PMC:7029759 / 19650-20537 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
419	47-56	Species	denotes	2019-nCoV	Tax:2697049
438	103-107	Gene	denotes	ACE2	Gene:59272
439	236-240	Gene	denotes	ACE2	Gene:59272
440	495-499	Gene	denotes	ACE2	Gene:59272
441	594-598	Gene	denotes	scFv	Gene:652070
442	630-634	Gene	denotes	ACE2	Gene:59272
443	817-821	Gene	denotes	ACE2	Gene:59272
444	878-882	Gene	denotes	ACE2	Gene:59272
445	780-785	Gene	denotes	spike	Gene:43740568
446	419-424	Gene	denotes	spike	Gene:43740568
447	179-184	Gene	denotes	spike	Gene:43740568
448	157-162	Species	denotes	human	Tax:9606
449	215-226	Species	denotes	coronavirus	Tax:11118
450	446-455	Species	denotes	2019-nCoV	Tax:2697049
451	693-704	Species	denotes	coronavirus	Tax:11118
452	735-739	Gene	denotes	ACE2	Gene:59272
453	244-252	Disease	denotes	infected	MESH:D007239
454	353-362	Disease	denotes	infection	MESH:D007239
455	438-442	Disease	denotes	SARS	MESH:D045169

Id	Subject	Object	Predicate	Lexical cue
T735	12-18	CHEBI:52217;CHEBI:52217	denotes	agents
T734	47-56	SP_7	denotes	2019-nCoV
T733	92-102	GO:0010467	denotes	expressing
T732	103-107	G_3;PG_10;PR:000003622	denotes	ACE2
T731	116-120	UBERON:0002048	denotes	lung
T730	125-141	UBERON:0001555	denotes	gastrointestinal
T729	142-149	UBERON:0000479	denotes	tissues
T728	157-162	SP_6;NCBITaxon:9606	denotes	human
T727	200-207	GO:0009986	denotes	surface
T726	215-226	NCBITaxon:11118	denotes	coronavirus
T725	236-240	G_3;PG_10;PR:000003622	denotes	ACE2
T724	271-281	GO:0035376	denotes	cell entry
T723	399-405	SO:0000417	denotes	domain
T722	438-442	SP_10	denotes	SARS
T721	446-455	SP_7	denotes	2019-nCoV
T720	495-499	G_3;PG_10;PR:000003622	denotes	ACE2
T719	550-558	GO:0042571	denotes	antibody
T718	562-568	SO:0000984	denotes	single
T717	575-583	GO:0042571	denotes	antibody
T716	630-634	G_3;PG_10;PR:000003622	denotes	ACE2
T715	693-704	NCBITaxon:11118	denotes	coronavirus
T714	735-739	G_3;PG_10;PR:000003622	denotes	ACE2
T713	740-753	GO:0005576	denotes	extracellular
T712	754-760	SO:0000417	denotes	domain
T711	801-807	SO:0000417	denotes	domain
T710	817-821	G_3;PG_10;PR:000003622	denotes	ACE2
T709	878-882	G_3;PG_10;PR:000003622	denotes	ACE2

Id	Subject	Object	Predicate	Lexical cue	fma_id
T105	72-77	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T106	86-91	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T107	116-120	Body_part	denotes	lung	http://purl.org/sig/ont/fma/fma7195
T108	142-149	Body_part	denotes	tissues	http://purl.org/sig/ont/fma/fma9637
T109	157-167	Body_part	denotes	human body	http://purl.org/sig/ont/fma/fma305853
T110	185-192	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T111	253-258	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T112	271-275	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T113	425-432	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T114	550-558	Body_part	denotes	antibody	http://purl.org/sig/ont/fma/fma62871
T115	575-583	Body_part	denotes	antibody	http://purl.org/sig/ont/fma/fma62871
T116	786-793	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T8	116-120	Body_part	denotes	lung	http://purl.obolibrary.org/obo/UBERON_0002048

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T58	353-362	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T59	438-442	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091

Id	Subject	Object	Predicate	Lexical cue
T168	72-77	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T169	86-91	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T170	116-120	http://purl.obolibrary.org/obo/UBERON_0002048	denotes	lung
T171	116-120	http://www.ebi.ac.uk/efo/EFO_0000934	denotes	lung
T172	157-162	http://purl.obolibrary.org/obo/NCBITaxon_9606	denotes	human
T173	253-258	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T174	271-275	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T175	659-660	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T176	798-800	http://purl.obolibrary.org/obo/CLO_0052676	denotes	Fc
T177	883-885	http://purl.obolibrary.org/obo/CLO_0052676	denotes	Fc

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T75	185-192	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T76	425-432	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T77	786-793	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080

Id	Subject	Object	Predicate	Lexical cue
T123	0-78	Sentence	denotes	Therapeutic agents that could be used to block 2019-nCoV from infecting cells.
T124	79-168	Sentence	denotes	Target cells expressing ACE2 include lung and gastrointestinal tissues in the human body.
T125	169-282	Sentence	denotes	The large spike protein on the surface of the coronavirus binds to ACE2 on infected cells, leading to cell entry.
T126	283-363	Sentence	denotes	Three proposed strategies would block this interaction would abrogate infection.
T127	364-531	Sentence	denotes	In the first, the receptor-binding domain (RBD) of the spike protein from SARS or 2019-nCoV would be administered, thereby binding ACE2 and saturating available sites.
T128	532-658	Sentence	denotes	Alternatively, an antibody or single chain antibody fragment (scFv) could be administered against ACE2 to accomplish the same.
T129	659-794	Sentence	denotes	A third strategy would target the coronavirus virions directly by using the ACE2 extracellular domain as bait to bind to spike protein.
T130	795-887	Sentence	denotes	An Fc domain fused to ACE2 would facilitate prolonged circulation of the biologic (ACE2-Fc).