:000003622 denotes ACE2
T597 871-885 GO:0019814 denotes immunoglobulin
T596 889-895 SO:0000417 denotes domain
T595 897-901 G_3;PG_10;PR:000003622 denotes ACE2
T594 929-937 UBERON:0000104 denotes lifespan
T593 957-965 CHEBI:36357;CHEBI:36357 denotes molecule
T592 989-997 CHEBI:35224;CHEBI:35224 denotes effector
T591 1015-1028 UBERON:0002405 denotes immune system
T590 1041-1046 NCBITaxon:10239 denotes virus
T589 1071-1077 NCBITaxon:33208 denotes animal
T588 1123-1127 G_3;PG_10;PR:000003622 denotes ACE2
T587 1128-1141 GO:0005576 denotes extracellular
T586 1142-1148 SO:0000417 denotes domain
T585 1162-1167 SP_6;NCBITaxon:9606 denotes human
T584 1173-1179 SO:0000417 denotes domain
T583 1181-1185 G_3;PG_10;PR:000003622 denotes ACE2
T582 1223-1227 SP_10 denotes SARS
T581 1228-1239 NCBITaxon:11118 denotes coronavirus
T580 1337-1341 G_3;PG_10;PR:000003622 denotes ACE2
T579 1369-1378 SP_7 denotes 2019-nCoV

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T145 60-68 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T146 148-153 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T147 280-287 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T148 510-515 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T149 584-591 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T150 871-885 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T151 1015-1028 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T16 1015-1028 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T76 372-376 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T77 484-488 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T78 577-581 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T79 1186-1188 Disease denotes NN http://purl.obolibrary.org/obo/MONDO_0009747
T80 1223-1227 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T213 0-1 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T214 148-153 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T215 216-217 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T216 326-331 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T217 377-382 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T218 489-494 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T219 510-515 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T220 700-703 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T221 755-756 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T222 886-888 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T223 902-904 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T224 1015-1028 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T225 1041-1046 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T226 1058-1064 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T227 1071-1077 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T228 1085-1086 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 1162-1167 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T230 1255-1256 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T231 1342-1344 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T86 74-82 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T87 280-287 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T88 584-591 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89 957-965 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T90 989-997 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T91 1186-1188 Chemical denotes NN http://purl.obolibrary.org/obo/CHEBI_73406

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T155 0-174 Sentence denotes A potentially more promising strategy would be to create an antibody-like molecule that would bind to the coronavirus itself, rather than shielding cells from being infected.
T156 175-344 Sentence denotes For this strategy, it is proposed to use a soluble version of the ACE2 receptor that would bind to the S protein of 2019-nCoV thereby neutralizing the virus ( Figure 1).
T157 345-431 Sentence denotes Again, the research on the SARS virus suggests this strategy is potentially promising.
T158 432-530 Sentence denotes Soluble ACE2 receptor was demonstrated to block the SARS virus from infecting cells in culture 42.
T159 531-730 Sentence denotes The reported affinity of soluble ACE2 for the SARS S protein was 1.70 nM, which is comparable to the affinities of monoclonal antibodies 55; it is likely that 2019-nCoV has similar affinity for ACE2.
T160 731-1047 Sentence denotes In order to use ACE2 as a therapy to treat patients, it would be advisable to convert soluble ACE2 into an immunoadhesin format fused to an immunoglobulin Fc domain (ACE2-Fc), thereby extending the lifespan of the circulating molecule, while also recruiting effector functions of the immune system against the virus.
T161 1048-1297 Sentence denotes While not tested in an animal model, a previous study demonstrated that an ACE2 extracellular domain fused to the human IgG1 domain (ACE2-NN-Ig) was effective in neutralizing SARS coronavirus in vitro, with a 50% inhibitory concentration of 2 nM 56.
T162 1298-1416 Sentence denotes This study provides evidence then that ACE2-Fc could similarly inhibit 2019-nCoV in vitro and potentially in patients.