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PMC:7029759 / 2181-39234 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
67 42-51 Disease denotes pneumonia MESH:D011014
162 3817-3826 Species denotes 2019-nCoV Tax:2697049
64 197-214 Species denotes novel coronavirus Tax:2697049
65 216-225 Species denotes 2019-nCoV Tax:2697049
66 585-591 Species denotes people Tax:9606
68 133-142 Disease denotes pneumonia MESH:D011014
69 239-272 Disease denotes Severe Acute Respiratory Syndrome MESH:D045169
70 274-278 Disease denotes SARS MESH:D045169
71 286-318 Disease denotes Middle East Respiratory Syndrome MESH:D018352
72 320-324 Disease denotes MERS MESH:D018352
73 341-345 Disease denotes SARS MESH:D045169
74 350-354 Disease denotes MERS MESH:D018352
75 437-441 Disease denotes SARS MESH:D045169
76 559-572 Disease denotes SARS infected MESH:D045169
77 607-613 Disease denotes deaths MESH:D003643
91 670-687 Species denotes novel coronavirus Tax:2697049
92 689-698 Species denotes 2019-nCoV Tax:2697049
93 772-777 Species denotes Human Tax:9606
94 781-786 Species denotes human Tax:9606
95 803-812 Species denotes 2019-nCoV Tax:2697049
96 1387-1398 Species denotes coronavirus Tax:11118
97 996-1015 Disease denotes 2019-nCoV infection MESH:C000657245
98 1024-1029 Disease denotes fever MESH:D005334
99 1031-1036 Disease denotes cough MESH:D003371
100 1042-1049 Disease denotes myalgia MESH:D063806
101 1053-1060 Disease denotes fatigue MESH:D005221
102 1066-1075 Disease denotes pneumonia MESH:D011014
103 1473-1478 Disease denotes fever MESH:D005334
112 1658-1669 Species denotes Ebola virus Tax:1570291
113 1805-1812 Species denotes patient Tax:9606
114 2047-2052 Species denotes Ebola Tax:1570291
115 2186-2195 Species denotes 2019-nCoV Tax:2697049
116 1626-1630 Disease denotes SARS MESH:D045169
117 1771-1779 Disease denotes infected MESH:D007239
118 1960-1968 Disease denotes infected MESH:D007239
119 2039-2043 Disease denotes SARS MESH:D045169
138 3182-3183 Gene denotes S Gene:43740568
139 3175-3180 Gene denotes spike Gene:43740568
140 2224-2232 Species denotes patients Tax:9606
141 2475-2483 Species denotes patients Tax:9606
142 2704-2709 Species denotes Ebola Tax:1570291
143 2959-2968 Species denotes 2019-nCoV Tax:2697049
144 2970-2975 Species denotes Ebola Tax:1570291
145 3133-3142 Species denotes 2019-nCoV Tax:2697049
146 3200-3211 Species denotes coronavirus Tax:11118
147 3505-3514 Species denotes 2019-nCoV Tax:2697049
148 3560-3568 Species denotes patients Tax:9606
149 3583-3592 Species denotes 2019-nCoV Tax:2697049
150 3628-3633 Species denotes Ebola Tax:1570291
151 3634-3642 Species denotes patients Tax:9606
152 3339-3343 Disease denotes SARS MESH:D045169
153 3348-3352 Disease denotes MERS MESH:D018352
154 3569-3577 Disease denotes infected MESH:D007239
155 3222-3232 CellLine denotes MN908947.3 CVCL:U508
163 3894-3902 Species denotes patients Tax:9606
164 3979-3988 Species denotes 2019-nCoV Tax:2697049
165 4048-4057 Species denotes 2019-nCoV Tax:2697049
166 4082-4090 Species denotes patients Tax:9606
167 4265-4273 Species denotes patients Tax:9606
172 4404-4405 Gene denotes S Gene:43740568
173 4602-4603 Gene denotes S Gene:43740568
174 4370-4381 Species denotes Coronavirus Tax:11118
175 4662-4670 Disease denotes infected MESH:D007239
191 5173-5174 Gene denotes S Gene:43740568
192 4842-4843 Gene denotes S Gene:43740568
193 4870-4879 Species denotes 2019-nCoV Tax:2697049
194 5057-5066 Species denotes 2019-nCoV Tax:2697049
195 5233-5237 Species denotes mice Tax:10090
196 5241-5248 Species denotes rabbits Tax:9986
197 5354-5359 Species denotes yeast Tax:4932
198 5641-5650 Species denotes 2019-nCoV Tax:2697049
199 5885-5898 Species denotes coronaviruses Tax:11118
200 6284-6292 Species denotes patients Tax:9606
201 6517-6522 Species denotes yeast Tax:4932
202 6588-6596 Species denotes patients Tax:9606
203 5663-5672 Disease denotes infection MESH:D007239
204 5912-5916 Disease denotes SARS MESH:D045169
205 5077-5087 CellLine denotes MN908947.3 CVCL:U508
212 6671-6680 Species denotes 2019-nCoV Tax:2697049
213 6727-6732 Species denotes sheep Tax:9940
214 6740-6743 Species denotes cow Tax:9913
215 6754-6763 Species denotes 2019-nCoV Tax:2697049
216 7150-7155 Species denotes human Tax:9606
217 7396-7405 Species denotes 2019-nCoV Tax:2697049
220 7486-7495 Species denotes 2019-nCoV Tax:2697049
221 7461-7477 Chemical denotes oligonucleotides MESH:D009841
236 7548-7557 Species denotes 2019-nCoV Tax:2697049
237 7648-7657 Species denotes 2019-nCoV Tax:2697049
238 7977-7985 Species denotes CoV-2019 Tax:2697049
239 8176-8185 Species denotes 2019-nCoV Tax:2697049
240 8193-8203 Species denotes SARS virus Tax:694009
241 8932-8937 Species denotes Ebola Tax:1570291
242 7809-7825 Chemical denotes oligonucleotides MESH:D009841
243 8113-8128 Chemical denotes oligonucleotide MESH:D009841
244 8308-8324 Chemical denotes oligonucleotides MESH:D009841
245 8415-8420 Chemical denotes lipid MESH:D008055
246 8596-8605 Disease denotes infection MESH:D007239
247 8851-8866 Disease denotes viral infection MESH:D001102
248 9168-9176 Disease denotes infected MESH:D007239
249 7691-7701 CellLine denotes MN908947.3 CVCL:U508
265 9420-9429 Species denotes 2019-nCoV Tax:2697049
266 10002-10007 Species denotes Ebola Tax:1570291
267 10128-10136 Species denotes patients Tax:9606
268 10145-10154 Species denotes 2019-nCoV Tax:2697049
269 10315-10324 Species denotes 2019-nCoV Tax:2697049
270 10495-10504 Species denotes 2019-nCoV Tax:2697049
271 10749-10754 Species denotes mouse Tax:10090
272 10840-10853 Species denotes coronaviruses Tax:11118
273 10969-10978 Species denotes 2019-nCoV Tax:2697049
274 10254-10257 Species denotes HIV Tax:12721
275 10219-10228 Chemical denotes lopinavir MESH:D061466
276 10655-10665 Chemical denotes remdesivir MESH:C000606551
277 9690-9740 Disease denotes immunodeficiency virus (HIV) and hepatitis C virus MESH:D006526
278 10370-10374 Disease denotes SARS MESH:D045169
279 10741-10745 Disease denotes MERS MESH:D018352
281 11095-11102 Species denotes patient Tax:9606
291 11217-11225 Species denotes patients Tax:9606
292 11269-11277 Species denotes patients Tax:9606
293 11319-11327 Species denotes Patients Tax:9606
294 11440-11449 Species denotes 2019-nCoV Tax:2697049
295 11565-11573 Species denotes patients Tax:9606
296 11613-11622 Species denotes 2019-nCoV Tax:2697049
297 11342-11357 Disease denotes viral infection MESH:D001102
298 11546-11555 Disease denotes infection MESH:D007239
299 11588-11597 Disease denotes infection MESH:D007239
307 11649-11657 Species denotes Patients Tax:9606
308 11681-11690 Species denotes 2019-nCoV Tax:2697049
309 11770-11778 Species denotes patients Tax:9606
310 12051-12056 Species denotes Ebola Tax:1570291
311 12057-12065 Species denotes patients Tax:9606
312 11761-11769 Disease denotes infected MESH:D007239
313 12177-12185 Disease denotes infected MESH:D007239
322 12222-12230 Species denotes patients Tax:9606
323 12316-12325 Species denotes 2019-nCoV Tax:2697049
324 12419-12427 Species denotes patients Tax:9606
325 12597-12605 Species denotes patients Tax:9606
326 12667-12674 Species denotes patient Tax:9606
327 12849-12856 Species denotes patient Tax:9606
328 12889-12896 Species denotes patient Tax:9606
329 12244-12253 Disease denotes infection MESH:D007239
331 13003-13012 Species denotes 2019-nCoV Tax:2697049
334 13074-13083 Species denotes 2019-nCoV Tax:2697049
335 13542-13547 Species denotes Ebola Tax:1570291
350 14091-14122 Gene denotes angiotensin-converting enzyme 2 Gene:59272
351 14124-14128 Gene denotes ACE2 Gene:59272
352 14278-14282 Gene denotes ACE2 Gene:59272
353 14583-14587 Gene denotes ACE2 Gene:59272
354 14072-14081 Species denotes 2019-nCoV Tax:2697049
355 14199-14215 Species denotes SARS coronavirus Tax:694009
356 14257-14268 Species denotes coronavirus Tax:11118
357 14567-14576 Species denotes 2019-nCoV Tax:2697049
358 14695-14704 Species denotes 2019-nCoV Tax:2697049
359 14558-14562 Disease denotes SARS MESH:D045169
360 14665-14669 Disease denotes SARS MESH:D045169
361 14719-14723 Disease denotes SARS MESH:D045169
362 14842-14851 Disease denotes infection MESH:D007239
363 14855-14859 Disease denotes SARS MESH:D045169
365 14898-14902 Gene denotes ACE2 Gene:59272
371 15002-15006 Gene denotes ACE2 Gene:59272
372 15048-15052 Gene denotes ACE2 Gene:59272
373 14965-14973 Species denotes patients Tax:9606
374 15375-15390 Species denotes influenza virus Tax:11308
375 15505-15516 Chemical denotes sialic acid MESH:D019158
397 15612-15616 Gene denotes ACE2 Gene:59272
398 15757-15761 Gene denotes ACE2 Gene:59272
399 16007-16011 Gene denotes ACE2 Gene:59272
400 16254-16258 Gene denotes ACE2 Gene:59272
401 16301-16305 Gene denotes ACE2 Gene:59272
402 15691-15692 Gene denotes S Gene:43740568
403 15975-15983 Species denotes patients Tax:9606
404 16126-16135 Species denotes 2019-nCoV Tax:2697049
405 16213-16222 Species denotes 2019-nCoV Tax:2697049
406 16337-16348 Species denotes coronavirus Tax:11118
407 17273-17277 Species denotes mice Tax:10090
408 16332-16336 Species denotes NL63 Tax:277944
409 15686-15690 Disease denotes SARS MESH:D045169
410 15893-15897 Disease denotes SARS MESH:D045169
411 15948-15952 Disease denotes SARS MESH:D045169
412 16049-16058 Disease denotes infection MESH:D007239
413 16204-16208 Disease denotes SARS MESH:D045169
414 16323-16327 Disease denotes SARS MESH:D045169
415 17090-17094 Disease denotes MERS MESH:D018352
416 17100-17104 Disease denotes MERS MESH:D018352
417 17153-17168 Disease denotes viral infection MESH:D001102
419 17516-17525 Species denotes 2019-nCoV Tax:2697049
438 17572-17576 Gene denotes ACE2 Gene:59272
439 17705-17709 Gene denotes ACE2 Gene:59272
440 17964-17968 Gene denotes ACE2 Gene:59272
441 18063-18067 Gene denotes scFv Gene:652070
442 18099-18103 Gene denotes ACE2 Gene:59272
443 18286-18290 Gene denotes ACE2 Gene:59272
444 18347-18351 Gene denotes ACE2 Gene:59272
445 18249-18254 Gene denotes spike Gene:43740568
446 17888-17893 Gene denotes spike Gene:43740568
447 17648-17653 Gene denotes spike Gene:43740568
448 17626-17631 Species denotes human Tax:9606
449 17684-17695 Species denotes coronavirus Tax:11118
450 17915-17924 Species denotes 2019-nCoV Tax:2697049
451 18162-18173 Species denotes coronavirus Tax:11118
452 18204-18208 Gene denotes ACE2 Gene:59272
453 17713-17721 Disease denotes infected MESH:D007239
454 17822-17831 Disease denotes infection MESH:D007239
455 17907-17911 Disease denotes SARS MESH:D045169
468 18438-18442 Gene denotes ACE2 Gene:59272
469 18604-18608 Gene denotes ACE2 Gene:59272
470 18827-18831 Gene denotes ACE2 Gene:59272
471 19006-19010 Gene denotes ACE2 Gene:59272
472 19176-19180 Gene denotes ACE2 Gene:59272
473 19595-19599 Gene denotes scFv Gene:652070
474 19615-19619 Gene denotes ACE2 Gene:59272
475 19353-19362 Species denotes mammalian Tax:9606
476 19485-19493 Species denotes patients Tax:9606
477 18471-18490 Disease denotes 2019-nCoV infection MESH:C000657245
478 18549-18553 Disease denotes SARS MESH:D045169
479 19111-19123 Disease denotes inflammation MESH:D007249
503 20490-20494 Gene denotes ACE2 Gene:59272
504 20581-20585 Gene denotes ACE2 Gene:59272
505 20674-20678 Gene denotes ACE2 Gene:59272
506 20900-20904 Gene denotes ACE2 Gene:59272
507 21086-21090 Gene denotes ACE2 Gene:59272
508 21244-21248 Gene denotes ACE2 Gene:59272
509 21391-21395 Gene denotes ACE2 Gene:70008
510 21472-21476 Gene denotes ACE2 Gene:70008
511 21577-21581 Gene denotes ACE2 Gene:70008
512 20115-20124 Species denotes 2019-nCoV Tax:2697049
513 20284-20293 Species denotes 2019-nCoV Tax:2697049
514 21399-21405 Species denotes murine Tax:10090
515 21738-21746 Species denotes patients Tax:9606
516 19955-19959 Disease denotes SARS MESH:D045169
517 20030-20034 Disease denotes SARS MESH:D045169
518 20095-20104 Disease denotes infection MESH:D007239
519 20649-20658 Disease denotes infection MESH:D007239
520 21122-21131 Disease denotes infection MESH:D007239
521 21363-21367 Disease denotes SARS MESH:D045169
522 21462-21467 Disease denotes edema MESH:D004487
523 21523-21534 Disease denotes lung injury MESH:D055370
524 21639-21648 Disease denotes infection MESH:D007239
525 21690-21705 Disease denotes viral infection MESH:D001102
527 21798-21802 Gene denotes ACE2 Gene:59272
552 22067-22071 Gene denotes ACE2 Gene:59272
553 22266-22270 Gene denotes ACE2 Gene:59272
554 22390-22394 Gene denotes ACE2 Gene:59272
555 22551-22555 Gene denotes ACE2 Gene:59272
556 22573-22577 Gene denotes ACE2 Gene:59272
557 22651-22655 Gene denotes ACE2 Gene:59272
558 22723-22727 Gene denotes ACE2 Gene:59272
559 22949-22953 Gene denotes ACE2 Gene:59272
560 23007-23011 Gene denotes ACE2 Gene:59272
561 23163-23167 Gene denotes ACE2 Gene:59272
562 22408-22409 Gene denotes S Gene:43740568
563 22104-22105 Gene denotes S Gene:43740568
564 21932-21943 Species denotes coronavirus Tax:11118
565 22117-22126 Species denotes 2019-nCoV Tax:2697049
566 22198-22208 Species denotes SARS virus Tax:694009
567 22310-22320 Species denotes SARS virus Tax:694009
568 22516-22525 Species denotes 2019-nCoV Tax:2697049
569 22600-22608 Species denotes patients Tax:9606
570 23049-23065 Species denotes SARS coronavirus Tax:694009
571 23195-23204 Species denotes 2019-nCoV Tax:2697049
572 23233-23241 Species denotes patients Tax:9606
573 22988-22993 Species denotes human Tax:9606
574 21991-21999 Disease denotes infected MESH:D007239
575 22403-22407 Disease denotes SARS MESH:D045169
615 23276-23280 Gene denotes ACE2 Gene:59272
616 23333-23337 Gene denotes ACE2 Gene:59272
617 23639-23643 Gene denotes ACE2 Gene:59272
618 23665-23669 Gene denotes ACE2 Gene:59272
619 23782-23786 Gene denotes ACE2 Gene:59272
620 23858-23872 Gene denotes angiotensin II Gene:183
621 23967-23971 Gene denotes ACE2 Gene:59272
622 24131-24135 Gene denotes ACE2 Gene:59272
623 24397-24403 Gene denotes Ang1-8 Gene:284
624 24640-24644 Gene denotes ACE2 Gene:59272
625 23296-23297 Gene denotes S Gene:43740568
626 23286-23295 Species denotes 2019-nCoV Tax:2697049
627 23423-23431 Species denotes patients Tax:9606
628 23996-24023 Species denotes respiratory syncytial virus Tax:12814
629 24031-24035 Species denotes H5N1 Tax:102793
630 24125-24130 Species denotes human Tax:9606
631 24217-24225 Species denotes patients Tax:9606
632 24687-24696 Species denotes 2019-nCoV Tax:2697049
633 24697-24705 Species denotes patients Tax:9606
634 24036-24045 Species denotes influenza Tax:11320
635 24463-24474 Species denotes respiratory Tax:12814
636 24137-24143 Chemical denotes rhACE2
637 24256-24262 Chemical denotes rhACE2
638 24520-24526 Chemical denotes rhACE2
639 23383-23392 Disease denotes pneumonia MESH:D011014
640 23437-23441 Disease denotes SARS MESH:D045169
641 23446-23465 Disease denotes 2019-nCoV infection MESH:C000657245
642 23474-23483 Disease denotes pneumonia MESH:D011014
643 23511-23526 Disease denotes pulmonary edema MESH:D011654
644 23531-23566 Disease denotes acute respiratory distress syndrome MESH:D012128
645 23568-23572 Disease denotes ARDS MESH:D012128
646 23612-23616 Disease denotes ARDS MESH:D012128
647 23827-23838 Disease denotes lung injury MESH:D055370
648 23988-23992 Disease denotes ARDS MESH:D012128
649 24049-24058 Disease denotes infection MESH:D007239
650 24194-24198 Disease denotes ARDS MESH:D012128
651 24202-24216 Disease denotes critically ill MESH:D016638
652 24585-24589 Disease denotes ARDS MESH:D012128
653 24679-24683 Disease denotes ARDS MESH:D012128
763 28201-28210 Species denotes 2019-nCoV Tax:2697049
673 24800-24804 Gene denotes ACE2 Gene:59272
674 24899-24903 Gene denotes ACE2 Gene:59272
937 33216-33220 Disease denotes ARDS MESH:D012128
675 25033-25037 Gene denotes ACE2 Gene:59272
676 25112-25116 Gene denotes ACE2 Gene:59272
677 25304-25308 Gene denotes ACE2 Gene:59272
678 25384-25388 Gene denotes ACE2 Gene:59272
679 25487-25491 Gene denotes ACE2 Gene:59272
680 25555-25559 Gene denotes ACE2 Gene:59272
681 25454-25455 Gene denotes S Gene:43740568
682 25340-25341 Gene denotes S Gene:43740568
683 24732-24741 Species denotes 2019-nCoV Tax:2697049
684 24742-24750 Species denotes patients Tax:9606
685 24824-24829 Species denotes human Tax:9606
686 25330-25339 Species denotes 2019-nCoV Tax:2697049
687 25444-25453 Species denotes 2019-nCoV Tax:2697049
688 25592-25602 Species denotes SARS virus Tax:694009
689 25621-25630 Species denotes 2019-nCoV Tax:2697049
690 24953-24957 Disease denotes SARS MESH:D045169
691 25242-25253 Disease denotes lung injury MESH:D055370
694 25684-25688 Gene denotes ACE2 Gene:59272
695 25728-25749 Species denotes 2019-nCoV coronavirus Tax:2697049
705 25784-25788 Gene denotes ACE2 Gene:59272
706 25916-25920 Gene denotes ACE2 Gene:59272
707 25966-25970 Gene denotes ACE2 Gene:59272
708 26006-26010 Gene denotes ACE2 Gene:59272
709 26062-26066 Gene denotes ACE2 Gene:59272
710 25810-25815 Species denotes human Tax:9606
711 26056-26061 Species denotes human Tax:9606
712 26123-26128 Species denotes human Tax:9606
713 26239-26244 Species denotes human Tax:9606
745 26548-26552 Gene denotes ACE2 Gene:70008
746 26648-26652 Gene denotes ACE2 Gene:70008
747 26948-26952 Gene denotes CD16 Gene:2214
748 27325-27329 Gene denotes ACE2 Gene:59272
749 27798-27802 Gene denotes ACE2 Gene:59272
750 27845-27849 Gene denotes ACE2 Gene:59272
751 27932-27936 Gene denotes ACE2 Gene:59272
752 28118-28122 Gene denotes ACE2 Gene:59272
753 28282-28286 Gene denotes ACE2 Gene:59272
754 26501-26509 Species denotes patients Tax:9606
755 26611-26615 Species denotes mice Tax:10090
756 27143-27148 Species denotes mouse Tax:10090
757 27540-27549 Species denotes 2019-nCoV Tax:2697049
758 27725-27747 Species denotes human coronavirus NL63 Tax:277944
759 27792-27797 Species denotes human Tax:9606
760 27900-27909 Species denotes 2019-nCoV Tax:2697049
761 28058-28068 Species denotes SARS virus Tax:694009
762 28112-28117 Species denotes human Tax:9606
764 27783-27787 Species denotes NL63 Tax:277944
765 27821-27825 Species denotes NL63 Tax:277944
766 26492-26500 Disease denotes infected MESH:D007239
767 26700-26712 Disease denotes hypertension MESH:D006973
768 26989-26997 Disease denotes infected MESH:D007239
769 27138-27142 Disease denotes SARS MESH:D045169
770 27216-27220 Disease denotes SARS MESH:D045169
771 27468-27477 Disease denotes infection MESH:D007239
772 27699-27703 Disease denotes SARS MESH:D045169
773 27810-27814 Disease denotes SARS MESH:D045169
774 27867-27871 Disease denotes SARS MESH:D045169
775 28151-28160 Disease denotes infection MESH:D007239
800 28484-28487 Gene denotes CD4 Gene:920
801 28494-28497 Gene denotes CD4 Gene:920
802 28625-28637 Gene denotes CD4 receptor Gene:920
803 28661-28666 Gene denotes gp120 Gene:3700
804 28705-28708 Gene denotes CD4 Gene:920
805 28927-28930 Gene denotes CD4 Gene:920
806 29024-29028 Gene denotes CCR5 Gene:1234
807 28820-28828 Species denotes patients Tax:9606
808 29144-29159 Species denotes rhesus macaques Tax:9544
809 29182-29217 Species denotes simian-human immunodeficiency virus Tax:57667
810 29251-29260 Species denotes 2019-nCoV Tax:2697049
811 29440-29449 Species denotes 2019-nCoV Tax:2697049
812 29464-29473 Species denotes 2019-nCoV Tax:2697049
813 29542-29553 Species denotes respiratory Tax:12814
814 28555-28558 Species denotes HIV Tax:12721
815 28737-28740 Species denotes HIV Tax:12721
816 29120-29123 Species denotes HIV Tax:12721
817 29243-29246 Species denotes HIV Tax:12721
818 29374-29377 Species denotes HIV Tax:12721
819 29603-29606 Species denotes HIV Tax:12721
820 28685-28697 Disease denotes infected HIV MESH:D015658
821 28762-28771 Disease denotes infection MESH:D007239
822 29585-29594 Disease denotes infection MESH:D007239
823 29621-29638 Disease denotes chronic infection MESH:D007239
851 29716-29720 Gene denotes ACE2 Gene:59272
852 29781-29785 Gene denotes ACE2 Gene:59272
853 29938-29942 Gene denotes ACE2 Gene:59272
854 30077-30081 Gene denotes ACE2 Gene:59272
855 30247-30251 Gene denotes ACE2 Gene:59272
856 30341-30345 Gene denotes ACE2 Gene:59272
857 30573-30577 Gene denotes ACE2 Gene:59272
858 30683-30687 Gene denotes ACE2 Gene:59272
859 30807-30811 Gene denotes ACE2 Gene:59272
860 30911-30915 Gene denotes ACE2 Gene:59272
861 30977-30981 Gene denotes ACE2 Gene:59272
862 31144-31155 Gene denotes Fc receptor
863 31157-31161 Gene denotes CD16 Gene:2214
864 31437-31441 Gene denotes ACE2 Gene:59272
865 30492-30493 Gene denotes S Gene:43740568
866 30120-30128 Species denotes patients Tax:9606
867 30156-30164 Species denotes patients Tax:9606
868 30223-30232 Species denotes 2019-nCoV Tax:2697049
869 30233-30241 Species denotes patients Tax:9606
870 30482-30491 Species denotes 2019-nCoV Tax:2697049
871 31117-31126 Species denotes 2019-nCoV Tax:2697049
872 30633-30642 Chemical denotes histidine MESH:D006639
873 30170-30181 Disease denotes lung injury MESH:D055370
874 30473-30477 Disease denotes SARS MESH:D045169
875 30777-30781 Disease denotes SARS MESH:D045169
876 30928-30939 Disease denotes lung injury MESH:D055370
877 31240-31244 Disease denotes MERS MESH:D018352
897 31909-31913 Gene denotes ACE2 Gene:59272
898 31974-31978 Gene denotes ACE2 Gene:59272
899 32096-32100 Gene denotes ACE2 Gene:59272
900 32313-32317 Gene denotes ACE2 Gene:59272
901 32591-32595 Gene denotes ACE2 Gene:59272
902 31537-31546 Species denotes 2019-nCoV Tax:2697049
903 31581-31589 Species denotes patients Tax:9606
904 31757-31765 Species denotes patients Tax:9606
905 31859-31868 Species denotes 2019-nCoV Tax:2697049
906 32086-32094 Species denotes patients Tax:9606
907 32456-32461 Species denotes yeast Tax:4932
908 32746-32754 Species denotes patients Tax:9606
909 31624-31632 Disease denotes infected MESH:D007239
910 31748-31756 Disease denotes infected MESH:D007239
911 31826-31831 Disease denotes death MESH:D003643
912 31979-31989 Disease denotes deficiency MESH:D007153
913 31994-32005 Disease denotes lung injury MESH:D055370
914 32077-32085 Disease denotes infected MESH:D007239
915 32443-32446 CellLine denotes CHO CVCL:0213
928 32779-32783 Gene denotes ACE2 Gene:59272
929 33064-33068 Gene denotes ACE2 Gene:59272
930 33391-33395 Gene denotes ACE2 Gene:59272
931 32820-32828 Species denotes patients Tax:9606
932 33163-33172 Species denotes 2019-nCoV Tax:2697049
933 33245-33252 Species denotes patient Tax:9606
934 33319-33326 Species denotes patient Tax:9606
935 32799-32808 Disease denotes infection MESH:D007239
936 32868-32873 Disease denotes death MESH:D003643
938 33253-33262 Disease denotes mortality MESH:D003643
939 33361-33369 Disease denotes infected MESH:D007239
951 34119-34123 Gene denotes ACE2 Gene:59272
952 34286-34290 Gene denotes ACE2 Gene:59272
953 33741-33742 Gene denotes S Gene:43740568
954 33623-33632 Species denotes 2019-nCoV Tax:2697049
955 34091-34100 Species denotes 2019-nCoV Tax:2697049
956 34233-34242 Species denotes 2019-nCoV Tax:2697049
957 34390-34412 Species denotes human coronavirus NL63 Tax:277944
958 34632-34640 Species denotes patients Tax:9606
959 34195-34204 Disease denotes infection MESH:D007239
960 34378-34382 Disease denotes SARS MESH:D045169
961 34659-34667 Disease denotes infected MESH:D007239
969 34793-34797 Gene denotes ACE2 Gene:59272
970 34877-34881 Gene denotes IgG3 Gene:3502
971 35022-35026 Gene denotes ACE2 Gene:59272
972 35054-35058 Gene denotes ACE2 Gene:59272
973 35421-35425 Gene denotes ACE2 Gene:59272
974 34754-34763 Species denotes 2019-nCoV Tax:2697049
975 34847-34852 Species denotes human Tax:9606
991 35551-35555 Gene denotes ACE2 Gene:59272
992 35763-35767 Gene denotes ACE2 Gene:59272
993 36181-36185 Gene denotes DPP4 Gene:1803
994 36248-36252 Gene denotes DPP4 Gene:1803
995 36395-36399 Gene denotes ACE2 Gene:59272
996 35661-35670 Species denotes 2019-nCoV Tax:2697049
997 35680-35695 Species denotes new coronavirus Tax:2697049
998 35798-35811 Species denotes coronaviruses Tax:11118
999 36284-36297 Species denotes coronaviruses Tax:11118
1000 35652-35656 Disease denotes SARS MESH:D045169
1001 35716-35724 Disease denotes zoonotic MESH:D015047
1002 36049-36057 Disease denotes zoonotic MESH:D015047
1003 36214-36218 Disease denotes MERS MESH:D018352
1004 36435-36439 Disease denotes ARDS MESH:D012128
1005 36482-36499 Disease denotes acute lung injury MESH:D055371
1010 36566-36570 Gene denotes ACE2 Gene:59272
1011 36842-36851 Species denotes 2019-nCoV Tax:2697049
1012 36570-36573 Chemical denotes -Fc
1013 36674-36693 Disease denotes 2019-nCoV infection MESH:C000657245

LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 15505-15516 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T569 23625-23630 NCBITaxon:10239 denotes viral
T568 23639-23643 G_3;PG_10;PR:000003622 denotes ACE2
T567 23665-23669 G_3;PG_10;PR:000003622 denotes ACE2
T566 23688-23698 GO:0010467 denotes expression
T565 23730-23739 PG_1 denotes S protein
T564 23782-23786 G_3;PG_10;PR:000003622 denotes ACE2
T563 23827-23831 UBERON:0002048 denotes lung
T562 23858-23872 PR:000036009;DG_37 denotes angiotensin II
T561 23919-23933 DG_37;PR:000001251 denotes angiotensin II
T560 23934-23950 PR:000001251 denotes type 1a receptor
T559 23967-23971 G_3;PG_10;PR:000003622 denotes ACE2
T558 23996-24007 UBERON:0001004;NCBITaxon:12814 denotes respiratory
T557 24008-24017 NCBITaxon:12814 denotes syncytial
T556 24018-24023 NCBITaxon:10239 denotes virus
T555 24125-24130 SP_6;NCBITaxon:9606;PG_10 denotes human
T554 24131-24135 PG_10;PR:000003622 denotes ACE2
T553 24310-24331 UBERON:0004535 denotes cardiovascular system
T552 24397-24401 PR:000004020 denotes Ang1
T551 24449-24459 GO:0065007 denotes modulation
T550 24463-24474 UBERON:0001004 denotes respiratory
T549 24613-24619 NCBITaxon:33208 denotes animal
T548 24640-24644 G_3;PG_10;PR:000003622 denotes ACE2
T547 24687-24696 SP_7 denotes 2019-nCoV
T546 24732-24741 SP_7 denotes 2019-nCoV
T545 24772-24785 GO:0005576 denotes extracellular
T544 24786-24792 SO:0000417 denotes domain
T543 24800-24804 G_3;PG_10;PR:000003622 denotes ACE2
T542 24824-24829 SP_6;NCBITaxon:9606 denotes human
T541 24830-24844 GO:0019814 denotes immunoglobulin
T540 24850-24856 SO:0000417 denotes domain
T539 24899-24903 G_3;PG_10;PR:000003622 denotes ACE2
T538 24953-24957 SP_10;PG_9 denotes SARS
T537 24958-24959 PG_9;PG_1 denotes S
T536 24960-24967 PG_1 denotes protein
T535 25012-25018 SO:0000417 denotes domain
T534 25033-25037 G_3;PG_10;PR:000003622 denotes ACE2
T533 25098-25111 GO:0005576 denotes extracellular
T532 25112-25116 G_3;PG_10 denotes ACE2
T531 25117-25123 SO:0000417 denotes domain
T530 25146-25155 PG_1 denotes S protein
T529 25242-25246 UBERON:0002048 denotes lung
T528 25304-25308 G_3;PG_10 denotes ACE2
T527 25309-25315 SO:0000417 denotes domain
T526 25330-25339 SP_7 denotes 2019-nCoV
T525 25340-25349 PG_1 denotes S protein
T524 25384-25388 G_3;PG_10;PR:000003622 denotes ACE2
T523 25444-25453 SP_7 denotes 2019-nCoV
T522 25454-25463 PG_1 denotes S protein
T521 25487-25491 G_3;PG_10;PR:000003622 denotes ACE2
T520 25555-25559 G_3;PG_10;PR:000003622 denotes ACE2
T519 25568-25575 SO:0000417 denotes domains
T518 25592-25596 SP_10;NCBITaxon:10633 denotes SARS
T517 25597-25602 NCBITaxon:10239 denotes virus
T516 25621-25630 SP_7 denotes 2019-nCoV
T515 26337-26343 SO:0000417 denotes domain
T514 26382-26386 CHEBI:23888;CHEBI:23888 denotes drug
T513 26450-26454 CHEBI:23888;CHEBI:23888 denotes drug
T512 26548-26552 G_3;PG_10;PR:000003622 denotes ACE2
T511 26611-26615 NCBITaxon:10088 denotes mice
T510 26648-26652 G_3;PG_10;PR:000003622 denotes ACE2
T509 26785-26793 CHEBI:35224;CHEBI:35224 denotes effector
T508 26814-26820 SO:0000417 denotes domain
T507 26847-26855 CHEBI:36357;CHEBI:36357 denotes molecule
T506 26881-26890 GO:0030425;CL:0000451 denotes dendritic
T505 26891-26896 CL:0000451 denotes cells
T504 26898-26909 CL:0000235 denotes macrophages
T503 26915-26935 CL:0000623 denotes natural killer cells
T502 26948-26952 PR:000001483 denotes CD16
T501 26970-26975 NCBITaxon:10239 denotes viral
T500 27065-27071 UBERON:0002405;GO:0006955 denotes immune
T499 27072-27080 GO:0006955 denotes response
T498 27104-27109 NCBITaxon:10239 denotes virus
T497 27138-27142 SP_10 denotes SARS
T496 27143-27148 NCBITaxon:10088 denotes mouse
T495 27173-27183 GO:0042571 denotes antibodies
T494 27216-27220 SP_10 denotes SARS
T493 27225-27238 GO:0001775 denotes activation of
T492 27239-27249 GO:0006909;CL:0000234 denotes phagocytic
T491 27250-27255 CL:0000234 denotes cells
T490 27268-27278 GO:0042571 denotes antibodies
T489 27296-27301 NCBITaxon:10239 denotes virus
T488 27325-27329 G_3;PG_10;PR:000003622 denotes ACE2
T487 27415-27423 GO:0042571 denotes antibody
T486 27540-27549 SP_7 denotes 2019-nCoV
T485 27682-27695 BV_19 denotes pathogenicity
T484 27699-27703 SP_10 denotes SARS
T483 27725-27730 SP_6;NCBITaxon:9606 denotes human
T482 27731-27742 NCBITaxon:11118 denotes coronavirus
T481 27792-27797 SP_6;NCBITaxon:9606;PG_10 denotes human
T480 27798-27802 PG_10;PR:000003622 denotes ACE2
T479 27810-27814 SP_10 denotes SARS
T478 27826-27835 PG_1 denotes S protein
T477 27845-27849 G_3;PG_10;PR:000003622 denotes ACE2
T476 27867-27871 SP_10;PG_9 denotes SARS
T475 27872-27873 PG_9;PG_1 denotes S
T474 27874-27881 PG_1 denotes protein
T473 27900-27909 SP_7 denotes 2019-nCoV
T472 27932-27936 G_3;PG_10;PR:000003622 denotes ACE2
T471 28016-28021 NCBITaxon:10239 denotes virus
T470 28058-28062 SP_10;NCBITaxon:10633 denotes SARS
T469 28063-28068 NCBITaxon:10239 denotes virus
T468 28112-28117 SP_6;NCBITaxon:9606;PG_10 denotes human
T467 28118-28122 PG_10;PR:000003622 denotes ACE2
T466 28201-28210 SP_7 denotes 2019-nCoV
T465 28282-28286 G_3;PG_10;PR:000003622 denotes ACE2
T464 28484-28487 PR:000001004 denotes CD4
T463 28494-28497 PR:000001004 denotes CD4
T462 28498-28501 GO:0071735 denotes IgG
T461 28610-28617 SO:0000417 denotes domains
T460 28625-28628 PR:000001004 denotes CD4
T459 28661-28666 PR:000003229 denotes gp120
T458 28674-28684 GO:0009986 denotes surface of
T457 28705-28708 PR:000001004 denotes CD4
T456 28709-28712 GO:0071735 denotes IgG
T455 28927-28930 PR:000001004 denotes CD4
T454 28931-28934 GO:0071735 denotes IgG
T453 29024-29028 PR:000001201 denotes CCR5
T452 29124-29132 SO:0001060 denotes isolates
T451 29144-29150 NCBITaxon:9654 denotes rhesus
T450 29151-29159 NCBITaxon:9539 denotes macaques
T449 29182-29188 NCBITaxon:10633 denotes simian
T448 29188-29189 NCBITaxon:57667 denotes -
T447 29189-29194 SP_6;NCBITaxon:9606 denotes human
T446 29212-29217 NCBITaxon:10633 denotes virus
T445 29251-29260 SP_7 denotes 2019-nCoV
T444 29280-29287 NCBITaxon:10239 denotes viruses
T443 29440-29449 SP_7 denotes 2019-nCoV
T442 29464-29473 SP_7 denotes 2019-nCoV
T441 29542-29553 NCBITaxon:11886;UBERON:0001004 denotes respiratory
T440 29554-29559 NCBITaxon:10239 denotes virus
T439 29716-29720 G_3;PG_10;PR:000003622 denotes ACE2
T438 29767-29780 GO:0005576 denotes extracellular
T437 29781-29785 G_3;PG_10;PR:000003622 denotes ACE2
T436 29881-29887 SO:0000417 denotes domain
T435 29924-29937 GO:0005576 denotes extracellular
T434 29938-29942 G_3;PG_10;PR:000003622 denotes ACE2
T433 29955-29963 GO:0032941 denotes secreted
T432 29967-29974 UBERON:0000479 denotes tissues
T431 30003-30016 GO:0005576 denotes extracellular
T430 30017-30023 SO:0000417 denotes domain
T429 30077-30081 G_3;PG_10;PR:000003622 denotes ACE2
T428 30170-30174 UBERON:0002048 denotes lung
T427 30223-30232 SP_7 denotes 2019-nCoV
T426 30247-30251 G_3;PG_10;PR:000003622 denotes ACE2
T425 30341-30345 G_3;PG_10;PR:000003622 denotes ACE2
T424 30473-30477 SP_10 denotes SARS
T423 30482-30491 SP_7 denotes 2019-nCoV
T422 30492-30501 PG_1 denotes S protein
T421 30573-30577 G_3;PG_10;PR:000003622 denotes ACE2
T404 14878-14884 CHEBI:38867;CHEBI:38867 denotes agents
T403 14898-14902 G_3;PG_10;PR:000003622 denotes ACE2
T402 15002-15006 G_3;PG_10;PR:000003622 denotes ACE2
T401 15048-15052 G_3;PG_10;PR:000003622 denotes ACE2
T400 15143-15148 CHEBI:52217;CHEBI:52217 denotes agent
T399 15164-15169 NCBITaxon:10239 denotes virus
T398 15375-15384 NCBITaxon:7719 denotes influenza
T397 15385-15390 NCBITaxon:10239 denotes virus
T396 15438-15446 GO:0042571 denotes antibody
T395 15505-15516 CHEBI:26667;CHEBI:26667 denotes sialic acid
T394 15529-15536 GO:0009986 denotes surface
T393 15612-15616 G_3;PG_10;PR:000003622 denotes ACE2
T392 15664-15670 SO:0000417 denotes domain
T391 15686-15690 SP_10;PG_9 denotes SARS
T390 15691-15692 PG_9;PG_1 denotes S
T389 15693-15700 PG_1 denotes protein
T388 15735-15741 SO:0000417 denotes domain
T387 15757-15761 G_3;PG_10;PR:000003622 denotes ACE2
T386 15811-15817 SO:0000417 denotes domain
T385 15893-15897 SP_10 denotes SARS
T384 15948-15952 SP_10 denotes SARS
T383 16007-16011 G_3;PG_10;PR:000003622 denotes ACE2
T382 16126-16135 SP_7 denotes 2019-nCoV
T381 16204-16208 SP_10 denotes SARS
T380 16213-16222 SP_7 denotes 2019-nCoV
T379 16238-16250 SO:0000409 denotes binding site
T378 16254-16258 G_3;PG_10;PR:000003622 denotes ACE2
T377 16301-16305 G_3;PG_10;PR:000003622 denotes ACE2
T376 16306-16319 SO:0000409 denotes binding sites
T375 16323-16327 SP_10 denotes SARS
T374 16337-16348 NCBITaxon:11118 denotes coronavirus
T373 16429-16439 GO:0042571 denotes antibodies
T372 16490-16497 UBERON:0000479 denotes tissues
T371 16526-16531 NCBITaxon:10239;GO:0035376 denotes viral
T370 16532-16537 GO:0035376 denotes entry
T369 16675-16683 NCBITaxon:2 denotes bacteria
T368 16746-16755 NCBITaxon:2 denotes bacterial
T367 17078-17084 SO:0000417 denotes domain
T366 17090-17094 SP_9 denotes MERS
T365 17100-17104 SP_9 denotes MERS
T364 17153-17158 NCBITaxon:10239;GO:0006260 denotes viral
T363 17219-17225 UBERON:0002405;GO:0006955 denotes immune
T362 17226-17234 GO:0006955 denotes response
T361 17257-17262 NCBITaxon:10239 denotes viral
T360 17263-17269 SO:0000417 denotes domain
T359 17273-17277 NCBITaxon:10088 denotes mice
T358 17384-17390 SO:0000417 denotes domain
T357 18410-18418 GO:0042571 denotes antibody
T356 18438-18442 G_3;PG_10;PR:000003622 denotes ACE2
T355 18471-18480 SP_7 denotes 2019-nCoV
T354 18549-18553 SP_10 denotes SARS
T353 18564-18575 GO:0006260 denotes replication
T352 18604-18608 G_3;PG_10;PR:000003622 denotes ACE2
T351 18609-18617 GO:0042571 denotes antibody
T350 18676-18686 GO:0042571 denotes antibodies
T349 18806-18811 NCBITaxon:10239 denotes viral
T348 18827-18831 G_3;PG_10;PR:000003622 denotes ACE2
T347 18840-18848 GO:0042571 denotes antibody
T346 18913-18922 PG_1 denotes S protein
T345 19006-19010 G_3;PG_10;PR:000003622 denotes ACE2
T344 19011-19019 GO:0042571 denotes antibody
T343 19034-19042 CHEBI:35224;CHEBI:35224 denotes effector
T342 19090-19096 SO:0000417 denotes domain
T341 19157-19164 UBERON:0000479 denotes tissues
T340 19165-19175 GO:0010467 denotes expressing
T339 19176-19180 G_3;PG_10;PR:000003622 denotes ACE2
T338 19237-19243 SO:0000417 denotes domain
T337 19310-19316 SO:0000417 denotes domain
T336 19353-19362 NCBITaxon:40674 denotes mammalian
T335 19363-19378 GO:0006412 denotes cell production
T334 19477-19481 CHEBI:23888;CHEBI:23888 denotes drug
T333 19615-19619 G_3;PG_10;PR:000003622 denotes ACE2
T332 19639-19646 SO:0000417 denotes domains
T331 19723-19731 NCBITaxon:2 denotes bacteria
T330 19800-19807 UBERON:0000479 denotes tissues
T329 19856-19865 CHEBI:36357;CHEBI:36357 denotes molecules
T328 19881-19887 SO:0000417 denotes domain
T327 19955-19959 SP_10 denotes SARS
T326 20007-20013 UBERON:0002405;GO:0006955 denotes immune
T325 20014-20022 GO:0006955 denotes response
T324 20030-20034 SP_10 denotes SARS
T323 20115-20124 SP_7 denotes 2019-nCoV
T322 20178-20184 UBERON:0002405;GO:0006955 denotes immune
T321 20185-20193 GO:0006955 denotes response
T320 20203-20210 NCBITaxon:10239 denotes viruses
T319 20284-20293 SP_7 denotes 2019-nCoV
T318 20307-20313 UBERON:0002405;GO:0006955 denotes immune
T317 20314-20322 GO:0006955 denotes response
T316 20490-20494 G_3;PG_10;PR:000003622 denotes ACE2
T315 20534-20540 UBERON:0000062 denotes organs
T314 20581-20585 G_3;PG_10;PR:000003622 denotes ACE2
T313 20674-20678 G_3;PG_10;PR:000003622 denotes ACE2
T312 20721-20725 UBERON:0002048 denotes lung
T311 20730-20746 UBERON:0001555 denotes gastrointestinal
T310 20747-20753 UBERON:0000062 denotes organs
T309 20765-20773 CL:0002139 denotes vascular
T308 20774-20785 CL:0002139;UBERON:0001986 denotes endothelial
T307 20786-20791 CL:0002139 denotes cells
T306 20804-20811 UBERON:0000479 denotes tissues
T305 20900-20904 G_3;PG_10;PR:000003622 denotes ACE2
T304 20921-20933 GO:0009986 denotes cell surface
T303 21086-21090 G_3;PG_10;PR:000003622 denotes ACE2
T302 21139-21144 UBERON:0000170 denotes lungs
T301 21174-21179 UBERON:0000170 denotes lungs
T300 21244-21248 G_3;PG_10;PR:000003622 denotes ACE2
T299 21285-21289 UBERON:0002048 denotes lung
T298 21363-21367 SP_10 denotes SARS
T297 21378-21384 SO:0000417 denotes domain
T296 21391-21395 G_3;PG_10;PR:000003622 denotes ACE2
T295 21399-21405 NCBITaxon:39107 denotes murine
T294 21406-21410 UBERON:0002048 denotes lung
T293 21411-21417 UBERON:0000479 denotes tissue
T292 21453-21461 UBERON:0003215 denotes alveolar
T291 21472-21476 G_3;PG_10;PR:000003622 denotes ACE2
T290 21523-21527 UBERON:0002048 denotes lung
T289 21577-21581 G_3;PG_10;PR:000003622 denotes ACE2
T288 21690-21695 NCBITaxon:10239 denotes viral
T287 13074-13083 SP_7 denotes 2019-nCoV
T286 13135-13140 NCBITaxon:10239 denotes virus
T285 13180-13190 GO:0042571 denotes antibodies
T284 13285-13295 GO:0042571 denotes antibodies
T283 13353-13361 GO:0042571 denotes antibody
T282 13418-13421 BV_22 denotes RNA
T281 13422-13427 BV_22;NCBITaxon:10239 denotes virus
T280 13466-13474 CHEBI:60004;CHEBI:60004 denotes cocktail
T279 13475-13483 GO:0042571 denotes antibody
T278 13714-13719 NCBITaxon:10239 denotes viral
T277 13720-13732 CHEBI:17089;BV_11;CHEBI:17089 denotes glycoprotein
T276 13818-13823 NCBITaxon:10239 denotes viral
T275 13848-13860 GO:0009986 denotes cell surface
T274 13883-13888 NCBITaxon:10239 denotes virus
T273 13994-13999 NCBITaxon:10239 denotes viral
T272 14072-14081 SP_7 denotes 2019-nCoV
T271 14091-14122 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T270 14124-14128 G_3;PG_10;PR:000003622 denotes ACE2
T269 14199-14203 SP_10 denotes SARS
T268 14204-14215 NCBITaxon:11118 denotes coronavirus
T267 14244-14251 NCBITaxon:10239 denotes viruses
T266 14257-14268 NCBITaxon:11118 denotes coronavirus
T265 14278-14282 G_3;PG_10;PR:000003622 denotes ACE2
T264 14295-14304 PG_1 denotes S protein
T263 14332-14341 GO:0061025 denotes fusion of
T262 14346-14351 NCBITaxon:10239;GO:0036338 denotes viral
T261 14352-14360 GO:0036338 denotes membrane
T260 14365-14378 GO:0005886 denotes cell membrane
T259 14409-14412 BV_22 denotes RNA
T258 14413-14418 BV_22;NCBITaxon:10239 denotes virus
T257 14424-14433 GO:0006260 denotes replicate
T256 14438-14444 SO:0001026 denotes genome
T255 14507-14515 GO:0046903 denotes secreted
T254 14558-14562 SP_10 denotes SARS
T253 14567-14576 SP_7 denotes 2019-nCoV
T252 14583-14587 G_3;PG_10;PR:000003622 denotes ACE2
T251 14665-14669 SP_10 denotes SARS
T250 14695-14704 SP_7 denotes 2019-nCoV
T249 14719-14723 SP_10 denotes SARS
T248 14855-14859 SP_10 denotes SARS
T247 11059-11067 GO:0042571 denotes antibody
T246 11208-11213 UBERON:0001977 denotes serum
T245 11254-11259 NCBITaxon:10239 denotes virus
T244 11282-11290 GO:0006936 denotes contract
T243 11295-11300 NCBITaxon:10239 denotes virus
T242 11342-11347 NCBITaxon:10239 denotes viral
T241 11384-11392 GO:0042571 denotes antibody
T240 11393-11399 UBERON:0002405;GO:0006955 denotes immune
T239 11400-11408 GO:0006955 denotes response
T238 11422-11427 NCBITaxon:10239 denotes viral
T237 11428-11436 CHEBI:59132;CHEBI:59132 denotes antigens
T236 11440-11449 SP_7 denotes 2019-nCoV
T235 11476-11486 GO:0042571 denotes antibodies
T234 11514-11519 NCBITaxon:10239 denotes virus
T233 11613-11622 SP_7 denotes 2019-nCoV
T232 11623-11633 GO:0042571 denotes antibodies
T231 11681-11690 SP_7 denotes 2019-nCoV
T230 11709-11715 UBERON:0001969 denotes plasma
T229 11731-11737 UBERON:0001969 denotes plasma
T228 11794-11800 UBERON:0001969 denotes plasma
T227 11854-11860 UBERON:0001969 denotes plasma
T226 12084-12089 UBERON:0001977 denotes serum
T225 12303-12311 UBERON:0001977 denotes antisera
T224 12316-12325 SP_7 denotes 2019-nCoV
T223 12351-12359 UBERON:0001977 denotes antisera
T222 12623-12629 UBERON:0001969 denotes plasma
T221 12675-12679 UBERON:0001977 denotes sera
T220 12857-12861 UBERON:0001977 denotes sera
T219 12959-12970 GO:0065007 denotes controlling
T218 9404-9410 CHEBI:36357;CHEBI:36357 denotes agents
T217 9420-9429 SP_7 denotes 2019-nCoV
T216 9454-9462 CHEBI:36357;CHEBI:36357 denotes molecule
T215 9463-9468 CHEBI:23888;CHEBI:23888 denotes drugs
T214 9513-9518 NCBITaxon:10239 denotes viral
T213 9519-9523 UBERON:0000104 denotes life
T212 9553-9564 GO:0006260 denotes replication
T211 9603-9608 NCBITaxon:10239 denotes viral
T210 9637-9647 CHEBI:37670;CHEBI:37670 denotes inhibitors
T209 9684-9689 SP_6;NCBITaxon:9606 denotes human
T208 9707-9712 NCBITaxon:10376 denotes virus
T207 9723-9732 NCBITaxon:5690 denotes hepatitis
T206 9733-9740 NCBITaxon:10376 denotes C virus
T205 9907-9912 NCBITaxon:10239 denotes viral
T204 10002-10007 NCBITaxon:10376 denotes Ebola
T203 10047-10055 CHEBI:36357;CHEBI:36357 denotes molecule
T202 10056-10061 CHEBI:23888;CHEBI:23888 denotes drugs
T201 10145-10154 SP_7 denotes 2019-nCoV
T200 10219-10228 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T199 10233-10242 DG_30 denotes ritonavir
T198 10267-10277 CHEBI:35660;CHEBI:35660 denotes inhibitors
T197 10315-10324 SP_7 denotes 2019-nCoV
T196 10370-10374 SP_10 denotes SARS
T195 10495-10504 SP_7 denotes 2019-nCoV
T194 10522-10526 CHEBI:23888;CHEBI:23888 denotes drug
T193 10569-10574 NCBITaxon:10239 denotes virus
T192 10655-10665 DG_28 denotes remdesivir
T191 10693-10698 NCBITaxon:10239 denotes viral
T190 10741-10745 SP_9 denotes MERS
T189 10749-10754 NCBITaxon:10088 denotes mouse
T188 10811-10815 CHEBI:23888;CHEBI:23888 denotes drug
T187 10840-10853 NCBITaxon:11118 denotes coronaviruses
T186 10969-10978 SP_7 denotes 2019-nCoV
T185 11033-11037 CHEBI:23888;CHEBI:23888 denotes drug
T184 7486-7495 SP_7 denotes 2019-nCoV
T183 7500-7506 SO:0001026 denotes genome
T182 7528-7535 GO:0009986 denotes surface
T181 7548-7557 SP_7 denotes 2019-nCoV
T180 7589-7595 SO:0001026 denotes genome
T179 7629-7635 SO:0001026 denotes genome
T178 7648-7657 SP_7 denotes 2019-nCoV
T177 7766-7787 SO:0000646 denotes small interfering RNA
T176 7789-7794 SO:0000646 denotes siRNA
T175 7799-7808 SO:0000077 denotes antisense
T174 7846-7851 NCBITaxon:10239 denotes virus
T173 7873-7879 SO:0001026 denotes genome
T172 7966-7973 SO:0000417 denotes domains
T171 8067-8072 SO:0000646 denotes siRNA
T170 8093-8098 NCBITaxon:10239 denotes viral
T169 8157-8163 SO:0001026 denotes genome
T168 8164-8172 SO:0000853 denotes homology
T167 8176-8185 SP_7 denotes 2019-nCoV
T166 8193-8203 NCBITaxon:10633 denotes SARS virus
T165 8353-8358 UBERON:0000170 denotes lungs
T164 8415-8420 CHEBI:18059;CHEBI:18059 denotes lipid
T757 25684-25688 G_3;PG_10;PR:000003622 denotes ACE2
T756 25728-25737 SP_7 denotes 2019-nCoV
T755 25738-25749 NCBITaxon:11118 denotes coronavirus
T754 25760-25773 GO:0005576 denotes extracellular
T753 25774-25780 SO:0000417 denotes domain
T752 25784-25788 G_3;PG_10;PR:000003622 denotes ACE2
T751 25810-25815 SP_6;NCBITaxon:9606 denotes human
T750 25816-25830 GO:0019814 denotes immunoglobulin
T749 25834-25840 SO:0000417 denotes domain
T748 25877-25883 SO:0000417 denotes domain
T747 25896-25908 GO:0046983 denotes dimerization
T746 25916-25920 G_3;PG_10 denotes ACE2
T745 25921-25928 SO:0000417 denotes domains
T744 25966-25970 G_3;PG_10;PR:000003622 denotes ACE2
T743 26006-26010 G_3;PG_10 denotes ACE2
T742 26011-26017 SO:0000417 denotes domain
T741 26056-26061 SP_6;NCBITaxon:9606;PG_10 denotes human
T740 26062-26066 PG_10;PR:000003622 denotes ACE2
T739 26123-26128 SP_6;NCBITaxon:9606 denotes human
T738 26129-26143 GO:0019814 denotes immunoglobulin
T737 26239-26244 SP_6;NCBITaxon:9606 denotes human
T736 26245-26257 CHEBI:60816;CHEBI:60816 denotes immunoglobin
T735 17481-17487 CHEBI:52217;CHEBI:52217 denotes agents
T734 17516-17525 SP_7 denotes 2019-nCoV
T733 17561-17571 GO:0010467 denotes expressing
T732 17572-17576 G_3;PG_10;PR:000003622 denotes ACE2
T731 17585-17589 UBERON:0002048 denotes lung
T730 17594-17610 UBERON:0001555 denotes gastrointestinal
T729 17611-17618 UBERON:0000479 denotes tissues
T728 17626-17631 SP_6;NCBITaxon:9606 denotes human
T727 17669-17676 GO:0009986 denotes surface
T726 17684-17695 NCBITaxon:11118 denotes coronavirus
T725 17705-17709 G_3;PG_10;PR:000003622 denotes ACE2
T724 17740-17750 GO:0035376 denotes cell entry
T723 17868-17874 SO:0000417 denotes domain
T722 17907-17911 SP_10 denotes SARS
T721 17915-17924 SP_7 denotes 2019-nCoV
T720 17964-17968 G_3;PG_10;PR:000003622 denotes ACE2
T719 18019-18027 GO:0042571 denotes antibody
T718 18031-18037 SO:0000984 denotes single
T717 18044-18052 GO:0042571 denotes antibody
T716 18099-18103 G_3;PG_10;PR:000003622 denotes ACE2
T715 18162-18173 NCBITaxon:11118 denotes coronavirus
T714 18204-18208 G_3;PG_10;PR:000003622 denotes ACE2
T713 18209-18222 GO:0005576 denotes extracellular
T712 18223-18229 SO:0000417 denotes domain
T711 18270-18276 SO:0000417 denotes domain
T710 18286-18290 G_3;PG_10;PR:000003622 denotes ACE2
T709 18347-18351 G_3;PG_10;PR:000003622 denotes ACE2
T708 31537-31546 SP_7 denotes 2019-nCoV
T707 31601-31612 NCBITaxon:1 denotes individuals
T706 31768-31778 CHEBI:23888;CHEBI:23888 denotes medication
T705 31826-31831 GO:0016265 denotes death
T704 31859-31868 SP_7 denotes 2019-nCoV
T703 31909-31913 G_3;PG_10;PR:000003622 denotes ACE2
T702 31974-31978 G_3;PG_10;PR:000003622 denotes ACE2
T701 31994-31998 UBERON:0002048 denotes lung
T700 32011-32016 NCBITaxon:10239 denotes virus
T699 32041-32047 UBERON:0002405 denotes immune
T698 32048-32056 CHEBI:35224;CHEBI:35224 denotes effector
T697 32096-32100 G_3;PG_10;PR:000003622 denotes ACE2
T696 32313-32317 G_3;PG_10;PR:000003622 denotes ACE2
T695 32413-32420 BV_20 denotes protein
T694 32421-32431 BV_20;GO:0010467 denotes expression
T693 32448-32454 NCBITaxon:6960 denotes insect
T692 32545-32549 SO:0000704 denotes Gene
T691 32591-32595 G_3;PG_10;PR:000003622 denotes ACE2
T690 32779-32783 G_3;PG_10;PR:000003622 denotes ACE2
T689 32868-32873 GO:0016265 denotes death
T688 32999-33010 NCBITaxon:1 denotes individuals
T687 33044-33049 NCBITaxon:10239 denotes virus
T686 33064-33068 G_3;PG_10;PR:000003622 denotes ACE2
T685 33105-33113 GO:0042571 denotes antibody
T684 33163-33172 SP_7 denotes 2019-nCoV
T683 33327-33331 UBERON:0001977 denotes sera
T682 33370-33381 NCBITaxon:1 denotes individuals
T681 33391-33395 G_3;PG_10;PR:000003622 denotes ACE2
T680 33421-33426 NCBITaxon:10239 denotes viral
T679 33484-33494 GO:0042571 denotes antibodies
T678 33623-33632 SP_7 denotes 2019-nCoV
T677 33709-33719 GO:0042571 denotes antibodies
T676 33741-33750 PG_1 denotes S protein
T675 33891-33905 BV_15 denotes immunogenicity
T674 33907-33914 CHEBI:59132;CHEBI:59132 denotes antigen
T673 33929-33937 CHEBI:60809;CHEBI:60809 denotes adjuvant
T672 33959-33967 GO:0042571 denotes antibody
T671 33985-33990 NCBITaxon:10239 denotes virus
T670 34091-34100 SP_7 denotes 2019-nCoV
T669 34119-34123 G_3;PG_10;PR:000003622 denotes ACE2
T668 34233-34242 SP_7 denotes 2019-nCoV
T667 34286-34290 G_3;PG_10;PR:000003622 denotes ACE2
T666 34378-34382 SP_10 denotes SARS
T665 34390-34395 SP_6;NCBITaxon:9606 denotes human
T664 34396-34407 NCBITaxon:11118 denotes coronavirus
T663 34519-34525 SO:0000440 denotes vector
T662 34539-34544 NCBITaxon:10239 denotes viral
T661 34545-34551 SO:0000440 denotes vector
T660 34677-34682 NCBITaxon:10239 denotes virus
T659 34754-34763 SP_7 denotes 2019-nCoV
T658 34793-34797 G_3;PG_10;PR:000003622 denotes ACE2
T657 34847-34852 SP_6;NCBITaxon:9606 denotes human
T656 34856-34863 SO:0000417 denotes domains
T655 35022-35026 G_3;PG_10;PR:000003622 denotes ACE2
T654 35054-35058 G_3;PG_10;PR:000003622 denotes ACE2
T653 35116-35120 GO:0006412;SO:0000704 denotes gene
T652 35121-35130 GO:0071897 denotes synthesis
T651 35180-35184 SO:0000704 denotes gene
T650 35212-35219 BV_20 denotes protein
T649 35220-35230 BV_20;GO:0010467 denotes expression
T648 35393-35403 GO:0042571 denotes antibodies
T647 35421-35425 G_3;PG_10;PR:000003622 denotes ACE2
T646 35466-35474 GO:0042571 denotes antibody
T645 35551-35555 G_3;PG_10;PR:000003622 denotes ACE2
T644 35613-35617 CHEBI:23888;CHEBI:23888 denotes drug
T643 35652-35656 SP_10 denotes SARS
T642 35661-35670 SP_7 denotes 2019-nCoV
T641 35684-35695 NCBITaxon:11118 denotes coronavirus
T640 35763-35767 G_3;PG_10;PR:000003622 denotes ACE2
T639 35798-35811 NCBITaxon:11118 denotes coronaviruses
T638 35817-35826 GO:0006260 denotes replicate
T637 35830-35837 NCBITaxon:33208 denotes animals
T636 35969-35976 NCBITaxon:33208 denotes animals
T635 36117-36125 CHEBI:36357;CHEBI:36357 denotes molecule
T634 36181-36185 PG_7;PR:000001341 denotes DPP4
T633 36214-36218 SP_9 denotes MERS
T632 36232-36237 NCBITaxon:10239 denotes viral
T631 36248-36252 PG_7;PR:000001341 denotes DPP4
T630 36267-36272 NCBITaxon:10239 denotes virus
T629 36284-36297 NCBITaxon:11118 denotes coronaviruses
T628 36341-36348 NCBITaxon:10239 denotes viruses
T627 36395-36399 G_3;PG_10;PR:000003622 denotes ACE2
T626 36460-36467 NCBITaxon:10239 denotes viruses
T625 36488-36492 UBERON:0002048 denotes lung
T624 36566-36570 G_3;PG_10;PR:000003622 denotes ACE2
T623 36615-36623 GO:0042571 denotes antibody
T622 36674-36683 SP_7 denotes 2019-nCoV
T621 36842-36851 SP_7 denotes 2019-nCoV
T620 36966-36974 CHEBI:36357;CHEBI:36357 denotes molecule
T619 21798-21802 G_3;PG_10;PR:000003622 denotes ACE2
T618 21886-21894 GO:0042571 denotes antibody
T617 21900-21908 CHEBI:36357;CHEBI:36357 denotes molecule
T616 21932-21943 NCBITaxon:11118 denotes coronavirus
T615 22067-22071 G_3;PG_10;PR:000003622 denotes ACE2
T614 22104-22113 PG_1 denotes S protein
T613 22117-22126 SP_7 denotes 2019-nCoV
T612 22152-22157 NCBITaxon:10239 denotes virus
T611 22198-22202 SP_10;NCBITaxon:10633 denotes SARS
T610 22203-22208 NCBITaxon:10239 denotes virus
T609 22266-22270 G_3;PG_10;PR:000003622 denotes ACE2
T608 22310-22314 SP_10;NCBITaxon:10633 denotes SARS
T607 22315-22320 NCBITaxon:10239 denotes virus
T606 22390-22394 G_3;PG_10;PR:000003622 denotes ACE2
T605 22403-22407 SP_10;PG_9 denotes SARS
T604 22408-22409 PG_9;PG_1 denotes S
T603 22410-22417 PG_1 denotes protein
T602 22483-22493 GO:0042571 denotes antibodies
T601 22516-22525 SP_7 denotes 2019-nCoV
T600 22551-22555 G_3;PG_10;PR:000003622 denotes ACE2
T599 22573-22577 G_3;PG_10;PR:000003622 denotes ACE2
T598 22651-22655 G_3;PG_10;PR:000003622 denotes ACE2
T597 22697-22711 GO:0019814 denotes immunoglobulin
T596 22715-22721 SO:0000417 denotes domain
T595 22723-22727 G_3;PG_10;PR:000003622 denotes ACE2
T594 22755-22763 UBERON:0000104 denotes lifespan
T593 22783-22791 CHEBI:36357;CHEBI:36357 denotes molecule
T592 22815-22823 CHEBI:35224;CHEBI:35224 denotes effector
T591 22841-22854 UBERON:0002405 denotes immune system
T590 22867-22872 NCBITaxon:10239 denotes virus
T589 22897-22903 NCBITaxon:33208 denotes animal
T588 22949-22953 G_3;PG_10;PR:000003622 denotes ACE2
T587 22954-22967 GO:0005576 denotes extracellular
T586 22968-22974 SO:0000417 denotes domain
T585 22988-22993 SP_6;NCBITaxon:9606 denotes human
T584 22999-23005 SO:0000417 denotes domain
T583 23007-23011 G_3;PG_10;PR:000003622 denotes ACE2
T582 23049-23053 SP_10 denotes SARS
T581 23054-23065 NCBITaxon:11118 denotes coronavirus
T580 23163-23167 G_3;PG_10;PR:000003622 denotes ACE2
T579 23195-23204 SP_7 denotes 2019-nCoV
T578 23276-23280 G_3;PG_10;PR:000003622 denotes ACE2
T577 23286-23295 SP_7 denotes 2019-nCoV
T576 23296-23305 PG_1 denotes S protein
T575 23333-23337 G_3;PG_10;PR:000003622 denotes ACE2
T574 23437-23441 SP_10 denotes SARS
T573 23446-23455 SP_7 denotes 2019-nCoV
T572 23511-23520 UBERON:0002048 denotes pulmonary
T571 23537-23548 UBERON:0001004 denotes respiratory
T570 23584-23591 NCBITaxon:10239 denotes viruses
T163 8475-8480 UBERON:0000170 denotes lungs
T162 8519-8524 SO:0000646 denotes siRNA
T161 8578-8583 UBERON:0000170 denotes lungs
T160 8674-8682 UBERON:0004821;CL:0000322 denotes alveolar
T159 8683-8693 CL:0000322;UBERON:0004821 denotes epithelial
T158 8694-8699 CL:0000322 denotes cells
T157 8707-8711 UBERON:0002048 denotes lung
T156 8716-8721 SO:0000646 denotes siRNA
T155 8795-8799 SO:0000704 denotes gene
T154 8851-8856 NCBITaxon:10239 denotes viral
T153 8907-8912 SO:0000646 denotes siRNA
T152 9002-9008 NCBITaxon:33208 denotes animal
T151 9057-9062 SO:0000646 denotes siRNA
T150 9145-9150 SO:0000646 denotes siRNA
T149 9151-9156 CHEBI:23888;CHEBI:23888 denotes drugs
T148 9197-9202 SO:0000646 denotes siRNA
T147 9322-9333 CHEBI:23888;CHEBI:23888 denotes medications
T146 4346-4356 GO:0042571 denotes antibodies
T145 4360-4369 SP_7 denotes 2019-nCoV
T144 4370-4381 NCBITaxon:11118 denotes Coronavirus
T143 4404-4413 PG_1 denotes S protein
T142 4450-4462 GO:0009986 denotes cell surface
T141 4502-4515 GO:0005886 denotes cell membrane
T140 4532-4537 NCBITaxon:10239 denotes viral
T139 4538-4550 GO:0000786 denotes nucleocapsid
T138 4582-4593 GO:0006260 denotes replication
T137 4602-4611 PG_1 denotes S protein
T136 4744-4753 PG_1 denotes S protein
T135 4819-4827 GO:0042571 denotes antibody
T134 4842-4851 PG_1 denotes S protein
T133 4870-4879 SP_7 denotes 2019-nCoV
T132 5038-5044 SO:0001026 denotes genome
T131 5057-5066 SP_7 denotes 2019-nCoV
T130 5119-5123 SO:0000704;GO:0006412 denotes gene
T129 5158-5168 GO:0010467 denotes expressing
T128 5173-5182 PG_1 denotes S protein
T127 5189-5198 CHEBI:60816;CHEBI:60816 denotes immunogen
T126 5233-5237 NCBITaxon:10088 denotes mice
T125 5241-5248 NCBITaxon:9986 denotes rabbits
T124 5266-5276 GO:0042571 denotes antibodies
T123 5383-5390 GO:0010467 denotes express
T122 5391-5399 GO:0042571 denotes antibody
T121 5464-5469 NCBITaxon:10239 denotes viral
T120 5519-5527 GO:0042571 denotes antibody
T119 5593-5599 NCBITaxon:33208 denotes animal
T118 5641-5650 SP_7 denotes 2019-nCoV
T117 5852-5860 GO:0042571 denotes antibody
T116 5885-5898 NCBITaxon:11118 denotes coronaviruses
T115 5899-5906 NCBITaxon:species denotes species
T114 5912-5916 SP_10 denotes SARS
T113 5965-5972 BV_9 denotes epitope
T112 6006-6016 GO:0042571 denotes antibodies
T111 6039-6045 SO:0000417 denotes domain
T110 6053-6062 PG_1 denotes S protein
T109 6215-6223 CHEBI:60004;CHEBI:60004 denotes cocktail
T108 6227-6237 GO:0042571 denotes antibodies
T107 6436-6443 GO:0010467 denotes express
T106 6473-6482 NCBITaxon:1 denotes organisms
T105 6487-6494 BV_20 denotes protein
T104 6495-6505 BV_20;GO:0010467 denotes expression
T103 6507-6515 NCBITaxon:2 denotes bacteria
T102 6524-6530 NCBITaxon:6960 denotes insect
T101 6652-6662 GO:0042571 denotes antibodies
T100 6671-6680 SP_7 denotes 2019-nCoV
T99 6681-6690 PG_1 denotes S protein
T98 6718-6725 NCBITaxon:33208 denotes animals
T97 6727-6732 NCBITaxon:9940 denotes sheep
T96 6734-6738 NCBITaxon:9925 denotes goat
T95 6740-6743 NCBITaxon:9913 denotes cow
T94 6754-6763 SP_7 denotes 2019-nCoV
T93 6764-6773 PG_1 denotes S protein
T92 6805-6815 GO:0042571 denotes antibodies
T91 6825-6832 NCBITaxon:33208 denotes animals
T90 7023-7029 NCBITaxon:33208 denotes animal
T89 7057-7065 UBERON:0001977 denotes antisera
T88 7079-7087 GO:0042571 denotes antibody
T87 7111-7117 NCBITaxon:33208 denotes animal
T86 7150-7155 SP_6;NCBITaxon:9606 denotes human
T85 7156-7162 UBERON:0002405;GO:0006959 denotes immune
T84 7163-7171 GO:0006959 denotes response
T83 7188-7203 GO:0019814 denotes immunoglobulins
T82 7213-7220 NCBITaxon:species denotes species
T81 7396-7405 SP_7 denotes 2019-nCoV
T80 92-99 GO:0040007 denotes growing
T79 133-142 UBERON:0002048 denotes pneumonia
T78 203-214 NCBITaxon:11118 denotes coronavirus
T77 216-225 SP_7 denotes 2019-nCoV
T76 274-278 SP_10 denotes SARS
T75 320-324 SP_9 denotes MERS
T74 341-345 SP_10 denotes SARS
T73 350-354 SP_9 denotes MERS
T72 437-441 SP_10 denotes SARS
T71 559-563 SP_10 denotes SARS
T70 585-591 NCBITaxon:9606 denotes people
T69 607-613 GO:0016265 denotes deaths
T68 676-687 NCBITaxon:11118 denotes coronavirus
T67 689-698 SP_7 denotes 2019-nCoV
T66 772-777 SP_6;NCBITaxon:9606 denotes Human
T65 781-786 SP_6;NCBITaxon:9606 denotes human
T64 803-812 SP_7 denotes 2019-nCoV
T63 996-1005 SP_7 denotes 2019-nCoV
T62 1031-1036 UBERON:0002048 denotes cough
T61 1092-1097 UBERON:0001443 denotes chest
T60 1200-1211 NCBITaxon:1 denotes individuals
T59 1270-1275 NCBITaxon:10239 denotes virus
T58 1387-1398 NCBITaxon:11118 denotes coronavirus
T57 1626-1630 SP_10 denotes SARS
T56 1658-1669 NCBITaxon:10376 denotes Ebola virus
T55 1780-1791 NCBITaxon:1 denotes individuals
T54 2039-2043 SP_10 denotes SARS
T53 2047-2052 NCBITaxon:10376 denotes Ebola
T52 2186-2195 SP_7 denotes 2019-nCoV
T51 2390-2394 CHEBI:23888;CHEBI:23888;GO:0017144 denotes drug
T50 2395-2406 GO:0017144 denotes development
T49 2492-2497 GO:0016265 denotes dying
T48 2885-2890 NCBITaxon:10239 denotes virus
T47 2959-2968 SP_7 denotes 2019-nCoV
T46 2970-2975 NCBITaxon:10376 denotes Ebola
T45 3083-3089 NCBITaxon:33208 denotes animal
T44 3133-3142 SP_7 denotes 2019-nCoV
T43 3200-3211 NCBITaxon:11118 denotes coronavirus
T42 3263-3274 CHEBI:60816;CHEBI:60816 denotes immunogenic
T41 3339-3343 SP_10 denotes SARS
T40 3348-3352 SP_9 denotes MERS
T39 3505-3514 SP_7 denotes 2019-nCoV
T38 3583-3592 SP_7 denotes 2019-nCoV
T37 3628-3633 NCBITaxon:10376 denotes Ebola
T36 3817-3826 SP_7 denotes 2019-nCoV
T35 3827-3832 NCBITaxon:10239 denotes virus
T34 3979-3988 SP_7 denotes 2019-nCoV
T33 4048-4057 SP_7 denotes 2019-nCoV
T420 30683-30687 G_3;PG_10;PR:000003622 denotes ACE2
T419 30688-30701 GO:0005576 denotes extracellular
T418 30702-30708 SO:0000417 denotes domain
T417 30777-30781 PR:000014459;SP_10;PG_9 denotes SARS
T416 30782-30783 PG_9;PG_1;PR:000005292 denotes S
T415 30784-30791 PG_1;PR:000005292 denotes protein
T414 30807-30811 G_3;PG_10;PR:000003622 denotes ACE2
T413 30911-30915 G_3;PG_10;PR:000003622 denotes ACE2
T412 30928-30932 UBERON:0002048 denotes lung
T411 30977-30981 G_3;PG_10;PR:000003622 denotes ACE2
T410 31074-31082 GO:0042571 denotes antibody
T409 31117-31126 SP_7 denotes 2019-nCoV
T408 31157-31161 PR:000001483 denotes CD16
T407 31226-31236 GO:0042571 denotes antibodies
T406 31240-31244 SP_9 denotes MERS
T405 31437-31441 G_3;PG_10;PR:000003622 denotes ACE2

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T10 1092-1097 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T11 3185-3192 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T12 3291-3298 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T13 4406-4413 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 4450-4462 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T15 4450-4454 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T16 4502-4515 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T17 4502-4506 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T18 4562-4566 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T19 4604-4611 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T20 4671-4676 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 4704-4709 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22 4746-4753 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T23 4819-4827 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T24 4844-4851 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T25 5038-5044 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T26 5119-5123 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T27 5175-5182 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T28 5391-5399 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T29 5519-5527 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T30 5576-5580 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T31 5852-5860 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T32 6055-6062 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 6487-6494 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T34 6531-6536 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T35 6683-6690 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T36 6766-6773 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 7079-7087 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T38 7188-7203 Body_part denotes immunoglobulins http://purl.org/sig/ont/fma/fma62871
T39 7496-7499 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T40 7500-7506 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T41 7536-7544 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T42 7585-7588 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T43 7589-7595 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T44 7625-7628 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T45 7629-7635 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T46 7784-7787 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T47 7869-7872 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T48 7873-7879 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T49 7953-7956 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T50 8157-8163 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T51 8353-8358 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T52 8415-8420 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T53 8475-8480 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T54 8578-8583 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T55 8674-8699 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T56 8694-8699 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T57 8707-8711 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T58 8795-8799 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T59 9714-9717 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T60 10254-10257 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T61 10472-10476 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T62 11059-11067 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T63 11208-11213 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T64 11384-11392 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T65 11709-11715 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T66 11731-11737 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T67 11794-11800 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T68 11854-11860 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T69 12084-12089 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T70 12623-12629 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T71 13155-13160 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T72 13215-13219 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T73 13353-13361 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T74 13418-13421 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T75 13475-13483 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T76 13720-13732 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T77 13833-13840 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T78 13848-13860 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T79 13848-13852 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T80 14012-14016 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T81 14148-14152 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T82 14297-14304 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T83 14365-14378 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T84 14365-14369 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T85 14409-14412 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T86 14438-14444 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T87 14456-14460 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T88 14532-14537 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T89 15053-15060 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T90 15438-15446 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T91 15524-15536 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T92 15524-15528 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T93 15693-15700 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T94 15823-15834 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T95 15901-15905 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T96 16012-16020 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T97 16031-16036 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T98 16490-16497 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T99 16616-16623 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T100 16783-16791 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T101 16960-16967 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T102 17067-17077 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T103 17176-17180 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T104 17336-17341 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T105 17541-17546 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T106 17555-17560 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T107 17585-17589 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T108 17611-17618 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T109 17626-17636 Body_part denotes human body http://purl.org/sig/ont/fma/fma305853
T110 17654-17661 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T111 17722-17727 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T112 17740-17744 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T113 17894-17901 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T114 18019-18027 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T115 18044-18052 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T116 18255-18262 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T117 18410-18418 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T118 18443-18450 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T119 18609-18617 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T120 18840-18848 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T121 18915-18922 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T122 19011-19019 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T123 19157-19164 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T124 19363-19367 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T125 19800-19807 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T126 19978-19982 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T127 20035-20042 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T128 20512-20516 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T129 20696-20700 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T130 20721-20725 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T131 20774-20791 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T132 20786-20791 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T133 20804-20811 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T134 20921-20933 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T135 20921-20925 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T136 20981-20988 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T137 21139-21144 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T138 21174-21179 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T139 21285-21289 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T140 21352-21359 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T141 21406-21410 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T142 21411-21417 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T143 21453-21461 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T144 21523-21527 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T145 21886-21894 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T146 21974-21979 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T147 22106-22113 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T148 22336-22341 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T149 22410-22417 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T150 22697-22711 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T151 22841-22854 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T152 23298-23305 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T153 23644-23651 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T154 23670-23677 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T155 23732-23739 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T156 23787-23794 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T157 23827-23831 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T158 23888-23896 Body_part denotes hormones http://purl.org/sig/ont/fma/fma12278
T159 24310-24331 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T160 24805-24812 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T161 24830-24846 Body_part denotes immunoglobulin G http://purl.org/sig/ont/fma/fma62872
T162 24904-24915 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T163 24960-24967 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T164 25148-25155 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T165 25242-25246 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T166 25342-25349 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T167 25392-25400 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T168 25456-25463 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T169 25560-25567 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T170 25641-25646 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T171 25699-25706 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 25816-25830 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T173 25939-25949 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T174 25981-25988 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T175 26030-26041 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T176 26067-26074 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T177 26129-26145 Body_part denotes immunoglobulin G http://purl.org/sig/ont/fma/fma62872
T178 26881-26896 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T179 26891-26896 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T180 26898-26909 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T181 26915-26935 Body_part denotes natural killer cells http://purl.org/sig/ont/fma/fma63147
T182 26930-26935 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T183 26998-27003 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T184 27250-27255 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T185 27340-27347 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 27415-27423 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T187 27602-27609 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T188 27635-27639 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T189 27828-27835 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T190 27874-27881 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T191 28498-28501 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T192 28555-28558 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T193 28578-28585 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T194 28694-28697 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T195 28698-28703 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T196 28709-28712 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T197 28737-28740 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T198 28777-28784 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T199 28931-28934 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T200 29120-29123 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T201 29243-29246 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T202 29304-29308 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T203 29374-29377 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T204 29603-29606 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T205 29820-29824 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T206 29967-29974 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T207 30082-30089 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T208 30170-30174 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T209 30323-30333 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T210 30494-30501 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T211 30594-30601 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T212 30633-30642 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T213 30784-30791 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T214 30891-30898 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T215 30928-30932 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T216 31074-31082 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T217 31172-31177 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T218 31994-31998 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T219 32413-32420 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T220 32545-32549 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T221 32606-32609 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T222 32613-32617 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T223 33105-33113 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T224 33743-33750 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T225 33777-33784 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T226 33959-33967 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T227 34559-34563 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T228 34571-34578 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T229 34769-34776 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T230 35116-35120 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T231 35180-35184 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T232 35212-35219 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T233 35280-35287 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T234 35328-35335 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T235 35466-35474 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T236 36488-36492 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T237 36615-36623 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 1092-1097 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T3 7383-7388 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T4 8707-8711 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T5 9119-9124 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T6 11208-11213 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T7 12084-12089 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T8 17585-17589 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T9 20534-20540 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T10 20721-20725 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T11 20747-20753 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T12 21285-21289 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T13 21406-21410 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T14 21411-21417 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T15 21523-21527 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T16 22841-22854 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T17 23827-23831 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T18 24310-24331 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T19 25242-25246 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T20 30170-30174 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T21 30928-30932 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T22 31994-31998 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T23 36488-36492 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p4463s12 10699-10709 MPA denotes polymerase
p4504s27 17424-17433 NegReg denotes eliminate
p4551s19 23678-23687 NegReg denotes decreased
p4551s20 23688-23698 MPA denotes expression
p4580s38 27850-27856 MPA denotes levels
p4588s25 29030-29039 PosReg denotes enhancing
p4588s26 29040-29048 MPA denotes affinity
p4596s33 30709-30718 NegReg denotes abolished
p4596s34 30719-30728 Enzyme denotes peptidase
p4596s35 30729-30737 MPA denotes activity
p4596s39 30752-30756 MPA denotes high
p4596s40 30757-30765 MPA denotes affinity
p4596s41 30766-30773 Interaction denotes binding
p4619s14 34278-34285 NegReg denotes reduced
p4619s15 34286-34290 Protein denotes ACE2

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T5 42-51 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T6 133-142 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T7 239-272 Disease denotes Severe Acute Respiratory Syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T8 274-278 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T9 341-345 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T10 437-441 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T11 559-563 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T12 996-1015 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T13 1006-1015 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T14 1066-1075 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T15 1626-1630 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T16 1658-1663 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T17 2039-2043 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T18 2047-2052 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T19 2704-2709 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T20 2970-2975 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T21 3339-3343 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T22 3628-3633 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T23 5663-5672 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T24 5912-5916 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T25 8193-8197 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T26 8596-8605 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 8851-8866 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T28 8857-8866 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 8932-8937 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T30 9690-9706 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T31 9723-9734 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T32 9723-9732 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T33 10002-10007 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T34 10370-10374 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T35 11173-11183 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T36 11342-11357 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T37 11348-11357 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T38 11546-11555 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T39 11588-11597 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 12051-12056 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T41 12244-12253 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T42 13542-13547 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T43 14199-14203 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T44 14558-14562 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T45 14665-14669 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T46 14719-14723 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T47 14842-14851 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T48 14855-14859 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T49 15375-15384 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T50 15686-15690 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T51 15893-15897 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T52 15948-15952 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T53 16049-16058 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54 16204-16208 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T55 16323-16327 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T56 17153-17168 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T57 17159-17168 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58 17822-17831 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59 17907-17911 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T60 18471-18490 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T61 18481-18490 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T62 18549-18553 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T63 19111-19123 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T64 19955-19959 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T65 20030-20034 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T66 20095-20104 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T67 20649-20658 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T68 21122-21131 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T69 21363-21367 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T70 21517-21534 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T72 21528-21534 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T73 21639-21648 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T74 21690-21705 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T75 21696-21705 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T76 22198-22202 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T77 22310-22314 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T78 22403-22407 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T79 23012-23014 Disease denotes NN http://purl.obolibrary.org/obo/MONDO_0009747
T80 23049-23053 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T81 23383-23392 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T82 23437-23441 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T83 23446-23465 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T84 23456-23465 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T85 23474-23483 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T86 23511-23526 Disease denotes pulmonary edema http://purl.obolibrary.org/obo/MONDO_0006932
T87 23531-23566 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T88 23537-23566 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T89 23568-23572 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T90 23612-23616 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T91 23821-23838 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T93 23832-23838 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T94 23988-23992 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T95 24036-24045 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T96 24049-24058 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T97 24194-24198 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T98 24585-24589 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T99 24679-24683 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T100 24953-24957 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 25247-25253 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T102 25592-25596 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 26700-26712 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T104 27138-27142 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 27216-27220 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T106 27468-27477 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T107 27699-27703 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T108 27810-27814 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T109 27867-27871 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T110 28058-28062 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T111 28151-28160 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T112 28762-28771 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T113 29195-29211 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T114 29585-29594 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T115 29629-29638 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T116 30175-30181 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T117 30473-30477 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T118 30777-30781 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T119 30933-30939 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T120 31999-32005 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T121 32799-32808 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T122 33216-33220 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T123 34195-34204 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T124 34378-34382 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T125 35652-35656 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T126 36435-36439 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T127 36482-36499 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T129 36493-36499 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T130 36674-36693 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T131 36684-36693 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T21 13-14 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T22 105-106 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 195-196 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T24 644-656 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T25 772-777 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T26 781-786 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T27 813-816 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T28 1092-1097 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T29 1175-1178 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T30 1270-1275 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T31 1319-1320 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 1373-1375 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T33 1564-1571 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T34 1664-1669 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T35 2113-2115 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T36 2126-2127 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 2170-2180 http://purl.obolibrary.org/obo/UBERON_0001456 denotes are facing
T38 2217-2223 http://purl.obolibrary.org/obo/UBERON_0001456 denotes facing
T39 2437-2438 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 2726-2727 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 2826-2827 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T42 2885-2890 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T43 3061-3067 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T44 3083-3089 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T45 3408-3409 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 3435-3436 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T47 3803-3804 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 3827-3832 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T49 3846-3851 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T50 3884-3890 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T51 4180-4182 http://purl.obolibrary.org/obo/CLO_0050475 denotes my
T52 4254-4261 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T53 4425-4426 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 4450-4454 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T55 4502-4506 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T56 4507-4515 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T57 4562-4566 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T58 4671-4676 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T59 4704-4709 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T60 4804-4805 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T61 5119-5123 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T62 5566-5572 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T63 5576-5580 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T64 5593-5599 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T65 5721-5727 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T66 6066-6067 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 6080-6082 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T68 6102-6103 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 6213-6214 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T70 6473-6482 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T71 6473-6482 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T72 6507-6515 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T73 6531-6536 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T74 6718-6725 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T75 6727-6732 http://purl.obolibrary.org/obo/NCBITaxon_9940 denotes sheep
T76 6734-6738 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T77 6825-6832 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T78 6916-6919 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T79 6990-6993 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T80 7023-7029 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T81 7111-7117 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T82 7150-7155 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T83 7281-7283 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T84 7288-7289 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T85 7348-7349 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86 7846-7851 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T87 8198-8203 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T88 8278-8279 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T89 8353-8358 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T90 8475-8480 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T91 8578-8583 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T92 8614-8615 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 8683-8711 http://purl.obolibrary.org/obo/CL_0000082 denotes epithelial cells in the lung
T94 8763-8764 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 8795-8799 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T96 8849-8850 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 9002-9008 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T98 9020-9022 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T99 9098-9099 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 9160-9161 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 9684-9689 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T102 9707-9712 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T103 9735-9740 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T104 9884-9887 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T105 10472-10476 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T106 10520-10521 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T107 10569-10574 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T108 10714-10717 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T109 10749-10754 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T110 10867-10869 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T111 10871-10873 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T112 11108-11109 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T113 11254-11259 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T114 11295-11300 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T115 11315-11317 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T116 11371-11372 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T117 11514-11519 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T118 11709-11715 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T119 11731-11737 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T120 11794-11800 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T121 11854-11860 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T122 12331-12332 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T123 12391-12392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T124 12623-12629 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T125 13135-13140 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T126 13155-13160 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T127 13330-13331 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T128 13375-13376 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T129 13422-13427 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T130 13464-13465 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T131 13761-13762 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 13848-13852 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T133 13883-13888 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T134 14012-14016 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T135 14026-14027 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T136 14133-14134 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 14148-14152 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T138 14159-14161 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T139 14244-14251 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T140 14352-14360 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T141 14365-14369 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T142 14370-14378 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T143 14413-14418 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T144 14456-14460 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T145 14532-14537 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T146 15164-15169 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T147 15385-15390 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T148 15488-15495 http://purl.obolibrary.org/obo/CLO_0009985 denotes focuses
T149 15524-15528 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T150 15706-15709 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T151 15844-15847 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T152 15901-15905 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T153 16031-16036 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T154 16163-16164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T155 16548-16550 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T156 16675-16683 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T157 16810-16811 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T158 16878-16881 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T159 16909-16921 http://purl.obolibrary.org/obo/OBI_0000245 denotes organization
T160 16992-16994 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T161 17109-17111 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T162 17176-17180 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T163 17305-17307 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T164 17336-17341 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T165 17381-17383 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T166 17434-17436 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T167 17454-17456 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T168 17541-17546 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T169 17555-17560 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T170 17585-17589 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T171 17585-17589 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T172 17626-17631 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T173 17722-17727 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T174 17740-17744 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T175 18128-18129 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T176 18267-18269 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T177 18352-18354 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T178 18357-18358 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T179 18715-18724 http://purl.obolibrary.org/obo/CLO_0036932 denotes hybridoma
T180 18754-18755 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T181 18934-18935 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T182 19087-19089 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T183 19234-19236 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T184 19307-19309 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T185 19336-19337 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T186 19363-19367 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T187 19561-19562 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 19621-19622 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T189 19723-19731 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T190 19878-19880 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T191 20203-20210 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T192 20383-20384 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 20405-20406 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 20426-20428 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T195 20534-20540 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T196 20721-20725 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T197 20721-20725 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T198 20747-20753 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T199 20774-20791 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T200 20921-20925 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T201 21139-21144 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T202 21174-21179 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T203 21285-21289 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T204 21285-21289 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T205 21324-21325 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T206 21343-21344 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T207 21375-21377 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T208 21406-21410 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T209 21406-21410 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T210 21523-21527 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T211 21523-21527 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T212 21655-21656 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T213 21826-21827 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T214 21974-21979 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T215 22042-22043 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T216 22152-22157 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T217 22203-22208 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T218 22315-22320 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T219 22336-22341 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T220 22526-22529 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T221 22581-22582 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T222 22712-22714 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T223 22728-22730 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T224 22841-22854 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T225 22867-22872 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T226 22884-22890 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T227 22897-22903 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T228 22911-22912 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 22988-22993 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T230 23081-23082 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T231 23168-23170 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T232 23284-23285 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 23410-23411 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T234 23584-23591 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T235 23795-23798 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T236 23827-23831 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T237 23827-23831 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T238 24018-24023 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T239 24125-24130 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T240 24227-24228 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T241 24310-24331 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system
T242 24310-24331 http://www.ebi.ac.uk/efo/EFO_0000791 denotes cardiovascular system
T243 24336-24337 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T244 24404-24411 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T245 24542-24545 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T246 24613-24619 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T247 24645-24647 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T248 24822-24823 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T249 24824-24829 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T250 24847-24849 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T251 24866-24868 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2A
T252 24916-24918 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T253 25073-25074 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T254 25174-25175 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T255 25210-25218 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T256 25242-25246 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T257 25242-25246 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T258 25389-25391 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T259 25597-25602 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T260 25641-25646 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T261 25689-25691 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T262 25710-25711 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T263 25753-25754 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T264 25810-25815 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T265 25831-25833 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T266 25874-25876 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T267 25932-25933 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T268 25971-25973 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T269 26042-26044 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T270 26056-26061 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T271 26123-26128 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T272 26213-26214 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T273 26225-26231 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T274 26237-26238 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T275 26239-26244 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T276 26334-26336 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T277 26356-26357 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 26634-26635 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 26653-26655 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T280 26667-26668 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T281 26811-26813 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T282 26881-26896 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T283 26915-26935 http://purl.obolibrary.org/obo/CL_0000623 denotes natural killer cells
T284 26998-27003 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T285 27032-27042 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T286 27104-27109 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T287 27136-27137 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T288 27143-27148 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T289 27161-27163 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T290 27225-27235 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T291 27239-27249 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytic
T292 27250-27255 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T293 27296-27301 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T294 27330-27332 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T295 27388-27389 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T296 27448-27449 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T297 27635-27639 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T298 27658-27661 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T299 27725-27730 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T300 27763-27764 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T301 27792-27797 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T302 27998-27999 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T303 28016-28021 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T304 28063-28068 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T305 28112-28117 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T306 28261-28266 http://purl.obolibrary.org/obo/UBERON_0001456 denotes faced
T307 28287-28289 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T308 28314-28315 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T309 28397-28398 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T310 28428-28429 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T311 28484-28487 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T312 28488-28490 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T313 28494-28497 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T314 28543-28544 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T315 28625-28628 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T316 28698-28703 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T317 28705-28708 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T318 28927-28930 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T319 28978-28979 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T320 28986-28993 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T321 29090-29098 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T322 29144-29159 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes rhesus macaques
T323 29189-29194 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T324 29212-29217 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T325 29233-29235 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T326 29280-29287 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T327 29304-29314 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T328 29413-29414 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T329 29554-29559 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T330 29721-29723 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T331 29857-29858 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T332 29878-29880 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T333 30132-30133 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T334 30170-30174 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T335 30170-30174 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T336 30185-30186 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T337 30252-30254 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T338 30356-30364 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T339 30729-30737 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T340 30928-30932 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T341 30928-30932 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T342 30989-30997 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T343 31144-31146 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T344 31172-31177 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T345 31185-31188 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T346 31442-31444 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T347 31494-31503 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T348 31655-31664 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T349 31766-31767 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T350 31914-31916 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T351 31927-31928 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T352 31994-31998 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T353 31994-31998 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T354 32011-32016 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T355 32101-32103 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T356 32318-32320 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T357 32390-32391 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T358 32443-32446 http://purl.obolibrary.org/obo/CLO_0002421 denotes CHO
T359 32443-32446 http://purl.obolibrary.org/obo/CLO_0052479 denotes CHO
T360 32443-32446 http://purl.obolibrary.org/obo/CLO_0052480 denotes CHO
T361 32443-32446 http://purl.obolibrary.org/obo/CLO_0052483 denotes CHO
T362 32443-32446 http://purl.obolibrary.org/obo/CLO_0052484 denotes CHO
T363 32443-32446 http://purl.obolibrary.org/obo/CLO_0052485 denotes CHO
T364 32545-32549 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T365 32596-32598 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T366 32604-32605 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T367 32784-32786 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T368 32897-32898 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T369 33044-33049 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T370 33069-33071 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T371 33396-33398 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T372 33554-33555 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T373 33985-33990 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T374 34124-34126 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T375 34390-34395 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T376 34590-34591 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T377 34677-34682 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T378 34798-34800 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T379 34847-34852 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T380 34853-34855 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T381 34943-34946 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T382 35027-35029 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T383 35047-35053 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T384 35116-35120 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T385 35168-35169 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T386 35180-35184 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T387 35336-35337 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T388 35426-35428 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T389 35523-35524 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T390 35556-35558 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T391 35599-35600 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T392 35714-35715 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T393 35830-35837 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T394 35969-35976 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T395 36008-36009 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T396 36088-36089 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T397 36156-36157 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T398 36186-36188 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T399 36267-36272 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T400 36341-36348 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T401 36400-36402 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T402 36460-36467 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T403 36488-36492 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T404 36488-36492 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T405 36571-36573 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T406 36574-36577 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T407 36856-36858 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T8 2014-2023 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T9 2390-2394 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T10 3185-3192 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T11 3291-3298 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 4406-4413 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13 4604-4611 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 4746-4753 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T15 4844-4851 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T16 5175-5182 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T17 5189-5198 Chemical denotes immunogen http://purl.obolibrary.org/obo/CHEBI_60816
T18 5965-5972 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T19 6055-6062 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20 6487-6494 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T21 6683-6690 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22 6766-6773 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T23 7461-7477 Chemical denotes oligonucleotides http://purl.obolibrary.org/obo/CHEBI_7754
T24 7536-7544 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T25 7809-7825 Chemical denotes oligonucleotides http://purl.obolibrary.org/obo/CHEBI_7754
T26 8113-8128 Chemical denotes oligonucleotide http://purl.obolibrary.org/obo/CHEBI_7754
T27 8308-8324 Chemical denotes oligonucleotides http://purl.obolibrary.org/obo/CHEBI_7754
T28 8415-8420 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T29 8421-8434 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T30 9151-9156 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T31 9376-9385 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T32 9454-9462 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T33 9463-9468 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T34 9628-9647 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T36 9637-9647 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T37 9747-9756 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T38 9858-9867 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T39 10047-10055 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T40 10056-10061 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T41 10219-10242 Chemical denotes lopinavir and ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T42 10219-10228 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T43 10233-10242 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T44 10254-10277 Chemical denotes HIV protease inhibitors http://purl.obolibrary.org/obo/CHEBI_35660
T45 10258-10277 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T47 10267-10277 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T48 10458-10468 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T49 10522-10526 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T50 10655-10665 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T51 10811-10815 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T52 11033-11037 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T53 11428-11436 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T54 12617-12622 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T55 12733-12742 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T56 12794-12802 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T57 13720-13732 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T58 13833-13840 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T59 14091-14102 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T60 14297-14304 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T61 15053-15060 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T62 15505-15516 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T63 15512-15516 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T64 15693-15700 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T65 15823-15834 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T66 15823-15828 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T67 15829-15834 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T68 16012-16020 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T69 16616-16623 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 16783-16791 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T71 16960-16967 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T72 17067-17077 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T73 17067-17072 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T74 17073-17077 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T75 17654-17661 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T76 17894-17901 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 18255-18262 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T78 18443-18450 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79 18915-18922 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T80 19034-19042 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T81 19477-19481 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T82 19856-19865 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T83 20035-20042 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T84 20981-20988 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T85 21352-21359 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T86 21900-21908 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T87 22106-22113 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T88 22410-22417 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89 22783-22791 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T90 22815-22823 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T91 23012-23014 Chemical denotes NN http://purl.obolibrary.org/obo/CHEBI_73406
T92 23298-23305 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T93 23644-23651 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T94 23670-23677 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T95 23732-23739 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T96 23787-23794 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T97 23858-23872 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T100 23858-23869 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T101 23870-23872 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T102 23888-23896 Chemical denotes hormones http://purl.obolibrary.org/obo/CHEBI_24621
T103 23919-23933 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T106 23919-23930 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T107 23931-23933 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T108 24344-24346 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T109 24404-24411 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T110 24805-24812 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T111 24904-24915 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T112 24904-24909 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T113 24910-24915 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T114 24960-24967 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T115 25148-25155 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T116 25342-25349 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T117 25392-25400 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T118 25456-25463 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T119 25560-25567 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T120 25699-25706 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T121 25939-25949 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T122 25939-25944 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T123 25945-25949 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T124 25981-25988 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T125 26030-26041 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T126 26030-26035 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T127 26036-26041 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T128 26067-26074 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T129 26382-26386 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T130 26450-26454 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T131 26785-26793 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T132 26847-26855 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T133 27055-27064 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T134 27340-27347 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T135 27602-27609 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T136 27828-27835 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T137 27874-27881 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T138 28440-28449 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T139 28578-28585 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T140 28777-28784 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T141 28986-28993 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T142 30082-30089 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T143 30193-30195 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T144 30323-30333 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T145 30323-30328 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T146 30329-30333 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T147 30494-30501 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T148 30594-30601 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 30633-30642 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T150 30784-30791 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 30891-30898 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T152 31457-31463 Chemical denotes Action http://purl.obolibrary.org/obo/CHEBI_5133
T153 32048-32056 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T154 32413-32420 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T155 32606-32609 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T156 33743-33750 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T157 33777-33784 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T158 33907-33914 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T159 33929-33937 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T160 34571-34578 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T161 34769-34776 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
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T167 36966-36974 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 4644-4653 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T2 5124-5133 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T3 7156-7171 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T4 7607-7618 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T5 8851-8866 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T6 9513-9529 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycle
T7 11342-11357 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T8 11393-11408 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T9 12460-12466 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T10 17153-17168 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T11 17219-17234 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T12 19111-19123 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T13 19405-19418 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T14 20007-20022 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T15 20178-20193 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T16 20307-20322 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T17 21690-21705 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T18 26215-26224 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T19 27065-27080 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T20 30346-30364 http://purl.obolibrary.org/obo/GO_0008233 denotes peptidase activity
T21 30719-30737 http://purl.obolibrary.org/obo/GO_0008233 denotes peptidase activity
T22 33907-33927 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T23 35121-35130 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T16 0-12 Sentence denotes Introduction
T17 13-126 Sentence denotes A mysterious illness causing pneumonia in December 2019 in Wuhan, China is now growing into a potential pandemic.
T18 127-340 Sentence denotes These pneumonia cases were eventually characterized to be caused by a novel coronavirus (2019-nCoV) 1, of which Severe Acute Respiratory Syndrome (SARS) 2 and Middle East Respiratory Syndrome (MERS) 3 are members.
T19 341-436 Sentence denotes SARS and MERS famously caused their own outbreak concerns when they were originally identified.
T20 437-546 Sentence denotes SARS caused significant economic damage to Hong Kong and Southern China, before spreading to other countries.
T21 547-665 Sentence denotes Ultimately, SARS infected up to 8,098 people and caused 774 deaths according to the World Health Organization (WHO) 4.
T22 666-771 Sentence denotes The novel coronavirus, 2019-nCoV, is now quickly spreading across the world after originating in Wuhan 1.
T23 772-974 Sentence denotes Human-to-human transmission of 2019-nCoV has been confirmed in familial case cluster reports 5, as additional cases continue to be identified in different cities in China and countries around the world.
T24 975-1116 Sentence denotes Clinical symptoms of 2019-nCoV infection include fever, cough, and myalgia or fatigue with pneumonia demonstrated on chest CT scan imaging 6.
T25 1117-1425 Sentence denotes Within China, the city of Wuhan along with several others has been shut down, with individuals not allowed to leave the city in an effort to contain the virus; such efforts are largely unprecedented in a city of this size ( https://www.nytimes.com/2020/01/22/world/asia/coronavirus-quarantines-history.html).
T26 1426-1574 Sentence denotes For now, many travelers are being screened for fever (≥38°C) and reported recent history of travel to Wuhan in order to triage diagnostic testing 7.
T27 1575-1692 Sentence denotes These efforts resemble not only what happened with SARS in 2002–2003, but also the Ebola virus outbreak in 2014–2015.
T28 1693-1832 Sentence denotes During those outbreaks, special protocols were put in place to quarantine any infected individuals and identify patient contacts at risk 8.
T29 1833-1989 Sentence denotes Healthcare workers were also at risk, and despite extensive personal protective equipment measures, clinical providers did get infected in both outbreaks 9.
T30 1990-2196 Sentence denotes There were no specific, antiviral treatments for SARS or Ebola at the time of the outbreaks beyond supportive measures 10, 11, which is a similar situation that healthcare systems are facing with 2019-nCoV.
T31 2197-2331 Sentence denotes The dire situations facing patients in outbreak scenarios demand quick responses by the healthcare community and the biotech industry.
T32 2332-2541 Sentence denotes Unfortunately, many of the traditional options that guide drug development are inadequate for outbreaks; a process that takes years can’t help patients who are dying today, and economies that are being halted.
T33 2542-2658 Sentence denotes In these situations, studies have often been conducted on compassionate use, and clinical trial approvals expedited.
T34 2659-2778 Sentence denotes This was most recently seen in the 2014–2015 Ebola outbreak, where a variety of clinical trial candidates were studied.
T35 2779-2894 Sentence denotes Many of these therapies failed, but ultimately a vaccine did emerge that was fully protective against the virus 12.
T36 2895-3128 Sentence denotes It is important to note that, unlike the current situation with 2019-nCoV, Ebola had already been studied for years and this particular neutralizing vaccine made and tested in preclinical animal models years prior to the outbreak 13.
T37 3129-3418 Sentence denotes For 2019-nCoV, beyond knowing the sequence of spike (S) protein of the coronavirus (GenBank: MN908947.3), there are no studies on how immunogenic this particular protein will be beyond surrogate comparisons to SARS and MERS, which limits the potential ability to quickly produce a vaccine.
T38 3419-3707 Sentence denotes Moreover, while a vaccine would be greatly effective in helping to stop the spread of 2019-nCoV, an effective therapy is also needed for the patients infected with 2019-nCoV today, similar to the situation of Ebola patients needing effective therapies while vaccines were being developed.
T39 3708-3989 Sentence denotes In this article, I will outline different potential treatment options that could be pursued as a therapy for 2019-nCoV virus, keeping the focus on agents that could be rapidly tested in patients today and broadly effective in spite of limited knowledge of the biology of 2019-nCoV.
T40 3990-4122 Sentence denotes Simply stated, there is limited time for basic studies of 2019-nCoV in research labs, while patients need effective therapies today.
T41 4123-4280 Sentence denotes I finally propose the best potential treatment option in my opinion, along with instructions on how to manufacture the therapy for testing in patients today.
T42 4282-4320 Sentence denotes Treatment strategies against 2019-nCoV
T43 4322-4369 Sentence denotes Developing neutralizing antibodies to 2019-nCoV
T44 4370-4597 Sentence denotes Coronavirus entry starts with the S protein binding to a target receptor on the cell surface, where after fusion is mediated at the cell membrane, delivering the viral nucleocapsid inside the cell for subsequent replication 14.
T45 4598-4803 Sentence denotes The S protein is famous for causing syncytial formation between infected cells and other receptor-bearing cells around them, emphasizing that the S protein does not function in just the virion state alone.
T46 4804-5014 Sentence denotes A neutralizing antibody targeting the S protein on the surface of 2019-nCoV is likely the first therapy contemplated by biomedical researchers in academia and industry, providing passive immunity to disease 15.
T47 5015-5199 Sentence denotes The recently published genome sequence of 2019-nCoV (GenBank: MN908947.3) allows researchers to perform gene synthesis in the lab and consider expressing the S protein as an immunogen.
T48 5200-5492 Sentence denotes Traditional methods of screening mice or rabbits for neutralizing antibodies may be too slow for this outbreak, but faster methods such as using phage or yeast display libraries that express antibody fragments could be used quickly to identify lead candidates for viral neutralization 16, 17.
T49 5493-5673 Sentence denotes The challenge is that any antibody candidate would need to be rigorously tested in cell culture and animal models to confirm that it can neutralize 2019-nCoV and prevent infection.
T50 5674-5861 Sentence denotes Furthermore, several isolates would need to be tested that are circulating in the population to try to assess if sufficient breadth of coverage is obtained with the neutralizing antibody.
T51 5862-6191 Sentence denotes Information from other coronaviruses species like SARS would be helpful as to where to target the best epitope in order to produce neutralizing antibodies (the receptor-binding domain in the S protein is a key target) 18, but again this is a slow and challenging process, which may not yield significant gains for several months.
T52 6192-6366 Sentence denotes Moreover, ultimately a cocktail of antibodies may be required to ensure full protection for patients, which would add additional complexity for formulation and manufacturing.
T53 6367-6600 Sentence denotes Like some of the therapeutic options discussed below, the ability to express any lead candidates in lower organisms for protein expression (bacteria, yeast, insect cells) would facilitate faster production of therapy for patients 19.
T54 6601-6836 Sentence denotes An alternative strategy of generating neutralizing antibodies against 2019-nCoV S protein would be to immunize large animals (sheep, goat, cow) with the 2019-nCoV S protein, and then purifying polyclonal antibodies from the animals 20.
T55 6837-7121 Sentence denotes This strategy may serve an expedited service in the setting of an outbreak and has many advantages such as simplifying production and manufacturing, but has limited guarantees that each animal would produce neutralizing antisera, or what the antibody titer would be in each animal 21.
T56 7122-7284 Sentence denotes Moreover, there is also the human immune response against foreign immunoglobulins to other species, which would potentially complicate any treatment scenarios 22.
T57 7285-7453 Sentence denotes In a truly desperate scenario, this strategy may be viable for a short-term, but would not easily scale in the 2019-nCoV outbreak, which is already rapidly multiplying.
T58 7455-7506 Sentence denotes Using oligonucleotides against 2019-nCoV RNA genome
T59 7507-7619 Sentence denotes Beyond targeting the surface proteins of 2019-nCoV, one could also target the RNA genome itself for degradation.
T60 7620-7883 Sentence denotes This RNA genome sequence of 2019-nCoV was recently published (GenBank: MN908947.3), and one strategy that could be considered then, is the use of small interfering RNA (siRNA) or antisense oligonucleotides (ASO) to combat the virus by targeting its RNA genome 23.
T61 7884-7931 Sentence denotes The challenge with this strategy is multi-fold.
T62 7932-8000 Sentence denotes First, the conserved RNA sequence domains of CoV-2019 are not known.
T63 8001-8138 Sentence denotes Identifying conserved sequences is essential in order to optimize siRNA targeting and avoid viral escape of the oligonucleotide strategy.
T64 8139-8277 Sentence denotes One could look at genome homology of 2019-nCoV to the SARS virus for comparison of conserved sequences, but this would still be guesswork.
T65 8278-8359 Sentence denotes A second challenge is how the oligonucleotides would be delivered into the lungs.
T66 8360-8484 Sentence denotes Advances have been made into delivery vehicles such as lipid nanoparticles that can mediate some delivery into the lungs 24.
T67 8485-8650 Sentence denotes It is unknown, however, if enough siRNA’s or ASO’s would be effectively delivered within the lungs to stop the infection or make a difference in its clinical course.
T68 8651-8867 Sentence denotes For example, if 25% of alveolar epithelial cells in the lung had siRNA or ASO in them, that efficiency might be a great success for traditional gene therapy, but would hardly make any difference in a viral infection.
T69 8868-9023 Sentence denotes Such an explanation is also likely why siRNA candidates against Ebola failed in trials 25, despite significant success in preclinical animal models 26, 27.
T70 9024-9188 Sentence denotes Lastly, even if one assumed that siRNA was effective clinically, there is a limited ability to scale up manufacturing of siRNA drugs to a large infected population.
T71 9189-9342 Sentence denotes Current siRNA and ASO therapies are manufactured for rare diseases, and there are no available resources existing to manufacture the medications quickly.
T72 9344-9397 Sentence denotes Repurposing currently available antiviral medications
T73 9398-9565 Sentence denotes Ideal agents to fight 2019-nCoV would be approved small molecule drugs that could inhibit different aspects of the viral life cycle, ultimately inhibiting replication.
T74 9566-9766 Sentence denotes Two classes of potential targets are viral polymerases 28 and protease inhibitors 29, both of which are components of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) antiviral regimens.
T75 9767-9878 Sentence denotes Pilot clinical studies are already ensuing by desperate clinicians with various repurposed antiviral medicines.
T76 9879-9982 Sentence denotes This has been done in every viral outbreak previously with limited success, outside of case reports 30.
T77 9983-10140 Sentence denotes Indeed, during the Ebola outbreak, none of the repurposed small molecule drugs were definitively shown to improve the clinical course across all patients 31.
T78 10141-10378 Sentence denotes The 2019-nCoV could be different, and there are initial positive reports that lopinavir and ritonavir, which are HIV protease inhibitors, have some clinical efficacy against 2019-nCoV, similar to prior studies using them against SARS 32.
T79 10379-10623 Sentence denotes Research should continue to be undertaken to screen other clinically available antivirals in cell culture models of 2019-nCoV, in hopes that a drug candidate would emerge useful against the virus that could be rapidly implemented in the clinic.
T80 10624-10765 Sentence denotes One promising example could be remdesivir, which interferes with the viral polymerase and has shown efficacy against MERS in mouse models 33.
T81 10766-10874 Sentence denotes For further information, reviews of previous drug repurposing efforts for coronaviruses are provided 34, 35.
T82 10875-11049 Sentence denotes Though these repurposed medications may hold promise, it is still reasonable to pursue novel, 2019-nCoV specific therapies to complement potential repurposed drug candidates.
T83 11051-11107 Sentence denotes Passive antibody transfer from convalescent patient sera
T84 11108-11318 Sentence denotes A simple but potentially very effective tool that can be used in infectious outbreaks is to use the serum of patients who have recovered from the virus to treat patients who contract the virus in the future 36.
T85 11319-11450 Sentence denotes Patients with resolved viral infection will develop a polyclonal antibody immune response to different viral antigens of 2019-nCoV.
T86 11451-11648 Sentence denotes Some of these polyclonal antibodies will likely neutralize the virus and prevent new rounds of infection, and the patients with resolved infection should produce 2019-nCoV antibodies in high titer.
T87 11649-11782 Sentence denotes Patients with resolved cases of 2019-nCoV can simply donate plasma, and then this plasma can be transfused into infected patients 37.
T88 11783-11986 Sentence denotes Given that plasma donation is well established, and the transfusion of plasma is also routine medical care, this proposal does not need any new science or medical approvals in order to be put into place.
T89 11987-12189 Sentence denotes Indeed, the same rationale was used in the treatment of several Ebola patients with convalescent serum during the outbreak in 2014–2015, including two American healthcare workers who became infected 38.
T90 12190-12428 Sentence denotes As the outbreak continues, more patients who survived infection will become available to serve as donors to make antisera for 2019-nCoV, and a sizeable stock of antisera could be developed to serve as a treatment for the sickest patients.
T91 12429-12643 Sentence denotes Unfortunately, the exponential growth of the outbreak would work against this strategy, since the growing number of cases would likely outstrip the ability of previous patients to provide donor plasma as treatment.
T92 12644-12775 Sentence denotes Moreover, convalescent patient sera would have significant variability in the potency of antiviral effect, making it less ideal 37.
T93 12776-12984 Sentence denotes While transfusion medicine services should certainly pursue convalescent patient sera as an option right now for patient treatment, it is ultimately limited in its effective scope of controlling the outbreak.
T94 12986-13022 Sentence denotes Proposal for new 2019-nCoV therapies
T95 13023-13223 Sentence denotes The simplest and most direct approach to combating 2019-nCoV during the outbreak would be one to neutralize the virus from entering cells, the function that antibodies normally perform in the body 39.
T96 13224-13463 Sentence denotes For the reasons mentioned above when discussing neutralizing antibodies, it will be difficult to validate a broadly neutralizing antibody quickly, and a challenge to make sure that the mutating RNA virus will not escape its neutralization.
T97 13464-13615 Sentence denotes A cocktail antibody approach could be undertaken as was explored to treat the Ebola pandemic 40, but would add complexity to the manufacturing process.
T98 13616-13742 Sentence denotes However, there is another strategy to pursue in this scenario that does not rely on targeting the viral glycoprotein directly.
T99 13743-13926 Sentence denotes In this strategy, a neutralizing effect could be obtained by targeting the viral receptor protein on the cell surface, thereby blocking the virus from binding to it and gaining entry.
T100 13927-14025 Sentence denotes Fortunately, scientists have already uncovered the identity of the viral receptor in cell culture.
T101 14026-14234 Sentence denotes A recent pre-print publication found that the 2019-nCoV uses the angiotensin-converting enzyme 2 (ACE2) as a receptor for cell entry 41, which is the same receptor that the SARS coronavirus uses for entry 42.
T102 14235-14390 Sentence denotes For both viruses, the coronavirus binds to ACE2 through its S protein on the virion, where after fusion of the viral membrane and cell membrane will occur.
T103 14391-14538 Sentence denotes Subsequently, the RNA virus will replicate its genome inside the cell, and ultimately make new virions that will be secreted to infect other cells.
T104 14539-14705 Sentence denotes The coincidence of SARS and 2019-nCoV using ACE2 receptor opens up the possibility of using the extensive research studied on SARS entry and applying it to 2019-nCoV.
T105 14706-14867 Sentence denotes Based on the SARS literature, several potential blocking strategies could be considered, which were shown to be effective in preventing infection in SARS models.
T106 14869-14911 Sentence denotes Blocking agents that bind to ACE2 receptor
T107 14912-15007 Sentence denotes The first strategy would consist of administering to patients an agent that would bind to ACE2.
T108 15008-15149 Sentence denotes The key advantage here is that the host ACE2 protein will not change, so there is no concern about escape from binding the therapeutic agent.
T109 15150-15358 Sentence denotes Moreover, the virus will not have the ability to mutate and bind an entirely new host receptor in the time frame of this outbreak; such functional relationships are established by evolution over long periods.
T110 15359-15561 Sentence denotes By analogy, the influenza virus changes the mutations on its surface to escape antibody neutralization every year, but it always focuses on using sialic acid on the cell surface as an entry receptor 43.
T111 15562-15617 Sentence denotes There are two known options for agents to bind to ACE2.
T112 15618-15787 Sentence denotes The first is using the small receptor-binding domain (RBD) from the SARS S protein that has been shown to be the key domain that binds the ACE2 receptor during entry 44.
T113 15788-15917 Sentence denotes Administration of this domain, 193 amino acids in size, has been shown to effectively block the entry of SARS in cell culture 44.
T114 15918-16071 Sentence denotes It is well within reason that SARS RBD could be given to patients, thereby binding their ACE2 proteins on target cells, preventing infection ( Figure 1).
T115 16072-16181 Sentence denotes There is also the potential for the equivalent RBD of 2019-nCoV to be produced and used as a therapy as well.
T116 16182-16551 Sentence denotes This strategy assumes SARS and 2019-nCoV share the same binding site on ACE2, which is highly likely given the similar ACE2 binding sites of SARS and NL63 coronavirus The small size of the therapy, similar in size in nanobody domains from camelid antibodies, would enhance the perfusion of the biologic into tissues to more effectively bind to viral entry receptors 45.
T117 16552-16735 Sentence denotes In regards to the outbreak situation that is ongoing, the small protein facilitates the rapid production of the therapy in bacteria potentially, which would help production yields 19.
T118 16736-16936 Sentence denotes Moreover, bacterial production would allow RBD proteins to be produced in a wide range of production facilities today in China, which already has numerous contract research organization operations 46.
T119 16937-17095 Sentence denotes Alternatively, the RBD protein could be attached to an Fc fragment for extended circulation, which was done for an equivalent 212 amino acid domain from MERS.
T120 17096-17281 Sentence denotes The MERS RBD-Fc fusion demonstrated the ability to block viral infection toward cell receptors, as well as to stimulate an immune response against that specific viral domain in mice 47.
T121 17282-17457 Sentence denotes Of note, since the RBD-Fc fusion would bind to normal cells, one would want to eliminate cytotoxic Fc domain functions through mutations that eliminate Fc receptor binding 48.
T122 17458-17467 Sentence denotes Figure 1.
T123 17469-17547 Sentence denotes Therapeutic agents that could be used to block 2019-nCoV from infecting cells.
T124 17548-17637 Sentence denotes Target cells expressing ACE2 include lung and gastrointestinal tissues in the human body.
T125 17638-17751 Sentence denotes The large spike protein on the surface of the coronavirus binds to ACE2 on infected cells, leading to cell entry.
T126 17752-17832 Sentence denotes Three proposed strategies would block this interaction would abrogate infection.
T127 17833-18000 Sentence denotes In the first, the receptor-binding domain (RBD) of the spike protein from SARS or 2019-nCoV would be administered, thereby binding ACE2 and saturating available sites.
T128 18001-18127 Sentence denotes Alternatively, an antibody or single chain antibody fragment (scFv) could be administered against ACE2 to accomplish the same.
T129 18128-18263 Sentence denotes A third strategy would target the coronavirus virions directly by using the ACE2 extracellular domain as bait to bind to spike protein.
T130 18264-18356 Sentence denotes An Fc domain fused to ACE2 would facilitate prolonged circulation of the biologic (ACE2-Fc).
T131 18357-18503 Sentence denotes A second, similar strategy would be to administer an antibody that would bind to ACE2 protein, thereby preventing 2019-nCoV infection ( Figure 1).
T132 18504-18594 Sentence denotes This strategy was shown to effectively block SARS entry and replication in experiments 42.
T133 18595-18771 Sentence denotes While no ACE2 antibody sequences are published in literature indexes, monoclonal antibodies do exist and the associated hybridoma sequences could be cloned in a matter of days.
T134 18772-18923 Sentence denotes There would be no concern for any viral escape from an ACE2 binding antibody, which is an advantage over neutralizing approaches against the S protein.
T135 18924-19029 Sentence denotes There are a couple of design considerations when thinking about how to employ the ACE2 antibody strategy.
T136 19030-19181 Sentence denotes Any effector functions would need to be removed from the Fc domain 49, such that inflammation would not be caused in different tissues expressing ACE2.
T137 19182-19276 Sentence denotes This would retain the long-half life endowed by the Fc domain without any of the side effects.
T138 19277-19519 Sentence denotes The downside of including the Fc domain is the need to use a more expensive mammalian cell production system to preserve proper glycosylation, which would decrease the turnaround time for getting the drug to patients in the outbreak scenario.
T139 19520-19620 Sentence denotes Alternatively, one could just administer a single chain variable fragment (scFv) that binds to ACE2.
T140 19621-19695 Sentence denotes A nanobody or VHH domains from camelids are another option as well 50, 51.
T141 19696-19808 Sentence denotes These could be produced in bacteria, and its small size would allow for rapid permeation into different tissues.
T142 19809-19888 Sentence denotes The downside is the shorter half-life of these molecules without the Fc domain.
T143 19889-19940 Sentence denotes There are several limitations to these two options.
T144 19941-20225 Sentence denotes Regarding the SARS RBD strategy, the body would likely develop an immune response to the SARS protein eventually, although the key intervention period of infection to combat 2019-nCoV would fall under this window of time, where after an immune response for both viruses would develop.
T145 20226-20429 Sentence denotes Alternatively, if one were to use the homologous RBD from 2019-nCoV itself, this immune response would likely be very advantageous since it could yield both a blocking effect and a vaccination effect 52.
T146 20430-20659 Sentence denotes For both strategies, the dose that would be needed to block ACE2 receptors in the body across different organs is unknown, and as is the percentage of ACE2 receptors that would need to be saturated in order to slow the infection.
T147 20660-20869 Sentence denotes The number of ACE2 receptors in the body, which are found in lung and gastrointestinal organs along with vascular endothelial cells among other tissues 53, could ultimately prove prohibitive for this strategy.
T148 20870-21019 Sentence denotes Moreover, the turnover of the ACE2 receptor on the cell surface would also influence how often the therapeutic protein would need to be administered.
T149 21020-21197 Sentence denotes To solve this issue, one could increase the concentration of anti-ACE2 therapy at the crucial site of infection in the lungs, via local administration to lungs via nebulization.
T150 21198-21323 Sentence denotes Lastly, there is the possibility that binding ACE2 directly could paradoxically worsen lung physiology and clinical symptoms.
T151 21324-21538 Sentence denotes A study found that a fusion protein of SARS RBD to Fc domain bound ACE2 in murine lung tissue after administration, exacerbating alveolar edema via ACE2 interaction, which normally counteracts acute lung injury 54.
T152 21539-21706 Sentence denotes This suggests that if one were use an ACE2 binding strategy, it would be best employed early during infection or as a prophylaxis to block the initial viral infection.
T153 21707-21796 Sentence denotes Ultimately, clinical trials in patients would need to investigate these potential issues.
T154 21798-21825 Sentence denotes ACE2 immunoadhesin strategy
T155 21826-22000 Sentence denotes A potentially more promising strategy would be to create an antibody-like molecule that would bind to the coronavirus itself, rather than shielding cells from being infected.
T156 22001-22170 Sentence denotes For this strategy, it is proposed to use a soluble version of the ACE2 receptor that would bind to the S protein of 2019-nCoV thereby neutralizing the virus ( Figure 1).
T157 22171-22257 Sentence denotes Again, the research on the SARS virus suggests this strategy is potentially promising.
T158 22258-22356 Sentence denotes Soluble ACE2 receptor was demonstrated to block the SARS virus from infecting cells in culture 42.
T159 22357-22556 Sentence denotes The reported affinity of soluble ACE2 for the SARS S protein was 1.70 nM, which is comparable to the affinities of monoclonal antibodies 55; it is likely that 2019-nCoV has similar affinity for ACE2.
T160 22557-22873 Sentence denotes In order to use ACE2 as a therapy to treat patients, it would be advisable to convert soluble ACE2 into an immunoadhesin format fused to an immunoglobulin Fc domain (ACE2-Fc), thereby extending the lifespan of the circulating molecule, while also recruiting effector functions of the immune system against the virus.
T161 22874-23123 Sentence denotes While not tested in an animal model, a previous study demonstrated that an ACE2 extracellular domain fused to the human IgG1 domain (ACE2-NN-Ig) was effective in neutralizing SARS coronavirus in vitro, with a 50% inhibitory concentration of 2 nM 56.
T162 23124-23242 Sentence denotes This study provides evidence then that ACE2-Fc could similarly inhibit 2019-nCoV in vitro and potentially in patients.
T163 23243-23409 Sentence denotes An additional advantage of using ACE2 as a 2019-nCoV S protein neutralizing agent is that ACE2 administration could also directly treat the pneumonia pathophysiology.
T164 23410-23579 Sentence denotes A portion of patients with SARS and 2019-nCoV infection develop pneumonia, which is characterized by pulmonary edema and acute respiratory distress syndrome (ARDS) 1, 2.
T165 23580-23751 Sentence denotes The viruses may, in part, cause ARDS through viral-induced ACE2 protein shedding and ACE2 protein decreased expression, both of which are mediated by S protein binding 54.
T166 23752-23954 Sentence denotes Administration of recombinant ACE2 protein has been shown to improve acute lung injury through decreasing angiotensin II levels and the hormones subsequent binding to angiotensin II type 1a receptor 57.
T167 23955-24066 Sentence denotes Recombinant ACE2 can also reduce ARDS in respiratory syncytial virus 58 and H5N1 influenza 59 infection models.
T168 24067-24226 Sentence denotes Based on these promising preclinical studies, recombinant human ACE2 (rhACE2) was moved into clinical trials in order to treat ARDS in critically ill patients.
T169 24227-24335 Sentence denotes A phase I trial demonstrated rhACE2 was well tolerated with no effects seen on the cardiovascular system 60.
T170 24336-24489 Sentence denotes A phase II trial demonstrated on-target efficacy in reducing Ang1-8 peptide levels, but did not show significant modulation of respiratory parameters 61.
T171 24490-24706 Sentence denotes It remains to be seen whether rhACE2 administration has the same clinical benefits in treating ARDS that have been seen in animal models, and whether ACE2-Fc administration could alleviate ARDS in 2019-nCoV patients.
T172 24707-24870 Sentence denotes The proposed therapy for 2019-nCoV patients would consist of the extracellular domain of the ACE2 protein fused to a human immunoglobulin G Fc domain ( Figure 2A).
T173 24871-25057 Sentence denotes Studies have shown that the ACE2 amino acids 18 – 615 appear to be sufficient for SARS S protein binding 62, which also covers the peptidase domain necessary for ACE2 enzymatic function.
T174 25058-25254 Sentence denotes It is possible a smaller portion of the extracellular ACE2 domain would be adequate for S protein binding, although a smaller version would lack enzyme activity beneficial in treating lung injury.
T175 25255-25401 Sentence denotes Further studies are needed to define the minimal ACE2 domain necessary for 2019-nCoV S protein binding to construct even smaller ACE2-Fc proteins.
T176 25402-25647 Sentence denotes While we do not know the structure of the 2019-nCoV S protein or how it binds to the ACE2 receptor yet, it is reasonable for now to assume that the same ACE2 protein domains utilized by the SARS virus are also bound by 2019-nCoV to infect cells.
T177 25648-25657 Sentence denotes Figure 2.
T178 25659-25750 Sentence denotes TherapeuticDesign of the ACE2-Fc fusion protein as a therapy against 2019-nCoV coronavirus.
T179 25751-25869 Sentence denotes ( A) The extracellular domain of ACE2 is appended onto the human immunoglobulin Fc domain, including the hinge region.
T180 25870-26001 Sentence denotes The Fc domain facilitates dimerization of two ACE2 domains. ( B) The amino acid sequence of the ACE2-Fc fusion protein is provided.
T181 26002-26102 Sentence denotes The ACE2 domain consists of amino acids 18–615 of the human ACE2 protein (blue; UniProtKB - Q9BYF1).
T182 26103-26212 Sentence denotes The sequence of the human immunoglobulin G isotype 1 constant region is provided (green; UniProtKB - P01857).
T183 26213-26312 Sentence denotes A secretion signal from a human immunoglobin heavy chain is provided (red; UniProtKB - A0A0C4DH39).
T184 26313-26510 Sentence denotes The advantage of the Fc domain is endowing a longer-half life of the drug, which could enable healthcare workers to potentially be given drug doses prophylactically before seeing infected patients.
T185 26511-26716 Sentence denotes Indeed, the half-life of recombinant ACE2 was extended from less than two hours to over one week in mice when formatted as a recombinant ACE2-Fc therapy in a study evaluating treatment for hypertension 63.
T186 26717-27004 Sentence denotes One difference from the prior blocking agent strategies is that the effector functions of the Fc domain could be retained in this molecule, allowing recruitment of dendritic cells, macrophages, and natural killer cells through the CD16 receptor against viral particles or infected cells.
T187 27005-27311 Sentence denotes This may facilitate faster activation of the host antiviral immune response and elimination of the virus, which was illustrated in a SARS mouse model where Fc engaging antibodies were more potent in eliminating SARS via activation of phagocytic cells compared to antibodies that neutralized virus alone 64.
T188 27312-27646 Sentence denotes Overall, the ACE2-Fc fusion protein would have many of the same benefits of a traditional neutralizing antibody that would be sought as a treatment for the infection, but represent one with maximal breadth and potency since the 2019-nCoV could not escape its neutralization, given the same protein is also its receptor for cell entry.
T189 27647-27885 Sentence denotes Indeed, it has been shown that the pathogenicity of SARS versus the more mild human coronavirus NL63 was related to a lower affinity of NL63 for human ACE2 versus SARS, with NL63 S protein reducing ACE2 levels less than SARS S protein 65.
T190 27886-28022 Sentence denotes Therefore, if 2019-nCoV were to try to escape ACE2 neutralization via decreasing affinity, it would mutate into a less pathogenic virus.
T191 28023-28194 Sentence denotes This is similar to the re-emergent SARS virus in 2003-2004, which had lower affinity for human ACE2 and resulted in less severe infection and no secondary transmission 66.
T192 28195-28344 Sentence denotes Thus, 2019-nCoV could be presented with an evolutionary trap when faced with potential ACE2-Fc therapy, leading toward a more benign clinical course.
T193 28345-28573 Sentence denotes To give some additional support to the potential of a receptor-immunoadhesin being a potential antiviral strategy, it should be noted that CD4-Fc or CD4-IgG was one of the early agents developed as a potential HIV medication 67.
T194 28574-28704 Sentence denotes The protein contained the first two domains of the CD4 receptor that are known to bind gp120 on the surface of infected HIV cells.
T195 28705-28772 Sentence denotes CD4-IgG was shown to neutralize HIV in vitro, preventing infection.
T196 28773-28897 Sentence denotes The protein was also safe when administered in patients, although only limited-to-mild clinical benefit was achieved 68, 69.
T197 28898-29236 Sentence denotes Updated enhanced versions of CD4-IgG have been developed that additionally have a small peptide derived from the co-receptor, CCR5, enhancing affinity and giving even more potent neutralizing activity, essentially 100% of HIV isolates and making rhesus macaques resistant to multiple simian-human immunodeficiency virus challenges 70, 71.
T198 29237-29450 Sentence denotes While HIV and 2019-nCoV are very different viruses, with different cell types, kinetics, and clinical courses, the previous results with HIV are encouraging that this could be a therapeutic strategy for 2019-nCoV.
T199 29451-29683 Sentence denotes If anything, 2019-nCoV is likely more amenable to this neutralizing therapy given that the respiratory virus will only cause an acute infection, unlike HIV, which causes chronic infection in hosts with different cellular reservoirs.
T200 29684-29907 Sentence denotes One potential limitation of the ACE2-Fc strategy is that the increase in levels of extracellular ACE2 could have unknown effects on the body, particularly when elevated for a prolonged time via Fc domain extended half-life.
T201 29908-30054 Sentence denotes Small levels of extracellular ACE2 are already secreted by tissues, so the circulation of this extracellular domain would not be unprecedented 72.
T202 30055-30275 Sentence denotes Moreover, recombinant ACE2 protein was well-tolerated by healthy patients in a phase I trial, and by patients with lung injury in a phase II trial, suggesting treating 2019-nCoV patients with ACE2-Fc will also tolerated.
T203 30276-30502 Sentence denotes If investigators are still concerned, critical amino acid(s) for ACE2 peptidase activity could be mutated to abolish the native function of this sequence, while retaining high affinity binding for SARS and 2019-nCoV S protein.
T204 30503-30795 Sentence denotes Indeed, this possibility was previously investigated in generating an ACE2 and IgG1 fusion protein, which showed that mutation of histidine residues at position 374 and 378 of the ACE2 extracellular domain abolished peptidase activity, but retained high affinity binding to SARS S protein 56.
T205 30796-31015 Sentence denotes Of course, ACE2 peptidase mutation would eliminate the beneficial effects from the recombinant protein delivery of ACE2 in treating lung injury, so it is recommended that retaining ACE2 enzyme activity be pursued first.
T206 31016-31248 Sentence denotes Another potential concern is that receptor binding via an antibody format could inadvertently direct 2019-nCoV toward infecting Fc receptor (CD16) positive cells, which has been shown in vitro for neutralizing antibodies in MERS 73.
T207 31249-31351 Sentence denotes It’s unclear what clinical significance this would have, and to what extent this would happen in vivo.
T208 31352-31455 Sentence denotes Ultimately, clinical trials will be needed to delineate any specific side effects of ACE2-Fc treatment.
T209 31457-31483 Sentence denotes Action plan and discussion
T210 31484-31649 Sentence denotes The chief objective of global health efforts against 2019-nCoV remains to effectively quarantine patients and screen individuals who may be infected to limit spread.
T211 31650-31695 Sentence denotes That objective should continue going forward.
T212 31696-31878 Sentence denotes What is proposed here is an option to at least give infected patients a medication quickly to help alleviate symptoms and prevent death, while vaccine efforts for 2019-nCoV continue.
T213 31879-32069 Sentence denotes This could be enabled through ACE2-Fc providing a triple mechanism of action: (1) Treatment of ACE2 deficiency and lung injury, (2) virus neutralization, and (3) immune effector recruitment.
T214 32070-32182 Sentence denotes Beyond infected patients, ACE2-Fc could provide passive immunity to healthcare works at risk as another benefit.
T215 32183-32389 Sentence denotes Going forward, it is recommended that physicians, scientists, and biotech industry in China and elsewhere pursue manufacturing an ACE2-Fc biologic agent right now, which can immediately advance into trials.
T216 32390-32544 Sentence denotes A variety of different protein expression platforms (CHO, insect, yeast) could be utilized, depending on the particular contract manufacturer’s expertise.
T217 32545-32755 Sentence denotes Gene therapy could even be considered to make ACE2-Fc from a DNA or mRNA platform, but would have additional risk of uncertain delivery strategies and ultimately may slow down progress toward treating patients.
T218 32756-33050 Sentence denotes The goal would be that ACE2-Fc could treat infection in current patients preventing significant morbidities and death, while also serving as a potential prophylactic to give passive immunity to clinical providers on the frontlines, as well as individuals who may have been exposed to the virus.
T219 33051-33263 Sentence denotes Essentially, ACE2-Fc could be the potent neutralizing antibody that the global health community needs to combat 2019-nCoV, today, while also treating the underlying ARDS pathophysiology causing patient mortality.
T220 33264-33390 Sentence denotes It could be scaled much more quickly than convalescent patient sera, which would be dependent on infected individuals to make.
T221 33391-33547 Sentence denotes ACE2-Fc would be resistant to viral escape as well, unlike potential neutralizing monoclonal antibodies that may be developed in the coming weeks to months.
T222 33548-33785 Sentence denotes While a therapeutic strategy is being outlined here, the long-term goal of 2019-nCoV research would remain developing an effective vaccine to yield neutralizing antibodies, likely based on the S protein and specifically, the RBD protein.
T223 33786-33980 Sentence denotes Such trials should happen as soon as possible, but may prove to be challenging to get the right level of immunogenicity, antigen presentation, adjuvant addition, and potent antibody stimulation.
T224 33981-34075 Sentence denotes The virus could continue mutating, foiling different efforts to stimulate protective immunity.
T225 34076-34205 Sentence denotes By comparison, 2019-nCoV cannot escape the ACE2-Fc treatment strategy, since it leverages its own cognate receptor for infection.
T226 34206-34416 Sentence denotes As mentioned above, should 2019-nCoV attempt to escape this therapy via reduced ACE2 affinity binding, it would likely become less pathogenic, similar to the comparison of SARS versus human coronavirus NL63 65.
T227 34417-34683 Sentence denotes Lastly, scaling the dose of any effective vaccine would also prove to be challenging depending on the vector format (e.g. viral vector versus mRNA versus protein), and even a fully protective vaccine would not help patients who are currently infected with the virus.
T228 34684-34836 Sentence denotes In an effort to help aide researchers and industry in China to combat 2019-nCoV, the protein sequence of the ACE2-Fc construct is provided ( Figure 2B).
T229 34837-35007 Sentence denotes Different human Fc domains (IgG1, IgG2, IgG3, or IgG4) could be contemplated, although IgG1 traditionally has the most potency for triggering anti-microbial responses 49.
T230 35008-35104 Sentence denotes Similarly, an ACE2-Fc biologic without active ACE2 peptidase function could be explored as well.
T231 35105-35307 Sentence denotes Given that gene synthesis of this sequence could happen within a week, the gene could be placed within the protein expression platform of choice shortly thereafter leading to protein production quickly.
T232 35308-35522 Sentence denotes The availability of protein A columns and other techniques in the industry to purify antibodies would facilitate ACE2-Fc to quickly be repurposed on existing antibody manufacturing infrastructure existing in China.
T233 35523-35787 Sentence denotes A final benefit of pursuing ACE2-Fc is that it could effectively be used as a therapeutic drug stockpile for future outbreaks of SARS and 2019-nCoV, and any new coronavirus that emerges from a zoonotic reservoir in the future that uses the ACE2 receptor for entry.
T234 35788-35930 Sentence denotes Moreover, coronaviruses that replicate in animals across China and other countries could be studied in order to assess their entry mechanisms.
T235 35931-36140 Sentence denotes By understanding entry in these other animals, one could effectively predict a receptor that could be utilized in any zoonotic transmission event, and build a new receptor immunoadhesin molecule in the future.
T236 36141-36276 Sentence denotes As an example, a similar immunoadhesin, DPP4-Fc, could be envisioned for MERS based on the viral receptor, DPP4, used by that virus 74.
T237 36277-36394 Sentence denotes Beyond coronaviruses, this strategy could be utilized for other viruses where the risk of outbreak potential is high.
T238 36395-36553 Sentence denotes ACE2-Fc could also find use in treating ARDS for other unrelated viruses and causes of acute lung injury, building on the previous clinical trial work 60, 61.
T239 36554-36826 Sentence denotes In summary, ACE2-Fc has the potential to be the neutralizing antibody that healthcare workers need to treat and prevent 2019-nCoV infection today and could play an important role in the cessation of the outbreak if manufacturing based on an available sequence starts soon.
T240 36827-36975 Sentence denotes An alternative 2019-nCoV RBD-Fc fusion could also be pursued, if one desired the dual function of receptor blocking and vaccination in one molecule.
T241 36977-36994 Sentence denotes Data availability
T242 36996-37011 Sentence denotes Underlying data
T243 37012-37053 Sentence denotes No data are associated with this article.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 42-51 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T3 133-142 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T4 1024-1029 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T5 1031-1036 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T6 1042-1049 Phenotype denotes myalgia http://purl.obolibrary.org/obo/HP_0003326
T7 1053-1060 Phenotype denotes fatigue http://purl.obolibrary.org/obo/HP_0012378
T8 1066-1075 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T9 1473-1478 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T10 9690-9706 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T11 9723-9732 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T12 21462-21467 Phenotype denotes edema http://purl.obolibrary.org/obo/HP_0000969
T13 21517-21534 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T14 23383-23392 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T15 23474-23483 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T16 23511-23526 Phenotype denotes pulmonary edema http://purl.obolibrary.org/obo/HP_0100598
T17 23537-23557 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T18 23821-23838 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T19 26700-26712 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T20 28144-28160 Phenotype denotes severe infection http://purl.obolibrary.org/obo/HP_0032169
T21 29195-29211 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T22 29621-29638 Phenotype denotes chronic infection http://purl.obolibrary.org/obo/HP_0031035
T23 36482-36499 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320